NP-MRD: Showing NP-Card for Seneganolide A (NP0081695)

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Record Information

Version

2.0

Created at

2022-04-29 02:45:32 UTC

Updated at

2022-04-29 02:45:32 UTC

NP-MRD ID

NP0081695

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Seneganolide A

Description

Methyl 2-[(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0²,¹¹.0⁵,¹⁰]Heptadeca-9,11-dien-16-yl]acetate belongs to the class of organic compounds known as naphthopyrans. Naphthopyrans are compounds containing a pyran ring fused to a naphthalene moiety. Furan is a 6 membered-ring non-aromatic ring with five carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings. Seneganolide A is found in Swietenia mahagoni . Based on a literature review very few articles have been published on methyl 2-[(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0²,¹¹.0⁵,¹⁰]Heptadeca-9,11-dien-16-yl]acetate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292204452D          

 34 38  0  0  1  0            999 V2000
    5.2667    2.2226    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.6330    2.9618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3693    3.7435    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6301    4.1098    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8484    3.8461    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4821    3.1069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7458    2.3252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4850    1.9589    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8264    3.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4597    2.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6587    3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2924    2.3153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4691    2.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1028    1.5237    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121    2.9498    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3784    3.6890    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2017    3.7414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5680    4.4806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3914    4.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7447    4.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9213    4.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0970    4.4098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1254    5.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5615    5.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2084    5.1493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6856    4.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    4.2863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8312    5.0958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0505    5.3624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4525    5.6385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2931    6.4480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467    2.5479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3958    3.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8095    1.6013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  1  8  1  0  0  0  0
  8  9  1  1  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
  5 19  1  0  0  0  0
 17 20  1  1  0  0  0
 16 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  2  0  0  0  0
  4 26  1  1  0  0  0
  3 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  2 32  1  0  0  0  0
  2 33  1  0  0  0  0
  1 34  1  6  0  0  0
M  END

     RDKit          3D

 66 70  0  0  0  0  0  0  0  0999 V2000
    3.2146    3.6557   -1.6956 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0185    2.2609   -1.5634 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7396    1.5169   -0.6263 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5516    2.1798    0.0649 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6000    0.0806   -0.4295 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2544   -0.4855   -0.0909 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4914   -1.9903   -0.0245 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8655   -2.3378    0.5093 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4973   -2.5457   -1.4632 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4856   -2.7703    0.7229 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.3673   -2.9899   -0.0803 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1156   -2.1452    2.0567 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.3174   -1.8246    1.9950 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7194   -0.8427    1.2352 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0517   -0.9016    0.6163 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7822   -2.0201    0.7187 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1005   -2.1139    0.1241 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7361   -3.1912    0.2546 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5821   -1.0169   -0.5503 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6814   -0.0923   -1.0779 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.4350    1.0921   -1.5583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4662    1.7635   -0.9321 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8641    2.7998   -1.7457 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1187    2.7604   -2.8041 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2523    1.7795   -2.7645 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5688    0.2648   -0.1222 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.0711    1.3353    0.8038 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4067    0.7504   -0.9731 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2748    1.2379   -0.1001 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1266    0.3397    1.0005 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6232    0.0959    1.0738 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1851    1.4107    1.5818 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8224   -0.8489    2.2392 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4736   -0.5989    3.2113 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8043    4.1680   -0.7941 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3235    3.8236   -1.6456 H   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3822   -0.2513    0.3086 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9793   -0.3691   -1.4104 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6703   -0.3394   -1.0607 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6534   -2.1810   -0.2852 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8920   -3.4570    0.6696 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1232   -1.9017    1.4653 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2265   -3.6345   -1.4546 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8395   -1.9545   -2.1120 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5158   -2.4927   -1.8999 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8966   -3.7735    0.9581 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2425   -2.3176   -0.7761 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3328   -2.8268    2.9073 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9910   -2.4064    2.5809 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3257   -2.8388    1.2593 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2549   -0.5724   -2.0092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9058    1.5298    0.0388 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6597    3.4832   -1.4870 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5040    1.5008   -3.5024 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9811    0.9386    1.3293 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3285    2.2703    0.2887 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3618    1.5644    1.6368 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7475    1.6093   -1.5862 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1091   -0.0842   -1.6385 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6148    2.2663    0.2421 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5424    1.4906   -0.8120 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0765    0.9437    1.9551 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0182    2.2667    0.9440 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1478    1.2988    2.0844 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4858    1.6310    2.4796 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  1
  7  9  1  0
  7 10  1  0
 10 11  1  0
 10 12  1  0
 12 13  1  0
 13 14  2  0
 14 30  1  0
 30 29  1  0
 29 28  1  0
 28 26  1  0
 26 27  1  1
 26 20  1  0
 20 19  1  0
 19 17  1  0
 17 18  2  0
 17 16  1  0
 16 15  2  0
 20 21  1  0
 21 25  2  0
 25 24  1  0
 24 23  1  0
 23 22  2  0
 30 31  1  0
 31 32  1  1
 31 33  1  0
 33 34  2  0
 31  6  1  0
 33 12  1  0
 15 14  1  0
 22 21  1  0
 15 26  1  0
  1 35  1  0
  1 36  1  0
  1 37  1  0
  5 38  1  0
  5 39  1  0
  6 40  1  6
  8 41  1  0
  8 42  1  0
  8 43  1  0
  9 44  1  0
  9 45  1  0
  9 46  1  0
 10 47  1  1
 11 48  1  0
 12 49  1  1
 13 50  1  0
 30 63  1  1
 29 61  1  0
 29 62  1  0
 28 59  1  0
 28 60  1  0
 27 56  1  0
 27 57  1  0
 27 58  1  0
 20 52  1  6
 16 51  1  0
 25 55  1  0
 23 54  1  0
 22 53  1  0
 32 64  1  0
 32 65  1  0
 32 66  1  0
M  END


  Mrv1652304292204452D          

 34 38  0  0  1  0            999 V2000
    5.2667    2.2226    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.6330    2.9618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3693    3.7435    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6301    4.1098    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8484    3.8461    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4821    3.1069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7458    2.3252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4850    1.9589    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8264    3.0162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4597    2.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6587    3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2924    2.3153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4691    2.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1028    1.5237    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121    2.9498    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3784    3.6890    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2017    3.7414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5680    4.4806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3914    4.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7447    4.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9213    4.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0970    4.4098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1254    5.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5615    5.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2084    5.1493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6856    4.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    4.2863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8312    5.0958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0505    5.3624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4525    5.6385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2931    6.4480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467    2.5479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3958    3.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8095    1.6013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  1  8  1  0  0  0  0
  8  9  1  1  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
  5 19  1  0  0  0  0
 17 20  1  1  0  0  0
 16 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  2  0  0  0  0
  4 26  1  1  0  0  0
  3 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  2 32  1  0  0  0  0
  2 33  1  0  0  0  0
  1 34  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0081695

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C[C@H]1C(C)(C)[C@H](O)[C@@H]2C=C3[C@H](CC[C@@]4(C)[C@@H](OC(=O)C=C34)C3=COC=C3)[C@@]1(C)C2=O

> <INCHI_IDENTIFIER>
InChI=1S/C27H32O7/c1-25(2)19(12-20(28)32-5)27(4)17-6-8-26(3)18(15(17)10-16(22(25)30)23(27)31)11-21(29)34-24(26)14-7-9-33-13-14/h7,9-11,13,16-17,19,22,24,30H,6,8,12H2,1-5H3/t16-,17-,19-,22+,24-,26+,27+/m0/s1

> <INCHI_KEY>
SWGGAYMXYUKZCM-OLJNMEOCSA-N

> <FORMULA>
C27H32O7

> <MOLECULAR_WEIGHT>
468.546

> <EXACT_MASS>
468.21480337

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
66

> <JCHEM_AVERAGE_POLARIZABILITY>
49.00254008832909

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl 2-[(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadeca-9,11-dien-16-yl]acetate

> <ALOGPS_LOGP>
3.55

> <JCHEM_LOGP>
3.2683935726666666

> <ALOGPS_LOGS>
-4.10

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.99086827818094

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.410087418722707

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8888565968978384

> <JCHEM_POLAR_SURFACE_AREA>
103.04000000000002

> <JCHEM_REFRACTIVITY>
123.7566

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.72e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl [(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadeca-9,11-dien-16-yl]acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0       9.831   4.149   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.515   5.529   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.023   6.988   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.643   7.672   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.184   7.179   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.500   5.800   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.992   4.340   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.372   3.657   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.009   5.630   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      10.191   4.643   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       4.963   5.702   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.279   4.322   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.742   4.224   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       2.059   2.844   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0       1.889   5.506   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       2.573   6.886   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.110   6.984   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.794   8.364   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.331   8.462   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.257   8.266   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       1.720   8.168   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       0.181   8.232   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      -0.234   9.715   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       1.048  10.568   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       2.256   9.612   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.747   9.208   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.183   8.001   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      10.885   9.512   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       9.428  10.010   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0      12.045  10.525   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0      11.747  12.036   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      11.847   4.756   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0      11.939   6.115   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      10.844   2.989   0.000  0.00  0.00           O+0
CONECT    1    2    8   34                                                  
CONECT    2    1    3   32   33                                             
CONECT    3    2    4   27                                                  
CONECT    4    3    5    9   26                                             
CONECT    5    4    6   19                                                  
CONECT    6    5    7   11                                                  
CONECT    7    6    8                                                       
CONECT    8    7    1    9                                                  
CONECT    9    8    4   10                                                  
CONECT   10    9                                                            
CONECT   11    6   12   17                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   17   21                                                  
CONECT   17   16   11   18   20                                             
CONECT   18   17   19                                                       
CONECT   19   18    5                                                       
CONECT   20   17                                                            
CONECT   21   16   22   25                                                  
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25                                                       
CONECT   25   24   21                                                       
CONECT   26    4                                                            
CONECT   27    3   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31                                                       
CONECT   31   30                                                            
CONECT   32    2                                                            
CONECT   33    2                                                            
CONECT   34    1                                                            
MASTER        0    0    0    0    0    0    0    0   34    0   76    0
END

View in JSmol

Synonyms

Value	Source
Methyl 2-[(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0,.0,]heptadeca-9,11-dien-16-yl]acetic acid	Generator

Chemical Formula

C₂₇H₃₂O₇

Average Mass

468.5460 Da

Monoisotopic Mass

468.21480 Da

IUPAC Name

methyl 2-[(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadeca-9,11-dien-16-yl]acetate

Traditional Name

methyl [(1R,2S,5R,6R,13S,14R,16S)-6-(furan-3-yl)-14-hydroxy-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadeca-9,11-dien-16-yl]acetate

CAS Registry Number

Not Available

SMILES

COC(=O)C[C@H]1C(C)(C)[C@H](O)[C@@H]2C=C3[C@H](CC[C@@]4(C)[C@@H](OC(=O)C=C34)C3=COC=C3)[C@@]1(C)C2=O

InChI Identifier

InChI=1S/C27H32O7/c1-25(2)19(12-20(28)32-5)27(4)17-6-8-26(3)18(15(17)10-16(22(25)30)23(27)31)11-21(29)34-24(26)14-7-9-33-13-14/h7,9-11,13,16-17,19,22,24,30H,6,8,12H2,1-5H3/t16-,17-,19-,22+,24-,26+,27+/m0/s1

InChI Key

SWGGAYMXYUKZCM-OLJNMEOCSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Swietenia mahagoni	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthopyrans. Naphthopyrans are compounds containing a pyran ring fused to a naphthalene moiety. Furan is a 6 membered-ring non-aromatic ring with five carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthopyrans

Sub Class

Not Available

Direct Parent

Naphthopyrans

Alternative Parents

Substituents

Naphthopyran
Naphthalene
Cyclohexenone
Dihydropyranone
Pyran
Dicarboxylic acid or derivatives
Heteroaromatic compound
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Methyl ester
Furan
Cyclic alcohol
Secondary alcohol
Lactone
Ketone
Carboxylic acid ester
Oxacycle
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.55	ALOGPS
logP	3.27	ChemAxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	12.41	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	103.04 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	123.76 m³·mol⁻¹	ChemAxon
Polarizability	49 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163106068

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Seneganolide A (NP0081695)

MOL for NP0081695 (Seneganolide A)

3D MOL for NP0081695 (Seneganolide A)

3D SDF for NP0081695 (Seneganolide A)

3D-SDF for NP0081695 (Seneganolide A)

PDB for NP0081695 (Seneganolide A)

3D PDB for NP0081695 (Seneganolide A)

SMILES for NP0081695 (Seneganolide A)

INCHI for NP0081695 (Seneganolide A)

Structure for NP0081695 (Seneganolide A)

3D Structure for NP0081695 (Seneganolide A)