NP-MRD: Showing NP-Card for (1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione (NP0181798)

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Record Information

Version

2.0

Created at

2022-09-03 20:22:51 UTC

Updated at

2022-09-03 20:22:51 UTC

NP-MRD ID

NP0181798

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione

Description

Isowalsuranolide belongs to the class of organic compounds known as steroid lactones. These are sterol lipids containing a lactone moiety linked to the steroid skeleton. (1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione is found in Walsura yunnanensis. Based on a literature review very few articles have been published on Isowalsuranolide.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309032222222D          

 33 38  0  0  1  0            999 V2000
    5.2038    1.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4904    1.1884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2063    1.9630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0222    0.5577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8343    0.7029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7419   -0.2182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9298   -0.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3979    0.2673    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1176   -0.5086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6782    1.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652309032222222D          

 33 38  0  0  1  0            999 V2000
    5.2038    1.6026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
NP0181798

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@]12CC[C@@H]3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]11O[C@@H]1C[C@H]2C1=CC(=O)OC1O

> <INCHI_IDENTIFIER>
InChI=1S/C26H30O7/c1-22(2)15(27)7-8-23(3)14-6-9-24(4)13(12-10-17(28)32-21(12)31)11-16-26(24,33-16)25(14,5)20(30)18(29)19(22)23/h7-8,10,13-14,16,21,29,31H,6,9,11H2,1-5H3/t13-,14+,16+,21?,23+,24-,25-,26+/m0/s1

> <INCHI_KEY>
DTCRNNQJLPCGCO-SNZFJDOJSA-N

> <FORMULA>
C26H30O7

> <MOLECULAR_WEIGHT>
454.519

> <EXACT_MASS>
454.199153306

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
63

> <JCHEM_AVERAGE_POLARIZABILITY>
47.05828077939072

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2R,4R,6R,7S,10R,11R)-17-hydroxy-6-(2-hydroxy-5-oxo-2,5-dihydrofuran-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0^{2,4}.0^{2,7}.0^{11,16}]octadeca-12,16-diene-14,18-dione

> <JCHEM_LOGP>
3.2404809546666664

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
8.522653920636438

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.950430264409107

> <JCHEM_PKA_STRONGEST_BASIC>
-4.005654699736984

> <JCHEM_POLAR_SURFACE_AREA>
113.43

> <JCHEM_REFRACTIVITY>
119.54799999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2R,4R,6R,7S,10R,11R)-17-hydroxy-6-(2-hydroxy-5-oxo-2H-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0^{2,4}.0^{2,7}.0^{11,16}]octadeca-12,16-diene-14,18-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0       9.714   2.992   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.382   2.218   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.852   3.664   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.375   1.041   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      10.891   1.312   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0       8.852  -0.407   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.336  -0.678   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.343   0.499   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.820  -0.949   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.866   1.947   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.873   3.125   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       6.397   4.573   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       4.357   2.854   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       3.365   4.031   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       3.834   1.405   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.254   2.832   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.827   0.228   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.304  -1.221   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.788  -1.492   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.795  -0.314   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.123  -1.700   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       0.256  -0.264   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.689  -1.480   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      -0.261  -2.959   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -1.536  -3.824   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0      -1.586  -5.363   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0      -2.752  -2.878   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      -2.229  -1.430   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0      -3.093  -0.155   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0      -0.172   1.215   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.102   2.079   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       2.529   2.660   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       2.318   1.134   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4   10                                             
CONECT    3    2                                                            
CONECT    4    2    5    6                                                  
CONECT    5    4                                                            
CONECT    6    4    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10   17                                             
CONECT    9    8                                                            
CONECT   10    8    2   11                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   17   33                                             
CONECT   16   15                                                            
CONECT   17   15    8   18                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22   33                                             
CONECT   21   20                                                            
CONECT   22   20   23   30                                                  
CONECT   23   22   24   28                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28                                                       
CONECT   28   27   23   29                                                  
CONECT   29   28                                                            
CONECT   30   22   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31   33                                                       
CONECT   33   32   31   20   15                                             
MASTER        0    0    0    0    0    0    0    0   33    0   76    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₆H₃₀O₇

Average Mass

454.5190 Da

Monoisotopic Mass

454.19915 Da

IUPAC Name

(1R,2R,4R,6R,7S,10R,11R)-17-hydroxy-6-(2-hydroxy-5-oxo-2,5-dihydrofuran-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0^{2,4}.0^{2,7}.0^{11,16}]octadeca-12,16-diene-14,18-dione

Traditional Name

(1R,2R,4R,6R,7S,10R,11R)-17-hydroxy-6-(2-hydroxy-5-oxo-2H-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0^{2,4}.0^{2,7}.0^{11,16}]octadeca-12,16-diene-14,18-dione

CAS Registry Number

Not Available

SMILES

C[C@@]12CC[C@@H]3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]11O[C@@H]1C[C@H]2C1=CC(=O)OC1O

InChI Identifier

InChI=1S/C26H30O7/c1-22(2)15(27)7-8-23(3)14-6-9-24(4)13(12-10-17(28)32-21(12)31)11-16-26(24,33-16)25(14,5)20(30)18(29)19(22)23/h7-8,10,13-14,16,21,29,31H,6,9,11H2,1-5H3/t13-,14+,16+,21?,23+,24-,25-,26+/m0/s1

InChI Key

DTCRNNQJLPCGCO-SNZFJDOJSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Walsura yunnanensis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroid lactones. These are sterol lipids containing a lactone moiety linked to the steroid skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroid lactones

Direct Parent

Steroid lactones

Alternative Parents

Substituents

Steroid lactone
3-oxo-delta-1-steroid
Oxosteroid
7-oxosteroid
Delta-1-steroid
Naphthopyran
Naphthalene
Cyclohexenone
2-furanone
Oxane
Pyran
Dihydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Cyclic ketone
Carboxylic acid ester
Hemiacetal
Ketone
Lactone
Carboxylic acid derivative
Organoheterocyclic compound
Dialkyl ether
Enol
Oxirane
Ether
Monocarboxylic acid or derivatives
Oxacycle
Organic oxygen compound
Carbonyl group
Organooxygen compound
Organic oxide
Hydrocarbon derivative
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.24	ChemAxon
pKa (Strongest Acidic)	6.95	ChemAxon
pKa (Strongest Basic)	-4	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	113.43 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	119.55 m³·mol⁻¹	ChemAxon
Polarizability	47.06 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00046785

Chemspider ID

8679297

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10503896

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione (NP0181798)

MOL for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

3D MOL for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

3D SDF for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

3D-SDF for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

PDB for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

3D PDB for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

SMILES for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

INCHI for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

Structure for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)

3D Structure for NP0181798 ((1r,2r,4r,6r,7s,10r,11r)-17-hydroxy-6-(2-hydroxy-5-oxo-2h-furan-3-yl)-1,7,11,15,15-pentamethyl-3-oxapentacyclo[8.8.0.0²,⁴.0²,⁷.0¹¹,¹⁶]octadeca-12,16-diene-14,18-dione)