NP-MRD: Showing NP-Card for methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate (NP0143712)

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Record Information

Version

2.0

Created at

2022-09-01 22:32:33 UTC

Updated at

2022-09-01 22:32:33 UTC

NP-MRD ID

NP0143712

Secondary Accession Numbers

None

Natural Product Identification

Common Name

methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate

Description

Vindoline belongs to the class of organic compounds known as plumeran-type alkaloids. These are alkaloids with a structure based on the plumeran skeleton. Plumeran is a pentacyclic compound that consists of a pyrrolidine ring shed to the quinoline moiety of pyrido[3,2-c]carbazole ring system. methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate is found in Catharanthus roseus and Catharanthus trichophyllus. methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate was first documented in 2022 (PMID: 35887145). Based on a literature review a small amount of articles have been published on Vindoline (PMID: 35947213) (PMID: 35873460) (PMID: 35722510) (PMID: 35697946).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652309022200322D          

 33 37  0  0  1  0            999 V2000
    0.1477    0.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9183    0.5096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5589   -0.0103    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7883   -0.3051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6584   -1.1198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.6397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0695   -1.3449    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0384   -1.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4885   -0.8770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9700   -0.2353    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7047   -0.6106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9173   -1.4077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140   -1.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2980   -1.0394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0946   -1.2537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6786   -0.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2886   -0.0279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9149    0.7076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2902    1.4423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0999    0.5794    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4593    1.0993    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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    3.0825    1.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8623    1.3704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9259    2.4499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491    2.9904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6888    0.8044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0482    1.3243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1781    2.1390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9486    2.4338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1995   -0.5302    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3 28  1  0  0  0  0
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 30 32  2  0  0  0  0
 10 33  1  0  0  0  0
 33  7  1  6  0  0  0
  3 33  1  0  0  0  0
M  END

     RDKit          3D

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    2.4201    2.1592    1.2731 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END


  Mrv1652309022200322D          

 33 37  0  0  1  0            999 V2000
    0.1477    0.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9183    0.5096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5589   -0.0103    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
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    0.6584   -1.1198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.6397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2886   -0.0279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2902    1.4423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0999    0.5794    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4593    1.0993    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0351    1.8069    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0825    1.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8623    1.3704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9486    2.4338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
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 10  9  1  1  0  0  0
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 10 33  1  0  0  0  0
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  3 33  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0143712

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC[C@@]12C=CCN3CC[C@@]4([C@@H]13)[C@H](N(C)C1=CC(OC)=CC=C41)[C@](O)(C2OC(C)=O)C(=O)OC

> <INCHI_IDENTIFIER>
InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21?,23-,24-,25+/m1/s1

> <INCHI_KEY>
CXBGOBGJHGGWIE-VJAGLATISA-N

> <FORMULA>
C25H32N2O6

> <MOLECULAR_WEIGHT>
456.539

> <EXACT_MASS>
456.226036758

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
65

> <JCHEM_AVERAGE_POLARIZABILITY>
48.97792167836665

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (1R,9S,10S,12R,19S)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate

> <ALOGPS_LOGP>
2.53

> <JCHEM_LOGP>
1.8826374543333317

> <ALOGPS_LOGS>
-3.07

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.868158007477678

> <JCHEM_PKA_STRONGEST_BASIC>
8.673438058558657

> <JCHEM_POLAR_SURFACE_AREA>
88.53999999999999

> <JCHEM_REFRACTIVITY>
122.2981

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.92e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl (1R,9S,10S,12R,19S)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 02-SEP-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   02-SEP-22         0                                  
HETATM    1  C   UNK     0       0.276   0.401   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       1.714   0.951   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       2.910  -0.019   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.472  -0.570   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.229  -2.090   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.425  -3.061   0.000  0.00  0.00           C+0
HETATM    7  N   UNK     0       3.863  -2.510   0.000  0.00  0.00           N+0
HETATM    8  C   UNK     0       5.672  -2.928   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.512  -1.637   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.544  -0.439   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.915  -1.140   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.312  -2.628   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.799  -3.028   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       9.890  -1.940   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      11.377  -2.340   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0      12.467  -1.253   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.493  -0.452   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       8.005  -0.052   0.000  0.00  0.00           C+0
HETATM   19  N   UNK     0       7.308   1.321   0.000  0.00  0.00           N+0
HETATM   20  C   UNK     0       8.008   2.692   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.786   1.082   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       4.591   2.052   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       3.799   3.373   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       5.754   3.061   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       7.210   2.558   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       5.462   4.573   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       6.625   5.582   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.152   1.502   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       1.957   2.472   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       2.199   3.993   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       1.003   4.963   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0       3.637   4.543   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0       4.106  -0.990   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4   28   33                                             
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   33                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   21   33                                             
CONECT   11   10   12   18                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   17                                                  
CONECT   15   14   16                                                       
CONECT   16   15                                                            
CONECT   17   14   18                                                       
CONECT   18   17   11   19                                                  
CONECT   19   18   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19   10   22                                                  
CONECT   22   21   23   24   28                                             
CONECT   23   22                                                            
CONECT   24   22   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26                                                            
CONECT   28   22    3   29                                                  
CONECT   29   28   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30                                                            
CONECT   33   10    7    3                                                  
MASTER        0    0    0    0    0    0    0    0   33    0   74    0
END

View in JSmol

Synonyms

Value	Source
Vindoline, citrate, (2beta,3beta,4beta,5alpha,12beta,19alpha)-isomer	MeSH
Vindoline, monohydrochloride, (2beta,3beta,4beta,5alpha,12beta,19alpha)-isomer	MeSH

Chemical Formula

C₂₅H₃₂N₂O₆

Average Mass

456.5390 Da

Monoisotopic Mass

456.22604 Da

IUPAC Name

methyl (1R,9S,10S,12R,19S)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate

Traditional Name

methyl (1R,9S,10S,12R,19S)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,13-tetraene-10-carboxylate

CAS Registry Number

Not Available

SMILES

CC[C@@]12C=CCN3CC[C@@]4([C@@H]13)[C@H](N(C)C1=CC(OC)=CC=C41)[C@](O)(C2OC(C)=O)C(=O)OC

InChI Identifier

InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21?,23-,24-,25+/m1/s1

InChI Key

CXBGOBGJHGGWIE-VJAGLATISA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Catharanthus roseus	LOTUS Database	35616633
Catharanthus trichophyllus	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as plumeran-type alkaloids. These are alkaloids with a structure based on the plumeran skeleton. Plumeran is a pentacyclic compound that consists of a pyrrolidine ring shed to the quinoline moiety of pyrido[3,2-c]carbazole ring system.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Plumeran-type alkaloids

Sub Class

Not Available

Direct Parent

Plumeran-type alkaloids

Alternative Parents

Substituents

Plumeran-type alkaloid
Carbazole
Indole or derivatives
Dialkylarylamine
Tertiary aliphatic/aromatic amine
Anisole
Aralkylamine
Alkyl aryl ether
Benzenoid
N-alkylpyrrolidine
Dicarboxylic acid or derivatives
Methyl ester
Tertiary alcohol
Pyrrolidine
Cyclic alcohol
Tertiary aliphatic amine
Tertiary amine
Carboxylic acid ester
Amino acid or derivatives
Azacycle
Organoheterocyclic compound
Ether
Carboxylic acid derivative
Organic nitrogen compound
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Carbonyl group
Amine
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.53	ALOGPS
logP	1.88	ChemAxon
logS	-3.1	ALOGPS
pKa (Strongest Acidic)	10.87	ChemAxon
pKa (Strongest Basic)	8.67	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	88.54 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	122.3 m³·mol⁻¹	ChemAxon
Polarizability	48.98 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00001784

Chemspider ID

78430067

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Vindoline

METLIN ID

Not Available

PubChem Compound

129316872

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Lemos Cruz P, Carqueijeiro I, Koudounas K, Bomzan DP, Stander EA, Abdallah C, Kulagina N, Oudin A, Lanoue A, Giglioli-Guivarc'h N, Nagegowda DA, Papon N, Besseau S, Clastre M, Courdavault V: Identification of a second 16-hydroxytabersonine-O-methyltransferase suggests an evolutionary relationship between alkaloid and flavonoid metabolisms in Catharanthus roseus. Protoplasma. 2023 Mar;260(2):607-624. doi: 10.1007/s00709-022-01801-x. Epub 2022 Aug 10. [PubMed:35947213 ]
Huang HH, Lin TL, Lee WJ, Chen SC, Lai WF, Lu CC, Lai HC, Chen CY: Impact of Metabolic Surgery on Gut Microbiota and Sera Metabolomic Patterns among Patients with Diabetes. Int J Mol Sci. 2022 Jul 14;23(14):7797. doi: 10.3390/ijms23147797. [PubMed:35887145 ]
Zhou P, Chen M: Exploration of the Mechanisms of Differential Indole Alkaloid Biosynthesis in Dedifferentiated and Cambial Meristematic Cells of Catharanthus roseus Using Transcriptome Sequencing. Front Genet. 2022 Jun 30;13:867064. doi: 10.3389/fgene.2022.867064. eCollection 2022. [PubMed:35873460 ]
Nishanth MJ, Simon B: Understanding the possible influence of Pumilio RNA binding proteins on terpenoid indole alkaloid biosynthesis in Catharanthus roseus. Physiol Mol Biol Plants. 2022 May;28(5):963-969. doi: 10.1007/s12298-022-01193-5. Epub 2022 Jun 6. [PubMed:35722510 ]
Raorane ML, Manz C, Hildebrandt S, Mielke M, Thieme M, Keller J, Bunzel M, Nick P: Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus. Protoplasma. 2023 Mar;260(2):349-369. doi: 10.1007/s00709-022-01781-y. Epub 2022 Jun 13. [PubMed:35697946 ]
LOTUS database [Link]

Showing NP-Card for methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate (NP0143712)

MOL for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

3D MOL for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

3D SDF for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

3D-SDF for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

PDB for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

3D PDB for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

SMILES for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

INCHI for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

Structure for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)

3D Structure for NP0143712 (methyl (1r,9s,10s,12r,19s)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0¹,⁹.0²,⁷.0¹⁶,¹⁹]nonadeca-2,4,6,13-tetraene-10-carboxylate)