NP-MRD: Showing NP-Card for (10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol (NP0166558)

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Record Information

Version

2.0

Created at

2022-09-03 01:57:50 UTC

Updated at

2022-09-03 01:57:50 UTC

NP-MRD ID

NP0166558

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol

Description

(+)-Frondosin B, also known as frondosin b, belongs to the class of organic compounds known as benzofurans. These are organic compounds containing a benzene ring fused to a furan. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom. (10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol is found in Dysidea frondosa. (10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol was first documented in 2016 (PMID: 28066535). Based on a literature review a small amount of articles have been published on (+)-Frondosin B (PMID: 29629112) (PMID: 29614734) (PMID: 27997203) (PMID: 27882364).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 46 49  0  0  0  0  0  0  0  0999 V2000
    0.2721    4.0300    0.7670 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0846    2.5639    0.7688 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.1103    2.3492   -0.3410 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0014    1.2236    0.0683 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3598   -0.1185    0.0358 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -0.5094    0.2063 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2140   -1.9358    0.4661 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0654   -2.5566    1.1445 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0879   -2.5235    0.0299 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4542   -1.1087   -0.2268 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5652   -0.7375    0.7668 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0306   -0.8791   -1.6066 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0570    0.3550    0.2136 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1075    1.7284    0.4851 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3335    2.1207    0.4421 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1331    1.1074    0.1565 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4977    1.0082    0.0004 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0486   -0.2143   -0.3049 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2653   -1.3344   -0.4577 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8153   -2.5550   -0.7637 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8741   -1.2483   -0.3018 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3362   -0.0435    0.0018 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9858    4.2297    1.5931 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7063    4.2769   -0.2028 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6377    4.6239    0.9274 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5012    2.2182    1.7366 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6010    2.0539   -1.2821 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7178    3.2517   -0.4379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3816    1.4671    1.0896 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8736    1.2372   -0.6193 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2443   -2.5640   -0.4383 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9550   -2.1105    1.2438 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8133   -3.5962    1.3553 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3597   -1.9465    1.9966 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6708   -3.0382   -0.8619 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9910   -3.0563    0.4006 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2408    0.0170    0.3633 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1189   -1.6580    1.0924 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1118   -0.3336    1.7153 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2911   -0.2720   -2.1908 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2607   -1.8400   -2.1003 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9536   -0.2806   -1.5771 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1084    1.8957    0.1215 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1256   -0.2460   -0.4157 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9734   -2.9173   -1.6766 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3352   -2.1339   -0.4644 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 10 12  1  0
  6 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 14  2  1  0
 22 16  1  0
 10  5  1  0
 22 13  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  2 26  1  1
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  7 31  1  0
  7 32  1  0
  8 33  1  0
  8 34  1  0
  9 35  1  0
  9 36  1  0
 11 37  1  0
 11 38  1  0
 11 39  1  0
 12 40  1  0
 12 41  1  0
 12 42  1  0
 17 43  1  0
 18 44  1  0
 20 45  1  0
 21 46  1  0
M  END


  Mrv1652309032203572D          

 22 25  0  0  1  0            999 V2000
    4.7304    2.9695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1218    2.2433    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.9460    2.2809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4892    1.6600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3425    0.8481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6163    0.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5922   -0.3680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2943   -0.8012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0205   -0.4097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0446    0.4149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8696    0.4196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5020    1.1015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8574    0.7804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6374    1.5755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8132    1.6119    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5238    0.8393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7561    0.5374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -0.2785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2791   -0.7924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1567   -1.6083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0468   -0.4905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1692    0.3254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  2  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 13 22  1  0  0  0  0
 16 22  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0166558

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1CCC2=C(CCCC2(C)C)C2=C1OC1=CC=C(O)C=C21

> <INCHI_IDENTIFIER>
InChI=1S/C20H24O2/c1-12-6-8-16-14(5-4-10-20(16,2)3)18-15-11-13(21)7-9-17(15)22-19(12)18/h7,9,11-12,21H,4-6,8,10H2,1-3H3/t12-/m0/s1

> <INCHI_KEY>
LSPMJSWSYGOLFD-LBPRGKRZSA-N

> <FORMULA>
C20H24O2

> <MOLECULAR_WEIGHT>
296.41

> <EXACT_MASS>
296.177630013

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
46

> <JCHEM_AVERAGE_POLARIZABILITY>
34.62830901294564

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(10S)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0^{2,7}.0^{13,18}]octadeca-1(11),2(7),13,15,17-pentaen-16-ol

> <ALOGPS_LOGP>
5.93

> <JCHEM_LOGP>
5.130705119666668

> <ALOGPS_LOGS>
-4.37

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.424644376775047

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8303934126797348

> <JCHEM_POLAR_SURFACE_AREA>
33.370000000000005

> <JCHEM_REFRACTIVITY>
89.57039999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.28e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(10S)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0^{2,7}.0^{13,18}]octadeca-1(11),2(7),13,15,17-pentaen-16-ol

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0       8.830   5.543   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.561   4.187   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      11.099   4.258   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      12.113   3.099   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.839   1.583   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.484   0.852   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      10.439  -0.687   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      11.749  -1.496   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      13.105  -0.765   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      13.150   0.774   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      14.690   0.783   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      14.004   2.056   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.067   1.457   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       8.656   2.941   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       7.118   3.009   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       6.578   1.567   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.145   1.003   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.916  -0.520   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.121  -1.479   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       5.892  -3.002   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       7.554  -0.916   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       7.783   0.607   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   14                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   10                                                  
CONECT    6    5    7   13                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9    5   11   12                                             
CONECT   11   10                                                            
CONECT   12   10                                                            
CONECT   13    6   14   22                                                  
CONECT   14   13    2   15                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17   22                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   13   16                                                  
MASTER        0    0    0    0    0    0    0    0   22    0   50    0
END

View in JSmol

Synonyms

Value	Source
Frondosin b	MeSH

Chemical Formula

C₂₀H₂₄O₂

Average Mass

296.4100 Da

Monoisotopic Mass

296.17763 Da

IUPAC Name

(10S)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0^{2,7}.0^{13,18}]octadeca-1(11),2(7),13,15,17-pentaen-16-ol

Traditional Name

(10S)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0^{2,7}.0^{13,18}]octadeca-1(11),2(7),13,15,17-pentaen-16-ol

CAS Registry Number

Not Available

SMILES

C[C@H]1CCC2=C(CCCC2(C)C)C2=C1OC1=CC=C(O)C=C21

InChI Identifier

InChI=1S/C20H24O2/c1-12-6-8-16-14(5-4-10-20(16,2)3)18-15-11-13(21)7-9-17(15)22-19(12)18/h7,9,11-12,21H,4-6,8,10H2,1-3H3/t12-/m0/s1

InChI Key

LSPMJSWSYGOLFD-LBPRGKRZSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Dysidea frondosa	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzofurans. These are organic compounds containing a benzene ring fused to a furan. Furan is a five-membered aromatic ring with four carbon atoms and one oxygen atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzofurans

Sub Class

Not Available

Direct Parent

Benzofurans

Alternative Parents

Substituents

Benzofuran
1-hydroxy-2-unsubstituted benzenoid
Phenol
Benzenoid
Heteroaromatic compound
Furan
Oxacycle
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.93	ALOGPS
logP	5.13	ChemAxon
logS	-4.4	ALOGPS
pKa (Strongest Acidic)	9.42	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	33.37 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	89.57 m³·mol⁻¹	ChemAxon
Polarizability	34.63 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

8261480

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10085943

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Joyce LA, Nawrat CC, Sherer EC, Biba M, Brunskill A, Martin GE, Cohen RD, Davies IW: Beyond optical rotation: what's left is not always right in total synthesis. Chem Sci. 2017 Oct 30;9(2):415-424. doi: 10.1039/c7sc04249c. eCollection 2018 Jan 14. [PubMed:29629112 ]
Zong Y, Wang W, Xu T: Total Synthesis of Bioactive Marine Meroterpenoids: The Cases of Liphagal and Frondosin B. Mar Drugs. 2018 Mar 31;16(4):115. doi: 10.3390/md16040115. [PubMed:29614734 ]
Trost BM, Debien L: Re-Orienting Coupling of Organocuprates with Propargyl Electrophiles from S(N)2' to S(N)2 with Stereocontrol. Chem Sci. 2016;7(8):4985-4989. doi: 10.1039/C6SC01086E. Epub 2016 May 10. [PubMed:28066535 ]
Huynh KQ, Seizert CA, Ozumerzifon TJ, Allegretti PA, Ferreira EM: Platinum-Catalyzed alpha,beta-Unsaturated Carbene Formation in the Formal Syntheses of Frondosin B and Liphagal. Org Lett. 2017 Jan 6;19(1):294-297. doi: 10.1021/acs.orglett.6b03682. Epub 2016 Dec 20. [PubMed:27997203 ]
Tharra P, Baire B: Regioselective, cascade [3+2] annulation of beta-naphthols (resorcinols) with Z-enoate propargylic alcohols: a novel entry for the synthesis of complex naphtho(benzo)furans. Chem Commun (Camb). 2016 Dec 6;52(99):14290-14293. doi: 10.1039/c6cc08126f. [PubMed:27882364 ]
LOTUS database [Link]

Showing NP-Card for (10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol (NP0166558)

MOL for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

3D MOL for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

3D SDF for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

3D-SDF for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

PDB for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

3D PDB for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

SMILES for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

INCHI for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

Structure for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)

3D Structure for NP0166558 ((10s)-6,6,10-trimethyl-12-oxatetracyclo[9.7.0.0²,⁷.0¹³,¹⁸]octadeca-1(11),2(7),13,15,17-pentaen-16-ol)