NP-MRD: Showing NP-Card for 3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid (NP0176268)

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Record Information

Version

2.0

Created at

2022-09-03 13:54:12 UTC

Updated at

2022-09-03 13:54:12 UTC

NP-MRD ID

NP0176268

Secondary Accession Numbers

None

Natural Product Identification

Common Name

3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid

Description

3-[15-(4,6-Dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid belongs to the class of organic compounds known as cyclic depsipeptides. These are natural or synthetic compounds having sequences of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids) connected in a ring. The residues are commonly but not necessarily regularly alternating. 3-[15-(4,6-Dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004231515112D          

 36 36  0  0  0  0            999 V2000
   -2.5527   -3.3199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8382   -2.9074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8382   -2.0824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4092   -2.9074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4092   -2.0824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3052   -3.3199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0197   -2.9074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 33 35  1  0  0  0  0
 10 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1533004231515112D          

 36 36  0  0  0  0            999 V2000
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    1.1564   -4.7206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5041   -5.2257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0451   -3.9031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2749   -3.6075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 28 26  1  4  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 10 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0176268

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)CC(C)CC(C)C1OC(=O)C(CCC(N)=O)NC(=O)CN(C)C(=O)C=CC(=C)NC(=O)C1C

> <INCHI_IDENTIFIER>
InChI=1S/C26H42N4O6/c1-15(2)12-16(3)13-17(4)24-19(6)25(34)28-18(5)8-11-23(33)30(7)14-22(32)29-20(26(35)36-24)9-10-21(27)31/h8,11,15-17,19-20,24H,5,9-10,12-14H2,1-4,6-7H3,(H2,27,31)(H,28,34)(H,29,32)

> <INCHI_KEY>
QWJSJIQOPXXDQH-UHFFFAOYSA-N

> <FORMULA>
C26H42N4O6

> <MOLECULAR_WEIGHT>
506.644

> <EXACT_MASS>
506.310435088

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
78

> <JCHEM_AVERAGE_POLARIZABILITY>
54.58988532965424

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
3-[15-(4,6-dimethylheptan-2-yl)-7,14-dimethyl-11-methylidene-2,5,8,13-tetraoxo-1-oxa-4,7,12-triazacyclopentadec-9-en-3-yl]propanamide

> <ALOGPS_LOGP>
2.40

> <JCHEM_LOGP>
1.2763674610000002

> <ALOGPS_LOGS>
-4.51

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.992533096004564

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.085843086823155

> <JCHEM_PKA_STRONGEST_BASIC>
-0.5327632180980325

> <JCHEM_POLAR_SURFACE_AREA>
147.9

> <JCHEM_REFRACTIVITY>
136.61329999999995

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.57e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
3-[15-(4,6-dimethylheptan-2-yl)-7,14-dimethyl-11-methylidene-2,5,8,13-tetraoxo-1-oxa-4,7,12-triazacyclopentadec-9-en-3-yl]propanamide

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  C   UNK     0      -4.765  -6.197   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -3.431  -5.427   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -3.431  -3.887   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -2.098  -6.197   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -0.764  -5.427   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -0.764  -3.887   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.570  -6.197   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.903  -5.427   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.903  -3.887   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.237  -6.197   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       3.511  -4.682   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       5.037  -4.474   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       5.766  -3.117   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       5.706  -5.861   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       6.785  -4.762   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       8.276  -5.148   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.355  -4.049   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       8.944  -2.565   0.000  0.00  0.00           O+0
HETATM   19  N   UNK     0      10.846  -4.434   0.000  0.00  0.00           N+0
HETATM   20  N   UNK     0       7.237  -6.566   0.000  0.00  0.00           N+0
HETATM   21  C   UNK     0       7.445  -8.092   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       6.227  -9.035   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       8.870  -8.675   0.000  0.00  0.00           C+0
HETATM   24  N   UNK     0       9.078 -10.201   0.000  0.00  0.00           N+0
HETATM   25  C   UNK     0      10.503 -10.784   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       7.860 -11.144   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       8.068 -12.670   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       6.435 -10.561   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       5.217 -11.504   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       3.792 -10.921   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       2.574 -11.864   0.000  0.00  0.00           C+0
HETATM   32  N   UNK     0       3.584  -9.395   0.000  0.00  0.00           N+0
HETATM   33  C   UNK     0       2.159  -8.812   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0       0.941  -9.755   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       1.951  -7.286   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       0.513  -6.734   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   35                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   20                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17                                                            
CONECT   20   14   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27   28                                                  
CONECT   27   26                                                            
CONECT   28   26   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   33                                                       
CONECT   33   32   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33   10   36                                                  
CONECT   36   35                                                            
MASTER        0    0    0    0    0    0    0    0   36    0   72    0
END

View in JSmol

Synonyms

Value	Source
3-[15-(4,6-Dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidate	Generator

Chemical Formula

C₂₆H₄₂N₄O₆

Average Mass

506.6440 Da

Monoisotopic Mass

506.31044 Da

IUPAC Name

3-[15-(4,6-dimethylheptan-2-yl)-7,14-dimethyl-11-methylidene-2,5,8,13-tetraoxo-1-oxa-4,7,12-triazacyclopentadec-9-en-3-yl]propanamide

Traditional Name

3-[15-(4,6-dimethylheptan-2-yl)-7,14-dimethyl-11-methylidene-2,5,8,13-tetraoxo-1-oxa-4,7,12-triazacyclopentadec-9-en-3-yl]propanamide

CAS Registry Number

Not Available

SMILES

CC(C)CC(C)CC(C)C1OC(=O)C(CCC(N)=O)NC(=O)CN(C)C(=O)C=CC(=C)NC(=O)C1C

InChI Identifier

InChI=1S/C26H42N4O6/c1-15(2)12-16(3)13-17(4)24-19(6)25(34)28-18(5)8-11-23(33)30(7)14-22(32)29-20(26(35)36-24)9-10-21(27)31/h8,11,15-17,19-20,24H,5,9-10,12-14H2,1-4,6-7H3,(H2,27,31)(H,28,34)(H,29,32)

InChI Key

QWJSJIQOPXXDQH-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cyclic depsipeptides. These are natural or synthetic compounds having sequences of amino and hydroxy carboxylic acid residues (usually α-amino and α-hydroxy acids) connected in a ring. The residues are commonly but not necessarily regularly alternating.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Peptidomimetics

Sub Class

Depsipeptides

Direct Parent

Cyclic depsipeptides

Alternative Parents

Substituents

Cyclic depsipeptide
Macrolide lactam
Alpha-amino acid ester
Macrolactam
Alpha-amino acid or derivatives
Tertiary carboxylic acid amide
Carboxamide group
Carboxylic acid ester
Lactam
Lactone
Secondary carboxylic acid amide
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Carboximidic acid derivative
Carboximidic acid
Oxacycle
Organoheterocyclic compound
Azacycle
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organic oxygen compound
Organopnictogen compound
Organic nitrogen compound
Organooxygen compound
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.4	ALOGPS
logP	1.28	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	11.09	ChemAxon
pKa (Strongest Basic)	-0.53	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	147.9 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	136.61 m³·mol⁻¹	ChemAxon
Polarizability	54.59 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

85210182

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid (NP0176268)

MOL for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

3D MOL for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

3D SDF for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

3D-SDF for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

PDB for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

3D PDB for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

SMILES for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

INCHI for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

Structure for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)

3D Structure for NP0176268 (3-[15-(4,6-dimethylheptan-2-yl)-5,13-dihydroxy-7,14-dimethyl-11-methylidene-2,8-dioxo-1-oxa-4,7,12-triazacyclopentadeca-4,9,12-trien-3-yl]propanimidic acid)