NP-MRD: Showing NP-Card for (1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate (NP0168475)

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Record Information

Version

2.0

Created at

2022-09-03 04:17:38 UTC

Updated at

2022-09-03 04:17:38 UTC

NP-MRD ID

NP0168475

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate

Description

(1S)-1-[(1S,3aR,7S,7aS)-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-1-yl]ethyl acetate belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units. (1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate is found in Petasites frigidus. Based on a literature review very few articles have been published on (1S)-1-[(1S,3aR,7S,7aS)-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-1-yl]ethyl acetate.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652309032206172D          

 20 21  0  0  1  0            999 V2000
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7179   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3740   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150   -2.6088    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  6  0  0  0
 10 11  1  1  0  0  0
 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 20 19  1  1  0  0  0
  2 20  1  0  0  0  0
  9 20  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0168475

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)[C@@H]1CCC(=C)[C@@H]2CC(=O)[C@H]([C@H](C)OC(C)=O)[C@@H]12

> <INCHI_IDENTIFIER>
InChI=1S/C17H26O3/c1-9(2)13-7-6-10(3)14-8-15(19)16(17(13)14)11(4)20-12(5)18/h9,11,13-14,16-17H,3,6-8H2,1-2,4-5H3/t11-,13-,14-,16-,17-/m0/s1

> <INCHI_KEY>
LXZVWWAMUYQSIZ-LLLJDESDSA-N

> <FORMULA>
C17H26O3

> <MOLECULAR_WEIGHT>
278.392

> <EXACT_MASS>
278.188194697

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
31.668352433984673

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S)-1-[(1S,3aR,7S,7aS)-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-1-yl]ethyl acetate

> <ALOGPS_LOGP>
2.09

> <JCHEM_LOGP>
3.120970919333333

> <ALOGPS_LOGS>
-3.96

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
19.262362532804268

> <JCHEM_PKA_STRONGEST_BASIC>
-6.877453175459829

> <JCHEM_POLAR_SURFACE_AREA>
43.370000000000005

> <JCHEM_REFRACTIVITY>
78.08719999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.08e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S)-1-[(1S,3aR,7S,7aS)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1H-inden-1-yl]ethyl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0       6.121   3.850   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.121   2.310   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.454   1.540   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.454   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.121  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.121  -2.310   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.787  -3.080   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.454  -3.080   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.787   0.000   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.322  -0.476   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.846  -1.941   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.340  -2.261   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       3.877  -3.085   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       3.401  -4.550   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.432  -5.694   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       1.895  -4.870   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       2.417   0.770   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       0.877   0.770   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       3.322   2.016   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       4.787   1.540   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   20                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9                                                  
CONECT    6    5    7    8                                                  
CONECT    7    6                                                            
CONECT    8    6                                                            
CONECT    9    5   10   20                                                  
CONECT   10    9   11   17                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14                                                       
CONECT   14   13   15   16                                                  
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   10   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20                                                       
CONECT   20   19    2    9                                                  
MASTER        0    0    0    0    0    0    0    0   20    0   42    0
END

View in JSmol

Synonyms

Value	Source
(1S)-1-[(1S,3AR,7S,7as)-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-1-yl]ethyl acetic acid	Generator

Chemical Formula

C₁₇H₂₆O₃

Average Mass

278.3920 Da

Monoisotopic Mass

278.18819 Da

IUPAC Name

(1S)-1-[(1S,3aR,7S,7aS)-4-methylidene-2-oxo-7-(propan-2-yl)-octahydro-1H-inden-1-yl]ethyl acetate

Traditional Name

(1S)-1-[(1S,3aR,7S,7aS)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1H-inden-1-yl]ethyl acetate

CAS Registry Number

Not Available

SMILES

CC(C)[C@@H]1CCC(=C)[C@@H]2CC(=O)[C@H]([C@H](C)OC(C)=O)[C@@H]12

InChI Identifier

InChI=1S/C17H26O3/c1-9(2)13-7-6-10(3)14-8-15(19)16(17(13)14)11(4)20-12(5)18/h9,11,13-14,16-17H,3,6-8H2,1-2,4-5H3/t11-,13-,14-,16-,17-/m0/s1

InChI Key

LXZVWWAMUYQSIZ-LLLJDESDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Petasites frigidus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as sesquiterpenoids. These are terpenes with three consecutive isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Sesquiterpenoids

Alternative Parents

Substituents

Oplopane sesquiterpenoid
Sesquiterpenoid
Cyclic ketone
Ketone
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.09	ALOGPS
logP	3.12	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	19.26	ChemAxon
pKa (Strongest Basic)	-6.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	43.37 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	78.09 m³·mol⁻¹	ChemAxon
Polarizability	31.67 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162933939

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate (NP0168475)

MOL for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

3D MOL for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

3D SDF for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

3D-SDF for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

PDB for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

3D PDB for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

SMILES for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

INCHI for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

Structure for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)

3D Structure for NP0168475 ((1s)-1-[(1s,3ar,7s,7as)-7-isopropyl-4-methylidene-2-oxo-hexahydro-1h-inden-1-yl]ethyl acetate)