NP-MRD: Showing NP-Card for (6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid (NP0182269)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-03 20:54:50 UTC

Updated at

2022-09-03 20:54:50 UTC

NP-MRD ID

NP0182269

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid

Description

Macamide belongs to the class of organic compounds known as n-acyl amines. N-acyl amines are compounds containing a fatty acid moiety linked to an amine group through an ester linkage. Thus, macamide is considered to be a fatty amide. (6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid is found in Lepidium meyenii. (6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid was first documented in 2021 (PMID: 34606547). Based on a literature review a small amount of articles have been published on Macamide (PMID: 35566104) (PMID: 35190953) (PMID: 35026191) (PMID: 34604630).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309032222542D          

 28 28  0  0  0  0            999 V2000
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  4  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
M  END

     RDKit          3D

 65 65  0  0  0  0  0  0  0  0999 V2000
   -8.2906   -2.8907   -0.5744 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4848   -1.8250   -1.6004 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5715   -0.6199   -1.3818 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7935    0.0263   -0.0796 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9842    1.2035    0.2781 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5611    1.0474    0.5284 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7141    0.4752   -0.5510 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2611    0.5783   -0.0263 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2918    0.0237   -1.0239 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9283    0.1474   -0.4777 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6458    0.6803    0.7172 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7216    0.7647    1.1808 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9741    1.2942    2.3558 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3192    1.4188    2.9021 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5044    1.9365    4.0291 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5009    0.9470    2.1611 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2344    2.0499    1.4299 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4215    1.4349    0.7136 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3408    0.7825    1.6534 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8962    1.5693    2.6669 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6130   -0.4612    1.5342 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0663   -1.3058    0.5084 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8766   -1.2028   -0.7337 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9831   -0.3792   -0.8313 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6879   -0.3430   -2.0234 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3391   -1.0940   -3.1302 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2350   -1.9116   -3.0237 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5266   -1.9487   -1.8268 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8052   -2.7041    0.3855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2191   -3.1774   -0.4613 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.7826   -3.8203   -0.9895 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3091   -2.2585   -2.6051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5530   -1.5008   -1.5588 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9479    0.1223   -2.1750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5745   -0.9094   -1.6692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8723    0.3208    0.0795 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6789   -0.8059    0.7037 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0949    1.9990   -0.5362 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4221    1.7384    1.1894 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1641    2.0989    0.7882 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3482    0.4982    1.5092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8191    0.8639   -1.5408 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8293   -0.6635   -0.5681 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1724    0.0186    0.9193 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0259    1.6417    0.1744 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4989   -1.0788   -1.1145 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4044    0.4716   -2.0252 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0462   -0.2015   -1.0379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4557    1.0429    1.3222 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5278    0.4022    0.5788 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1411    1.6683    2.9737 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2409    0.5627    2.9252 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2888    0.0706    1.5196 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5390    2.7889    2.1880 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5883    2.4818    0.6364 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9890    2.3103    0.2734 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0905    0.8477   -0.1351 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3670    1.1721    3.4628 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1819   -2.3668    0.8966 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9960   -1.1054    0.3426 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.2546    0.2077    0.0346 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.5587    0.2998   -2.1114 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.9250   -1.0381   -4.0598 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9551   -2.5000   -3.8783 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6664   -2.6158   -1.8118 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 21  2  0
 21 22  1  0
 22 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 28 23  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
  2 32  1  0
  2 33  1  0
  3 34  1  0
  3 35  1  0
  4 36  1  0
  4 37  1  0
  5 38  1  0
  5 39  1  0
  6 40  1  0
  6 41  1  0
  7 42  1  0
  7 43  1  0
  8 44  1  0
  8 45  1  0
  9 46  1  0
  9 47  1  0
 10 48  1  0
 11 49  1  0
 12 50  1  0
 13 51  1  0
 16 52  1  0
 16 53  1  0
 17 54  1  0
 17 55  1  0
 18 56  1  0
 18 57  1  0
 20 58  1  0
 22 59  1  0
 22 60  1  0
 24 61  1  0
 25 62  1  0
 26 63  1  0
 27 64  1  0
 28 65  1  0
M  END


  Mrv1652309032222542D          

 28 28  0  0  0  0            999 V2000
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  4  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 23 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0182269

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCCCCC\C=C\C=C\C(=O)CCCC(O)=NCC1=CC=CC=C1

> <INCHI_IDENTIFIER>
InChI=1S/C25H37NO2/c1-2-3-4-5-6-7-8-9-10-11-15-19-24(27)20-16-21-25(28)26-22-23-17-13-12-14-18-23/h10-15,17-19H,2-9,16,20-22H2,1H3,(H,26,28)/b11-10+,19-15+

> <INCHI_KEY>
DKMGVACNAAKVRR-MRBSYODNSA-N

> <FORMULA>
C25H37NO2

> <MOLECULAR_WEIGHT>
383.576

> <EXACT_MASS>
383.282429435

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
47.701315129830675

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(6E,8E)-N-benzyl-5-oxooctadeca-6,8-dienimidic acid

> <JCHEM_LOGP>
7.563214911666667

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.165041143957391

> <JCHEM_PKA_STRONGEST_BASIC>
4.022464872093561

> <JCHEM_POLAR_SURFACE_AREA>
49.66

> <JCHEM_REFRACTIVITY>
120.9901

> <JCHEM_ROTATABLE_BOND_COUNT>
16

> <JCHEM_RULE_OF_FIVE>
0

> <JCHEM_TRADITIONAL_IUPAC>
(6E,8E)-N-benzyl-5-oxooctadeca-6,8-dienimidic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0      10.669 -21.560   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      12.003 -20.790   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      13.337 -21.560   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      14.670 -20.790   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      16.004 -21.560   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      17.338 -20.790   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      18.672 -21.560   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      20.005 -20.790   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      21.339 -21.560   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      22.673 -20.790   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      24.006 -21.560   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      25.340 -20.790   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      26.674 -21.560   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      28.007 -20.790   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      28.007 -19.250   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0      29.341 -21.560   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      30.675 -20.790   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      32.008 -21.560   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      33.342 -20.790   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      33.342 -19.250   0.000  0.00  0.00           O+0
HETATM   21  N   UNK     0      34.676 -21.560   0.000  0.00  0.00           N+0
HETATM   22  C   UNK     0      36.009 -20.790   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      37.343 -21.560   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      38.677 -20.790   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      40.010 -21.560   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      40.010 -23.100   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      38.677 -23.870   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      37.343 -23.100   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   23                                                       
MASTER        0    0    0    0    0    0    0    0   28    0   56    0
END

View in JSmol

Synonyms

Value	Source
Macamide 2	MeSH
N-Benzyl-5-oxo-6E,8E-octadecadienamide	MeSH
N-Benzyl-5-oxo-6,8-octadecadienamide	MeSH
N-Benzyl-5-oxo-6E, 8E-octadecadienamide	MeSH

Chemical Formula

C₂₅H₃₇NO₂

Average Mass

383.5760 Da

Monoisotopic Mass

383.28243 Da

IUPAC Name

(6E,8E)-N-benzyl-5-oxooctadeca-6,8-dienimidic acid

Traditional Name

(6E,8E)-N-benzyl-5-oxooctadeca-6,8-dienimidic acid

CAS Registry Number

Not Available

SMILES

CCCCCCCCC\C=C\C=C\C(=O)CCCC(O)=NCC1=CC=CC=C1

InChI Identifier

InChI=1S/C25H37NO2/c1-2-3-4-5-6-7-8-9-10-11-15-19-24(27)20-16-21-25(28)26-22-23-17-13-12-14-18-23/h10-15,17-19H,2-9,16,20-22H2,1H3,(H,26,28)/b11-10+,19-15+

InChI Key

DKMGVACNAAKVRR-MRBSYODNSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Lepidium meyenii	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as n-acyl amines. N-acyl amines are compounds containing a fatty acid moiety linked to an amine group through an ester linkage.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty amides

Direct Parent

N-acyl amines

Alternative Parents

Substituents

Monocyclic benzene moiety
N-acyl-amine
Benzenoid
Acryloyl-group
Enone
Alpha,beta-unsaturated ketone
Carboxamide group
Ketone
Secondary carboxylic acid amide
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organic nitrogen compound
Carbonyl group
Organonitrogen compound
Organooxygen compound
Organic oxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	7.56	ChemAxon
pKa (Strongest Acidic)	6.17	ChemAxon
pKa (Strongest Basic)	4.02	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	49.66 Å²	ChemAxon
Rotatable Bond Count	16	ChemAxon
Refractivity	120.99 m³·mol⁻¹	ChemAxon
Polarizability	47.7 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

21378506

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

71770342

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Guo L, Gao Q, Zhu J, Jin X, Yin H, Liu T: A Docosahexaenoic Acid Derivative (N-Benzyl Docosahexaenamide) as a Potential Therapeutic Candidate for Treatment of Ovarian Injury in the Mouse Model. Molecules. 2022 Apr 25;27(9). pii: molecules27092754. doi: 10.3390/molecules27092754. [PubMed:35566104 ]
Yang X, Wang M, Zhou Q, Bai Y, Liu J, Yang J, Li L, Li G, Luo L: Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway. Mol Neurobiol. 2022 May;59(5):2776-2798. doi: 10.1007/s12035-022-02751-4. Epub 2022 Feb 22. [PubMed:35190953 ]
Zhu H, Wang R, Hua H, Cheng Y, Guo Y, Qian H, Du P: The macamide relieves fatigue by acting as inhibitor of inflammatory response in exercising mice: From central to peripheral. Eur J Pharmacol. 2022 Feb 15;917:174758. doi: 10.1016/j.ejphar.2022.174758. Epub 2022 Jan 10. [PubMed:35026191 ]
Yu Z, Li D, Zhai S, Xu H, Liu H, Ao M, Zhao C, Jin W, Yu L: Neuroprotective effects of macamide from maca (Lepidium meyenii Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties. Food Funct. 2021 Oct 4;12(19):9211-9228. doi: 10.1039/d1fo01720a. [PubMed:34606547 ]
Xia C, Deng J, Pan Y, Lin C, Zhu Y, Xiang Z, Li W, Chen J, Zhang Y, Zhu B, Huang Q: Comprehensive Profiling of Macamides and Fatty Acid Derivatives in Maca with Different Postharvest Drying Processes Using UPLC-QTOF-MS. ACS Omega. 2021 Sep 18;6(38):24484-24492. doi: 10.1021/acsomega.1c02926. eCollection 2021 Sep 28. [PubMed:34604630 ]
LOTUS database [Link]

Showing NP-Card for (6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid (NP0182269)

MOL for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

3D MOL for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

3D SDF for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

3D-SDF for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

PDB for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

3D PDB for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

SMILES for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

INCHI for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

Structure for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)

3D Structure for NP0182269 ((6e,8e)-n-benzyl-5-oxooctadeca-6,8-dienimidic acid)