NP-MRD: Showing NP-Card for spiramycin ii (NP0157783)

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Record Information

Version

2.0

Created at

2022-09-02 15:15:03 UTC

Updated at

2022-09-02 15:15:03 UTC

NP-MRD ID

NP0157783

Secondary Accession Numbers

None

Natural Product Identification

Common Name

spiramycin ii

Description

Spiramycin II, also known as foromacidin b or acetylspiramycin, belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars. Thus, spiramycin II is considered to be an ansamycin. Spiramycin II is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. spiramycin ii was first documented in 1990 (PMID: 2232146). Based on a literature review a significant number of articles have been published on spiramycin II (PMID: 28278108) (PMID: 20490499) (PMID: 19306580) (PMID: 15127585) (PMID: 16496680) (PMID: 20843520).

Structure

MOL 3D MOL SDF PDB SMILES InChI

  Mrv1652309022217152D          

 62 65  0  0  1  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
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    0.7145   -5.3625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  4  5  1  1  0  0  0
  6  5  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
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 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
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 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
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 19 20  1  1  0  0  0
 19 21  1  0  0  0  0
 12 21  1  0  0  0  0
 10 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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  6 26  1  0  0  0  0
 26 27  1  1  0  0  0
  4 28  1  0  0  0  0
 28 29  1  6  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
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 60 62  2  0  0  0  0
M  END

     RDKit          3D

138141  0  0  0  0  0  0  0  0999 V2000
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M  END

  Mrv1652309022217152D          

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M  END
> <DATABASE_ID>
NP0157783

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O[C@H]2CC[C@@H]([C@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(51)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(52)29(5)57-37)42(54-12)34(59-30(6)49)23-35(50)55-26(2)16-14-13-15-17-33(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,51-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27+,28-,29+,31+,32+,33+,34-,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

> <INCHI_KEY>
ZPCCSZFPOXBNDL-RSMXASMKSA-N

> <FORMULA>
C45H76N2O15

> <MOLECULAR_WEIGHT>
885.102

> <EXACT_MASS>
884.524569755

> <JCHEM_ACCEPTOR_COUNT>
15

> <JCHEM_ATOM_COUNT>
138

> <JCHEM_AVERAGE_POLARIZABILITY>
95.14889368110046

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl acetate

> <ALOGPS_LOGP>
3.51

> <JCHEM_LOGP>
2.9372387893333336

> <ALOGPS_LOGS>
-4.01

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
2

> <JCHEM_PKA>
13.187616948420821

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.554863864345869

> <JCHEM_PKA_STRONGEST_BASIC>
9.27955779829933

> <JCHEM_POLAR_SURFACE_AREA>
201.45

> <JCHEM_REFRACTIVITY>
228.39730000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
13

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
8.75e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
acetylspiramycin

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0       4.001  -5.390   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       2.667  -4.620   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    5  O   UNK     0      -0.000  -3.080   0.000  0.00  0.00           O+0
HETATM    6  C   UNK     0      -0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       1.334  -5.390   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       1.334  -6.930   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.667  -7.700   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.000  -7.700   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0      -0.000  -9.240   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       1.334 -10.010   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.334 -11.550   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.667 -12.320   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.677 -13.500   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       3.657 -13.500   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       4.001 -11.550   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       5.335 -12.320   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       4.001 -10.010   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       5.335  -9.240   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       2.667  -9.240   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -1.334  -6.930   0.000  0.00  0.00           C+0
HETATM   23  N   UNK     0      -2.667  -7.700   0.000  0.00  0.00           N+0
HETATM   24  C   UNK     0      -4.001  -6.930   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -2.667  -9.240   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      -1.334  -5.390   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -2.667  -4.620   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -0.000  -1.540   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.334   0.770   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -0.000   0.000   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      -0.000   1.540   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      -1.334   2.310   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0       1.334   3.850   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0       2.667   4.620   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       2.667   6.160   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       4.001   6.930   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0       5.335   6.160   0.000  0.00  0.00           C+0
HETATM   41  N   UNK     0       6.668   6.930   0.000  0.00  0.00           N+0
HETATM   42  C   UNK     0       6.668   8.470   0.000  0.00  0.00           C+0
HETATM   43  C   UNK     0       8.002   6.160   0.000  0.00  0.00           C+0
HETATM   44  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM   45  C   UNK     0       6.668   3.850   0.000  0.00  0.00           C+0
HETATM   46  O   UNK     0       4.001   3.850   0.000  0.00  0.00           O+0
HETATM   47  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   48  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   49  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   50  C   UNK     0       6.668   2.310   0.000  0.00  0.00           C+0
HETATM   51  C   UNK     0       8.002   1.540   0.000  0.00  0.00           C+0
HETATM   52  C   UNK     0       8.002   0.000   0.000  0.00  0.00           C+0
HETATM   53  C   UNK     0       9.336  -0.770   0.000  0.00  0.00           C+0
HETATM   54  O   UNK     0       6.668  -0.770   0.000  0.00  0.00           O+0
HETATM   55  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   56  O   UNK     0       8.002  -3.080   0.000  0.00  0.00           O+0
HETATM   57  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   58  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   59  O   UNK     0       4.001  -3.850   0.000  0.00  0.00           O+0
HETATM   60  C   UNK     0       5.335  -4.620   0.000  0.00  0.00           C+0
HETATM   61  C   UNK     0       6.668  -3.850   0.000  0.00  0.00           C+0
HETATM   62  O   UNK     0       5.335  -6.160   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   58                                                  
CONECT    4    3    5   28                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7   26                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   22                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   21                                                  
CONECT   13   12   14                                                       
CONECT   14   13   15   16   17                                             
CONECT   15   14                                                            
CONECT   16   14                                                            
CONECT   17   14   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   12                                                       
CONECT   22   10   23   26                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23                                                            
CONECT   26   22    6   27                                                  
CONECT   27   26                                                            
CONECT   28    4   29   32                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30                                                            
CONECT   32   28   33                                                       
CONECT   33   32   34   35                                                  
CONECT   34   33                                                            
CONECT   35   33   36   47                                                  
CONECT   36   35   37                                                       
CONECT   37   36   38   46                                                  
CONECT   38   37   39                                                       
CONECT   39   38   40                                                       
CONECT   40   39   41   44                                                  
CONECT   41   40   42   43                                                  
CONECT   42   41                                                            
CONECT   43   41                                                            
CONECT   44   40   45   46                                                  
CONECT   45   44                                                            
CONECT   46   44   37                                                       
CONECT   47   35   48                                                       
CONECT   48   47   49                                                       
CONECT   49   48   50                                                       
CONECT   50   49   51                                                       
CONECT   51   50   52                                                       
CONECT   52   51   53   54                                                  
CONECT   53   52                                                            
CONECT   54   52   55                                                       
CONECT   55   54   56   57                                                  
CONECT   56   55                                                            
CONECT   57   55   58                                                       
CONECT   58   57    3   59                                                  
CONECT   59   58   60                                                       
CONECT   60   59   61   62                                                  
CONECT   61   60                                                            
CONECT   62   60                                                            
MASTER        0    0    0    0    0    0    0    0   62    0  130    0
END

View in JSmol

Synonyms

Value	Source
Acetylspiramycin	ChEBI
Acetylspiramycinum	ChEBI
Foromacidin b	ChEBI
Foromacidine b	ChEBI
Spiramycin 2	ChEBI
Spiramycin b	ChEBI

Chemical Formula

C₄₅H₇₆N₂O₁₅

Average Mass

885.1020 Da

Monoisotopic Mass

884.52457 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O[C@H]2CC[C@@H]([C@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O

InChI Identifier

InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(51)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(52)29(5)57-37)42(54-12)34(59-30(6)49)23-35(50)55-26(2)16-14-13-15-17-33(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,51-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27+,28-,29+,31+,32+,33+,34-,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1

InChI Key

ZPCCSZFPOXBNDL-RSMXASMKSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aminoglycosides. These are molecules or a portion of a molecule composed of amino-modified sugars.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Aminoglycosides

Alternative Parents

Substituents

Aminoglycoside core
Macrolide
Disaccharide
Glycosyl compound
O-glycosyl compound
Dicarboxylic acid or derivatives
Oxane
Alpha-hydrogen aldehyde
Tertiary alcohol
Carboxylic acid ester
1,2-aminoalcohol
Lactone
Amino acid or derivatives
Tertiary aliphatic amine
Tertiary amine
Secondary alcohol
Dialkyl ether
Organoheterocyclic compound
Carboxylic acid derivative
Oxacycle
Ether
Acetal
Organic oxide
Carbonyl group
Organic nitrogen compound
Organopnictogen compound
Amine
Alcohol
Aldehyde
Organonitrogen compound
Hydrocarbon derivative
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

tertiary amino compound (CHEBI:31168 )
acetate ester (CHEBI:31168 )
disaccharide derivative (CHEBI:31168 )
ether (CHEBI:31168 )
macrolide (CHEBI:31168 )
aldehyde (CHEBI:31168 )
Ansamycins and related polyketides (LMPK05000002 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.51	ALOGPS
logS	-4	ALOGPS

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

4445368

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5282173

PDB ID

Not Available

ChEBI ID

31168

Good Scents ID

Not Available

References

General References

Li Z, Hu F, Ye R, Lv H, Zeng J: Influence of Al(3+) on the titer of spiramycin and effective components in fermentor. Prep Biochem Biotechnol. 2017 May 28;47(5):481-488. doi: 10.1080/10826068.2017.1292290. Epub 2017 Feb 17. [PubMed:28278108 ]
Ma C, Zhou H, Li J, Dai J, He W, Wang H, Wu L, Wang Y: Construction of 4"-isovalerylspiramycin-I-producing strain by in-frame partial deletion of 3-O-acyltransferase gene in Streptomyces spiramyceticus WSJ-1, the bitespiramycin producer. Curr Microbiol. 2011 Jan;62(1):16-20. doi: 10.1007/s00284-010-9664-8. Epub 2010 May 19. [PubMed:20490499 ]
Ma C, Wu L, Dai J, Zhou H, Li J, Sun X, Zhang K, Xia H, Wang Y: [Acylation specificity of midecamycin 3-O-acyltransferase within Streptomyces spiramyceticus F21]. Sheng Wu Gong Cheng Xue Bao. 2008 Dec;24(12):2086-92. [PubMed:19306580 ]
Luan XJ, Song ZH, Xiao Z: Monitoring sub-nanogram amount of acetylspiramycin in human urine using flow injection analysis with chemiluminescence detection. Yao Xue Xue Bao. 2004 Jan;39(1):64-7. [PubMed:15127585 ]
Wang FM: [Parallel catalytic hydrogen wave of acetylspiramycin caused by dissolved oxygen and its application]. Yao Xue Xue Bao. 2005 Dec;40(12):1135-8. [PubMed:16496680 ]
Wang MJ, Pendela M, Hu CQ, Jin SH, Hoogmartens J, Van Schepdael A, Adams E: Impurity profiling of acetylspiramycin by liquid chromatography-ion trap mass spectrometry. J Chromatogr A. 2010 Oct 15;1217(42):6531-44. doi: 10.1016/j.chroma.2010.08.061. Epub 2010 Sep 16. [PubMed:20843520 ]
Kondo A, Nakatani T, Kuzuya Y, Suzuki H, Sano H, Yamaguchi K, Shirahata K, Takahashi K, Kita K, Nishiie Y, et al.: [Studies on acetylspiramycin. 1. Separation and chemical structures of acetylspiramycin components]. Jpn J Antibiot. 1990 Jun;43(6):1152-63. [PubMed:2232146 ]
Yang AM, Song JH, Huang R, Jin SJ, Yang P: [Mycoplasma pneumoniae infection and drug resistance in children: an analysis of 1026 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2013 Jul;15(7):522-5. [PubMed:23866271 ]
Arai H, Sakai T, Okano K, Aoyagi R, Imai A, Takase H, Mochizuki M, Tsuneoka H: Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing. Clin Ophthalmol. 2014 Apr 23;8:789-92. doi: 10.2147/OPTH.S58669. eCollection 2014. [PubMed:24790408 ]
Wang QY, Li RH, Zheng LQ, Shang XH: Prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in female outpatients, 2009-2013. J Microbiol Immunol Infect. 2016 Jun;49(3):359-62. doi: 10.1016/j.jmii.2014.06.007. Epub 2014 Jul 28. [PubMed:25081985 ]
LOTUS database [Link]

Showing NP-Card for spiramycin ii (NP0157783)

MOL for NP0157783 (spiramycin ii)

3D MOL for NP0157783 (spiramycin ii)

3D SDF for NP0157783 (spiramycin ii)

3D-SDF for NP0157783 (spiramycin ii)

PDB for NP0157783 (spiramycin ii)

3D PDB for NP0157783 (spiramycin ii)

SMILES for NP0157783 (spiramycin ii)

INCHI for NP0157783 (spiramycin ii)

Structure for NP0157783 (spiramycin ii)

3D Structure for NP0157783 (spiramycin ii)