NP-MRD: Showing NP-Card for (1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione (NP0170714)

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Record Information

Version

2.0

Created at

2022-09-03 06:57:06 UTC

Updated at

2022-09-03 06:57:07 UTC

NP-MRD ID

NP0170714

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione

Description

Pseudolarolide O belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring. (1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione is found in Pseudolarix amabilis. Based on a literature review very few articles have been published on Pseudolarolide O.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309032208572D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309032208572D          

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   -1.5229   -5.6079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3715   -5.9035    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1943   -5.9640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6290   -6.6652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  1  0  0  0
  6  8  1  0  0  0  0
  8  9  1  6  0  0  0
  9 10  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 17 26  1  0  0  0  0
 26 27  1  0  0  0  0
 13 27  1  1  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
  8 30  1  0  0  0  0
 11 30  1  0  0  0  0
 30 31  1  6  0  0  0
  9 32  1  0  0  0  0
  4 32  1  0  0  0  0
  4 33  1  6  0  0  0
 33 34  1  0  0  0  0
  2 34  1  0  0  0  0
 34 35  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0170714

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@H]1C[C@]2(C[C@@H](C)[C@H]3[C@@H](C[C@@]4(C)[C@@H]5CC[C@@H]6C(CC5=CC[C@]34C)=CCC(=O)OC6(C)C)O2)OC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C30H42O5/c1-17-14-30(15-18(2)26(32)35-30)33-23-16-29(6)22-9-8-21-19(7-10-24(31)34-27(21,3)4)13-20(22)11-12-28(29,5)25(17)23/h7,11,17-18,21-23,25H,8-10,12-16H2,1-6H3/t17-,18-,21-,22-,23-,25+,28-,29+,30+/m1/s1

> <INCHI_KEY>
GNGQIYWNWWWRFG-KNLPWXKFSA-N

> <FORMULA>
C30H42O5

> <MOLECULAR_WEIGHT>
482.661

> <EXACT_MASS>
482.303224452

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
77

> <JCHEM_AVERAGE_POLARIZABILITY>
56.25026258021913

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1'R,2S,2'S,4R,4'R,8'R,9'R,10'R,21'R)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0^{2,10}.0^{4,9}.0^{15,21}]tricosane]-12',15'-diene-5,18'-dione

> <ALOGPS_LOGP>
5.96

> <JCHEM_LOGP>
5.1043086263333315

> <ALOGPS_LOGS>
-5.68

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.362173464216154

> <JCHEM_POLAR_SURFACE_AREA>
61.830000000000005

> <JCHEM_REFRACTIVITY>
134.9212

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.02e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1'R,2S,2'S,4R,4'R,8'R,9'R,10'R,21'R)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0^{2,10}.0^{4,9}.0^{15,21}]tricosane]-12',15'-diene-5,18'-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0      -8.040  -9.340   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -6.545  -9.707   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -5.369  -8.713   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -4.060  -9.524   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -3.851  -7.999   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.425  -7.417   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.216  -5.891   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.208  -8.360   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.417  -9.886   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.030 -10.556   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.035  -9.445   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.617 -10.870   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.575  -9.493   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.092 -10.943   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.549 -11.443   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.848 -10.616   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.011  -9.084   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.310  -8.257   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       8.766  -8.757   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.284 -10.207   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      10.815 -10.370   0.000  0.00  0.00           O+0
HETATM   22  O   UNK     0       8.473 -11.516   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       6.943 -11.698   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       7.159 -13.223   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       5.837 -12.769   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       4.915  -8.002   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       3.386  -8.184   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.658  -6.827   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.119  -6.778   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       0.308  -8.087   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -0.558  -6.814   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0      -2.843 -10.468   0.000  0.00  0.00           O+0
HETATM   33  O   UNK     0      -4.427 -11.020   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0      -5.963 -11.133   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      -6.774 -12.442   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   34                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   32   33                                             
CONECT    5    4    6                                                       
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6    9   30                                                  
CONECT    9    8   10   32                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   13   30                                             
CONECT   12   11                                                            
CONECT   13   11   14   27                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   23                                                  
CONECT   17   16   18   26                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22   16   24   25                                             
CONECT   24   23                                                            
CONECT   25   23                                                            
CONECT   26   17   27                                                       
CONECT   27   26   13   28                                                  
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29    8   11   31                                             
CONECT   31   30                                                            
CONECT   32    9    4                                                       
CONECT   33    4   34                                                       
CONECT   34   33    2   35                                                  
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₀H₄₂O₅

Average Mass

482.6610 Da

Monoisotopic Mass

482.30322 Da

IUPAC Name

(1'R,2S,2'S,4R,4'R,8'R,9'R,10'R,21'R)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0^{2,10}.0^{4,9}.0^{15,21}]tricosane]-12',15'-diene-5,18'-dione

Traditional Name

(1'R,2S,2'S,4R,4'R,8'R,9'R,10'R,21'R)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0^{2,10}.0^{4,9}.0^{15,21}]tricosane]-12',15'-diene-5,18'-dione

CAS Registry Number

Not Available

SMILES

C[C@@H]1C[C@]2(C[C@@H](C)[C@H]3[C@@H](C[C@@]4(C)[C@@H]5CC[C@@H]6C(CC5=CC[C@]34C)=CCC(=O)OC6(C)C)O2)OC1=O

InChI Identifier

InChI=1S/C30H42O5/c1-17-14-30(15-18(2)26(32)35-30)33-23-16-29(6)22-9-8-21-19(7-10-24(31)34-27(21,3)4)13-20(22)11-12-28(29,5)25(17)23/h7,11,17-18,21-23,25H,8-10,12-16H2,1-6H3/t17-,18-,21-,22-,23-,25+,28-,29+,30+/m1/s1

InChI Key

GNGQIYWNWWWRFG-KNLPWXKFSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Pseudolarix amabilis	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Terpene lactones

Alternative Parents

Substituents

Terpene lactone
Sesquiterpenoid
Pinguisane sesquiterpenoid
Ketal
Dicarboxylic acid or derivatives
Gamma butyrolactone
Oxane
Oxolane
Lactone
Carboxylic acid ester
Oxacycle
Acetal
Carboxylic acid derivative
Organoheterocyclic compound
Hydrocarbon derivative
Organooxygen compound
Organic oxide
Organic oxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.96	ALOGPS
logP	5.1	ChemAxon
logS	-5.7	ALOGPS
pKa (Strongest Basic)	-4.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	61.83 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	134.92 m³·mol⁻¹	ChemAxon
Polarizability	56.25 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

10001620

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11826970

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione (NP0170714)

MOL for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

3D MOL for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

3D SDF for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

3D-SDF for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

PDB for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

3D PDB for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

SMILES for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

INCHI for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

Structure for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)

3D Structure for NP0170714 ((1'r,2s,2's,4r,4'r,8'r,9'r,10'r,21'r)-2',4,8',10',20',20'-hexamethyl-5',19'-dioxaspiro[oxolane-2,6'-pentacyclo[11.10.0.0²,¹⁰.0⁴,⁹.0¹⁵,²¹]tricosane]-12',15'-diene-5,18'-dione)