NP-MRD: Showing NP-Card for (3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione (NP0152460)

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Record Information

Version

2.0

Created at

2022-09-02 08:56:12 UTC

Updated at

2022-09-02 08:56:12 UTC

NP-MRD ID

NP0152460

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

Description

Pateamine belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members. Pateamine is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. (3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione is found in Apis cerana. (3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione was first documented in 2020 (PMID: 33104139). Based on a literature review a significant number of articles have been published on pateamine (PMID: 33507727) (PMID: 34214439) (PMID: 33412110) (PMID: 32209692) (PMID: 32014999) (PMID: 32008367).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022210562D          

 39 40  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652309022210562D          

 39 40  0  0  1  0            999 V2000
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    0.6117    1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5758    0.5995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    0.8708    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5980    1.6799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0687    0.3403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8440    0.6222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9876    1.4346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4758    0.0917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2512    0.3735    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3947    1.1860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8830   -0.1570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7394   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3712   -1.4999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9641   -1.2513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8205   -2.0637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0452   -2.3456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4134   -1.8151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5569   -1.0026    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6380   -2.0969    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0638   -5.3466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9202   -6.1590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1449   -6.4409    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0013   -7.2533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5131   -5.9104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  1  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  1  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  1  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
  8 34  1  0  0  0  0
  2 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0152460

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1C\C(C)=C\C=C/C(=O)O[C@@H](CC2=NC(=CS2)[C@@H](C)C[C@@H](N)CC(=O)O1)\C=C(/C)\C=C\C(\C)=C\CN(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C31H45N3O4S/c1-21(13-14-34(6)7)11-12-23(3)16-27-19-29-33-28(20-39-29)24(4)17-26(32)18-31(36)37-25(5)15-22(2)9-8-10-30(35)38-27/h8-13,16,20,24-27H,14-15,17-19,32H2,1-7H3/b10-8-,12-11+,21-13+,22-9+,23-16+/t24-,25-,26+,27+/m0/s1

> <INCHI_KEY>
DSPNTLCJTJBXTD-IRNRRZNASA-N

> <FORMULA>
C31H45N3O4S

> <MOLECULAR_WEIGHT>
555.78

> <EXACT_MASS>
555.313078115

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
84

> <JCHEM_AVERAGE_POLARIZABILITY>
64.33470078592933

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3S,6Z,8E,11S,15R,17S)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

> <ALOGPS_LOGP>
5.08

> <JCHEM_LOGP>
5.049212721666666

> <ALOGPS_LOGS>
-5.61

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
2

> <JCHEM_PKA_STRONGEST_BASIC>
9.505497931096471

> <JCHEM_POLAR_SURFACE_AREA>
94.75

> <JCHEM_REFRACTIVITY>
163.28170000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.37e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3S,6Z,8E,11S,15R,17S)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0       6.479 -10.444   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.300  -9.454   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.568  -7.938   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.388  -6.947   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.656  -5.431   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.104  -4.905   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.477  -4.440   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.745  -2.924   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.298  -3.450   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.118  -2.460   0.000  0.00  0.00           C+0
HETATM   11  N   UNK     0       1.339  -0.789   0.000  0.00  0.00           N+0
HETATM   12  C   UNK     0       0.524   0.517   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.713  -0.770   0.000  0.00  0.00           C+0
HETATM   14  S   UNK     0      -0.411  -2.280   0.000  0.00  0.00           S+0
HETATM   15  C   UNK     0       1.514   1.696   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.142   3.191   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       2.942   1.119   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.549   1.626   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0       4.850   3.136   0.000  0.00  0.00           N+0
HETATM   20  C   UNK     0       5.728   0.635   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.175   1.161   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       7.443   2.678   0.000  0.00  0.00           O+0
HETATM   23  O   UNK     0       8.355   0.171   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       9.802   0.697   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      10.070   2.214   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      10.982  -0.293   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      10.714  -1.810   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      11.893  -2.800   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       9.266  -2.336   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       8.998  -3.852   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       7.551  -4.378   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       6.372  -3.388   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       6.640  -1.872   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0       4.924  -3.914   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       3.852  -9.980   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       3.584 -11.497   0.000  0.00  0.00           C+0
HETATM   37  N   UNK     0       2.137 -12.023   0.000  0.00  0.00           N+0
HETATM   38  C   UNK     0       1.869 -13.540   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0       0.958 -11.033   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   35                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5                                                            
CONECT    7    5    8                                                       
CONECT    8    7    9   34                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   14                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13   15                                                  
CONECT   13   12   14                                                       
CONECT   14   13   10                                                       
CONECT   15   12   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   21                                                       
CONECT   21   20   22   23                                                  
CONECT   22   21                                                            
CONECT   23   21   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27   30                                                       
CONECT   30   29   31                                                       
CONECT   31   30   32                                                       
CONECT   32   31   33   34                                                  
CONECT   33   32                                                            
CONECT   34   32    8                                                       
CONECT   35    2   36                                                       
CONECT   36   35   37                                                       
CONECT   37   36   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   80    0
END

View in JSmol

Synonyms

Value	Source
(-)-Pateamine	ChEBI
Pateamine a	ChEBI

Chemical Formula

C₃₁H₄₅N₃O₄S

Average Mass

555.7800 Da

Monoisotopic Mass

555.31308 Da

IUPAC Name

(3S,6Z,8E,11S,15R,17S)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

Traditional Name

(3S,6Z,8E,11S,15R,17S)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione

CAS Registry Number

Not Available

SMILES

C[C@H]1C\C(C)=C\C=C/C(=O)O[C@@H](CC2=NC(=CS2)[C@@H](C)C[C@@H](N)CC(=O)O1)\C=C(/C)\C=C\C(\C)=C\CN(C)C

InChI Identifier

InChI=1S/C31H45N3O4S/c1-21(13-14-34(6)7)11-12-23(3)16-27-19-29-33-28(20-39-29)24(4)17-26(32)18-31(36)37-25(5)15-22(2)9-8-10-30(35)38-27/h8-13,16,20,24-27H,14-15,17-19,32H2,1-7H3/b10-8-,12-11+,21-13+,22-9+,23-16+/t24-,25-,26+,27+/m0/s1

InChI Key

DSPNTLCJTJBXTD-IRNRRZNASA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Apis cerana	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Macrolides and analogues

Sub Class

Not Available

Direct Parent

Macrolides and analogues

Alternative Parents

Substituents

Macrolide
Aralkylamine
Dicarboxylic acid or derivatives
Azole
Thiazole
Heteroaromatic compound
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Amino acid or derivatives
Carboxylic acid ester
Lactone
Tertiary amine
Tertiary aliphatic amine
Carboxylic acid derivative
Oxacycle
Azacycle
Organoheterocyclic compound
Organic nitrogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic oxide
Organic oxygen compound
Amine
Hydrocarbon derivative
Carbonyl group
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.08	ALOGPS
logP	5.05	ChemAxon
logS	-5.6	ALOGPS
pKa (Strongest Basic)	9.51	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	94.75 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	163.28 m³·mol⁻¹	ChemAxon
Polarizability	64.33 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

25053851

KEGG Compound ID

C19917

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10053416

PDB ID

Not Available

ChEBI ID

134184

Good Scents ID

Not Available

References

General References

Furstner A: Lessons from Natural Product Total Synthesis: Macrocyclization and Postcyclization Strategies. Acc Chem Res. 2021 Feb 16;54(4):861-874. doi: 10.1021/acs.accounts.0c00759. Epub 2021 Jan 28. [PubMed:33507727 ]
Ingolia NT: eIF4A inhibitors PatA and RocA stack the deck against translation. Structure. 2021 Jul 1;29(7):638-639. doi: 10.1016/j.str.2021.06.009. [PubMed:34214439 ]
Naineni SK, Liang J, Hull K, Cencic R, Zhu M, Northcote P, Teesdale-Spittle P, Romo D, Nagar B, Pelletier J: Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. Cell Chem Biol. 2021 Jun 17;28(6):825-834.e6. doi: 10.1016/j.chembiol.2020.12.006. Epub 2021 Jan 6. [PubMed:33412110 ]
Truax NJ, Romo D: Bridging the gap between natural product synthesis and drug discovery. Nat Prod Rep. 2020 Nov 1;37(11):1436-1453. doi: 10.1039/d0np00048e. Epub 2020 Oct 26. [PubMed:33104139 ]
Storey MA, Andreassend SK, Bracegirdle J, Brown A, Keyzers RA, Ackerley DF, Northcote PT, Owen JG: Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts. mBio. 2020 Mar 24;11(2):e02997-19. doi: 10.1128/mBio.02997-19. [PubMed:32209692 ]
Naineni SK, Itoua Maiga R, Cencic R, Putnam AA, Amador LA, Rodriguez AD, Jankowsky E, Pelletier J: A comparative study of small molecules targeting eIF4A. RNA. 2020 May;26(5):541-549. doi: 10.1261/rna.072884.119. Epub 2020 Feb 3. [PubMed:32014999 ]
Kommaraju SS, Aulicino J, Gobbooru S, Li J, Zhu M, Romo D, Low WK: Investigation of the mechanism of action of a potent pateamine A analog, des-methyl, des-amino pateamine A (DMDAPatA). Biochem Cell Biol. 2020 Aug;98(4):502-510. doi: 10.1139/bcb-2019-0307. Epub 2020 Feb 2. [PubMed:32008367 ]
Adedoja AN, McMahan T, Neal JP, Hamal Dhakal S, Jois S, Romo D, Hull K, Garlapati S: Translation initiation factors GleIF4E2 and GleIF4A can interact directly with the components of the pre-initiation complex to facilitate translation initiation in Giardia lamblia. Mol Biochem Parasitol. 2020 Mar;236:111258. doi: 10.1016/j.molbiopara.2020.111258. Epub 2020 Jan 20. [PubMed:31968220 ]
LOTUS database [Link]

Showing NP-Card for (3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione (NP0152460)

MOL for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

3D MOL for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

3D SDF for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

3D-SDF for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

PDB for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

3D PDB for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

SMILES for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

INCHI for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

Structure for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)

3D Structure for NP0152460 ((3s,6z,8e,11s,15r,17s)-15-amino-3-[(1e,3e,5e)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione)