NP-MRD: Showing NP-Card for Macrocalyxin E (NP0081363)

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Record Information

Version

2.0

Created at

2022-04-29 02:20:01 UTC

Updated at

2022-04-29 02:20:01 UTC

NP-MRD ID

NP0081363

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Macrocalyxin E

Description

(1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0¹,¹⁰.0⁴,⁹]Hexadecane-5-carbaldehyde belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D. Macrocalyxin E is found in Isodon macrocalyx, Isodon phyllostachys and Isodon scoparius. Based on a literature review very few articles have been published on (1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0¹,¹⁰.0⁴,⁹]Hexadecane-5-carbaldehyde.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292204202D          

 26 29  0  0  1  0            999 V2000
    0.8807   -0.8586    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3562   -0.3259    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6615    0.4607    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4709    0.6276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0251    0.0085    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8307    0.1863    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3876   -0.4224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1388   -1.2090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3332   -1.3869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7764   -0.7782    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9553   -0.9800    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7099   -1.8247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643   -2.4357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8644   -1.9834    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3044   -1.3242    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0766   -0.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8896   -0.4095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5463    0.0570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4106    0.8708    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5888   -2.7610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5369   -1.5676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6811    0.9976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4196    0.7641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2138    1.5630    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1288    1.0907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4495   -1.4561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  6  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
  2 18  1  1  0  0  0
 18 19  2  0  0  0  0
 14 20  1  6  0  0  0
 10 21  1  6  0  0  0
  6 22  1  6  0  0  0
  6 23  1  1  0  0  0
 23 24  2  0  0  0  0
  3 25  1  6  0  0  0
  1 26  1  6  0  0  0
M  END

     RDKit          3D

 52 55  0  0  0  0  0  0  0  0999 V2000
    4.6821   -0.1500   -1.6687 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5798   -0.1251   -0.9787 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2939    0.3753   -1.3790 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9172    0.6774   -2.5531 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3825    0.5116   -0.1782 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5613   -0.7030   -0.1186 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2656   -1.8423    0.5146 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7506   -2.7087    1.1916 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7309   -1.9602    0.3203 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2976   -2.8624    1.2390 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3669   -0.6187    0.4289 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.4200    0.4595    0.9356 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1696    1.6338    1.0004 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8498   -0.4983    0.4304 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7236   -0.1316    1.8717 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5618   -1.8015    0.3133 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9750   -1.7643   -0.1064 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4109   -0.6467   -0.9664 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9160    0.6786   -0.4274 C   0  0  2  0  0  0  0  0  0  0  0  0
   -3.5229    1.0283    0.8931 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3023    1.7452   -1.3927 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6645    1.4767   -2.5239 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4231    0.6000   -0.4256 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7479    1.8959   -0.1227 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7187    1.8210   -0.2854 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2855    2.6639    0.7058 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6127   -0.5500   -1.2821 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6876    0.2410   -2.6721 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3692   -1.0527   -1.1811 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8570   -2.4135   -0.7076 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1237   -3.7620    0.8857 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3146   -0.6141    0.9974 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0274    0.1444    1.8978 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6385    1.6980    0.1124 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7068   -0.2093    2.4216 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0826   -0.8894    2.3674 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2563    0.8442    2.0692 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5412   -2.3331    1.3135 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0086   -2.5207   -0.3613 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6633   -1.7922    0.7898 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2298   -2.7255   -0.6457 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5363   -0.5899   -0.9161 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0671   -0.7122   -2.0189 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8708    0.1267    1.4429 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8787    1.6766    1.5152 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4641    1.6340    0.7317 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2721    2.7918   -1.1161 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1316    0.3401   -1.4876 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0425    2.3018    0.8902 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2071    2.6565   -0.8261 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9773    2.3650   -1.2449 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0268    3.5903    0.4613 H   0  0  0  0  0  0  0  0  0  0  0  0
 19 20  1  1
 19 18  1  0
 18 17  1  0
 17 16  1  0
 16 14  1  0
 14 15  1  1
 14 23  1  0
 23 24  1  0
 24 25  1  0
 25 26  1  0
 25  5  1  0
  5 12  1  0
 12 13  1  0
 12 11  1  0
 11  9  1  0
  9 10  1  0
  9  7  1  0
  7  8  2  0
  7  6  1  0
 11  2  1  0
  2  1  2  3
  2  3  1  0
  3  4  2  0
 19 21  1  0
 21 22  2  0
 23 19  1  0
  6  5  1  0
  6 14  1  0
  5  3  1  6
 20 44  1  0
 20 45  1  0
 20 46  1  0
 18 42  1  0
 18 43  1  0
 17 40  1  0
 17 41  1  0
 16 38  1  0
 16 39  1  0
 15 35  1  0
 15 36  1  0
 15 37  1  0
 23 48  1  6
 24 49  1  0
 24 50  1  0
 25 51  1  6
 26 52  1  0
 12 33  1  1
 13 34  1  0
 11 32  1  1
  9 30  1  6
 10 31  1  0
  6 29  1  6
  1 27  1  0
  1 28  1  0
 21 47  1  0
M  END


  Mrv1652304292204202D          

 26 29  0  0  1  0            999 V2000
    0.8807   -0.8586    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3562   -0.3259    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.6615    0.4607    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4709    0.6276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0251    0.0085    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8307    0.1863    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3876   -0.4224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1388   -1.2090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3332   -1.3869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7764   -0.7782    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9553   -0.9800    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7099   -1.8247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2643   -2.4357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8644   -1.9834    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3044   -1.3242    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.0766   -0.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8896   -0.4095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5463    0.0570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4106    0.8708    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5888   -2.7610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5369   -1.5676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6811    0.9976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4196    0.7641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2138    1.5630    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1288    1.0907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4495   -1.4561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  6  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  1 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
  2 18  1  1  0  0  0
 18 19  2  0  0  0  0
 14 20  1  6  0  0  0
 10 21  1  6  0  0  0
  6 22  1  6  0  0  0
  6 23  1  1  0  0  0
 23 24  2  0  0  0  0
  3 25  1  6  0  0  0
  1 26  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0081363

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@]1(CCC[C@]2(C)[C@@H]1C[C@@H](O)[C@@]13[C@H](O)[C@@H]([C@@H](O)C(=O)[C@@H]21)C(=C)C3=O)C=O

> <INCHI_IDENTIFIER>
InChI=1S/C20H26O6/c1-9-12-13(23)14(24)15-19(3)6-4-5-18(2,8-21)10(19)7-11(22)20(15,16(9)25)17(12)26/h8,10-13,15,17,22-23,26H,1,4-7H2,2-3H3/t10-,11-,12-,13-,15+,17-,18-,19-,20-/m1/s1

> <INCHI_KEY>
YSIQZGSHAOVHTQ-OMNYJYFXSA-N

> <FORMULA>
C20H26O6

> <MOLECULAR_WEIGHT>
362.422

> <EXACT_MASS>
362.172938557

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
52

> <JCHEM_AVERAGE_POLARIZABILITY>
37.26555981702397

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carbaldehyde

> <ALOGPS_LOGP>
1.00

> <JCHEM_LOGP>
0.35743737366666734

> <ALOGPS_LOGS>
-2.08

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.68184791993836

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.262609538945531

> <JCHEM_PKA_STRONGEST_BASIC>
-3.058802426223215

> <JCHEM_POLAR_SURFACE_AREA>
111.9

> <JCHEM_REFRACTIVITY>
92.19789999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.05e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carbaldehyde

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0       1.644  -1.603   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       2.532  -0.608   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       3.102   0.860   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       4.612   1.171   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       5.647   0.016   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.151   0.348   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.190  -0.788   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.726  -2.257   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       6.222  -2.589   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.183  -1.453   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       3.650  -1.829   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.192  -3.406   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       4.227  -4.547   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       1.613  -3.702   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       0.568  -2.472   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      -0.143  -1.026   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      -1.661  -0.764   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.020   0.106   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       0.767   1.625   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0       1.099  -5.154   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       4.736  -2.926   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       6.871   1.862   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       8.250   1.426   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       7.866   2.918   0.000  0.00  0.00           O+0
HETATM   25  O   UNK     0       2.107   2.036   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       2.706  -2.718   0.000  0.00  0.00           O+0
CONECT    1    2   15   26                                                  
CONECT    2    1    3   11   18                                             
CONECT    3    2    4   25                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   10                                                  
CONECT    6    5    7   22   23                                             
CONECT    7    6    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9    5   11   21                                             
CONECT   11   10    2   12                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12   15   20                                                  
CONECT   15   14    1   16                                                  
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16    2   19                                                  
CONECT   19   18                                                            
CONECT   20   14                                                            
CONECT   21   10                                                            
CONECT   22    6                                                            
CONECT   23    6   24                                                       
CONECT   24   23                                                            
CONECT   25    3                                                            
CONECT   26    1                                                            
MASTER        0    0    0    0    0    0    0    0   26    0   58    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₀H₂₆O₆

Average Mass

362.4220 Da

Monoisotopic Mass

362.17294 Da

IUPAC Name

(1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carbaldehyde

Traditional Name

(1R,2R,4S,5S,9R,10S,12R,13S,16R)-2,12,16-trihydroxy-5,9-dimethyl-14-methylidene-11,15-dioxotetracyclo[11.2.1.0^{1,10}.0^{4,9}]hexadecane-5-carbaldehyde

CAS Registry Number

Not Available

SMILES

C[C@@]1(CCC[C@]2(C)[C@@H]1C[C@@H](O)[C@@]13[C@H](O)[C@@H]([C@@H](O)C(=O)[C@@H]21)C(=C)C3=O)C=O

InChI Identifier

InChI=1S/C20H26O6/c1-9-12-13(23)14(24)15-19(3)6-4-5-18(2,8-21)10(19)7-11(22)20(15,16(9)25)17(12)26/h8,10-13,15,17,22-23,26H,1,4-7H2,2-3H3/t10-,11-,12-,13-,15+,17-,18-,19-,20-/m1/s1

InChI Key

YSIQZGSHAOVHTQ-OMNYJYFXSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Isodon macrocalyx	Plant	KNApSAcK
Isodon phyllostachys	LOTUS Database	35616633
Isodon scoparius	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as kaurane diterpenoids. These are diterpene alkaloids with a structure that is based on the kaurane skeleton. Kaurane is a tetracyclic compound that arises by cyclisation of a pimarane precursor followed by rearrangement. It possesses a [3,2,1]-bicyclic ring system with C15-C16 bridge connected to C13, forming the five-membered ring D.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Kaurane diterpenoids

Alternative Parents

Substituents

Kaurane diterpenoid
Cyclic alcohol
Secondary alcohol
Ketone
Polyol
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aldehyde
Alcohol
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1	ALOGPS
logP	0.36	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	12.26	ChemAxon
pKa (Strongest Basic)	-3.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	111.9 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	92.2 m³·mol⁻¹	ChemAxon
Polarizability	37.27 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163010750

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for Macrocalyxin E (NP0081363)

MOL for NP0081363 (Macrocalyxin E)

3D MOL for NP0081363 (Macrocalyxin E)

3D SDF for NP0081363 (Macrocalyxin E)

3D-SDF for NP0081363 (Macrocalyxin E)

PDB for NP0081363 (Macrocalyxin E)

3D PDB for NP0081363 (Macrocalyxin E)

SMILES for NP0081363 (Macrocalyxin E)

INCHI for NP0081363 (Macrocalyxin E)

Structure for NP0081363 (Macrocalyxin E)

3D Structure for NP0081363 (Macrocalyxin E)