NP-MRD: Showing NP-Card for (1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate (NP0152309)

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Record Information

Version

2.0

Created at

2022-09-02 08:45:19 UTC

Updated at

2022-09-02 08:45:19 UTC

NP-MRD ID

NP0152309

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate

Description

Daphnezomine D belongs to the class of organic compounds known as steroids and steroid derivatives. Steroids and steroid derivatives are compounds based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. (1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate is found in Daphniphyllum macropodum. Based on a literature review very few articles have been published on Daphnezomine D.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022210452D          

 37 43  0  0  1  0            999 V2000
    7.0428   -1.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9944   -0.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6834    0.0421    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2348   -0.0306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5854    0.5593    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.1339    1.1756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9940    1.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2711    2.3862    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.3372    3.2465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5096    2.0689    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2828    1.2757    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9812    0.2899    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7616    0.6038    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.6628   -0.3113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7936    1.5587    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.9228    1.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3325    1.2593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6158   -1.1040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  6  0  0  0
 11 13  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  6  0  0  0
 13 15  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 18 17  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  1  0  0  0
 24 25  1  0  0  0  0
 26 25  1  6  0  0  0
 22 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 30 29  1  1  0  0  0
 26 30  1  0  0  0  0
 18 30  1  0  0  0  0
 23 31  1  0  0  0  0
 18 31  1  0  0  0  0
 31 32  1  6  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 19 34  1  0  0  0  0
 34 35  1  6  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END

     RDKit          2D

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 36 35  1  0
 35 37  1  0
 35 34  1  0
 34 33  1  0
 33 32  1  0
 32 31  1  0
 31 23  1  0
 23 24  1  0
 24 25  1  0
 26 25  1  6
 26 27  1  0
 27 28  1  0
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 29 30  1  0
 30 18  1  0
 18 17  1  1
 17 16  1  0
 16 15  1  0
 15  8  1  0
  8  9  1  6
  8  7  1  0
  7  6  1  0
  6  5  1  0
  5  4  1  0
  4  2  1  0
  2  1  1  0
  2  3  2  0
  5 13  1  0
 13 14  1  6
 13 11  1  0
 11 12  1  0
 11 10  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 20 22  1  0
 19 34  1  0
 18 31  1  0
 13 15  1  0
 22 23  1  0
 30 26  1  0
 10  8  1  0
 22 26  1  0
 36 79  1  0
 36 80  1  0
 36 81  1  0
 35 78  1  0
 37 82  1  0
 37 83  1  0
 37 84  1  0
 34 77  1  6
 33 75  1  0
 33 76  1  0
 32 73  1  0
 32 74  1  0
 31 72  1  6
 23 60  1  1
 24 61  1  0
 24 62  1  0
 25 63  1  0
 25 64  1  0
 27 65  1  0
 27 66  1  0
 28 67  1  0
 28 68  1  0
 29 69  1  0
 29 70  1  0
 30 71  1  6
 17 57  1  0
 17 58  1  0
 16 55  1  0
 16 56  1  0
 15 54  1  1
  9 46  1  0
  9 47  1  0
  9 48  1  0
  7 44  1  0
  7 45  1  0
  6 42  1  0
  6 43  1  0
  5 41  1  1
  1 38  1  0
  1 39  1  0
  1 40  1  0
 14 51  1  0
 14 52  1  0
 14 53  1  0
 11 49  1  1
 12 50  1  0
 22 59  1  0
M  CHG  2  20   1  21  -1
M  END


  Mrv1652309022210452D          

 37 43  0  0  1  0            999 V2000
    7.0428   -1.2352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9944   -0.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9940    1.9886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1718    0.4930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4692    1.1884    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5818    0.6013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2168    1.3176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0451    1.5115    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5822    2.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0752    2.9159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8466    2.6191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8184    1.7569    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3592    1.6669    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2562    1.7457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7727    1.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3880    0.2890    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7107   -0.6177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2166   -1.3396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6158   -1.1040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  6  0  0  0
 11 13  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  6  0  0  0
 13 15  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 18 17  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  1  0  0  0
 24 25  1  0  0  0  0
 26 25  1  6  0  0  0
 22 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 30 29  1  1  0  0  0
 26 30  1  0  0  0  0
 18 30  1  0  0  0  0
 23 31  1  0  0  0  0
 18 31  1  0  0  0  0
 31 32  1  6  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 19 34  1  0  0  0  0
 34 35  1  6  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
> <DATABASE_ID>
NP0152309

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(C)[C@H]1CC[C@H]2[C@@H]3CC[C@]45CCC[C@H]4[C@]2(CC[C@H]2[C@]4(C)CC[C@H](OC(C)=O)[C@@]2(C)[C@H](O)O4)C1=[N+]([O-])C35

> <INCHI_IDENTIFIER>
InChI=1S/C31H47NO5/c1-17(2)19-8-9-21-20-10-15-30-13-6-7-23(30)31(21,26(19)32(35)25(20)30)16-11-22-28(4)14-12-24(36-18(3)33)29(22,5)27(34)37-28/h17,19-25,27,34H,6-16H2,1-5H3/t19-,20+,21+,22+,23-,24+,25?,27-,28+,29+,30-,31-/m1/s1

> <INCHI_KEY>
KBWVUHRNDGZVAA-PMCOSGHLSA-N

> <FORMULA>
C31H47NO5

> <MOLECULAR_WEIGHT>
513.719

> <EXACT_MASS>
513.345423617

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
84

> <JCHEM_AVERAGE_POLARIZABILITY>
68.3214063331255

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2R,3R,7R,10S,14R)-2-{2-[(1S,2S,5S,7R,8R)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-(propan-2-yl)-12-azapentacyclo[8.6.0.0^{2,13}.0^{3,7}.0^{7,11}]hexadec-12-en-12-ium-12-olate

> <ALOGPS_LOGP>
2.38

> <JCHEM_LOGP>
2.2124435498615864

> <ALOGPS_LOGS>
-4.94

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
11.862910969821622

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.36984230881266

> <JCHEM_PKA_STRONGEST_BASIC>
-4.170963605334122

> <JCHEM_POLAR_SURFACE_AREA>
81.83

> <JCHEM_REFRACTIVITY>
141.26930000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
5.85e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2R,3R,7R,10S,14R)-2-{2-[(1S,2S,5S,7R,8R)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0^{2,13}.0^{3,7}.0^{7,11}]hexadec-12-en-12-ium-12-olate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0      13.910  -1.615   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      13.345  -0.183   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      14.302   1.023   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      11.776   0.050   0.000  0.00  0.00           O+0
HETATM    5  C   UNK     0      10.426   1.044   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      11.450   2.194   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.189   3.712   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.839   4.454   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      10.006   6.047   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       8.418   3.862   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       7.995   2.381   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       8.490   0.660   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       8.888   1.127   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.661  -0.419   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       8.948   2.910   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.274   3.508   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       6.094   2.147   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.597   2.058   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.758   0.534   0.000  0.00  0.00           C+0
HETATM   20  N   UNK     0       3.346  -0.049   0.000  0.00  0.00           N+1
HETATM   21  O   UNK     0       2.806  -1.549   0.000  0.00  0.00           O-1
HETATM   22  C   UNK     0       2.187   0.920   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       2.742   2.218   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       1.086   1.122   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       0.405   2.459   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       1.951   2.821   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       1.087   4.200   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       2.007   5.443   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       3.447   4.889   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       3.394   3.280   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       4.404   3.112   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       6.078   3.259   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       7.042   1.949   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       6.324   0.540   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       6.168  -1.201   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       5.731  -2.747   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       6.830  -2.696   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5                                                       
CONECT    5    4    6   13                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   10   15                                             
CONECT    9    8                                                            
CONECT   10    8   11                                                       
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11    5   14   15                                             
CONECT   14   13                                                            
CONECT   15   13    8   16                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19   30   31                                             
CONECT   19   18   20   34                                                  
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   26                                                  
CONECT   23   22   24   31                                                  
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   22   27   30                                             
CONECT   27   26   28                                                       
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   26   18                                                  
CONECT   31   23   18   32                                                  
CONECT   32   31   33                                                       
CONECT   33   32   34                                                       
CONECT   34   33   19   35                                                  
CONECT   35   34   36   37                                                  
CONECT   36   35                                                            
CONECT   37   35                                                            
MASTER        0    0    0    0    0    0    0    0   37    0   86    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₁H₄₇NO₅

Average Mass

513.7190 Da

Monoisotopic Mass

513.34542 Da

IUPAC Name

(1S,2R,3R,7R,10S,14R)-2-{2-[(1S,2S,5S,7R,8R)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-(propan-2-yl)-12-azapentacyclo[8.6.0.0^{2,13}.0^{3,7}.0^{7,11}]hexadec-12-en-12-ium-12-olate

Traditional Name

(1S,2R,3R,7R,10S,14R)-2-{2-[(1S,2S,5S,7R,8R)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0^{2,13}.0^{3,7}.0^{7,11}]hexadec-12-en-12-ium-12-olate

CAS Registry Number

Not Available

SMILES

CC(C)[C@H]1CC[C@H]2[C@@H]3CC[C@]45CCC[C@H]4[C@]2(CC[C@H]2[C@]4(C)CC[C@H](OC(C)=O)[C@@]2(C)[C@H](O)O4)C1=[N+]([O-])C35

InChI Identifier

InChI=1S/C31H47NO5/c1-17(2)19-8-9-21-20-10-15-30-13-6-7-23(30)31(21,26(19)32(35)25(20)30)16-11-22-28(4)14-12-24(36-18(3)33)29(22,5)27(34)37-28/h17,19-25,27,34H,6-16H2,1-5H3/t19-,20+,21+,22+,23-,24+,25?,27-,28+,29+,30-,31-/m1/s1

InChI Key

KBWVUHRNDGZVAA-PMCOSGHLSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Daphniphyllum macropodum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroids and steroid derivatives. Steroids and steroid derivatives are compounds based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Not Available

Direct Parent

Steroids and steroid derivatives

Alternative Parents

Substituents

Steroid
Tetrahydropyridine
Oxepane
Tetrahydrofuran
Nitrone
Hemiacetal
Carboxylic acid ester
Oxacycle
Azacycle
Organoheterocyclic compound
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Allyl-type 1,3-dipolar organic compound
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organic zwitterion
Organooxygen compound
Organonitrogen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.38	ALOGPS
logP	2.21	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	6.37	ChemAxon
pKa (Strongest Basic)	-4.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	81.83 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	141.27 m³·mol⁻¹	ChemAxon
Polarizability	68.32 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

100947300

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for (1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate (NP0152309)

MOL for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

3D MOL for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

3D SDF for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

3D-SDF for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

PDB for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

3D PDB for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

SMILES for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

INCHI for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

Structure for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)

3D Structure for NP0152309 ((1s,2r,3r,7r,10s,14r)-2-{2-[(1s,2s,5s,7r,8r)-2-(acetyloxy)-7-hydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]octan-8-yl]ethyl}-14-isopropyl-12-azapentacyclo[8.6.0.0²,¹³.0³,⁷.0⁷,¹¹]hexadec-12-en-12-ium-12-olate)