NP-MRD: Showing NP-Card for Polyphyllin II (NP0139058)

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Record Information

Version

2.0

Created at

2022-06-29 19:37:41 UTC

Updated at

2022-06-29 19:37:41 UTC

NP-MRD ID

NP0139058

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Polyphyllin II

Description

Polyphyllin II belongs to the class of organic compounds known as steroidal saponins. These are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative. Polyphyllin II is found in Paris polyphylla. Polyphyllin II was first documented in 2013 (PMID: 24012730). Based on a literature review a significant number of articles have been published on Polyphyllin II (PMID: 33915023) (PMID: 32661907) (PMID: 35116689) (PMID: 35327385) (PMID: 34582523) (PMID: 34007265).

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652306292221372D          

 60 68  0  0  0  0            999 V2000
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M  END

     RDKit          3D

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M  END


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M  END
> <DATABASE_ID>
NP0139058

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1C2C(CC3C4CC=C5CC(CCC5(C)C4CCC23C)OC2OC(CO)C(OC3OC(CO)C(O)C3O)C(OC3OC(C)C(O)C(O)C3O)C2O)OC11CCC(C)CO1

> <INCHI_IDENTIFIER>
InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-36(52)38(59-39-35(51)33(49)31(47)21(3)54-39)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3

> <INCHI_KEY>
AWKXNOOUWFJCMU-UHFFFAOYSA-N

> <FORMULA>
C44H70O16

> <MOLECULAR_WEIGHT>
855.028

> <EXACT_MASS>
854.466386174

> <JCHEM_ACCEPTOR_COUNT>
16

> <JCHEM_ATOM_COUNT>
130

> <JCHEM_AVERAGE_POLARIZABILITY>
93.70653722648804

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
8

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-[(3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-5-hydroxy-2-(hydroxymethyl)-6-{5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18'-eneoxy}oxan-4-yl)oxy]-6-methyloxane-3,4,5-triol

> <ALOGPS_LOGP>
1.42

> <JCHEM_LOGP>
1.292043425666667

> <ALOGPS_LOGS>
-3.54

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
9

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.263862080337969

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.80476325551334

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9811434808673622

> <JCHEM_POLAR_SURFACE_AREA>
235.67999999999995

> <JCHEM_REFRACTIVITY>
209.99960000000007

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.49e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2-[(3-{[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-5-hydroxy-2-(hydroxymethyl)-6-{5,7',9',13'-tetramethyl-5'-oxaspiro[oxane-2,6'-pentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosan]-18'-eneoxy}oxan-4-yl)oxy]-6-methyloxane-3,4,5-triol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-JUN-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-JUN-22         0                                  
HETATM    1  C   UNK     0      16.028   0.271   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      14.508   0.520   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      13.532  -0.671   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      12.013  -0.421   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      11.469   1.020   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.374  -0.063   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.006   0.644   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.255   2.164   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      10.778   2.396   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       7.887   2.871   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.792   1.788   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       7.483   0.412   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       6.637  -0.875   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       5.100  -0.785   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.408   0.591   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.255   1.878   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.563   3.254   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       3.026   3.343   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.180   2.057   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       2.871   0.681   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.025  -0.606   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       0.487  -0.517   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.204   0.859   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.642   2.146   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0      -1.741   0.949   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0      -2.432   2.325   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -3.970   2.415   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      -4.661   3.791   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      -3.815   5.077   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      -2.277   4.988   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0      -1.586   3.612   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0      -1.431   6.275   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       0.106   6.185   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0      -4.506   6.454   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      -3.660   7.740   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      -4.203   9.181   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      -3.001  10.143   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0      -1.714   9.297   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0      -2.121   7.812   0.000  0.00  0.00           O+0
HETATM   40  C   UNK     0      -0.273   9.841   0.000  0.00  0.00           C+0
HETATM   41  O   UNK     0       0.918   8.865   0.000  0.00  0.00           O+0
HETATM   42  O   UNK     0      -3.073  11.682   0.000  0.00  0.00           O+0
HETATM   43  O   UNK     0      -5.688   9.588   0.000  0.00  0.00           O+0
HETATM   44  O   UNK     0      -6.198   3.880   0.000  0.00  0.00           O+0
HETATM   45  C   UNK     0      -7.045   2.594   0.000  0.00  0.00           C+0
HETATM   46  C   UNK     0      -8.582   2.683   0.000  0.00  0.00           C+0
HETATM   47  C   UNK     0      -9.428   1.396   0.000  0.00  0.00           C+0
HETATM   48  C   UNK     0      -8.737   0.020   0.000  0.00  0.00           C+0
HETATM   49  C   UNK     0      -7.200  -0.069   0.000  0.00  0.00           C+0
HETATM   50  O   UNK     0      -6.353   1.217   0.000  0.00  0.00           O+0
HETATM   51  C   UNK     0      -6.508  -1.445   0.000  0.00  0.00           C+0
HETATM   52  O   UNK     0      -9.583  -1.266   0.000  0.00  0.00           O+0
HETATM   53  O   UNK     0     -10.966   1.486   0.000  0.00  0.00           O+0
HETATM   54  O   UNK     0      -9.273   4.059   0.000  0.00  0.00           O+0
HETATM   55  O   UNK     0      -4.816   1.128   0.000  0.00  0.00           O+0
HETATM   56  C   UNK     0       3.562  -0.696   0.000  0.00  0.00           C+0
HETATM   57  C   UNK     0       8.315  -0.884   0.000  0.00  0.00           C+0
HETATM   58  C   UNK     0      10.606  -1.585   0.000  0.00  0.00           C+0
HETATM   59  O   UNK     0      12.445   2.211   0.000  0.00  0.00           O+0
HETATM   60  C   UNK     0      13.965   1.961   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   60                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9   59                                             
CONECT    6    5    7   58                                                  
CONECT    7    6    8   12                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8    5                                                       
CONECT   10    8   11                                                       
CONECT   11   10   12   16                                                  
CONECT   12   11    7   13   57                                             
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16   20                                                  
CONECT   16   15   11   17                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20   24                                                  
CONECT   20   19   15   21   56                                             
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24   25                                                  
CONECT   24   23   19                                                       
CONECT   25   23   26                                                       
CONECT   26   25   27   31                                                  
CONECT   27   26   28   55                                                  
CONECT   28   27   29   44                                                  
CONECT   29   28   30   34                                                  
CONECT   30   29   31   32                                                  
CONECT   31   30   26                                                       
CONECT   32   30   33                                                       
CONECT   33   32                                                            
CONECT   34   29   35                                                       
CONECT   35   34   36   39                                                  
CONECT   36   35   37   43                                                  
CONECT   37   36   38   42                                                  
CONECT   38   37   39   40                                                  
CONECT   39   38   35                                                       
CONECT   40   38   41                                                       
CONECT   41   40                                                            
CONECT   42   37                                                            
CONECT   43   36                                                            
CONECT   44   28   45                                                       
CONECT   45   44   46   50                                                  
CONECT   46   45   47   54                                                  
CONECT   47   46   48   53                                                  
CONECT   48   47   49   52                                                  
CONECT   49   48   50   51                                                  
CONECT   50   49   45                                                       
CONECT   51   49                                                            
CONECT   52   48                                                            
CONECT   53   47                                                            
CONECT   54   46                                                            
CONECT   55   27                                                            
CONECT   56   20                                                            
CONECT   57   12                                                            
CONECT   58    6                                                            
CONECT   59    5   60                                                       
CONECT   60   59    2                                                       
MASTER        0    0    0    0    0    0    0    0   60    0  136    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₄₄H₇₀O₁₆

Average Mass

855.0280 Da

Monoisotopic Mass

854.46639 Da

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

CC1C2C(CC3C4CC=C5CC(CCC5(C)C4CCC23C)OC2OC(CO)C(OC3OC(CO)C(O)C3O)C(OC3OC(C)C(O)C(O)C3O)C2O)OC11CCC(C)CO1

InChI Identifier

InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-36(52)38(59-39-35(51)33(49)31(47)21(3)54-39)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3

InChI Key

AWKXNOOUWFJCMU-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Paris polyphylla	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as steroidal saponins. These are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroidal glycosides

Direct Parent

Steroidal saponins

Alternative Parents

Substituents

Steroidal saponin
Triterpenoid
Spirostane skeleton
Oligosaccharide
Delta-5-steroid
Glycosyl compound
O-glycosyl compound
Ketal
Oxane
Tetrahydrofuran
Secondary alcohol
Oxacycle
Polyol
Acetal
Organoheterocyclic compound
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Alcohol
Organic oxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

46200821

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

You LJ, Geng H, Yang XF, Wei GL, Zhu YD, Ge GB, Lei M, Wang DD: The comparison analysis of polyphyllin I and its analogues induced apoptosis of colon and lung cancer cells via mitochondrial dysfunction. Basic Clin Pharmacol Toxicol. 2021 Jul;129(1):15-25. doi: 10.1111/bcpt.13596. Epub 2021 May 13. [PubMed:33915023 ]
Lu W, Pan M, Zhang P, Zheng T, Huang L, Ye F, Lei P: The Pharmacokinetics and Tissue Distributions of Nine Steroidal Saponins from Paris polyphylla in Rats. Eur J Drug Metab Pharmacokinet. 2020 Oct;45(5):665-673. doi: 10.1007/s13318-020-00633-5. [PubMed:32661907 ]
Cheng G, Xue YY, Fang F, Sun GQ, Lu YY, Ji YQ, Qiu PC, Tang HF: Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells. Transl Cancer Res. 2021 Sep;10(9):3894-3905. doi: 10.21037/tcr-21-966. [PubMed:35116689 ]
Siripuram R, Bartolek Z, Patil K, Gill SS, Pai SB: Disruption of Colorectal Cancer Network by Polyphyllins Reveals Pivotal Entities with Implications for Chemoimmunotherapy. Biomedicines. 2022 Mar 2;10(3):583. doi: 10.3390/biomedicines10030583. [PubMed:35327385 ]
Yang Y, Yang Y, Chen M, Chen J, Wang J, Ma Y, Qian H: Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages. Biomater Sci. 2021 Sep 28;9(19):6597-6608. doi: 10.1039/d1bm01053k. [PubMed:34582523 ]
Yang MZ, Zhang BB, Huang JC, Bai XY, Liang ZQ, Yi X, Xu N, Huang YJ, Jiao AJ: Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma. Bioinorg Chem Appl. 2021 Apr 29;2021:9959634. doi: 10.1155/2021/9959634. eCollection 2021. [PubMed:34007265 ]
Wang G, Hao R, Luo C, Wang Y, Man S, Gao W: Pharmacokinetics profiles of polyphyllin II and polyphyllin VII in rats by liquid chromatography with tandem mass spectrometry. Biomed Chromatogr. 2021 Jun;35(6):e5083. doi: 10.1002/bmc.5083. Epub 2021 Feb 17. [PubMed:33544400 ]
Qiao X, Qu C, Luo Q, Wang Y, Yang J, Yang H, Wen X: UHPLC-qMS spectrum-effect relationships for Rhizoma Paridis extracts. J Pharm Biomed Anal. 2021 Feb 5;194:113770. doi: 10.1016/j.jpba.2020.113770. Epub 2020 Nov 24. [PubMed:33288343 ]
Niu W, Xu L, Li J, Zhai Y, Sun Z, Shi W, Jiang Y, Ma C, Lin H, Guo Y, Liu Z: Polyphyllin II inhibits human bladder cancer migration and invasion by regulating EMT-associated factors and MMPs. Oncol Lett. 2020 Sep;20(3):2928-2936. doi: 10.3892/ol.2020.11839. Epub 2020 Jul 9. [PubMed:32782609 ]
Yang Q, Li H, Gui M, Li Z, Sun H: Development and validation of a rapid and sensitive LC-MS/MS method for the determination of polyphyllin II in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2020 Aug;34(8):e4861. doi: 10.1002/bmc.4861. Epub 2020 Jun 26. [PubMed:32657482 ]
Pang D, Yang C, Li C, Zou Y, Feng B, Li L, Liu W, Luo Q, Chen Z, Huang C: Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-kappaB pathway. Biol Open. 2020 Feb 7;9(2):bio046854. doi: 10.1242/bio.046854. [PubMed:31988091 ]
Yang Q, Li H, Gui M, Li Z, Sun H: Development and validation of a rapid and sensitive LC-MS/MS method for the determination of polyphyllin II in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2020 Mar;34(3):e4780. doi: 10.1002/bmc.4780. Epub 2020 Jan 12. [PubMed:31830305 ]
Wang W, Dong X, You L, Sai N, Leng X, Yang C, Yin X, Ni J: Apoptosis in HepaRG and HL-7702 cells inducted by polyphyllin II through caspases activation and cell-cycle arrest. J Cell Physiol. 2019 May;234(5):7078-7089. doi: 10.1002/jcp.27462. Epub 2018 Oct 26. [PubMed:30362578 ]
Yang Y, Zhang J, Jin H, Zhang J, Wang Y: Quantitative Analysis in Combination with Fingerprint Technology and Chemometric Analysis Applied for Evaluating Six Species of Wild Paris Using UHPLC-UV-MS. J Anal Methods Chem. 2016;2016:3182796. doi: 10.1155/2016/3182796. Epub 2016 Dec 21. [PubMed:28097038 ]
Zheng R, Jiang H, Li J, Liu X, Xu H: Polyphyllin II Restores Sensitization of the Resistance of PC-9/ZD Cells to Gefitinib by a Negative Regulation of the PI3K/Akt/mTOR Signaling Pathway. Curr Cancer Drug Targets. 2017;17(4):376-385. doi: 10.2174/1568009616666161213141608. [PubMed:28093061 ]
Ning LH, Zhou B, Zhang YX, Li XP: [Study on hemolytic mechanism of polyphyllin II]. Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3623-9. [PubMed:26983211 ]
Zhao Y, Zhang J, Yuan T, Shen T, Li W, Yang S, Hou Y, Wang Y, Jin H: Discrimination of wild Paris based on near infrared spectroscopy and high performance liquid chromatography combined with multivariate analysis. PLoS One. 2014 Feb 18;9(2):e89100. doi: 10.1371/journal.pone.0089100. eCollection 2014. [PubMed:24558477 ]
Wang B, Ji S, Zhang H, Zhao L, Lv L, Li Y, Zhou G, Zhang G: Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats. Steroids. 2013 Dec 11;78(12-13):1164-70. doi: 10.1016/j.steroids.2013.08.009. Epub 2013 Sep 5. [PubMed:24012730 ]
Yin X, Qu C, Li Z, Zhai Y, Cao S, Lin L, Feng L, Yan L, Ni J: Simultaneous determination and pharmacokinetic study of polyphyllin I, polyphyllin II, polyphyllin VI and polyphyllin VII in beagle dog plasma after oral administration of Rhizoma Paridis extracts by LC-MS-MS. Biomed Chromatogr. 2013 Mar;27(3):343-8. doi: 10.1002/bmc.2797. Epub 2012 Aug 17. [PubMed:22903625 ]

Showing NP-Card for Polyphyllin II (NP0139058)

MOL for NP0139058 (Polyphyllin II)

3D MOL for NP0139058 (Polyphyllin II)

3D SDF for NP0139058 (Polyphyllin II)

3D-SDF for NP0139058 (Polyphyllin II)

PDB for NP0139058 (Polyphyllin II)

3D PDB for NP0139058 (Polyphyllin II)

SMILES for NP0139058 (Polyphyllin II)

INCHI for NP0139058 (Polyphyllin II)

Structure for NP0139058 (Polyphyllin II)

3D Structure for NP0139058 (Polyphyllin II)