NP-MRD: Showing NP-Card for [8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid (NP0163161)

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Record Information

Version

2.0

Created at

2022-09-02 21:43:28 UTC

Updated at

2022-09-02 21:43:29 UTC

NP-MRD ID

NP0163161

Secondary Accession Numbers

None

Natural Product Identification

Common Name

[8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid

Description

2-[8-Hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-1,2,3,4,4a,9,10b,11,12,12a-decahydrochrysen-2-yl]acetic acid belongs to the class of organic compounds known as 16-oxosteroids. These are steroid derivatives carrying a C=O group at the 16-position of the steroid skeleton. 2-[8-Hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-1,2,3,4,4a,9,10b,11,12,12a-decahydrochrysen-2-yl]acetic acid is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004191517552D          

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M  END

     RDKit          3D

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M  END


  Mrv1533004191517552D          

 33 36  0  0  0  0            999 V2000
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M  END
> <DATABASE_ID>
NP0163161

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)CC1C(C)(CC(O)=O)CCC2(C)C3=CC=C4C(C)=C(O)C(=O)C=C4C3(C)CCC12C

> <INCHI_IDENTIFIER>
InChI=1S/C28H36O5/c1-16(29)13-22-25(3,15-23(31)32)9-11-27(5)21-8-7-18-17(2)24(33)20(30)14-19(18)26(21,4)10-12-28(22,27)6/h7-8,14,22,33H,9-13,15H2,1-6H3,(H,31,32)

> <INCHI_KEY>
GJOZEYAHNFNJCB-UHFFFAOYSA-N

> <FORMULA>
C28H36O5

> <MOLECULAR_WEIGHT>
452.591

> <EXACT_MASS>
452.256274259

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
69

> <JCHEM_AVERAGE_POLARIZABILITY>
50.65550721010352

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-1,2,3,4,4a,9,10b,11,12,12a-decahydrochrysen-2-yl]acetic acid

> <ALOGPS_LOGP>
4.99

> <JCHEM_LOGP>
3.7045829023333345

> <ALOGPS_LOGS>
-5.24

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
9.752589502800642

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.7366736499503554

> <JCHEM_PKA_STRONGEST_BASIC>
-3.4624791827286865

> <JCHEM_POLAR_SURFACE_AREA>
91.67000000000002

> <JCHEM_REFRACTIVITY>
130.68929999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.58e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1H-chrysen-2-yl]acetic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 19-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   19-APR-15         0                                  
HETATM    1  C   UNK     0       6.164  -9.380   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.668  -7.924   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       8.181  -7.633   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       5.660  -6.760   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.164  -5.305   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       5.156  -4.141   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.185  -5.336   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.811  -3.392   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.787  -1.852   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       2.441  -1.103   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       5.108  -1.061   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       5.660  -2.686   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.172  -2.395   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       8.181  -3.559   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.685  -2.104   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       9.693  -3.268   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      10.197  -1.813   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      11.709  -1.522   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      12.717  -2.686   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      14.230  -2.395   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      15.238  -3.559   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0      16.750  -3.268   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0      14.734  -5.014   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0      15.742  -6.178   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0      13.221  -5.305   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      12.213  -4.141   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      10.701  -4.432   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.709  -5.596   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      10.197  -5.887   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       8.685  -6.178   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       7.677  -5.014   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       7.172  -6.469   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      14.734  -0.940   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   31                                                  
CONECT    6    5    7    8   12                                             
CONECT    7    6                                                            
CONECT    8    6    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9                                                            
CONECT   12    6   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   16   31                                             
CONECT   15   14                                                            
CONECT   16   14   17   27                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   26                                                  
CONECT   20   19   21   33                                                  
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   19   27                                                  
CONECT   27   26   16   28   29                                             
CONECT   28   27                                                            
CONECT   29   27   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30    5   14   32                                             
CONECT   32   31                                                            
CONECT   33   20                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
2-[8-Hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-1,2,3,4,4a,9,10b,11,12,12a-decahydrochrysen-2-yl]acetate	Generator

Chemical Formula

C₂₈H₃₆O₅

Average Mass

452.5910 Da

Monoisotopic Mass

452.25627 Da

IUPAC Name

2-[8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-1,2,3,4,4a,9,10b,11,12,12a-decahydrochrysen-2-yl]acetic acid

Traditional Name

[8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1H-chrysen-2-yl]acetic acid

CAS Registry Number

Not Available

SMILES

CC(=O)CC1C(C)(CC(O)=O)CCC2(C)C3=CC=C4C(C)=C(O)C(=O)C=C4C3(C)CCC12C

InChI Identifier

InChI=1S/C28H36O5/c1-16(29)13-22-25(3,15-23(31)32)9-11-27(5)21-8-7-18-17(2)24(33)20(30)14-19(18)26(21,4)10-12-28(22,27)6/h7-8,14,22,33H,9-13,15H2,1-6H3,(H,31,32)

InChI Key

GJOZEYAHNFNJCB-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 16-oxosteroids. These are steroid derivatives carrying a C=O group at the 16-position of the steroid skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Oxosteroids

Direct Parent

16-oxosteroids

Alternative Parents

Substituents

20-hydroxysteroid
17-carboxy steroid
Steroid acid
Hydroxysteroid
16-oxosteroid
Ketone
Cyclic ketone
Carboxylic acid derivative
Carboxylic acid
Enol
Monocarboxylic acid or derivatives
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Carbonyl group
Organooxygen compound
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.99	ALOGPS
logP	3.7	ChemAxon
logS	-5.2	ALOGPS
pKa (Strongest Acidic)	4.74	ChemAxon
pKa (Strongest Basic)	-3.5	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	91.67 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	130.69 m³·mol⁻¹	ChemAxon
Polarizability	50.66 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for [8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid (NP0163161)

MOL for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

3D MOL for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

3D SDF for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

3D-SDF for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

PDB for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

3D PDB for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

SMILES for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

INCHI for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

Structure for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)

3D Structure for NP0163161 ([8-hydroxy-2,4a,7,10b,12a-pentamethyl-9-oxo-1-(2-oxopropyl)-3,4,11,12-tetrahydro-1h-chrysen-2-yl]acetic acid)