NP-MRD: Showing NP-Card for 5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one (NP0161150)

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Record Information

Version

2.0

Created at

2022-09-02 19:15:32 UTC

Updated at

2022-09-02 19:15:32 UTC

NP-MRD ID

NP0161150

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one

Description

3-((1-Hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindolin-3-yl)methyl)-1-methyl-3,4-dihydrobenzo[e][1,4]diazepine-2,5-dione belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine. Based on a literature review very few articles have been published on 3-((1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindolin-3-yl)methyl)-1-methyl-3,4-dihydrobenzo[e][1,4]diazepine-2,5-dione.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022221152D          

 31 34  0  0  0  0            999 V2000
   -3.0471   -1.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3327   -0.6719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6182   -1.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0307   -1.7988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2057   -0.3699    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9037   -1.4969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5682   -0.7432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0531   -0.0758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8648   -0.2231    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4861    0.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2447   -0.0045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4491    1.1439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2028    1.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2890    2.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6216    2.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8679    2.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7817    1.6288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9864    1.4093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4436    2.0306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1620    0.6137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3886   -2.1643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -2.1643    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9037   -2.8318    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1587   -3.6164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1191   -2.5768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5954   -2.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3098   -2.5768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3098   -1.7518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5954   -1.3393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1191   -1.7518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 31  1  0  0  0  0
M  END

     RDKit          3D

 56 59  0  0  0  0  0  0  0  0999 V2000
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   -3.0618   -1.6920   -0.4633 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0204    1.4837    1.0355 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6542    2.7967    1.1694 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8359    1.2245    1.7865 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6481    2.0096    2.7432 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3452   -0.1370    1.5971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9903   -0.6751    2.6541 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5615    0.4914    1.3360 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6721    0.5731    2.1412 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4915    1.0717    0.0427 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4301    1.8587   -0.6401 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END


  Mrv1652309022221152D          

 31 34  0  0  0  0            999 V2000
   -3.0471   -1.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3327   -0.6719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6182   -1.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0307   -1.7988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9037   -1.4969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5682   -0.7432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0531   -0.0758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8648   -0.2231    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4861    0.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2447   -0.0045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4491    1.1439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
NP0161150

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CN1C2=CC=CC=C2C(O)=NC(CC2(C(=O)N(O)C3=CC=CC=C23)C(C)(C)C=C)C1=O

> <INCHI_IDENTIFIER>
InChI=1S/C24H25N3O4/c1-5-23(2,3)24(16-11-7-9-13-19(16)27(31)22(24)30)14-17-21(29)26(4)18-12-8-6-10-15(18)20(28)25-17/h5-13,17,31H,1,14H2,2-4H3,(H,25,28)

> <INCHI_KEY>
CAIGWSRMYOIDFV-UHFFFAOYSA-N

> <FORMULA>
C24H25N3O4

> <MOLECULAR_WEIGHT>
419.481

> <EXACT_MASS>
419.184506297

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
56

> <JCHEM_AVERAGE_POLARIZABILITY>
43.38976542526969

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

> <ALOGPS_LOGP>
2.65

> <JCHEM_LOGP>
3.389169769333333

> <ALOGPS_LOGS>
-4.13

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
8.394302317060303

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.634463241366728

> <JCHEM_PKA_STRONGEST_BASIC>
1.576550183891224

> <JCHEM_POLAR_SURFACE_AREA>
93.44000000000001

> <JCHEM_REFRACTIVITY>
116.90229999999995

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.08e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3H-1,4-benzodiazepin-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0      -5.688  -2.024   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -4.354  -1.254   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -3.021  -2.024   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -3.791  -3.358   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.251  -0.690   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.687  -2.794   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.061  -1.387   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -1.966  -0.141   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0      -3.481  -0.416   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0      -4.641   0.597   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -6.057  -0.008   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0      -4.572   2.135   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -5.979   2.762   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -6.139   4.293   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -4.894   5.198   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -3.487   4.572   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -3.326   3.040   0.000  0.00  0.00           C+0
HETATM   18  N   UNK     0      -1.841   2.631   0.000  0.00  0.00           N+0
HETATM   19  C   UNK     0      -0.828   3.790   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -1.236   1.215   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       0.302   1.146   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -2.592  -4.040   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      -4.132  -4.040   0.000  0.00  0.00           O+0
HETATM   24  N   UNK     0      -1.687  -5.286   0.000  0.00  0.00           N+0
HETATM   25  O   UNK     0      -2.163  -6.751   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      -0.222  -4.810   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.111  -5.580   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.445  -4.810   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       2.445  -3.270   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       1.111  -2.500   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      -0.222  -3.270   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5    6                                             
CONECT    4    3                                                            
CONECT    5    3                                                            
CONECT    6    3    7   22   31                                             
CONECT    7    6    8                                                       
CONECT    8    7    9   20                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13   17                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   12   18                                                  
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18    8   21                                                  
CONECT   21   20                                                            
CONECT   22    6   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27   31                                                  
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   26    6                                                  
MASTER        0    0    0    0    0    0    0    0   31    0   68    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₄H₂₅N₃O₄

Average Mass

419.4810 Da

Monoisotopic Mass

419.18451 Da

IUPAC Name

5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Traditional Name

5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3H-1,4-benzodiazepin-2-one

CAS Registry Number

Not Available

SMILES

CN1C2=CC=CC=C2C(O)=NC(CC2(C(=O)N(O)C3=CC=CC=C23)C(C)(C)C=C)C1=O

InChI Identifier

InChI=1S/C24H25N3O4/c1-5-23(2,3)24(16-11-7-9-13-19(16)27(31)22(24)30)14-17-21(29)26(4)18-12-8-6-10-15(18)20(28)25-17/h5-13,17,31H,1,14H2,2-4H3,(H,25,28)

InChI Key

CAIGWSRMYOIDFV-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzodiazepines

Sub Class

1,4-benzodiazepines

Direct Parent

1,4-benzodiazepines

Alternative Parents

Substituents

1,4-benzodiazepine
Alpha-amino acid or derivatives
Indole or derivatives
Benzenoid
Tertiary carboxylic acid amide
Vinylogous amide
Carboxamide group
Hydroxamic acid
Lactam
Secondary carboxylic acid amide
Carboxylic acid derivative
Azacycle
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Carbonyl group
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.65	ALOGPS
logP	3.39	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	7.63	ChemAxon
pKa (Strongest Basic)	1.58	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	93.44 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	116.9 m³·mol⁻¹	ChemAxon
Polarizability	43.39 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

32675111

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102339291

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one (NP0161150)

MOL for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

3D MOL for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

3D SDF for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

3D-SDF for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

PDB for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

3D PDB for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

SMILES for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

INCHI for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

Structure for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)

3D Structure for NP0161150 (5-hydroxy-3-{[1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindol-3-yl]methyl}-1-methyl-3h-1,4-benzodiazepin-2-one)