NP-MRD: Showing NP-Card for (1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate (NP0175361)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-03 12:48:04 UTC

Updated at

2022-09-03 12:48:04 UTC

NP-MRD ID

NP0175361

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate

Description

(1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-10-yl benzoate belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations. Based on a literature review very few articles have been published on (1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[4,4a-c]furan-10-yl benzoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309032214482D          

 39 42  0  0  1  0            999 V2000
   -0.5332   -5.1485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1911   -4.7535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2117   -3.9033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5874   -3.6190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9410   -3.3807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0658   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4884   -1.6677    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9949   -2.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7768   -1.2503    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0630   -1.5546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7825   -0.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2739   -0.0766    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1313    0.8794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4256    1.5190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5906    1.3963    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8664    2.3696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3061    2.9752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5503    3.7632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3549    3.9457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9152    3.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6709    2.5521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2114   -0.4351    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9286   -0.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6403   -0.4449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6346   -1.2699    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3865   -1.6675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -1.6775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2057   -1.2601    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7627    0.7806    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5579    1.2352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0246    2.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4420    2.7285    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9428    0.8725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6021    0.1211    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5944    0.2154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1749    0.7456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0081    0.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1659    1.7075    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  0  0  0  0
 28 27  1  6  0  0  0
  7 28  1  0  0  0  0
 22 28  1  0  0  0  0
 23 29  1  0  0  0  0
 29 30  1  6  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 29 34  1  0  0  0  0
 34 35  1  0  0  0  0
 22 35  1  0  0  0  0
 35 36  1  1  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  2  0  0  0  0
M  END

     RDKit          3D

 77 80  0  0  0  0  0  0  0  0999 V2000
    6.0696    4.1527   -0.3400 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3196    3.2718    0.2486 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9410    2.0115   -0.3366 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3668    1.5631   -1.7018 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1439    1.1566    0.3805 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7342   -0.1035   -0.1455 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3161   -0.4625   -0.4735 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5150   -1.8790   -1.1282 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6544    0.4458   -1.4708 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6383   -0.0484   -2.8847 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3241    0.9912   -1.1095 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6471    0.0909   -0.4344 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6632    0.7968    0.2057 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9717    0.7740   -0.2307 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2322    0.0653   -1.2704 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0372    1.5044    0.4273 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7593    2.2588    1.5343 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7342    2.9772    2.2040 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0113    2.9106    1.7177 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3156    2.1596    0.6071 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3130    1.4425   -0.0523 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0055   -0.9913    0.4237 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6347   -1.1583    1.7717 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4624   -0.2809    2.7118 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3849    0.9038    2.4417 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8315    1.3139    3.7376 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5990    0.4964    1.6274 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4244   -0.7011    0.7113 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.3241   -2.5127    1.7169 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.6277   -2.4563    1.2712 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7175   -2.9988    1.9337 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1038   -2.9150    1.4181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5307   -3.5934    3.0270 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4363   -3.2081    0.8363 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4638   -2.2538   -0.1665 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1696   -2.6513   -1.4194 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0332   -2.8489   -2.4419 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5118   -3.2876   -3.7679 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585   -2.6790   -2.3250 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3366    5.0996    0.1353 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.4634    3.9950   -1.3170 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9656    3.5173    1.2406 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1013    0.7071   -1.6082 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5262    1.3001   -2.3545 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9209    2.3593   -2.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9224    1.5247    1.3498 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1945   -0.9836    0.4710 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3928   -0.2691   -1.0812 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2346   -2.6699   -0.4211 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1900   -1.9138   -2.1462 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6419   -2.0746   -1.2348 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3155    1.3741   -1.5229 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6575   -0.3070   -3.2792 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8544   -0.7628   -3.1326 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3780    0.8676   -3.5056 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3540    2.0248   -0.6353 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1456    1.2907   -2.1161 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1831   -0.4300   -1.3017 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7401    2.3156    1.9273 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4502    3.5550    3.0740 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7779    3.4748    2.2433 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3328    2.1320    0.2541 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6080    0.8635   -0.9274 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9600   -0.4617    3.6752 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1352    1.7976    2.0801 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0603    1.3044    4.3636 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7887    1.3951    1.0246 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3686    0.2578    2.3874 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8389   -1.5959    1.2438 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2649   -3.0423    2.6620 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7746   -2.8085    2.2952 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2251   -2.0064    0.8044 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4023   -3.8389    0.8757 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6235   -2.0804   -0.2374 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4058   -2.4242   -4.4575 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4576   -3.7646   -3.6313 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2326   -3.9795   -4.2602 H   0  0  0  0  0  0  0  0  0  0  0  0
 10  9  1  0
  9 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 14 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 12 22  1  0
 22 35  1  0
 35 36  1  0
 36 37  1  0
 37 38  1  0
 37 39  2  0
 35 34  1  0
 34 29  1  0
 29 30  1  0
 30 31  1  0
 31 32  1  0
 31 33  2  0
 29 23  1  0
 23 24  2  0
 24 25  1  0
 25 26  1  0
 25 27  1  0
 27 28  1  0
 28  7  1  0
  7  8  1  6
  7  6  1  0
  6  5  1  0
  5  3  2  0
  3  4  1  0
  3  2  1  0
  2  1  2  0
  7  9  1  0
 21 16  1  0
 22 23  1  1
 28 22  1  0
 10 53  1  0
 10 54  1  0
 10 55  1  0
  9 52  1  6
 11 56  1  0
 11 57  1  0
 12 58  1  6
 17 59  1  0
 18 60  1  0
 19 61  1  0
 20 62  1  0
 21 63  1  0
 35 74  1  6
 38 75  1  0
 38 76  1  0
 38 77  1  0
 29 70  1  1
 32 71  1  0
 32 72  1  0
 32 73  1  0
 24 64  1  0
 25 65  1  6
 26 66  1  0
 27 67  1  0
 27 68  1  0
 28 69  1  1
  8 49  1  0
  8 50  1  0
  8 51  1  0
  6 47  1  0
  6 48  1  0
  5 46  1  0
  4 43  1  0
  4 44  1  0
  4 45  1  0
  2 42  1  0
  1 40  1  0
  1 41  1  0
M  END


  Mrv1652309032214482D          

 39 42  0  0  1  0            999 V2000
   -0.5332   -5.1485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1911   -4.7535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2117   -3.9033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5874   -3.6190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9410   -3.3807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0658   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4884   -1.6677    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9949   -2.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7768   -1.2503    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0630   -1.5546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7825   -0.4253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2739   -0.0766    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1313    0.8794    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4256    1.5190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5906    1.3963    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8664    2.3696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3061    2.9752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5503    3.7632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3549    3.9457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9152    3.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6709    2.5521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2114   -0.4351    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9286   -0.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6403   -0.4449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6346   -1.2699    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3865   -1.6675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -1.6775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2057   -1.2601    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7627    0.7806    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5579    1.2352    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0246    2.8401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4420    2.7285    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9428    0.8725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6021    0.1211    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5944    0.2154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1749    0.7456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0081    0.4288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1659    1.7075    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  1  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  0  0  0  0
 28 27  1  6  0  0  0
  7 28  1  0  0  0  0
 22 28  1  0  0  0  0
 23 29  1  0  0  0  0
 29 30  1  6  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 29 34  1  0  0  0  0
 34 35  1  0  0  0  0
 22 35  1  0  0  0  0
 35 36  1  1  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0175361

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1C[C@H](OC(=O)C2=CC=CC=C2)[C@]23[C@@H](OC(C)=O)O[C@H](OC(C)=O)C2=C[C@@H](O)C[C@@H]3[C@]1(C)C\C=C(/C)C=C

> <INCHI_IDENTIFIER>
InChI=1S/C31H38O8/c1-7-18(2)13-14-30(6)19(3)15-26(38-27(35)22-11-9-8-10-12-22)31-24(16-23(34)17-25(30)31)28(36-20(4)32)39-29(31)37-21(5)33/h7-13,16,19,23,25-26,28-29,34H,1,14-15,17H2,2-6H3/b18-13+/t19-,23+,25+,26-,28-,29-,30+,31-/m0/s1

> <INCHI_KEY>
VGCCUPIWJIILLU-HACPLIHYSA-N

> <FORMULA>
C31H38O8

> <MOLECULAR_WEIGHT>
538.637

> <EXACT_MASS>
538.256668184

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
77

> <JCHEM_AVERAGE_POLARIZABILITY>
57.34230982387363

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[1,8a-c]furan-10-yl benzoate

> <ALOGPS_LOGP>
4.24

> <JCHEM_LOGP>
4.865801857333331

> <ALOGPS_LOGS>
-5.34

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.845246651866653

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8664891144735254

> <JCHEM_POLAR_SURFACE_AREA>
108.36000000000001

> <JCHEM_REFRACTIVITY>
144.6508

> <JCHEM_ROTATABLE_BOND_COUNT>
10

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.45e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,8H,9H,10H-naphtho[1,8a-c]furan-10-yl benzoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0      -0.995  -9.611   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.357  -8.873   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.395  -7.286   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.096  -6.755   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.756  -6.311   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.989  -4.620   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.778  -3.113   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.724  -4.419   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       1.450  -2.334   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.118  -2.902   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.461  -0.794   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.378  -0.143   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       2.112   1.642   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       0.795   2.836   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      -1.102   2.606   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       1.617   4.423   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       0.571   5.554   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.027   7.025   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.529   7.365   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.575   6.235   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.119   4.764   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.128  -0.812   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.467  -0.051   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.795  -0.831   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.785  -2.370   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       8.188  -3.113   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       5.446  -3.131   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       4.117  -2.352   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       5.157   1.457   0.000  0.00  0.00           C+0
HETATM   30  O   UNK     0       6.641   2.306   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0       7.325   3.775   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       7.513   5.302   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       8.292   5.093   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0       3.627   1.629   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       2.991   0.226   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0       1.109   0.402   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      -0.327   1.392   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      -1.882   0.800   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0      -0.310   3.187   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8    9   28                                             
CONECT    8    7                                                            
CONECT    9    7   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13   22                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14   17   21                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   16                                                       
CONECT   22   12   23   28   35                                             
CONECT   23   22   24   29                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25   28                                                       
CONECT   28   27    7   22                                                  
CONECT   29   23   30   34                                                  
CONECT   30   29   31                                                       
CONECT   31   30   32   33                                                  
CONECT   32   31                                                            
CONECT   33   31                                                            
CONECT   34   29   35                                                       
CONECT   35   34   22   36                                                  
CONECT   36   35   37                                                       
CONECT   37   36   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   84    0
END

View in JSmol

Synonyms

Value	Source
(1R,3R,5S,6AR,7R,8S,10S,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6ah,7H,8H,9H,10H-naphtho[4,4a-c]furan-10-yl benzoic acid	Generator

Chemical Formula

C₃₁H₃₈O₈

Average Mass

538.6370 Da

Monoisotopic Mass

538.25667 Da

IUPAC Name

(1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,7H,8H,9H,10H-naphtho[1,8a-c]furan-10-yl benzoate

Traditional Name

(1R,3R,5S,6aR,7R,8S,10S,10aR)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2E)-3-methylpenta-2,4-dien-1-yl]-1H,3H,5H,6H,6aH,8H,9H,10H-naphtho[1,8a-c]furan-10-yl benzoate

CAS Registry Number

Not Available

SMILES

C[C@H]1C[C@H](OC(=O)C2=CC=CC=C2)[C@]23[C@@H](OC(C)=O)O[C@H](OC(C)=O)C2=C[C@@H](O)C[C@@H]3[C@]1(C)C\C=C(/C)C=C

InChI Identifier

InChI=1S/C31H38O8/c1-7-18(2)13-14-30(6)19(3)15-26(38-27(35)22-11-9-8-10-12-22)31-24(16-23(34)17-25(30)31)28(36-20(4)32)39-29(31)37-21(5)33/h7-13,16,19,23,25-26,28-29,34H,1,14-15,17H2,2-6H3/b18-13+/t19-,23+,25+,26-,28-,29-,30+,31-/m0/s1

InChI Key

VGCCUPIWJIILLU-HACPLIHYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as colensane and clerodane diterpenoids. These are diterpenoids with a structure based on the clerodane or the colensane skeleton. Clerodanes arise from labdanes by two methyl migrations.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Colensane and clerodane diterpenoids

Alternative Parents

Substituents

Clerodane diterpenoid
Naphthofuran
Benzoate ester
Benzoic acid or derivatives
Tricarboxylic acid or derivatives
Benzoyl
Monocyclic benzene moiety
Benzenoid
Tetrahydrofuran
Secondary alcohol
Carboxylic acid ester
Oxacycle
Carboxylic acid derivative
Acetal
Organoheterocyclic compound
Organooxygen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.24	ALOGPS
logP	4.87	ChemAxon
logS	-5.3	ALOGPS
pKa (Strongest Acidic)	14.85	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	108.36 Å²	ChemAxon
Rotatable Bond Count	10	ChemAxon
Refractivity	144.65 m³·mol⁻¹	ChemAxon
Polarizability	57.34 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163191297

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate (NP0175361)

MOL for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

3D MOL for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

3D SDF for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

3D-SDF for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

PDB for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

3D PDB for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

SMILES for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

INCHI for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

Structure for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)

3D Structure for NP0175361 ((1r,3r,5s,6ar,7r,8s,10s,10ar)-1,3-bis(acetyloxy)-5-hydroxy-7,8-dimethyl-7-[(2e)-3-methylpenta-2,4-dien-1-yl]-1h,3h,5h,6h,6ah,8h,9h,10h-naphtho[1,8a-c]furan-10-yl benzoate)