NP-MRD: Showing NP-Card for (2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid (NP0153474)

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Record Information

Version

2.0

Created at

2022-09-02 10:08:17 UTC

Updated at

2022-09-02 10:08:18 UTC

NP-MRD ID

NP0153474

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid

Description

CHEMBL136251 belongs to the class of organic compounds known as azasteroids and derivatives. These are steroid derivatives in which one carbon atom in the steroidal skeleton has been substituted with a nitrogen atom. (2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid is found in Sarcococca saligna. Based on a literature review very few articles have been published on CHEMBL136251.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022212082D          

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M  END

     RDKit          3D

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  Mrv1652309022212082D          

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M  END
> <DATABASE_ID>
NP0153474

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C=C(/C)C(O)=N[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC=C4[C@@H]3CCC2=C1)[C@H](C)N(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C28H44N2O/c1-8-18(2)26(31)29-21-13-15-27(4)20(17-21)9-10-22-24-12-11-23(19(3)30(6)7)28(24,5)16-14-25(22)27/h8,12,17,19,21-23,25H,9-11,13-16H2,1-7H3,(H,29,31)/b18-8+/t19-,21-,22-,23+,25-,27-,28+/m0/s1

> <INCHI_KEY>
WKBYYEDQGZSMCP-CNLUTGEBSA-N

> <FORMULA>
C28H44N2O

> <MOLECULAR_WEIGHT>
424.673

> <EXACT_MASS>
424.345364045

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
75

> <JCHEM_AVERAGE_POLARIZABILITY>
53.46513690532854

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2E)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,11-dien-5-yl]-2-methylbut-2-enimidic acid

> <ALOGPS_LOGP>
6.54

> <JCHEM_LOGP>
3.194617032574591

> <ALOGPS_LOGS>
-5.52

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.728005414934838

> <JCHEM_PKA_STRONGEST_BASIC>
10.408777869337984

> <JCHEM_POLAR_SURFACE_AREA>
35.830000000000005

> <JCHEM_REFRACTIVITY>
133.50889999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.29e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2E)-N-[(1S,2R,5S,10R,14S,15R)-14-[(1S)-1-(dimethylamino)ethyl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,11-dien-5-yl]-2-methylbut-2-enimidic acid

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0      -2.245  -0.185   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.729  -0.456   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.206  -1.904   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.199  -3.081   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.310  -2.175   0.000  0.00  0.00           C+0
HETATM    6  O   UNK     0       1.833  -3.624   0.000  0.00  0.00           O+0
HETATM    7  N   UNK     0       2.303  -0.998   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       3.819  -1.269   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.811  -0.092   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       6.327  -0.363   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       7.320   0.815   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.836   0.544   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.359  -0.905   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      10.875  -1.176   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      12.091  -0.231   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      13.366  -1.095   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      12.938  -2.574   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      13.883  -3.790   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      15.408  -3.579   0.000  0.00  0.00           C+0
HETATM   20  N   UNK     0      13.303  -5.217   0.000  0.00  0.00           N+0
HETATM   21  C   UNK     0      14.248  -6.432   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      11.777  -5.427   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      11.399  -2.624   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      12.070  -4.010   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      10.406  -3.802   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.890  -3.531   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.367  -2.082   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       6.851  -1.811   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       7.374  -3.259   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       5.858  -2.988   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.342  -2.717   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   31                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   28                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   27                                                  
CONECT   14   13   15   23                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18   23                                                  
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20                                                            
CONECT   23   17   14   24   25                                             
CONECT   24   23                                                            
CONECT   25   23   26                                                       
CONECT   26   25   27                                                       
CONECT   27   26   13   28                                                  
CONECT   28   27   10   29   30                                             
CONECT   29   28                                                            
CONECT   30   28   31                                                       
CONECT   31   30    8                                                       
MASTER        0    0    0    0    0    0    0    0   31    0   68    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₄N₂O

Average Mass

424.6730 Da

Monoisotopic Mass

424.34536 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

C\C=C(/C)C(O)=N[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC=C4[C@@H]3CCC2=C1)[C@H](C)N(C)C

InChI Identifier

InChI=1S/C28H44N2O/c1-8-18(2)26(31)29-21-13-15-27(4)20(17-21)9-10-22-24-12-11-23(19(3)30(6)7)28(24,5)16-14-25(22)27/h8,12,17,19,21-23,25H,9-11,13-16H2,1-7H3,(H,29,31)/b18-8+/t19-,21-,22-,23+,25-,27-,28+/m0/s1

InChI Key

WKBYYEDQGZSMCP-CNLUTGEBSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Sarcococca saligna	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as azasteroids and derivatives. These are steroid derivatives in which one carbon atom in the steroidal skeleton has been substituted with a nitrogen atom.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Azasteroids and derivatives

Direct Parent

Azasteroids and derivatives

Alternative Parents

Substituents

22-azasteroid
Azasteroid
N-acyl-amine
Amino acid or derivatives
Carboxamide group
Secondary carboxylic acid amide
Tertiary amine
Tertiary aliphatic amine
Carboxylic acid derivative
Organonitrogen compound
Organic oxide
Amine
Carbonyl group
Organooxygen compound
Organic nitrogen compound
Organic oxygen compound
Hydrocarbon derivative
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	6.54	ALOGPS
logS	-5.5	ALOGPS

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

9548549

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11373632

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid (NP0153474)

MOL for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D MOL for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D SDF for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D-SDF for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

PDB for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D PDB for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

SMILES for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

INCHI for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

Structure for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)

3D Structure for NP0153474 ((2e)-n-[(1s,3br,7s,9ar,9bs,11ar)-1-[(1s)-1-(dimethylamino)ethyl]-9a,11a-dimethyl-1h,2h,3bh,4h,5h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-yl]-2-methylbut-2-enimidic acid)