Record Information |
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Version | 1.0 |
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Created at | 2022-06-29 22:19:09 UTC |
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Updated at | 2022-06-29 22:19:09 UTC |
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NP-MRD ID | NP0141237 |
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Secondary Accession Numbers | None |
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Natural Product Identification |
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Common Name | ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid |
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Description | Ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D. It was first documented in 2022 (PMID: 35868842). Based on a literature review a significant number of articles have been published on ent-9-Hydroxy-15-oxo-16-kauren-19-oic acid (PMID: 35868820) (PMID: 35868806) (PMID: 35868798) (PMID: 35868796) (PMID: 35868785) (PMID: 35868778). |
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Structure | C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](CC[C@@]21O)C(=C)C3=O)C(O)=O InChI=1S/C20H28O4/c1-12-13-5-10-20(24)18(3)8-4-7-17(2,16(22)23)14(18)6-9-19(20,11-13)15(12)21/h13-14,24H,1,4-11H2,2-3H3,(H,22,23)/t13-,14+,17+,18+,19-,20+/m0/s1 |
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Synonyms | Value | Source |
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ent-9-Hydroxy-15-oxo-16-kauren-19-Oate | Generator |
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Chemical Formula | C20H28O4 |
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Average Mass | 332.4400 Da |
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Monoisotopic Mass | 332.19876 Da |
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IUPAC Name | Not Available |
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Traditional Name | Not Available |
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CAS Registry Number | Not Available |
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SMILES | C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](CC[C@@]21O)C(=C)C3=O)C(O)=O |
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InChI Identifier | InChI=1S/C20H28O4/c1-12-13-5-10-20(24)18(3)8-4-7-17(2,16(22)23)14(18)6-9-19(20,11-13)15(12)21/h13-14,24H,1,4-11H2,2-3H3,(H,22,23)/t13-,14+,17+,18+,19-,20+/m0/s1 |
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InChI Key | AURKCYFYZBQUIZ-LJIVFDACSA-N |
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Experimental Spectra |
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| Not Available | Predicted Spectra |
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| Spectrum Type | Description | Depositor ID | Depositor Organization | Depositor | Deposition Date | View |
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1D NMR | 13C NMR Spectrum (1D, 25 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 100 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 252 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 50 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 200 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 75 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 300 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 101 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 400 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 126 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 151 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 176 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 201 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 800 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 13C NMR Spectrum (1D, 226 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum | 1D NMR | 1H NMR Spectrum (1D, 900 MHz, H2O, predicted) | Wishart Lab | Wishart Lab | David Wishart | 2021-06-20 | View Spectrum |
| Chemical Shift Submissions |
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| Not Available | Species |
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Species of Origin | Not Available |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Prenol lipids |
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Sub Class | Diterpenoids |
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Direct Parent | Kaurane diterpenoids |
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Alternative Parents | |
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Substituents | - Kaurane diterpenoid
- Tertiary alcohol
- Cyclic alcohol
- Ketone
- Monocarboxylic acid or derivatives
- Carboxylic acid
- Carboxylic acid derivative
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Alcohol
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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General References | - Bouillet L, Fain O, Armengol G, Aubineau M, Blanchard-Delaunay C, Dalmas MC, De Moreuil C, Du Thanh A, Gobert D, Guez S, Hoarau C, Jaussaud R, Jeandel PY, Maillard H, Marmion N, Masseau A, Menetrey C, Ollivier Y, Pelletier F, Plu-Bureau G, Sailler L, Vincent D, Bouquillon B, Verdier E, Clerson P, Boccon-Gibod I, Launay D: Long-term prophylaxis in hereditary angioedema management: Current practices in France and unmet needs. Allergy Asthma Proc. 2022 Sep 22;43(5):406-412. doi: 10.2500/aap.2022.43.220046. Epub 2022 Jul 22. [PubMed:35868842 ]
- Solomou G, Gharooni AA, Patel W, Gillespie CS, Gough M, Venkatesh A, Poon MTC, Wykes V, Price SJ, Jenkinson MD, Watts C, Plaha P: Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review. BMJ Open. 2022 Jul 22;12(7):e056059. doi: 10.1136/bmjopen-2021-056059. [PubMed:35868820 ]
- Morgan AA, Mahmood A, Russell GK, Kon OM: Intestinal perforation due to miliary tuberculosis in a patient with myasthenia gravis. BMJ Case Rep. 2022 Jul 22;15(7). pii: 15/7/e249547. doi: 10.1136/bcr-2022-249547. [PubMed:35868806 ]
- Tabatabaei M, Ebrahimi B, Rajaei A, Movahednejad MH, Rastegari H, Taghavi E, Aghbashlo M, Gupta VK, Lam SS: Producing submicron chitosan-stabilized oil Pickering emulsion powder by an electrostatic collector-equipped spray dryer. Carbohydr Polym. 2022 Oct 15;294:119791. doi: 10.1016/j.carbpol.2022.119791. Epub 2022 Jun 28. [PubMed:35868798 ]
- Reddy VJ, Dixit P, Singh J, Chattopadhyay S: Understanding the core-shell interactions in macrocapsules of organic phase change materials and polysaccharide shell. Carbohydr Polym. 2022 Oct 15;294:119786. doi: 10.1016/j.carbpol.2022.119786. Epub 2022 Jun 28. [PubMed:35868796 ]
- Fani N, Enayati MH, Rostamabadi H, Falsafi SR: Encapsulation of bioactives within electrosprayed kappa-carrageenan nanoparticles. Carbohydr Polym. 2022 Oct 15;294:119761. doi: 10.1016/j.carbpol.2022.119761. Epub 2022 Jun 22. [PubMed:35868785 ]
- Sood A, Gupta A, Bharadwaj R, Ranganath P, Silverman N, Agrawal G: Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer. Carbohydr Polym. 2022 Oct 15;294:119833. doi: 10.1016/j.carbpol.2022.119833. Epub 2022 Jul 7. [PubMed:35868778 ]
- Weng H, Jia W, Li M, Chen Z: New injectable chitosan-hyaluronic acid based hydrogels for hemostasis and wound healing. Carbohydr Polym. 2022 Oct 15;294:119767. doi: 10.1016/j.carbpol.2022.119767. Epub 2022 Jun 23. [PubMed:35868789 ]
- Gao D, Asghar S, Ye J, Zhang M, Hu R, Wang Y, Huang L, Yuan C, Chen Z, Xiao Y: Dual-targeted enzyme-sensitive hyaluronic acid nanogels loading paclitaxel for the therapy of breast cancer. Carbohydr Polym. 2022 Oct 15;294:119785. doi: 10.1016/j.carbpol.2022.119785. Epub 2022 Jun 28. [PubMed:35868795 ]
- Luo Y, Cui L, Zou L, Zhao Y, Chen L, Guan Y, Zhang Y: Mechanically strong and on-demand dissoluble chitosan hydrogels for wound dressing applications. Carbohydr Polym. 2022 Oct 15;294:119774. doi: 10.1016/j.carbpol.2022.119774. Epub 2022 Jun 28. [PubMed:35868791 ]
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