NP-MRD: Showing NP-Card for 4-Hydroxyretinoic acid (NP0087472)

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Record Information

Version

2.0

Created at

2022-05-11 16:50:37 UTC

Updated at

2022-05-11 16:50:37 UTC

NP-MRD ID

NP0087472

Secondary Accession Numbers

None

Natural Product Identification

Common Name

4-Hydroxyretinoic acid

Description

4-Hydroxyretinoic acid, also known as 4-hydroxy-13-cis-retinoate or 4-OH-retinoate, belongs to the class of organic compounds known as retinoids. These are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof. 4-Hydroxyretinoic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Within humans, 4-hydroxyretinoic acid participates in a number of enzymatic reactions. In particular, 4-hydroxyretinoic acid can be biosynthesized from all-trans-retinoic acid; which is catalyzed by the enzyme cytochrome P450 26A1. In addition, 4-hydroxyretinoic acid can be converted into 4-oxo-retinoic acid through the action of the enzyme cytochrome P450 26A1. A retinoid that consists of all-trans-retinoic acid bearing a hydroxy substituent at position 4 on the cyclohexenyl ring. 4-Hydroxyretinoic acid was first documented in 1988 (PMID: 2851384). In humans, 4-hydroxyretinoic acid is involved in retinol metabolism (PMID: 1932598) (PMID: 1538719) (PMID: 10702251) (PMID: 1328295).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 51 51  0  0  0  0  0  0  0  0999 V2000
   -2.7012    2.2521    2.6629 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3353    1.9051    1.3648 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6274    1.2598    0.4522 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2156    0.8976    0.7590 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4426    0.2561   -0.0383 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9364   -0.0578    0.3400 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5059    0.3410    1.6270 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7031   -0.7196   -0.5164 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0927   -1.0424   -0.1789 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8688   -1.6987   -1.0192 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2538   -2.0728   -0.7965 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015   -1.7724    0.4314 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9008   -2.7320   -1.7462 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2570   -3.1821   -1.7131 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7277   -3.8106   -2.7263 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0636   -2.9607   -0.6323 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1634    0.9198   -0.8574 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.3353    1.5476   -2.0003 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1967   -0.5872   -1.0735 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5442    1.5057   -1.0517 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4165    1.4301    0.1526 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7654    2.2976    1.2294 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.4894    2.1851    2.3913 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4266    1.3582    3.2548 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3595    2.8603    3.3142 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8331    2.9122    2.4342 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8857    1.2452    1.7595 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8195   -0.0830   -1.0087 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0272   -0.5691    2.0612 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2803    1.1570    1.5158 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    0.6774    2.4010 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2629   -1.0095   -1.4630 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5290   -0.7551    0.7576 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3743   -1.9659   -1.9675 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.8747   -1.1229    0.1523 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.3393   -2.7555    0.8454 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3687   -1.3101    1.1874 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3220   -2.9568   -2.6607 H   0  0  0  0  0  0  0  0  0  0  0  0
    8.5010   -3.7226   -0.1479 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4864    2.0511   -1.5294 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0999    0.7609   -2.7198 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9780    2.2805   -2.5554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7870   -0.8977   -2.0491 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7941   -1.0994   -0.1957 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2850   -0.9028   -1.1330 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3523    2.6132   -1.2198 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0484    1.1090   -1.9592 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4928    0.4264    0.5855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3855    1.9090   -0.0855 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7916    3.3450    0.8787 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9546    1.3359    2.4867 H   0  0  0  0  0  0  0  0  0  0  0  0
  7  6  1  0
  6  5  1  0
  5  4  2  0
  4  3  1  0
  3  2  2  0
  2  1  1  0
  2 22  1  0
 22 23  1  0
 22 21  1  0
 21 20  1  0
 20 17  1  0
 17 18  1  6
 17 19  1  0
  6  8  2  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
 13 14  1  0
 14 16  1  0
 14 15  2  0
 17  3  1  0
  7 29  1  0
  7 30  1  0
  7 31  1  0
  5 28  1  0
  4 27  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
 22 50  1  6
 23 51  1  0
 21 48  1  0
 21 49  1  0
 20 46  1  0
 20 47  1  0
 18 40  1  0
 18 41  1  0
 18 42  1  0
 19 43  1  0
 19 44  1  0
 19 45  1  0
  8 32  1  0
  9 33  1  0
 10 34  1  0
 12 35  1  0
 12 36  1  0
 12 37  1  0
 13 38  1  0
 16 39  1  0
M  END


  Mrv0541 02231220352D          

 23 23  0  0  0  0            999 V2000
   18.1898  -11.2750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   20.3333   -3.4375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   18.9042   -3.4375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.0464  -10.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.0464  -10.8625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7608  -11.2750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7608   -9.6250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4754  -10.8625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4754  -10.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2212  -10.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6337   -9.3231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7608   -8.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1898   -9.6250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4754   -8.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4754   -7.5625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7608   -7.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1898   -7.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1898   -6.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9042   -5.9125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9042   -5.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1898   -4.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.6187   -4.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.6187   -3.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  8  1  0  0  0  0
  2 23  1  0  0  0  0
  3 23  2  0  0  0  0
  4  5  1  0  0  0  0
  4  7  1  0  0  0  0
  4 10  1  0  0  0  0
  4 11  1  0  0  0  0
  5  6  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 12  1  0  0  0  0
  8  9  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0087472

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C(\C=C\C1=C(C)C(O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H28O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13,18,21H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+

> <INCHI_KEY>
KGUMXGDKXYTTEY-FRCNGJHJSA-N

> <FORMULA>
C20H28O3

> <MOLECULAR_WEIGHT>
316.4345

> <EXACT_MASS>
316.203844762

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_AVERAGE_POLARIZABILITY>
37.3273712112017

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

> <ALOGPS_LOGP>
5.04

> <JCHEM_LOGP>
3.783556644

> <ALOGPS_LOGS>
-4.55

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
18.183567392005994

> <JCHEM_PKA_STRONGEST_ACIDIC>
4.996647916720609

> <JCHEM_PKA_STRONGEST_BASIC>
-1.4063077944597322

> <JCHEM_POLAR_SURFACE_AREA>
57.53

> <JCHEM_REFRACTIVITY>
99.3063

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.01e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-hydroxyretinoic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      33.954 -21.047   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      37.955  -6.417   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      35.288  -6.417   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      29.953 -18.737   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      29.953 -20.277   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      31.287 -21.047   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      31.287 -17.967   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      32.621 -20.277   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      32.621 -18.737   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      28.413 -18.737   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      29.183 -17.403   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      31.287 -16.427   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      33.954 -17.967   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      32.621 -15.657   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      32.621 -14.117   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      31.287 -13.347   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      33.954 -13.347   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      33.954 -11.807   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      35.288 -11.037   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      35.288  -9.497   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      33.954  -8.727   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      36.622  -8.727   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      36.622  -7.187   0.000  0.00  0.00           C+0
CONECT    1    8                                                            
CONECT    2   23                                                            
CONECT    3   23                                                            
CONECT    4    5    7   10   11                                             
CONECT    5    4    6                                                       
CONECT    6    5    8                                                       
CONECT    7    4    9   12                                                  
CONECT    8    1    6    9                                                  
CONECT    9    7    8   13                                                  
CONECT   10    4                                                            
CONECT   11    4                                                            
CONECT   12    7   14                                                       
CONECT   13    9                                                            
CONECT   14   12   15                                                       
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23    2    3   22                                                  
MASTER        0    0    0    0    0    0    0    0   23    0   46    0
END

View in JSmol

Synonyms

Value	Source
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-3-hydroxy-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid	ChEBI
(2E,4E,6E,8E)-9-(3-Hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid	ChEBI
(7E,9E,11E,13E)-4-Hydroxyretinoic acid	ChEBI
4-Hydroxy-(7E,9E,11E,13E)-retinoic acid	ChEBI
4-Hydroxy-all-trans-retinoic acid	ChEBI
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-3-hydroxy-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate	Generator
(2E,4E,6E,8E)-9-(3-Hydroxy-2,6,6-trimethyl-1-cyclohexenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoate	Generator
(7E,9E,11E,13E)-4-Hydroxyretinoate	Generator
4-Hydroxy-(7E,9E,11E,13E)-retinoate	Generator
4-Hydroxy-all-trans-retinoate	Generator
4-Hydroxyretinoate	Generator
4-Hydroxy-13-cis-retinoate	HMDB
4-Hydroxy-13-cis-retinoic acid	HMDB
4-Hydroxy-retinoate	HMDB
4-Hydroxy-retinoic acid	HMDB
4-OH-Retinoate	HMDB
4-OH-Retinoic acid	HMDB
all-trans-4-Hydroxyretinoate	HMDB
all-trans-4-Hydroxyretinoic acid	HMDB
rac-4-Hydroxy-all-trans-retinoate	HMDB
rac-4-Hydroxy-all-trans-retinoic acid	HMDB
4-Hydroxy-13-retinoic acid	HMDB
4-Hydroxyretinoic acid, (13-cis)-isomer	HMDB

Chemical Formula

C₂₀H₂₈O₃

Average Mass

316.4345 Da

Monoisotopic Mass

316.20384 Da

IUPAC Name

(2E,4E,6E,8E)-9-(3-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Traditional Name

4-hydroxyretinoic acid

CAS Registry Number

Not Available

SMILES

C\C(\C=C\C1=C(C)C(O)CCC1(C)C)=C/C=C/C(/C)=C/C(O)=O

InChI Identifier

InChI=1S/C20H28O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13,18,21H,11-12H2,1-5H3,(H,22,23)/b8-6+,10-9+,14-7+,15-13+

InChI Key

KGUMXGDKXYTTEY-FRCNGJHJSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Anas platyrhynchos	FooDB	FooDB
Anatidae	FooDB	FooDB
Anser anser	FooDB	FooDB
Bison bison	FooDB	FooDB
Bos taurus	FooDB	FooDB
Bos taurus X Bison bison	FooDB	FooDB
Bubalus bubalis	FooDB	FooDB
Capra aegagrus hircus	FooDB	FooDB
Cervidae	FooDB	FooDB
Cervus canadensis	FooDB	FooDB
Columba	FooDB	FooDB
Columbidae	FooDB	FooDB
Dromaius novaehollandiae	FooDB	FooDB
Equus caballus	FooDB	FooDB
Gallus gallus	FooDB	FooDB
Lagopus muta	FooDB	FooDB
Leporidae	FooDB	FooDB
Lepus timidus	FooDB	FooDB
Melanitta fusca	FooDB	FooDB
Meleagris gallopavo	FooDB	FooDB
Numida meleagris	FooDB	FooDB
Odocoileus	FooDB	FooDB
Oryctolagus	FooDB	FooDB
Ovis aries	FooDB	FooDB
Phasianidae	FooDB	FooDB
Phasianus colchicus	FooDB	FooDB
Struthio camelus	FooDB	FooDB
Sus scrofa	FooDB	FooDB
Sus scrofa domestica	FooDB	FooDB

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as retinoids. These are oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Retinoids

Direct Parent

Retinoids

Alternative Parents

Substituents

Retinoic acid
Diterpenoid
Retinoid skeleton
Medium-chain fatty acid
Branched fatty acid
Hydroxy fatty acid
Methyl-branched fatty acid
Unsaturated fatty acid
Fatty acyl
Fatty acid
Secondary alcohol
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organic oxygen compound
Carbonyl group
Alcohol
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

retinoid (CHEBI:63795 )
Retinoids (C16677 )
Retinoids (LMPR01090025 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.04	ALOGPS
logP	3.78	ChemAxon
logS	-4.6	ALOGPS
pKa (Strongest Acidic)	5	ChemAxon
pKa (Strongest Basic)	-1.4	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	99.31 m³·mol⁻¹	ChemAxon
Polarizability	37.33 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0006254

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB023862

KNApSAcK ID

Not Available

Chemspider ID

4943093

KEGG Compound ID

C16677

BioCyc ID

Not Available

BiGG ID

2299866

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6438629

PDB ID

Not Available

ChEBI ID

63795

Good Scents ID

Not Available

References

General References

Napoli JL, Posch KP, Fiorella PD, Boerman MH: Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP) in the pathway of retinoic acid homeostasis. Biomed Pharmacother. 1991;45(4-5):131-43. [PubMed:1932598 ]
Roberts ES, Vaz AD, Coon MJ: Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol Pharmacol. 1992 Feb;41(2):427-33. [PubMed:1538719 ]
Spear PA, Garcin H, Narbonne JF: Increased retinoic acid metabolism following 3,3',4,4',5,5'-hexabromobiphenyl injection. Can J Physiol Pharmacol. 1988 Sep;66(9):1181-6. doi: 10.1139/y88-194. [PubMed:2851384 ]
Samokyszyn VM, Gall WE, Zawada G, Freyaldenhoven MA, Chen G, Mackenzie PI, Tephly TR, Radominska-Pandya A: 4-hydroxyretinoic acid, a novel substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. J Biol Chem. 2000 Mar 10;275(10):6908-14. doi: 10.1074/jbc.275.10.6908. [PubMed:10702251 ]
Duell EA, Astrom A, Griffiths CE, Chambon P, Voorhees JJ: Human skin levels of retinoic acid and cytochrome P-450-derived 4-hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor-mediated transcription in vitro. J Clin Invest. 1992 Oct;90(4):1269-74. doi: 10.1172/JCI115990. [PubMed:1328295 ]

Showing NP-Card for 4-Hydroxyretinoic acid (NP0087472)

MOL for NP0087472 (4-Hydroxyretinoic acid)

3D MOL for NP0087472 (4-Hydroxyretinoic acid)

3D SDF for NP0087472 (4-Hydroxyretinoic acid)

3D-SDF for NP0087472 (4-Hydroxyretinoic acid)

PDB for NP0087472 (4-Hydroxyretinoic acid)

3D PDB for NP0087472 (4-Hydroxyretinoic acid)

SMILES for NP0087472 (4-Hydroxyretinoic acid)

INCHI for NP0087472 (4-Hydroxyretinoic acid)

Structure for NP0087472 (4-Hydroxyretinoic acid)

3D Structure for NP0087472 (4-Hydroxyretinoic acid)