NP-MRD: Showing NP-Card for Thromboxane (NP0087035)

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Record Information

Version

2.0

Created at

2022-05-11 16:38:02 UTC

Updated at

2022-05-11 16:38:02 UTC

NP-MRD ID

NP0087035

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Thromboxane

Description

Thromboxane belongs to the class of organic compounds known as thromboxanes. These are eicosanoids structurally characterized by the presence of a 6-member ether containing ring. Thus, thromboxane is considered to be an eicosanoid lipid molecule. Thromboxane is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Thromboxane is a vasoconstrictor, potent hypertensive agent, and facilitates the clumping of platelets. Thromboxane is a member of the family of lipids known as eicosanoids. It is in homeostatic balance in the circulatory system with prostacyclin, a related compound. In humans, thromboxane is involved in mefenamic acid action pathway. All eicosanoids function locally at the site of synthesis, through receptor-mediated G-protein linked signaling pathways. Thromboxane was first documented in 1983 (PMID: 6338043). All mammalian cells except erythrocytes synthesize eicosanoids (PMID: 12075265) (PMID: 8607099) (PMID: 14966927) (PMID: 10086775) (PMID: 11350265) (PMID: 15992996).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 61 61  0  0  0  0  0  0  0  0999 V2000
   -5.5305    3.9686    0.5633 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7900    2.5009    0.8298 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0123    1.6827   -0.2010 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2952    0.2334    0.0961 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5846   -0.6982   -0.8541 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0862   -0.5355   -0.7999 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4724   -1.5170   -1.7918 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9621   -1.4269   -1.8109 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3463   -1.7327   -0.4607 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7104   -3.0029   -0.1179 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0931   -3.6565    0.7675 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5437   -3.7391    0.3510 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7732   -2.8645   -0.8756 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1438   -1.5299   -0.5781 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6780   -0.8774    0.6482 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1455   -0.6314    0.6412 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5612    0.2646   -0.4894 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0536    0.5174   -0.4965 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5258    1.1722    0.7591 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8717    2.5090    1.0021 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1221    3.5030   -0.0870 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2489    4.0734   -0.4999 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7046    4.2786    1.2408 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4420    4.5791    0.8037 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8658    2.2829    0.6431 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4810    2.1969    1.8392 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3925    1.9962   -1.1931 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9466    1.9424   -0.0442 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3905    0.0790    0.0216 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0236    0.0429    1.1535 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -1.7346   -0.5475 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9754   -0.5424   -1.8660 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7435    0.4607   -1.0740 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7328   -0.7477    0.2298 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7240   -2.5465   -1.4166 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8440   -1.3621   -2.8023 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6395   -0.4199   -2.1831 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6219   -2.1427   -2.5902 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7080   -0.9481    0.2462 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0264   -3.3027    1.8240 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2684   -4.7277    0.8029 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9022   -4.7611    0.1952 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1439   -3.2933    1.1642 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8540   -2.8025   -1.0443 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2661   -3.2874   -1.7645 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3449   -0.8637   -1.4416 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4281   -1.4110    1.5869 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1742    0.1172    0.7367 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7529   -1.5572    0.6853 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3749   -0.0878    1.6050 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0360    1.2408   -0.3478 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2224   -0.1241   -1.4691 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3051    1.0683   -1.4098 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5444   -0.4764   -0.5675 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6168    1.3679    0.6821 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3108    0.5217    1.6173 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7825    2.4086    1.2467 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3410    2.9228    1.9366 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2371    3.0813   -1.0855 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2489    4.2037   -0.1230 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0047    4.1347    0.1396 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 14  9  1  0
  1 22  1  0
  1 23  1  0
  1 24  1  0
  2 25  1  0
  2 26  1  0
  3 27  1  0
  3 28  1  0
  4 29  1  0
  4 30  1  0
  5 31  1  0
  5 32  1  0
  6 33  1  0
  6 34  1  0
  7 35  1  0
  7 36  1  0
  8 37  1  0
  8 38  1  0
  9 39  1  1
 11 40  1  0
 11 41  1  0
 12 42  1  0
 12 43  1  0
 13 44  1  0
 13 45  1  0
 14 46  1  6
 15 47  1  0
 15 48  1  0
 16 49  1  0
 16 50  1  0
 17 51  1  0
 17 52  1  0
 18 53  1  0
 18 54  1  0
 19 55  1  0
 19 56  1  0
 20 57  1  0
 20 58  1  0
 21 59  1  0
 21 60  1  0
 21 61  1  0
M  END


  Mrv0541 02231219402D          

 21 21  0  0  1  0            999 V2000
   25.4204  -13.3293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.2771  -15.3919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.5625  -15.8044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.2771   -9.6167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.2771  -14.5668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.2771  -10.4417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.5625  -16.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.5625   -9.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.9915  -14.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.9915  -10.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8480  -17.0419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.5625   -8.3792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.9915  -13.3293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.9915  -11.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8480  -17.8669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.8480   -7.9667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.7060  -12.9168    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   24.7060  -12.0918    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   26.1350  -12.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   25.4204  -11.6793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   26.1350  -12.0918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 17  1  0  0  0  0
  1 19  1  0  0  0  0
  2  3  1  0  0  0  0
  2  5  1  0  0  0  0
  3  7  1  0  0  0  0
  4  6  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 17 13  1  6  0  0  0
 18 14  1  1  0  0  0
 17 18  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0087035

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC

> <INCHI_IDENTIFIER>
InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1

> <INCHI_KEY>
RZWIIPASKMUIAC-VQTJNVASSA-N

> <FORMULA>
C20H40O

> <MOLECULAR_WEIGHT>
296.531

> <EXACT_MASS>
296.307915902

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_AVERAGE_POLARIZABILITY>
41.151988367096905

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R,3S)-3-heptyl-2-octyloxane

> <ALOGPS_LOGP>
8.56

> <JCHEM_LOGP>
7.613809792666666

> <ALOGPS_LOGS>
-7.39

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-4.146399761315378

> <JCHEM_POLAR_SURFACE_AREA>
9.23

> <JCHEM_REFRACTIVITY>
93.7809

> <JCHEM_ROTATABLE_BOND_COUNT>
13

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.22e-05 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2R,3S)-3-heptyl-2-octyl-oxane

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1  O   UNK     0      47.451 -24.881   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      43.451 -28.732   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      42.117 -29.502   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      43.451 -17.951   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      43.451 -27.191   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      43.451 -19.491   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      42.117 -31.042   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      42.117 -17.181   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      44.784 -26.421   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      44.784 -20.261   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      40.783 -31.812   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      42.117 -15.641   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      44.784 -24.881   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      44.784 -21.801   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      40.783 -33.352   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      40.783 -14.871   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      46.118 -24.111   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      46.118 -22.571   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      48.785 -24.111   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      47.451 -21.801   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      48.785 -22.571   0.000  0.00  0.00           C+0
CONECT    1   17   19                                                       
CONECT    2    3    5                                                       
CONECT    3    2    7                                                       
CONECT    4    6    8                                                       
CONECT    5    2    9                                                       
CONECT    6    4   10                                                       
CONECT    7    3   11                                                       
CONECT    8    4   12                                                       
CONECT    9    5   13                                                       
CONECT   10    6   14                                                       
CONECT   11    7   15                                                       
CONECT   12    8   16                                                       
CONECT   13    9   17                                                       
CONECT   14   10   18                                                       
CONECT   15   11                                                            
CONECT   16   12                                                            
CONECT   17    1   13   18                                                  
CONECT   18   14   17   20                                                  
CONECT   19    1   21                                                       
CONECT   20   18   21                                                       
CONECT   21   19   20                                                       
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

View in JSmol

Synonyms

Value	Source
Thromboxane a2	HMDB

Chemical Formula

C₂₀H₄₀O

Average Mass

296.5310 Da

Monoisotopic Mass

296.30792 Da

IUPAC Name

(2R,3S)-3-heptyl-2-octyloxane

Traditional Name

(2R,3S)-3-heptyl-2-octyl-oxane

CAS Registry Number

Not Available

SMILES

CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC

InChI Identifier

InChI=1S/C20H40O/c1-3-5-7-9-11-13-17-20-19(16-14-18-21-20)15-12-10-8-6-4-2/h19-20H,3-18H2,1-2H3/t19-,20+/m0/s1

InChI Key

RZWIIPASKMUIAC-VQTJNVASSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Anas platyrhynchos	FooDB	FooDB
Anatidae	FooDB	FooDB
Anser anser	FooDB	FooDB
Bison bison	FooDB	FooDB
Bos taurus	FooDB	FooDB
Bos taurus X Bison bison	FooDB	FooDB
Bubalus bubalis	FooDB	FooDB
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Chemical Taxonomy

Description

Belongs to the class of organic compounds known as thromboxanes. These are eicosanoids structurally characterized by the presence of a 6-member ether containing ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Eicosanoids

Direct Parent

Thromboxanes

Alternative Parents

Substituents

Thromboxane
Oxane
Oxacycle
Organoheterocyclic compound
Ether
Dialkyl ether
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	8.56	ALOGPS
logP	7.61	ChemAxon
logS	-7.4	ALOGPS
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	9.23 Å²	ChemAxon
Rotatable Bond Count	13	ChemAxon
Refractivity	93.78 m³·mol⁻¹	ChemAxon
Polarizability	41.15 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

HMDB0003208

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB023124

KNApSAcK ID

Not Available

Chemspider ID

102829

KEGG Compound ID

C02198

BioCyc ID

Not Available

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

1221363

Good Scents ID

Not Available

References

General References

Gurbel PA, Gattis WA, Fuzaylov SF, Gaulden L, Hasselblad V, Serebruany VL, O'Connor CM: Evaluation of platelets in heart failure: is platelet activity related to etiology, functional class, or clinical outcomes? Am Heart J. 2002 Jun;143(6):1068-75. doi: 10.1067/mhj.2002.121261. [PubMed:12075265 ]
Rocca B, Ciabattoni G, Tartaglione R, Cortelazzo S, Barbui T, Patrono C, Landolfi R: Increased thromboxane biosynthesis in essential thrombocythemia. Thromb Haemost. 1995 Nov;74(5):1225-30. [PubMed:8607099 ]
Dong WG, Liu SP, Zhu HH, Luo HS, Yu JP: Abnormal function of platelets and role of angelica sinensis in patients with ulcerative colitis. World J Gastroenterol. 2004 Feb 15;10(4):606-9. doi: 10.3748/wjg.v10.i4.606. [PubMed:14966927 ]
van Genderen PJ, Prins FJ, Michiels JJ, Schror K: Thromboxane-dependent platelet activation in vivo precedes arterial thrombosis in thrombocythaemia: a rationale for the use of low-dose aspirin as an antithrombotic agent. Br J Haematol. 1999 Mar;104(3):438-41. doi: 10.1046/j.1365-2141.1999.01224.x. [PubMed:10086775 ]
FitzGerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ 2nd, Lawson JA, Brash AR: Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest. 1983 Mar;71(3):676-88. doi: 10.1172/jci110814. [PubMed:6338043 ]
Karamouzis M, Langberg H, Skovgaard D, Bulow J, Kjaer M, Saltin B: In situ microdialysis of intramuscular prostaglandin and thromboxane in contracting skeletal muscle in humans. Acta Physiol Scand. 2001 Jan;171(1):71-6. doi: 10.1046/j.1365-201X.2001.00775.x. [PubMed:11350265 ]
Wacker MJ, Tyburski JB, Ammar CP, Adams MC, Orr JA: Detection of thromboxane A(2) receptor mRNA in rabbit nodose ganglion neurons. Neurosci Lett. 2005 Sep 30;386(2):121-6. doi: 10.1016/j.neulet.2005.05.066. [PubMed:15992996 ]
Pfister SL, Hughes MJ, Rosolowsky M, Campbell WB: Role of contaminating platelets in thromboxane synthesis in primary cultures of human umbilical vein endothelial cells. Prostaglandins Other Lipid Mediat. 2002 Sep;70(1-2):39-49. doi: 10.1016/s0090-6980(02)00009-6. [PubMed:12428677 ]
Hsu CY, Halushka PV, Hogan EL, Cox RD: Increased thromboxane level in experimental spinal cord injury. J Neurol Sci. 1986 Jul;74(2-3):289-96. doi: 10.1016/0022-510x(86)90114-0. [PubMed:3525758 ]
Dogne JM, de Leval X, Delarge J, David JL, Masereel B: New trends in thromboxane and prostacyclin modulators. Curr Med Chem. 2000 Jun;7(6):609-28. doi: 10.2174/0929867003374868. [PubMed:10702629 ]

Showing NP-Card for Thromboxane (NP0087035)

MOL for NP0087035 (Thromboxane)

3D MOL for NP0087035 (Thromboxane)

3D SDF for NP0087035 (Thromboxane)

3D-SDF for NP0087035 (Thromboxane)

PDB for NP0087035 (Thromboxane)

3D PDB for NP0087035 (Thromboxane)

SMILES for NP0087035 (Thromboxane)

INCHI for NP0087035 (Thromboxane)

Structure for NP0087035 (Thromboxane)

3D Structure for NP0087035 (Thromboxane)