NP-MRD: Showing NP-Card for 1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone (NP0147731)

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Record Information

Version

2.0

Created at

2022-09-02 03:23:38 UTC

Updated at

2022-09-02 03:23:38 UTC

NP-MRD ID

NP0147731

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone

Description

1-[25-(3,3-Dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]Pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethan-1-one belongs to the class of organic compounds known as alpha carbolines. These are organic compounds containing a pyrido[2,3-b]indole core (which is a pyridine fused to an indole). 1-[25-(3,3-Dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]Pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethan-1-one is a very strong basic compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1533004231518452D          

 33 40  0  0  0  0            999 V2000
    6.6392    3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3679    3.0534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0672    3.4912    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3974    2.2289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1398    1.8451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6590    1.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8160    0.9531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7040    1.8052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8972    1.9576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2877    2.3403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4436   -0.6276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 22 33  1  0  0  0  0
M  END

     RDKit          3D

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M  END


  Mrv1533004231518452D          

 33 40  0  0  0  0            999 V2000
    6.6392    3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
> <DATABASE_ID>
NP0147731

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)N1CCC23C1N1CCC22C(NC4=CC=CC(C1C1OC1(C)C)=C24)NC1=CC=CC=C31

> <INCHI_IDENTIFIER>
InChI=1S/C27H30N4O2/c1-15(32)30-13-11-26-17-8-4-5-9-18(17)28-23-27(26)12-14-31(24(26)30)21(22-25(2,3)33-22)16-7-6-10-19(29-23)20(16)27/h4-10,21-24,28-29H,11-14H2,1-3H3

> <INCHI_KEY>
XJXBCJLZWKPOFG-UHFFFAOYSA-N

> <FORMULA>
C27H30N4O2

> <MOLECULAR_WEIGHT>
442.563

> <EXACT_MASS>
442.236876222

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
63

> <JCHEM_AVERAGE_POLARIZABILITY>
48.337603745090775

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethan-1-one

> <ALOGPS_LOGP>
3.40

> <JCHEM_LOGP>
2.423195459

> <ALOGPS_LOGS>
-3.53

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
8

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.576363572507951

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.34256538149632

> <JCHEM_PKA_STRONGEST_BASIC>
6.156210159125793

> <JCHEM_POLAR_SURFACE_AREA>
60.14000000000001

> <JCHEM_REFRACTIVITY>
128.2059

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.30e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-APR-15         0                                  
HETATM    1  C   UNK     0      12.393   6.422   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      13.753   5.700   0.000  0.00  0.00           C+0
HETATM    3  O   UNK     0      15.059   6.517   0.000  0.00  0.00           O+0
HETATM    4  N   UNK     0      13.808   4.161   0.000  0.00  0.00           N+0
HETATM    5  C   UNK     0      15.194   3.444   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      14.297   2.144   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      12.723   1.779   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      12.514   3.370   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0      11.008   3.654   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0       9.870   4.369   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      10.484   2.671   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.141   1.190   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      11.352  -0.385   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0      12.405  -1.577   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0      13.895  -1.172   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      15.358  -1.651   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      16.505  -0.622   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      16.188   0.885   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      14.724   1.364   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      13.578   0.335   0.000  0.00  0.00           C+0
HETATM   21  N   UNK     0      10.234  -1.462   0.000  0.00  0.00           N+0
HETATM   22  C   UNK     0       8.795  -0.929   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       7.592  -2.010   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.598  -0.827   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       7.059   0.703   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.378   1.645   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       9.335   3.004   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       8.386   4.217   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       6.957   4.793   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       8.170   5.742   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       7.823   7.242   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       9.461   6.581   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       9.544   0.558   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3    4                                                  
CONECT    3    2                                                            
CONECT    4    2    5    8                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   12   20                                             
CONECT    8    7    4    9                                                  
CONECT    9    8   10   27                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11    7   13   33                                             
CONECT   13   12   14   21                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   20                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19    7   15                                                  
CONECT   21   13   22                                                       
CONECT   22   21   23   33                                                  
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   26                                                       
CONECT   26   25   27   33                                                  
CONECT   27   26    9   28                                                  
CONECT   28   27   29   30                                                  
CONECT   29   28   30                                                       
CONECT   30   29   28   31   32                                             
CONECT   31   30                                                            
CONECT   32   30                                                            
CONECT   33   26   12   22                                                  
MASTER        0    0    0    0    0    0    0    0   33    0   80    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₇H₃₀N₄O₂

Average Mass

442.5630 Da

Monoisotopic Mass

442.23688 Da

IUPAC Name

1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethan-1-one

Traditional Name

1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone

CAS Registry Number

Not Available

SMILES

CC(=O)N1CCC23C1N1CCC22C(NC4=CC=CC(C1C1OC1(C)C)=C24)NC1=CC=CC=C31

InChI Identifier

InChI=1S/C27H30N4O2/c1-15(32)30-13-11-26-17-8-4-5-9-18(17)28-23-27(26)12-14-31(24(26)30)21(22-25(2,3)33-22)16-7-6-10-19(29-23)20(16)27/h4-10,21-24,28-29H,11-14H2,1-3H3

InChI Key

XJXBCJLZWKPOFG-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Not Available

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alpha carbolines. These are organic compounds containing a pyrido[2,3-b]indole core (which is a pyridine fused to an indole).

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Pyridoindoles

Direct Parent

Alpha carbolines

Alternative Parents

Substituents

Alpha-carboline
Aminoquinoline
Benzazepine
Diazanaphthalene
Tetrahydroquinoline
Naphthyridine
Dihydroindole
N-acylpyrrolidine
Azepine
Secondary aliphatic/aromatic amine
Benzenoid
Piperidine
Acetamide
Tertiary carboxylic acid amide
Pyrrolidine
Amino acid or derivatives
Carboxamide group
Secondary amine
Azacycle
Oxacycle
Carboxylic acid derivative
Ether
Oxirane
Dialkyl ether
Organooxygen compound
Hydrocarbon derivative
Amine
Carbonyl group
Organic oxide
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.4	ALOGPS
logP	2.42	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Acidic)	15.34	ChemAxon
pKa (Strongest Basic)	6.16	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	60.14 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	128.21 m³·mol⁻¹	ChemAxon
Polarizability	48.34 Å³	ChemAxon
Number of Rings	8	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

LOTUS database [Link]

Showing NP-Card for 1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone (NP0147731)

MOL for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

3D MOL for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

3D SDF for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

3D-SDF for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

PDB for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

3D PDB for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

SMILES for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

INCHI for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

Structure for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)

3D Structure for NP0147731 (1-[25-(3,3-dimethyloxiran-2-yl)-1,3,13,15-tetraazaheptacyclo[18.4.1.0²,⁶.0⁶,²².0⁷,¹².0¹⁴,²².0¹⁶,²¹]pentacosa-7,9,11,16,18,20-hexaen-3-yl]ethanone)