NP-MRD: Showing NP-Card for Illudin M (NP0139324)

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Record Information

Version

2.0

Created at

2022-06-29 19:49:14 UTC

Updated at

2026-04-17 01:00:37 UTC

NP-MRD ID

NP0139324

Natural Product DOI

https://doi.org/10.57994/8522

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Illudin M

Description

(-)-Illudin m belongs to the class of organic compounds known as illudanes and illudins. These are sesquiterpenoids containing either the illudane moiety (based on a 3,6,6,7b-tetramethyl-decahydro-1H-cyclobuta[e]indene ring system), the illudin moiety (2',2',4',6'-tetramethyl-octahydrospiro[cyclopropane-1,5'-indene]), or a derivative thereof. Illudin M is found in Granulobasidium vellereum and Omphalotus illudens. Thus, (-)-illudin m is considered to be an isoprenoid lipid molecule (-)-illudin m is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral (-)-illudin m is a potentially toxic compound.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 38 40  0  0  0  0  0  0  0  0999 V2000
   -0.7209   -2.4097   -0.6400 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386   -0.9516   -0.2862 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4528   -0.3648   -0.0684 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5375    1.0368    0.2780 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7981    1.4015    0.4462 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7095    0.2646    0.2269 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207    0.5702   -0.8680 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5086   -0.0632    1.4794 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8345   -0.8893   -0.1092 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1834   -1.3015   -1.4065 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7381    1.7773    0.3780 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7415    3.0168    0.2936 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9932    1.0180    0.5782 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.1598    1.8970    0.1925 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1041    0.7494    1.9413 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0164   -0.2630   -0.1990 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2363   -1.1252    0.0838 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0294   -0.5006   -1.2555 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3071   -2.7677   -0.8497 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0591   -2.9424    0.2751 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4036   -2.6167   -1.4882 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0832    2.4311    0.7148 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0888   -0.3913   -1.2426 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5598    1.1118   -0.3608 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2443    1.1901   -1.6401 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9722   -0.8579    2.0599 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633    0.8022    2.1261 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4625   -0.5290    1.1565 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9706   -1.7611    0.5718 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9413   -0.5951   -2.0634 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1720    2.1429   -0.8883 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1036    1.4492    0.5134 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0272    2.8548    0.7523 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2116    0.4642    2.2648 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0481   -2.2069    0.2091 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0193   -0.7416    0.7657 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7459   -1.1944   -2.0785 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7695    0.2950   -1.5189 H   0  0  0  0  0  0  0  0  0  0  0  0
  9 10  1  0
  9  3  1  0
  3  2  2  0
  2  1  1  0
  2 16  1  0
 16 17  1  0
 17 18  1  0
 16 13  1  0
 13 14  1  0
 13 15  1  1
 13 11  1  0
 11 12  2  0
 11  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  1  0
  6  8  1  0
  6  9  1  0
  4  3  1  0
 18 16  1  0
  9 29  1  1
 10 30  1  0
  1 19  1  0
  1 20  1  0
  1 21  1  0
 17 35  1  0
 17 36  1  0
 18 37  1  0
 18 38  1  0
 14 31  1  0
 14 32  1  0
 14 33  1  0
 15 34  1  0
  5 22  1  0
  7 23  1  0
  7 24  1  0
  7 25  1  0
  8 26  1  0
  8 27  1  0
  8 28  1  0
M  END


  Mrv0541 08291401182D          

 19 21  0  0  1  0            999 V2000
    0.4149   -0.1955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4963    1.2533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2085    0.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5588    2.0555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7486    1.4006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5367    0.6033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4664    1.6510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6300    0.6010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6424    1.6094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4273    0.8130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0602    2.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1184    0.3623    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7605    0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2629    1.9820    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0478    1.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2753    2.9904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1599   -0.4617    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1927    2.8040    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4031   -0.0488    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  6  5  1  0  0  0  0
  8  1  1  0  0  0  0
  9  7  2  0  0  0  0
 10  8  2  0  0  0  0
 10  9  1  0  0  0  0
 11  9  1  0  0  0  0
 12 10  1  0  0  0  0
 13  2  1  0  0  0  0
 13  3  1  0  0  0  0
 13  7  1  0  0  0  0
 13 12  1  0  0  0  0
 14  4  1  6  0  0  0
 14 11  1  0  0  0  0
 15  5  1  0  0  0  0
 15  6  1  0  0  0  0
 15  8  1  0  0  0  0
 15 14  1  0  0  0  0
 16 11  2  0  0  0  0
 12 17  1  6  0  0  0
 14 18  1  1  0  0  0
 12 19  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0139324

> <DATABASE_NAME>
NP-MRD

> <SMILES>
[H][C@@]1(O)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=CC1(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1

> <INCHI_KEY>
QVMDIQLUNODCTG-OCCSQVGLSA-N

> <FORMULA>
C15H20O3

> <MOLECULAR_WEIGHT>
248.3175

> <EXACT_MASS>
248.141244506

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
38

> <JCHEM_AVERAGE_POLARIZABILITY>
27.38935196373754

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-indene]-7'-one

> <ALOGPS_LOGP>
1.33

> <JCHEM_LOGP>
1.340322241

> <ALOGPS_LOGS>
-2.16

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.02097085666951

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.74328021981195

> <JCHEM_PKA_STRONGEST_BASIC>
-3.239673372302769

> <JCHEM_POLAR_SURFACE_AREA>
57.53

> <JCHEM_REFRACTIVITY>
69.83539999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.72e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
illudin M

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-AUG-14   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-AUG-14         0                                  
HETATM    1  C   UNK     0       0.775  -0.365   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.527   2.339   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.989   0.350   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.043   3.837   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -1.397   2.615   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.002   1.126   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.604   3.082   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       1.176   1.122   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.066   3.004   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.664   1.518   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.979   4.095   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.954   0.676   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.153   1.643   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.491   3.700   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.089   2.213   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.381   5.582   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       4.032  -0.862   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       0.360   5.234   0.000  0.00  0.00           O+0
HETATM   19  H   UNK     0       2.619  -0.091   0.000  0.00  0.00           H+0
CONECT    1    8                                                            
CONECT    2   13                                                            
CONECT    3   13                                                            
CONECT    4   14                                                            
CONECT    5    6   15                                                       
CONECT    6    5   15                                                       
CONECT    7    9   13                                                       
CONECT    8    1   10   15                                                  
CONECT    9    7   10   11                                                  
CONECT   10    8    9   12                                                  
CONECT   11    9   14   16                                                  
CONECT   12   10   13   17   19                                             
CONECT   13    2    3    7   12                                             
CONECT   14    4   11   15   18                                             
CONECT   15    5    6    8   14                                             
CONECT   16   11                                                            
CONECT   17   12                                                            
CONECT   18   14                                                            
CONECT   19   12                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   42    0
END

View in JSmol

Synonyms

Value	Source
(3's-trans)-2',3'-Dihydro-3'b,6'a-dihydroxy-2',2',4',6'-tetramethylspiro(cyclopropane-1,5'-(5H)inden)-7'(6'H)-one	MeSH

Chemical Formula

C₁₅H₂₀O₃

Average Mass

248.3175 Da

Monoisotopic Mass

248.14124 Da

IUPAC Name

(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-indene]-7'-one

Traditional Name

illudin M

CAS Registry Number

Not Available

SMILES

[H][C@@]1(O)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=CC1(C)C

InChI Identifier

InChI=1S/C15H20O3/c1-8-10-9(7-13(2,3)12(10)17)11(16)14(4,18)15(8)5-6-15/h7,12,17-18H,5-6H2,1-4H3/t12-,14+/m1/s1

InChI Key

QVMDIQLUNODCTG-OCCSQVGLSA-N

Experimental Spectra

Spectrum Type	Description	Depositor Email	Depositor Organization	Depositor	Deposition Date	View

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Anthracophyllum discolor		Not Available
Granulobasidium vellereum	LOTUS Database	35616633
Omphalotus illudens	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as illudanes and illudins. These are sesquiterpenoids containing either the illudane moiety (based on a 3,6,6,7b-tetramethyl-decahydro-1H-cyclobuta[e]indene ring system), the illudin moiety (2',2',4',6'-tetramethyl-octahydrospiro[cyclopropane-1,5'-indene]), or a derivative thereof.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Illudanes and illudins

Alternative Parents

Substituents

Illudine sesquiterpenoid
Cyclohexenone
Acyloin
Tertiary alcohol
Secondary alcohol
Ketone
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

sesquiterpenoid (CHEBI:5866 )
Illudane and protoilludane sesquiterpenoids (C09687 )
Terpenoids (C09687 )
Illudane and protoilludane sesquiterpenoids (LMPR0103590001 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.33	ALOGPS
logP	1.34	ChemAxon
logS	-2.2	ALOGPS
pKa (Strongest Acidic)	12.74	ChemAxon
pKa (Strongest Basic)	-3.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	69.84 m³·mol⁻¹	ChemAxon
Polarizability	27.39 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00003150

Chemspider ID

Not Available

KEGG Compound ID

C09687

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

344199

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for Illudin M (NP0139324)

MOL for NP0139324 (Illudin M)

3D MOL for NP0139324 (Illudin M)

3D SDF for NP0139324 (Illudin M)

3D-SDF for NP0139324 (Illudin M)

PDB for NP0139324 (Illudin M)

3D PDB for NP0139324 (Illudin M)

SMILES for NP0139324 (Illudin M)

INCHI for NP0139324 (Illudin M)

Structure for NP0139324 (Illudin M)

3D Structure for NP0139324 (Illudin M)