NP-MRD: Showing NP-Card for (9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione (NP0165257)

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Record Information

Version

2.0

Created at

2022-09-03 00:19:55 UTC

Updated at

2022-09-03 00:19:55 UTC

NP-MRD ID

NP0165257

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione

Description

Cytochalasin a belongs to the class of organic compounds known as cytochalasins. These are cytochalasans in which the hydrogenated isoindolone bears a benzyl group. Thus, cytochalasin a is considered to be a cytochalasin. (9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione is found in Boeremia exigua. (9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione was first documented in 2014 (PMID: 25398795). Based on a literature review a small amount of articles have been published on Cytochalasin a (PMID: 29595339) (PMID: 34849851) (PMID: 25349049) (PMID: 24995502).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309032202192D          

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M  END

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M  END


  Mrv1652309032202192D          

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 15 16  1  0  0  0  0
 17 15  1  1  0  0  0
  5 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 33 32  1  1  0  0  0
 17 33  1  0  0  0  0
 33 34  1  0  0  0  0
  2 34  1  0  0  0  0
 34 35  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0165257

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1[C@H]2[C@H](CC3=CC=CC=C3)N=C(O)[C@]22OC(=O)\C=C\C(=O)CCC[C@@H](C)C\C=C\[C@H]2[C@H](O)C1=C

> <INCHI_IDENTIFIER>
InChI=1S/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,23+,24+,26+,27-,29-/m1/s1

> <INCHI_KEY>
ZMAODHOXRBLOQO-TZVKRXPSSA-N

> <FORMULA>
C29H35NO5

> <MOLECULAR_WEIGHT>
477.601

> <EXACT_MASS>
477.251523231

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
70

> <JCHEM_AVERAGE_POLARIZABILITY>
50.59987099065887

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(9R,13S,15S,15aS,16S,18aS,18bS)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-2H,5H,6H,7H,8H,9H,10H,13H,14H,15H,15aH,16H,18bH-oxacyclotetradeca[3,2-e]isoindole-2,5-dione

> <ALOGPS_LOGP>
4.18

> <JCHEM_LOGP>
3.9360829356095377

> <ALOGPS_LOGS>
-5.56

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.222163056674514

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.9000127228605384

> <JCHEM_PKA_STRONGEST_BASIC>
4.791546276523363

> <JCHEM_POLAR_SURFACE_AREA>
96.19000000000001

> <JCHEM_REFRACTIVITY>
136.04129999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.32e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(9R,13S,15S,15aS,16S,18aS,18bS)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6H,7H,8H,9H,10H,13H,15H,15aH,16H,18bH-oxacyclotetradeca[3,2-e]isoindole-2,5-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 03-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-22         0                                  
HETATM    1  C   UNK     0       3.709  -4.704   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.189  -4.277   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.559  -2.782   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.449  -1.714   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.038  -2.355   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.711  -0.970   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.986   0.389   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.799   1.696   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       7.074   3.055   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.888   4.362   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.427   4.311   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      10.152   2.953   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.338   1.645   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0       9.236  -1.181   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0       9.502  -2.480   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      10.892  -3.370   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       8.148  -3.423   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       9.628  -2.996   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       9.997  -1.501   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       8.888  -0.433   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      11.477  -1.074   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      12.587  -2.142   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      14.066  -1.714   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      14.436  -0.219   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      15.176  -2.782   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      14.806  -4.277   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      13.327  -4.704   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      12.957  -6.199   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      14.066  -7.267   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      11.477  -6.626   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      10.367  -5.558   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       8.888  -5.986   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       7.778  -4.918   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       6.298  -5.345   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0       5.929  -6.840   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3   34                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6   17                                                  
CONECT    6    5    7   14                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   13                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12    8                                                       
CONECT   14    6   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15    5   18   33                                             
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   33                                                       
CONECT   33   32   17   34                                                  
CONECT   34   33    2   35                                                  
CONECT   35   34                                                            
MASTER        0    0    0    0    0    0    0    0   35    0   76    0
END

View in JSmol

Synonyms

Value	Source
(7S,13E,16R,21E)-7-Hydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13,21-triene-1,20,23-trione	Kegg

Chemical Formula

C₂₉H₃₅NO₅

Average Mass

477.6010 Da

Monoisotopic Mass

477.25152 Da

IUPAC Name

(9R,13S,15S,15aS,16S,18aS,18bS)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-2H,5H,6H,7H,8H,9H,10H,13H,14H,15H,15aH,16H,18bH-oxacyclotetradeca[3,2-e]isoindole-2,5-dione

Traditional Name

(9R,13S,15S,15aS,16S,18aS,18bS)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6H,7H,8H,9H,10H,13H,15H,15aH,16H,18bH-oxacyclotetradeca[3,2-e]isoindole-2,5-dione

CAS Registry Number

Not Available

SMILES

C[C@H]1[C@H]2[C@H](CC3=CC=CC=C3)N=C(O)[C@]22OC(=O)\C=C\C(=O)CCC[C@@H](C)C\C=C\[C@H]2[C@H](O)C1=C

InChI Identifier

InChI=1S/C29H35NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,23-24,26-27,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,23+,24+,26+,27-,29-/m1/s1

InChI Key

ZMAODHOXRBLOQO-TZVKRXPSSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Phoma exigua	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cytochalasins. These are cytochalasans in which the hydrogenated isoindolone bears a benzyl group.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Cytochalasans

Sub Class

Cytochalasins

Direct Parent

Cytochalasins

Alternative Parents

Substituents

Lactone cytochalasin skeleton
Cytochalasin
Isoindolone
Isoindoline
Isoindole
Isoindole or derivatives
Monocyclic benzene moiety
Pyrrolidone
Benzenoid
2-pyrrolidone
Cyclic alcohol
Pyrrolidine
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Cyclic ketone
Secondary carboxylic acid amide
Secondary alcohol
Carboxamide group
Carboxylic acid ester
Ketone
Lactone
Lactam
Organoheterocyclic compound
Carboxylic acid derivative
Oxacycle
Azacycle
Monocarboxylic acid or derivatives
Organopnictogen compound
Organic oxygen compound
Alcohol
Organonitrogen compound
Organic nitrogen compound
Organic oxide
Hydrocarbon derivative
Carbonyl group
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Cytochalasins (LMPK11000001 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.18	ALOGPS
logP	3.94	ChemAxon
logS	-5.6	ALOGPS
pKa (Strongest Acidic)	1.9	ChemAxon
pKa (Strongest Basic)	4.79	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	96.19 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	136.04 m³·mol⁻¹	ChemAxon
Polarizability	50.6 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00011321

Chemspider ID

4572348

KEGG Compound ID

C19953

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5458383

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

rw1233451

References

General References

Aznar-Fernandez T, Cimmino A, Masi M, Rubiales D, Evidente A: Antifeedant activity of long-chain alcohols, and fungal and plant metabolites against pea aphid (Acyrthosiphon pisum) as potential biocontrol strategy. Nat Prod Res. 2019 Sep;33(17):2471-2479. doi: 10.1080/14786419.2018.1452013. Epub 2018 Mar 29. [PubMed:29595339 ]
Trendowski M, Wong V, Wellington K, Hatfield S, Fondy TP: Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerated doses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumor model systems in vivo. In Vivo. 2014 Nov-Dec;28(6):1021-31. [PubMed:25398795 ]
Wernet V, Wackerle J, Fischer R: The STRIPAK component SipC is involved in morphology and cell-fate determination in the nematode-trapping fungus Duddingtonia flagrans. Genetics. 2022 Jan 4;220(1):iyab153. doi: 10.1093/genetics/iyab153. [PubMed:34849851 ]
Piwowarski JP, Kiss AK: Contribution of C-glucosidic ellagitannins to Lythrum salicaria L. influence on pro-inflammatory functions of human neutrophils. J Nat Med. 2015 Jan;69(1):100-10. doi: 10.1007/s11418-014-0873-5. Epub 2014 Oct 28. [PubMed:25349049 ]
Piwowarski JP, Granica S, Kiss AK: Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils. Planta Med. 2014 Jul;80(11):887-95. doi: 10.1055/s-0034-1368615. Epub 2014 Jul 4. [PubMed:24995502 ]
LOTUS database [Link]

Showing NP-Card for (9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione (NP0165257)

MOL for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

3D MOL for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

3D SDF for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

3D-SDF for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

PDB for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

3D PDB for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

SMILES for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

INCHI for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

Structure for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)

3D Structure for NP0165257 ((9r,12as,13s,15s,15as,16s,18as)-16-benzyl-13,18-dihydroxy-9,15-dimethyl-14-methylidene-6h,7h,8h,9h,10h,12ah,13h,15h,15ah,16h-oxacyclotetradeca[2,3-d]isoindole-2,5-dione)