NP-MRD: Showing NP-Card for (1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol (NP0156217)

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Record Information

Version

2.0

Created at

2022-09-02 13:23:53 UTC

Updated at

2022-09-02 13:23:53 UTC

NP-MRD ID

NP0156217

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol

Description

Geodisterol belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. (1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol was first documented in 2009 (PMID: 19653640). Based on a literature review very few articles have been published on Geodisterol.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022215232D          

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M  END

     RDKit          3D

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M  END


  Mrv1652309022215232D          

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M  END
> <DATABASE_ID>
NP0156217

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C(\CC[C@](C)(O)[C@H]1[C@@H](O)C[C@H]2[C@@H]3CCC4=CC(O)=CC=C4[C@H]3CC[C@]12C)C(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C28H42O3/c1-6-18(17(2)3)11-14-28(5,31)26-25(30)16-24-23-9-7-19-15-20(29)8-10-21(19)22(23)12-13-27(24,26)4/h6,8,10,15,17,22-26,29-31H,7,9,11-14,16H2,1-5H3/b18-6-/t22-,23-,24+,25+,26+,27+,28+/m1/s1

> <INCHI_KEY>
CUSJYXLJHWOVEL-COWZIQHRSA-N

> <FORMULA>
C28H42O3

> <MOLECULAR_WEIGHT>
426.641

> <EXACT_MASS>
426.313395212

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
73

> <JCHEM_AVERAGE_POLARIZABILITY>
51.75403707919132

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,10S,11S,13S,14R,15S)-14-[(2S,5Z)-2-hydroxy-5-(propan-2-yl)hept-5-en-2-yl]-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,13-diol

> <ALOGPS_LOGP>
5.76

> <JCHEM_LOGP>
5.725852264333334

> <ALOGPS_LOGS>
-5.23

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.44951481356214

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.32703338116063

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8717674399887727

> <JCHEM_POLAR_SURFACE_AREA>
60.69

> <JCHEM_REFRACTIVITY>
128.2924

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.49e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,10S,11S,13S,14R,15S)-14-[(2S,5Z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,13-diol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0      -1.104  -9.089   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.159  -7.873   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.366  -8.084   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.312  -6.868   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       3.837  -7.079   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.782  -5.863   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.998  -6.808   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       3.566  -4.918   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       5.727  -4.647   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.299  -3.168   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       3.851  -2.645   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       6.574  -2.304   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.790  -3.249   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.306  -2.978   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       9.829  -1.529   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      11.345  -1.258   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.338  -2.436   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.854  -2.164   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      14.846  -3.342   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0      16.362  -3.071   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0      14.323  -4.790   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      12.807  -5.061   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.814  -3.884   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      10.299  -4.155   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       9.775  -5.603   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.259  -5.874   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       7.267  -4.697   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       6.595  -6.083   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       1.947  -9.510   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       3.472  -9.721   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.001 -10.726   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   29                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7    8    9                                             
CONECT    7    6                                                            
CONECT    8    6                                                            
CONECT    9    6   10   27                                                  
CONECT   10    9   11   12                                                  
CONECT   11   10                                                            
CONECT   12   10   13                                                       
CONECT   13   12   14   27                                                  
CONECT   14   13   15   24                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   23                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   17   24                                                  
CONECT   24   23   14   25                                                  
CONECT   25   24   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   13    9   28                                             
CONECT   28   27                                                            
CONECT   29    3   30   31                                                  
CONECT   30   29                                                            
CONECT   31   29                                                            
MASTER        0    0    0    0    0    0    0    0   31    0   68    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₂O₃

Average Mass

426.6410 Da

Monoisotopic Mass

426.31340 Da

IUPAC Name

(1S,10S,11S,13S,14R,15S)-14-[(2S,5Z)-2-hydroxy-5-(propan-2-yl)hept-5-en-2-yl]-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,13-diol

Traditional Name

(1S,10S,11S,13S,14R,15S)-14-[(2S,5Z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,13-diol

CAS Registry Number

Not Available

SMILES

C\C=C(\CC[C@](C)(O)[C@H]1[C@@H](O)C[C@H]2[C@@H]3CCC4=CC(O)=CC=C4[C@H]3CC[C@]12C)C(C)C

InChI Identifier

InChI=1S/C28H42O3/c1-6-18(17(2)3)11-14-28(5,31)26-25(30)16-24-23-9-7-19-15-20(29)8-10-21(19)22(23)12-13-27(24,26)4/h6,8,10,15,17,22-26,29-31H,7,9,11-14,16H2,1-5H3/b18-6-/t22-,23-,24+,25+,26+,27+,28+/m1/s1

InChI Key

CUSJYXLJHWOVEL-COWZIQHRSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Cholestane steroids

Direct Parent

Cholesterols and derivatives

Alternative Parents

Substituents

Cholesterol-skeleton
20-hydroxysteroid
16-hydroxysteroid
16-beta-hydroxysteroid
Hydroxysteroid
3-hydroxysteroid
Phenanthrene
Tetralin
1-hydroxy-2-unsubstituted benzenoid
Benzenoid
Tertiary alcohol
Cyclic alcohol
Secondary alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Alcohol
Aromatic homopolycyclic compound

Molecular Framework

Aromatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.76	ALOGPS
logP	5.73	ChemAxon
logS	-5.2	ALOGPS
pKa (Strongest Acidic)	10.33	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	60.69 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	128.29 m³·mol⁻¹	ChemAxon
Polarizability	51.75 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102585662

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Digirolamo JA, Li XC, Jacob MR, Clark AM, Ferreira D: Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp. J Nat Prod. 2009 Aug;72(8):1524-8. doi: 10.1021/np900177m. [PubMed:19653640 ]
LOTUS database [Link]

Showing NP-Card for (1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol (NP0156217)

MOL for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

3D MOL for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

3D SDF for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

3D-SDF for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

PDB for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

3D PDB for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

SMILES for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

INCHI for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

Structure for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)

3D Structure for NP0156217 ((1r,2s,3as,3bs,9bs,11as)-1-[(2s,5z)-2-hydroxy-5-isopropylhept-5-en-2-yl]-11a-methyl-1h,2h,3h,3ah,3bh,4h,5h,9bh,10h,11h-cyclopenta[a]phenanthrene-2,7-diol)