NP-MRD: Showing NP-Card for Triptobenzene S (NP0086115)

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Record Information

Version

2.0

Created at

2022-04-29 06:29:01 UTC

Updated at

2022-04-29 06:29:01 UTC

NP-MRD ID

NP0086115

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Triptobenzene S

Description

CHEMBL3798344 belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units. Triptobenzene S is found in Tripterygium wilfordii . Based on a literature review very few articles have been published on CHEMBL3798344.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 49 51  0  0  0  0  0  0  0  0999 V2000
   -2.2043    0.8542   -3.1782 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1360    1.3116   -1.8372 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6567    0.4524   -0.8307 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5504   -0.3525   -0.1587 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0066   -0.3150   -0.4924 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.7952   -1.2306    0.4189 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5767    1.0913   -0.3002 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0463   -1.1818    0.8213 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6933   -1.2030    1.1166 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2405   -2.0654    2.1210 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2115   -0.4028    0.4519 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2948    0.4241   -0.5259 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6069    1.3185   -1.2919 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6229    1.8814   -0.3199 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3716    0.7317    0.2268 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6930    0.6660    0.2472 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4960    1.7972   -0.3034 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4037   -0.4809    0.7919 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5953   -0.3782    1.1911 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7127   -1.7767    0.8745 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3413   -1.6738    0.2423 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6641   -0.4627    0.8091 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.8564   -0.3595    2.3115 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2321    0.9976   -3.7013 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4954   -0.2122   -3.1608 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0229    1.4249   -3.6849 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1826   -0.6766   -1.5222 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8771   -1.0793    0.1960 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5824   -0.9275    1.4795 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5831   -2.3041    0.2489 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5215    1.0740    0.2838 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8606    1.7110    0.3086 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8082    1.5683   -1.2708 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7572   -1.8212    1.3542 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8916   -2.6564    2.6150 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1767    0.7083   -2.0255 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0162    2.1263   -1.7771 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3078    2.5274   -0.8849 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0577    2.4170    0.4650 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5484    1.7504    0.0523 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.4388    1.6850   -1.4229 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.0968    2.7596    0.0552 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3100   -2.6011    0.4296 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5953   -2.0236    1.9644 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4944   -1.5543   -0.8487 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8224   -2.6149    0.4287 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8679   -1.3609    2.8070 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7501    0.2321    2.5363 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9573    0.2046    2.6891 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 16 18  1  0
 18 19  2  0
 18 20  1  0
 20 21  1  0
 21 22  1  0
 22 23  1  1
 22 11  1  0
 11  9  2  0
  9 10  1  0
  9  8  1  0
  8  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  4  3  1  0
 11 12  1  0
 22 15  1  0
  1 24  1  0
  1 25  1  0
  1 26  1  0
 13 36  1  0
 13 37  1  0
 14 38  1  0
 14 39  1  0
 17 40  1  0
 17 41  1  0
 17 42  1  0
 20 43  1  0
 20 44  1  0
 21 45  1  0
 21 46  1  0
 23 47  1  0
 23 48  1  0
 23 49  1  0
 10 35  1  0
  8 34  1  0
  5 27  1  6
  6 28  1  0
  6 29  1  0
  6 30  1  0
  7 31  1  0
  7 32  1  0
  7 33  1  0
M  END


  Mrv1652304292208292D          

 23 25  0  0  1  0            999 V2000
    1.2079   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.0954   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 12 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  8 19  1  0  0  0  0
 19 20  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  1  6  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  2 23  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0086115

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=C2CCC3=C(C)C(=O)CC[C@]3(C)C2=C(O)C=C1C(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C20H26O3/c1-11(2)14-10-17(22)18-13(19(14)23-5)6-7-15-12(3)16(21)8-9-20(15,18)4/h10-11,22H,6-9H2,1-5H3/t20-/m0/s1

> <INCHI_KEY>
QMDCLEYBHPVIBC-FQEVSTJZSA-N

> <FORMULA>
C20H26O3

> <MOLECULAR_WEIGHT>
314.425

> <EXACT_MASS>
314.188194697

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
49

> <JCHEM_AVERAGE_POLARIZABILITY>
35.89054560970641

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(4aS)-5-hydroxy-8-methoxy-1,4a-dimethyl-7-(propan-2-yl)-2,3,4,4a,9,10-hexahydrophenanthren-2-one

> <ALOGPS_LOGP>
4.21

> <JCHEM_LOGP>
4.679267754333333

> <ALOGPS_LOGS>
-4.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
19.251532184762407

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.876228291338256

> <JCHEM_PKA_STRONGEST_BASIC>
-4.599526420922374

> <JCHEM_POLAR_SURFACE_AREA>
46.53

> <JCHEM_REFRACTIVITY>
92.9724

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.92e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(4aS)-5-hydroxy-7-isopropyl-8-methoxy-1,4a-dimethyl-3,4,9,10-tetrahydrophenanthren-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  O   UNK     0       2.255  -1.540   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0       3.795  -1.540   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       4.565  -0.206   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       3.795   1.127   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.105  -0.206   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.875   1.127   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.415   1.127   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.185  -0.206   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      10.725  -0.206   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      11.495   1.127   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      13.035   1.127   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.495  -1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      13.035  -1.540   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      13.805  -0.206   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      13.805  -2.874   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      10.725  -2.874   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       9.185  -2.874   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       8.415  -4.207   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       8.415  -1.540   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.875  -1.540   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       7.645  -2.874   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.105  -2.874   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       4.565  -2.874   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3   23                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6   20                                                  
CONECT    6    5    7                                                       
CONECT    7    6    8                                                       
CONECT    8    7    9   19                                                  
CONECT    9    8   10   12                                                  
CONECT   10    9   11                                                       
CONECT   11   10                                                            
CONECT   12    9   13   16                                                  
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13                                                            
CONECT   16   12   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17    8   20                                                  
CONECT   20   19    5   21   22                                             
CONECT   21   20                                                            
CONECT   22   20   23                                                       
CONECT   23   22    2                                                       
MASTER        0    0    0    0    0    0    0    0   23    0   50    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₀H₂₆O₃

Average Mass

314.4250 Da

Monoisotopic Mass

314.18819 Da

IUPAC Name

(4aS)-5-hydroxy-8-methoxy-1,4a-dimethyl-7-(propan-2-yl)-2,3,4,4a,9,10-hexahydrophenanthren-2-one

Traditional Name

(4aS)-5-hydroxy-7-isopropyl-8-methoxy-1,4a-dimethyl-3,4,9,10-tetrahydrophenanthren-2-one

CAS Registry Number

Not Available

SMILES

COC1=C2CCC3=C(C)C(=O)CC[C@]3(C)C2=C(O)C=C1C(C)C

InChI Identifier

InChI=1S/C20H26O3/c1-11(2)14-10-17(22)18-13(19(14)23-5)6-7-15-12(3)16(21)8-9-20(15,18)4/h10-11,22H,6-9H2,1-5H3/t20-/m0/s1

InChI Key

QMDCLEYBHPVIBC-FQEVSTJZSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Tripterygium wilfordii	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diterpenoids. These are terpene compounds formed by four isoprene units.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Diterpenoids

Alternative Parents

Substituents

Abietane diterpenoid
Diterpenoid
Hydrophenanthrene
Phenanthrene
Tetralin
Anisole
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Cyclohexenone
Benzenoid
Ketone
Cyclic ketone
Ether
Organic oxygen compound
Hydrocarbon derivative
Carbonyl group
Organic oxide
Organooxygen compound
Aromatic homopolycyclic compound

Molecular Framework

Aromatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.21	ALOGPS
logP	4.68	ChemAxon
logS	-4.2	ALOGPS
pKa (Strongest Acidic)	9.88	ChemAxon
pKa (Strongest Basic)	-4.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	46.53 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	92.97 m³·mol⁻¹	ChemAxon
Polarizability	35.89 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00056252

Chemspider ID

58922839

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

127047060

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Triptobenzene S (NP0086115)

MOL for NP0086115 (Triptobenzene S)

3D MOL for NP0086115 (Triptobenzene S)

3D SDF for NP0086115 (Triptobenzene S)

3D-SDF for NP0086115 (Triptobenzene S)

PDB for NP0086115 (Triptobenzene S)

3D PDB for NP0086115 (Triptobenzene S)

SMILES for NP0086115 (Triptobenzene S)

INCHI for NP0086115 (Triptobenzene S)

Structure for NP0086115 (Triptobenzene S)

3D Structure for NP0086115 (Triptobenzene S)