NP-MRD: Showing NP-Card for 2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid (NP0154534)

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Record Information

Version

2.0

Created at

2022-09-02 11:27:53 UTC

Updated at

2022-09-02 11:27:53 UTC

NP-MRD ID

NP0154534

Secondary Accession Numbers

None

Natural Product Identification

Common Name

2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid

Description

2-[(1-Carboxy-2-phenylethyl)amino]pentanedioic acid belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. 2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid is found in Clitocybe acromelalga. 2-[(1-Carboxy-2-phenylethyl)amino]pentanedioic acid is a very strong basic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 38 38  0  0  0  0  0  0  0  0999 V2000
    5.7167    0.7257    1.4130 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7318    0.6925    0.6290 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1006    1.8992    0.3623 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2878   -0.6550    0.1122 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0184   -0.4220   -0.6851 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9652   -0.0834    0.3372 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8350    0.4600   -0.1589 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4472   -0.0761   -0.4023 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.2635    0.2373    0.8885 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6754    0.2672    0.5706 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4502    1.2360    0.2780 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5936    1.6510   -0.1503 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3200    0.3547   -0.3447 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6958   -0.8082   -0.0839 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4281   -0.9582    0.3418 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0126    0.5743   -1.5329 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2891    1.7870   -1.5359 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2880   -0.1813   -2.7347 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6803   -1.3042    1.2038 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1159   -1.2233    2.2780 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0687   -2.5737    0.7865 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2172    2.2171   -0.6187 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1646   -1.3357    0.9410 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1094   -0.9100   -0.5879 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7877   -1.2864   -1.3258 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1416    0.4540   -1.3341 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4128    0.6260    1.0732 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1201    0.8218   -1.2203 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3708   -1.1847   -0.5238 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2434   -0.6662    1.5928 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9691    1.1662    1.3346 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9292    2.2729    0.8540 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0361    2.5346   -0.3358 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2999    0.4902   -0.8067 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3644   -1.6944   -0.0781 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9274   -1.9194    0.4163 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3224   -0.3405   -3.2013 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4526   -2.8451   -0.0662 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  1  0
  2  1  2  0
  2  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
  8 16  1  0
 16 18  1  0
 16 17  2  0
  6 19  1  0
 19 21  1  0
 19 20  2  0
 15 10  1  0
  3 22  1  0
  4 23  1  0
  4 24  1  0
  5 25  1  0
  5 26  1  0
  6 27  1  1
  7 28  1  0
  8 29  1  6
  9 30  1  0
  9 31  1  0
 11 32  1  0
 12 33  1  0
 13 34  1  0
 14 35  1  0
 15 36  1  0
 18 37  1  0
 21 38  1  0
M  END


  Mrv1533004241505162D          

 21 21  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 10 15  1  0  0  0  0
  8 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
  6 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0154534

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC(=O)CCC(NC(CC1=CC=CC=C1)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C14H17NO6/c16-12(17)7-6-10(13(18)19)15-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11,15H,6-8H2,(H,16,17)(H,18,19)(H,20,21)

> <INCHI_KEY>
HXHOXUIZVFYTTR-UHFFFAOYSA-N

> <FORMULA>
C14H17NO6

> <MOLECULAR_WEIGHT>
295.291

> <EXACT_MASS>
295.105587271

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
38

> <JCHEM_AVERAGE_POLARIZABILITY>
28.529561600477084

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid

> <ALOGPS_LOGP>
-0.69

> <JCHEM_LOGP>
-1.5353514850233003

> <ALOGPS_LOGS>
-2.30

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
3.254839744373325

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.6271797855521295

> <JCHEM_PKA_STRONGEST_BASIC>
8.942827458902222

> <JCHEM_POLAR_SURFACE_AREA>
123.93000000000002

> <JCHEM_REFRACTIVITY>
71.25980000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.48e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 24-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   24-APR-15         0                                  
HETATM    1  O   UNK     0       1.334 -10.010   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       2.667  -9.240   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0       2.667  -7.700   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0       4.001 -10.010   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.335  -9.240   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.668 -10.010   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       8.002  -9.240   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       9.336 -10.010   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.336 -11.550   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      10.669 -12.320   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      12.003 -11.550   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      13.337 -12.320   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      13.337 -13.860   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      12.003 -14.630   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      10.669 -13.860   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.669  -9.240   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      10.669  -7.700   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0      12.003 -10.010   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       6.668 -11.550   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       8.002 -12.320   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       5.335 -12.320   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   19                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   16                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   15                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   10                                                       
CONECT   16    8   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16                                                            
CONECT   19    6   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

View in JSmol

Synonyms

Value	Source
2-[(1-Carboxy-2-phenylethyl)amino]pentanedioate	Generator

Chemical Formula

C₁₄H₁₇NO₆

Average Mass

295.2910 Da

Monoisotopic Mass

295.10559 Da

IUPAC Name

2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid

Traditional Name

2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid

CAS Registry Number

Not Available

SMILES

OC(=O)CCC(NC(CC1=CC=CC=C1)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C14H17NO6/c16-12(17)7-6-10(13(18)19)15-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11,15H,6-8H2,(H,16,17)(H,18,19)(H,20,21)

InChI Key

HXHOXUIZVFYTTR-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Clitocybe acromelalga	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Phenylalanine and derivatives

Alternative Parents

Substituents

Phenylalanine or derivatives
Glutamic acid or derivatives
3-phenylpropanoic-acid
Alpha-amino acid
Amphetamine or derivatives
Tricarboxylic acid or derivatives
Amino fatty acid
Aralkylamine
Monocyclic benzene moiety
Fatty acyl
Benzenoid
Amino acid
Carboxylic acid
Secondary aliphatic amine
Secondary amine
Organonitrogen compound
Amine
Organic nitrogen compound
Carbonyl group
Organic oxide
Organopnictogen compound
Organooxygen compound
Hydrocarbon derivative
Organic oxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.69	ALOGPS
logP	-1.5	ChemAxon
logS	-2.3	ALOGPS
pKa (Strongest Acidic)	2.63	ChemAxon
pKa (Strongest Basic)	8.94	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	123.93 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	71.26 m³·mol⁻¹	ChemAxon
Polarizability	28.53 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid (NP0154534)

MOL for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

3D MOL for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

3D SDF for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

3D-SDF for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

PDB for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

3D PDB for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

SMILES for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

INCHI for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

Structure for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)

3D Structure for NP0154534 (2-[(1-carboxy-2-phenylethyl)amino]pentanedioic acid)