NP-MRD: Showing NP-Card for 6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one (NP0148236)

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Record Information

Version

2.0

Created at

2022-09-02 03:57:38 UTC

Updated at

2022-09-02 03:57:38 UTC

NP-MRD ID

NP0148236

Secondary Accession Numbers

None

Natural Product Identification

Common Name

6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one

Description

(17Alpha,23S)-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units (17alpha,23S)-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione is an extremely weak basic (essentially neutral) compound (based on its pKa). Outside of the human body, (17alpha,23S)-epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione has been detected, but not quantified in, herbs and spices. 6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one is found in Leopoldia comosa. This could make (17alpha,23S)-epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione a potential biomarker for the consumption of these foods.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv0541 05061308362D          

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  Mrv0541 05061308362D          

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    2.4648    3.3028    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9718    2.6318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3154   -0.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  5  1  0  0  0  0
  2  3  1  0  0  0  0
  2 30  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4 29  1  0  0  0  0
  5  6  1  0  0  0  0
  5  9  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 13  1  0  0  0  0
  8 34  1  0  0  0  0
  9 10  1  0  0  0  0
  9 26  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 17  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 21  1  0  0  0  0
 17 18  1  0  0  0  0
 17 27  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 28  2  0  0  0  0
 21 22  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
 31 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0148236

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCC(=O)C1CC(C)C2(CCC3(C)C4=C(CCC23C)C2(C)CCC(=O)C(CO)(CO)C2CC4)O1

> <INCHI_IDENTIFIER>
InChI=1S/C29H44O5/c1-6-21(32)22-15-18(2)29(34-22)14-13-26(4)20-7-8-23-25(3,19(20)9-12-27(26,29)5)11-10-24(33)28(23,16-30)17-31/h18,22-23,30-31H,6-17H2,1-5H3

> <INCHI_KEY>
DIKWKAQBKMFLHS-UHFFFAOYSA-N

> <FORMULA>
C29H44O5

> <MOLECULAR_WEIGHT>
472.6567

> <EXACT_MASS>
472.318874518

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_AVERAGE_POLARIZABILITY>
54.90642618660025

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethyl-5-propanoylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-1'(10')-en-5'-one

> <ALOGPS_LOGP>
4.46

> <JCHEM_LOGP>
3.857292189666666

> <ALOGPS_LOGS>
-4.88

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.270020519486955

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.573736955302948

> <JCHEM_PKA_STRONGEST_BASIC>
-2.853352747664827

> <JCHEM_POLAR_SURFACE_AREA>
83.82999999999998

> <JCHEM_REFRACTIVITY>
131.94779999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.18e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethyl-5-propanoylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-1'(10')-en-5'-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 06-MAY-13   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   06-MAY-13         0                                  
HETATM    1  O   UNK     0       3.518   2.187   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       3.518   3.727   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.052   4.202   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.149   2.957   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.052   1.709   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.958   0.464   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       2.052  -0.780   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.589  -0.305   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       0.589   1.234   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      -0.746   2.005   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      -2.080   1.234   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -2.080  -0.305   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      -0.746  -1.075   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      -0.746  -2.615   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -2.080  -3.386   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -3.412  -2.615   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -3.412  -1.075   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -4.747  -0.305   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -6.079  -1.075   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      -6.079  -2.615   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      -4.747  -3.386   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -4.025  -4.746   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      -4.842  -6.051   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      -5.471  -4.745   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      -7.010  -4.798   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       0.033   2.767   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -3.413   0.465   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0      -7.413  -3.385   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0      -0.186   3.727   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       4.762   4.633   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       6.169   4.007   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       4.601   6.165   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       7.414   4.913   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       0.589  -1.846   0.000  0.00  0.00           C+0
CONECT    1    2    5                                                       
CONECT    2    1    3   30                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   29                                                  
CONECT    5    1    4    6    9                                             
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   13   34                                             
CONECT    9    5    8   10   26                                             
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   17                                                  
CONECT   13    8   12   14                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17   21                                                  
CONECT   17   12   16   18   27                                             
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   28                                                  
CONECT   21   16   20   22   24                                             
CONECT   22   21   23                                                       
CONECT   23   22                                                            
CONECT   24   21   25                                                       
CONECT   25   24                                                            
CONECT   26    9                                                            
CONECT   27   17                                                            
CONECT   28   20                                                            
CONECT   29    4                                                            
CONECT   30    2   31   32                                                  
CONECT   31   30   33                                                       
CONECT   32   30                                                            
CONECT   33   31                                                            
CONECT   34    8                                                            
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

View in JSmol

Synonyms

Value	Source
(17a,23S)-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione	Generator
(17Α,23S)-epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione	Generator
17a,23S-Epoxy-28,29-dihydroxy-27-norlanost-8-ene-3,24-dione	HMDB

Chemical Formula

C₂₉H₄₄O₅

Average Mass

472.6567 Da

Monoisotopic Mass

472.31887 Da

IUPAC Name

6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethyl-5-propanoylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-1'(10')-en-5'-one

Traditional Name

6',6'-bis(hydroxymethyl)-2',3,11',15'-tetramethyl-5-propanoylspiro[oxolane-2,14'-tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan]-1'(10')-en-5'-one

CAS Registry Number

Not Available

SMILES

CCC(=O)C1CC(C)C2(CCC3(C)C4=C(CCC23C)C2(C)CCC(=O)C(CO)(CO)C2CC4)O1

InChI Identifier

InChI=1S/C29H44O5/c1-6-21(32)22-15-18(2)29(34-22)14-13-26(4)20-7-8-23-25(3,19(20)9-12-27(26,29)5)11-10-24(33)28(23,16-30)17-31/h18,22-23,30-31H,6-17H2,1-5H3

InChI Key

DIKWKAQBKMFLHS-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Muscari comosum	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as triterpenoids. These are terpene molecules containing six isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Triterpenoids

Direct Parent

Triterpenoids

Alternative Parents

Not Available

Substituents

Not Available

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.46	ALOGPS
logP	3.86	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	14.57	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	83.83 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	131.95 m³·mol⁻¹	ChemAxon
Polarizability	54.91 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0035624

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB014330

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

131751817

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one (NP0148236)

MOL for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

3D MOL for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

3D SDF for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

3D-SDF for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

PDB for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

3D PDB for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

SMILES for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

INCHI for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

Structure for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)

3D Structure for NP0148236 (6,6-bis(hydroxymethyl)-3',3a,9a,11a-tetramethyl-5'-propanoyl-3,4,5,5a,8,9,10,11-octahydro-2h-spiro[cyclopenta[a]phenanthrene-1,2'-oxolan]-7-one)