NP-MRD: Showing NP-Card for (2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol (NP0152796)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-09-02 09:20:55 UTC

Updated at

2022-09-02 09:20:55 UTC

NP-MRD ID

NP0152796

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

Description

2-(3,5-Dimethoxy-4-hydroxyphenyl)-3-[(beta-D-glucopyranosyloxy)methyl]-7-methoxybenzofuran-5-(1-propanol) belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety. (2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol is found in Selaginella moellendorffii. Based on a literature review very few articles have been published on 2-(3,5-Dimethoxy-4-hydroxyphenyl)-3-[(beta-D-glucopyranosyloxy)methyl]-7-methoxybenzofuran-5-(1-propanol).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022211202D          

 39 42  0  0  1  0            999 V2000
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
  8 19  1  0  0  0  0
 19 20  1  0  0  0  0
  6 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 23 22  1  6  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  6  0  0  0
 26 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 30 31  1  6  0  0  0
 30 32  1  0  0  0  0
 23 32  1  0  0  0  0
 32 33  1  1  0  0  0
  5 34  2  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  2  0  0  0  0
  3 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END

     RDKit          3D

 73 76  0  0  0  0  0  0  0  0999 V2000
    5.1696    5.2174    1.2618 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9429    5.8798    1.2991 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7255    5.2498    1.1476 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6761    3.9066    0.9486 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4945    3.1921    0.7864 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6003    1.7290    0.5819 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7639    1.1111    0.5769 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6731   -0.1644    0.3851 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6366   -1.1588    0.3105 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9790   -0.8865    0.4480 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9747   -1.8693    0.3776 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2291   -2.4464    0.0933 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9091   -2.7581   -0.0484 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4462   -4.1397   -0.2851 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3940   -4.4113   -1.7909 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9154   -5.8417   -2.0345 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8692   -6.0853   -3.4041 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9679   -1.7327    0.0324 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3200   -0.4267    0.2484 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6289    0.7897    0.3747 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8122    0.9736    0.2856 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5221   -0.2460    0.0761 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8799    0.0645   -0.0041 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.6232   -0.5071    0.9608 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0654   -1.7648    0.8286 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9621   -2.8141    0.9123 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5844   -4.0802    0.7773 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8735   -1.9925   -0.4169 C   0  0  1  0  0  0  0  0  0  0  0  0
   -6.2044   -2.3729   -0.1348 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8435   -0.7642   -1.2820 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.2432   -1.0580   -2.5901 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3774   -0.3486   -1.3832 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.2081    0.7167   -2.2472 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3405    3.8820    0.8312 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3591    5.2754    1.0359 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8155    5.9729    1.0806 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0421    5.3147    0.9243 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5442    5.9593    1.1937 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6137    7.3258    1.3970 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4534    5.0042    0.1917 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2199    4.2869    1.8323 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9662    5.8905    1.6814 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6367    3.3824    0.9186 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.7669   -2.4801   -0.5467 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9052   -2.4928    1.2940 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9663   -1.3628    0.2939 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9411   -3.2842    0.0232 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0943   -4.9103    0.1539 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3956   -4.2361    0.0683 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6507   -3.7367   -2.2574 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3816   -4.2301   -2.2643 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5988   -6.5760   -1.5795 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1219   -5.9090   -1.6514 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968   -6.9668   -3.6335 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0727   -1.9728   -0.0809 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1502    1.6622   -0.5334 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2629    1.3445    1.2290 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9928    1.1845    0.1074 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7661   -2.0655    1.6770 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2720   -2.7559    0.0542 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4876   -2.7793    1.8922 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4934   -4.0482    1.2119 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4067   -2.8168   -1.0259 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6463   -1.5534    0.2485 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4617    0.0120   -0.8164 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7216   -0.2798   -2.9861 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8115   -1.2452   -1.6850 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7272    1.4780   -1.8932 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6014    3.4114    0.7194 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1238    4.9881   -0.1288 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1530    4.4667    1.6344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9147    5.9781    1.1089 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7976    7.9213    1.4443 H   0  0  0  0  0  0  0  0  0  0  0  0
 11 10  1  0
 10  9  1  0
  9  8  2  0
  8  7  1  0
  7  6  1  0
  6 20  2  0
 20 21  1  0
 21 22  1  0
 22 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 26 27  1  0
 25 28  1  0
 28 29  1  0
 28 30  1  0
 30 31  1  0
 30 32  1  0
 32 33  1  0
 20 19  1  0
 19 18  2  0
 18 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 13 12  2  0
  6  5  1  0
  5  4  2  0
  4  3  1  0
  3  2  1  0
  2  1  1  0
  3 38  2  0
 38 39  1  0
 38 35  1  0
 35 36  1  0
 36 37  1  0
 35 34  2  0
 12  9  1  0
 34  5  1  0
 19  8  1  0
 32 23  1  0
 11 44  1  0
 11 45  1  0
 11 46  1  0
 21 56  1  0
 21 57  1  0
 23 58  1  6
 25 59  1  1
 26 60  1  0
 26 61  1  0
 27 62  1  0
 28 63  1  6
 29 64  1  0
 30 65  1  1
 31 66  1  0
 32 67  1  6
 33 68  1  0
 18 55  1  0
 14 48  1  0
 14 49  1  0
 15 50  1  0
 15 51  1  0
 16 52  1  0
 16 53  1  0
 17 54  1  0
 12 47  1  0
  4 43  1  0
  1 40  1  0
  1 41  1  0
  1 42  1  0
 39 73  1  0
 37 70  1  0
 37 71  1  0
 37 72  1  0
 34 69  1  0
M  END


  Mrv1652309022211202D          

 39 42  0  0  1  0            999 V2000
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
  8 19  1  0  0  0  0
 19 20  1  0  0  0  0
  6 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 23 22  1  6  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  6  0  0  0
 26 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 30 31  1  6  0  0  0
 30 32  1  0  0  0  0
 23 32  1  0  0  0  0
 32 33  1  1  0  0  0
  5 34  2  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  2  0  0  0  0
  3 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0152796

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=C2OC(=C(CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C2=CC(CCCO)=C1)C1=CC(OC)=C(O)C(OC)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C27H34O12/c1-34-17-9-14(10-18(35-2)21(17)30)25-16(12-37-27-24(33)23(32)22(31)20(11-29)38-27)15-7-13(5-4-6-28)8-19(36-3)26(15)39-25/h7-10,20,22-24,27-33H,4-6,11-12H2,1-3H3/t20-,22-,23+,24-,27-/m1/s1

> <INCHI_KEY>
OFYVHBYUENYMQK-UFOFBUIZSA-N

> <FORMULA>
C27H34O12

> <MOLECULAR_WEIGHT>
550.557

> <EXACT_MASS>
550.205026535

> <JCHEM_ACCEPTOR_COUNT>
11

> <JCHEM_ATOM_COUNT>
73

> <JCHEM_AVERAGE_POLARIZABILITY>
57.796143274630055

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3R,4S,5S,6R)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

> <ALOGPS_LOGP>
1.10

> <JCHEM_LOGP>
0.35071127333333424

> <ALOGPS_LOGS>
-2.96

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.210579689221653

> <JCHEM_PKA_STRONGEST_ACIDIC>
8.831224127599077

> <JCHEM_PKA_STRONGEST_BASIC>
-2.3774161780186702

> <JCHEM_POLAR_SURFACE_AREA>
180.67

> <JCHEM_REFRACTIVITY>
136.6844

> <JCHEM_ROTATABLE_BOND_COUNT>
11

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
6.04e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2R,3R,4S,5S,6R)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0      -4.940   1.365   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0      -3.400   1.365   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0      -2.630   0.031   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.090   0.031   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -0.320  -1.303   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.220  -1.303   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       2.126  -0.057   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       4.924   1.777   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       6.258   2.547   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       7.591  -2.843   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.925  -2.073   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.259  -2.843   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0      11.592  -2.073   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.126  -2.549   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.650  -4.013   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       2.680  -5.158   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       2.204  -6.622   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       3.235  -7.767   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       2.759  -9.231   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       3.789 -10.376   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       3.313 -11.841   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       1.253  -9.552   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       0.777 -11.016   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       0.222  -8.407   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.284  -8.727   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       0.698  -6.943   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      -0.333  -5.798   0.000  0.00  0.00           O+0
HETATM   34  C   UNK     0      -1.090  -2.637   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0      -2.630  -2.637   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      -3.400  -3.970   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      -4.940  -3.970   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      -3.400  -1.303   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0      -4.940  -1.303   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   38                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   34                                                  
CONECT    6    5    7   20                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   19                                                  
CONECT    9    8   10   12                                                  
CONECT   10    9   11                                                       
CONECT   11   10                                                            
CONECT   12    9   13                                                       
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16                                                            
CONECT   18   13   19                                                       
CONECT   19   18    8   20                                                  
CONECT   20   19    6   21                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   32                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26   28                                                  
CONECT   26   25   27                                                       
CONECT   27   26                                                            
CONECT   28   25   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30   23   33                                                  
CONECT   33   32                                                            
CONECT   34    5   35                                                       
CONECT   35   34   36   38                                                  
CONECT   36   35   37                                                       
CONECT   37   36                                                            
CONECT   38   35    3   39                                                  
CONECT   39   38                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   84    0
END

View in JSmol

Synonyms

Value	Source
2-(3,5-Dimethoxy-4-hydroxyphenyl)-3-[(b-D-glucopyranosyloxy)methyl]-7-methoxybenzofuran-5-(1-propanol)	Generator
2-(3,5-Dimethoxy-4-hydroxyphenyl)-3-[(β-D-glucopyranosyloxy)methyl]-7-methoxybenzofuran-5-(1-propanol)	Generator

Chemical Formula

C₂₇H₃₄O₁₂

Average Mass

550.5570 Da

Monoisotopic Mass

550.20503 Da

IUPAC Name

(2R,3R,4S,5S,6R)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

Traditional Name

(2R,3R,4S,5S,6R)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol

CAS Registry Number

Not Available

SMILES

COC1=C2OC(=C(CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C2=CC(CCCO)=C1)C1=CC(OC)=C(O)C(OC)=C1

InChI Identifier

InChI=1S/C27H34O12/c1-34-17-9-14(10-18(35-2)21(17)30)25-16(12-37-27-24(33)23(32)22(31)20(11-29)38-27)15-7-13(5-4-6-28)8-19(36-3)26(15)39-25/h7-10,20,22-24,27-33H,4-6,11-12H2,1-3H3/t20-,22-,23+,24-,27-/m1/s1

InChI Key

OFYVHBYUENYMQK-UFOFBUIZSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Selaginella moellendorffii	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

2-arylbenzofuran flavonoids

Sub Class

Not Available

Direct Parent

2-arylbenzofuran flavonoids

Alternative Parents

Substituents

2-arylbenzofuran flavonoid
Lignan glycoside
Neolignan skeleton
2-phenylbenzofuran
Phenylbenzofuran
Hexose monosaccharide
O-glycosyl compound
Glycosyl compound
Methoxyphenol
M-dimethoxybenzene
Dimethoxybenzene
Benzofuran
Phenoxy compound
Anisole
Phenol ether
Methoxybenzene
Alkyl aryl ether
Phenol
Oxane
Monocyclic benzene moiety
Monosaccharide
Benzenoid
Heteroaromatic compound
Furan
Secondary alcohol
Acetal
Ether
Organoheterocyclic compound
Oxacycle
Polyol
Primary alcohol
Organic oxygen compound
Hydrocarbon derivative
Alcohol
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.1	ALOGPS
logP	0.35	ChemAxon
logS	-3	ALOGPS
pKa (Strongest Acidic)	8.83	ChemAxon
pKa (Strongest Basic)	-2.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	180.67 Å²	ChemAxon
Rotatable Bond Count	11	ChemAxon
Refractivity	136.68 m³·mol⁻¹	ChemAxon
Polarizability	57.8 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

102262568

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol (NP0152796)

MOL for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

3D MOL for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

3D SDF for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

3D-SDF for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

PDB for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

3D PDB for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

SMILES for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

INCHI for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

Structure for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)

3D Structure for NP0152796 ((2r,3r,4s,5s,6r)-2-{[2-(4-hydroxy-3,5-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-1-benzofuran-3-yl]methoxy}-6-(hydroxymethyl)oxane-3,4,5-triol)