NP-MRD: Showing NP-Card for (-)-Taxuyunnanine N (NP0081195)

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Record Information

Version

2.0

Created at

2022-04-29 02:09:51 UTC

Updated at

2022-04-29 02:09:51 UTC

NP-MRD ID

NP0081195

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(-)-Taxuyunnanine N

Description

Taxuyunnanine N belongs to the class of organic compounds known as taxanes and derivatives. These are diterpenoids with a structure based either on the taxane skeleton, or a derivative thereof. In term of phytochemistry, several derivatives of the taxane skeleton exist: 2(3->20)-Abeotaxane, 3,11-cyclotaxane, 11(15->1),11(10->9)-abeotaxane, 3,8-seco-taxane, and 11(15->1)-abeotaxane, among others. More complex skeletons have been found recently, which include the taxane-derived [3.3.3] Propellane ring system. (-)-Taxuyunnanine N is found in Taxus wallichiana and Taxus yunnanensis. Based on a literature review very few articles have been published on Taxuyunnanine N.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292204092D          

 37 39  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652304292204092D          

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  1  6  1  0  0  0  0
  6  7  1  6  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
  4 18  1  0  0  0  0
 18 19  1  1  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 15 24  1  1  0  0  0
 14 25  1  0  0  0  0
 12 26  1  6  0  0  0
 11 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
  5 31  1  6  0  0  0
  3 32  1  6  0  0  0
 32 33  1  0  0  0  0
  2 34  1  1  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0081195

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)O[C@H]1C[C@H](OC(C)=O)[C@]2(C)[C@@H]([C@@H]1CO)[C@H](O)[C@@]1(C[C@H](O)C(C)=C1[C@@H](O)[C@@H]2OC(C)=O)C(C)(C)O

> <INCHI_IDENTIFIER>
InChI=1S/C26H40O11/c1-11-16(31)9-26(24(5,6)34)19(11)21(32)23(37-14(4)30)25(7)18(36-13(3)29)8-17(35-12(2)28)15(10-27)20(25)22(26)33/h15-18,20-23,27,31-34H,8-10H2,1-7H3/t15-,16+,17+,18+,20+,21-,22+,23+,25-,26+/m1/s1

> <INCHI_KEY>
CARDVZMKNDWLLP-LKGHEZQFSA-N

> <FORMULA>
C26H40O11

> <MOLECULAR_WEIGHT>
528.595

> <EXACT_MASS>
528.257062108

> <JCHEM_ACCEPTOR_COUNT>
8

> <JCHEM_ATOM_COUNT>
77

> <JCHEM_AVERAGE_POLARIZABILITY>
53.711366062142034

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S,3aS,4S,4aR,5R,6S,8S,8aS,9R,10R)-6,8-bis(acetyloxy)-2,4,10-trihydroxy-5-(hydroxymethyl)-3a-(2-hydroxypropan-2-yl)-1,8a-dimethyl-2H,3H,3aH,4H,4aH,5H,6H,7H,8H,8aH,9H,10H-cyclohexa[f]azulen-9-yl acetate

> <ALOGPS_LOGP>
0.10

> <JCHEM_LOGP>
-2.410004253666666

> <ALOGPS_LOGS>
-2.61

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.067889362438883

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.391464357141508

> <JCHEM_PKA_STRONGEST_BASIC>
-2.635238876951888

> <JCHEM_POLAR_SURFACE_AREA>
180.04999999999998

> <JCHEM_REFRACTIVITY>
128.08829999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.30e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2S,3aS,4S,4aR,5R,6S,8S,8aS,9R,10R)-6,8-bis(acetyloxy)-2,4,10-trihydroxy-5-(hydroxymethyl)-3a-(2-hydroxypropan-2-yl)-1,8a-dimethyl-2H,3H,4H,4aH,5H,6H,7H,8H,9H,10H-cyclohexa[f]azulen-9-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0      10.912   1.453   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.586   2.958   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       9.120   3.429   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       7.979   2.394   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.305   0.889   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       9.772   0.418   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      10.098  -1.087   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      11.564  -1.557   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0      11.890  -3.062   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0      12.705  -0.522   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       7.332  -0.304   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.792  -0.287   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.845   0.927   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.310   0.807   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.721   2.229   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       3.892   3.230   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.205   2.425   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       6.599   3.078   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       6.617   4.617   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       5.291   3.963   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       5.377   5.500   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       6.264   5.156   0.000  0.00  0.00           O+0
HETATM   23  C   UNK     0       3.753   4.049   0.000  0.00  0.00           C+0
HETATM   24  O   UNK     0       1.223   2.589   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       2.505  -0.507   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       5.108  -1.667   0.000  0.00  0.00           O+0
HETATM   27  O   UNK     0       7.984  -1.699   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       7.103  -2.962   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       7.755  -4.357   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       5.568  -2.830   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       8.743  -0.588   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       8.794   4.934   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0       9.935   5.969   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0      11.727   3.993   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      13.193   3.523   0.000  0.00  0.00           C+0
HETATM   36  O   UNK     0      14.334   4.558   0.000  0.00  0.00           O+0
HETATM   37  C   UNK     0      13.519   2.018   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3   34                                                  
CONECT    3    2    4   32                                                  
CONECT    4    3    5   18                                                  
CONECT    5    4    6   11   31                                             
CONECT    6    5    1    7                                                  
CONECT    7    6    8                                                       
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    5   12   27                                                  
CONECT   12   11   13   26                                                  
CONECT   13   12   14   17                                                  
CONECT   14   13   15   25                                                  
CONECT   15   14   16   24                                                  
CONECT   16   15   17                                                       
CONECT   17   16   13   18   20                                             
CONECT   18   17    4   19                                                  
CONECT   19   18                                                            
CONECT   20   17   21   22   23                                             
CONECT   21   20                                                            
CONECT   22   20                                                            
CONECT   23   20                                                            
CONECT   24   15                                                            
CONECT   25   14                                                            
CONECT   26   12                                                            
CONECT   27   11   28                                                       
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28                                                            
CONECT   31    5                                                            
CONECT   32    3   33                                                       
CONECT   33   32                                                            
CONECT   34    2   35                                                       
CONECT   35   34   36   37                                                  
CONECT   36   35                                                            
CONECT   37   35                                                            
MASTER        0    0    0    0    0    0    0    0   37    0   78    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₆H₄₀O₁₁

Average Mass

528.5950 Da

Monoisotopic Mass

528.25706 Da

IUPAC Name

(2S,3aS,4S,4aR,5R,6S,8S,8aS,9R,10R)-6,8-bis(acetyloxy)-2,4,10-trihydroxy-5-(hydroxymethyl)-3a-(2-hydroxypropan-2-yl)-1,8a-dimethyl-2H,3H,3aH,4H,4aH,5H,6H,7H,8H,8aH,9H,10H-cyclohexa[f]azulen-9-yl acetate

Traditional Name

(2S,3aS,4S,4aR,5R,6S,8S,8aS,9R,10R)-6,8-bis(acetyloxy)-2,4,10-trihydroxy-5-(hydroxymethyl)-3a-(2-hydroxypropan-2-yl)-1,8a-dimethyl-2H,3H,4H,4aH,5H,6H,7H,8H,9H,10H-cyclohexa[f]azulen-9-yl acetate

CAS Registry Number

Not Available

SMILES

CC(=O)O[C@H]1C[C@H](OC(C)=O)[C@]2(C)[C@@H]([C@@H]1CO)[C@H](O)[C@@]1(C[C@H](O)C(C)=C1[C@@H](O)[C@@H]2OC(C)=O)C(C)(C)O

InChI Identifier

InChI=1S/C26H40O11/c1-11-16(31)9-26(24(5,6)34)19(11)21(32)23(37-14(4)30)25(7)18(36-13(3)29)8-17(35-12(2)28)15(10-27)20(25)22(26)33/h15-18,20-23,27,31-34H,8-10H2,1-7H3/t15-,16+,17+,18+,20+,21-,22+,23+,25-,26+/m1/s1

InChI Key

CARDVZMKNDWLLP-LKGHEZQFSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Taxus wallichiana	LOTUS Database	35616633
Taxus wallichiana var. yunnanensis	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as taxanes and derivatives. These are diterpenoids with a structure based either on the taxane skeleton, or a derivative thereof. In term of phytochemistry, several derivatives of the taxane skeleton exist: 2(3->20)-Abeotaxane, 3,11-cyclotaxane, 11(15->1),11(10->9)-abeotaxane, 3,8-seco-taxane, and 11(15->1)-abeotaxane, among others. More complex skeletons have been found recently, which include the taxane-derived [3.3.3] Propellane ring system.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Taxanes and derivatives

Alternative Parents

Substituents

11(15->1)-abeotaxane diterpenoid
Tricarboxylic acid or derivatives
Cyclic alcohol
Tertiary alcohol
Carboxylic acid ester
Secondary alcohol
Polyol
Carboxylic acid derivative
Primary alcohol
Organooxygen compound
Organic oxygen compound
Alcohol
Carbonyl group
Organic oxide
Hydrocarbon derivative
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.1	ALOGPS
logP	-2.4	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Acidic)	13.39	ChemAxon
pKa (Strongest Basic)	-2.6	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	8	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	180.05 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	128.09 m³·mol⁻¹	ChemAxon
Polarizability	53.71 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00046949

Chemspider ID

8967585

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10792273

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for (-)-Taxuyunnanine N (NP0081195)

MOL for NP0081195 ((-)-Taxuyunnanine N)

3D MOL for NP0081195 ((-)-Taxuyunnanine N)

3D SDF for NP0081195 ((-)-Taxuyunnanine N)

3D-SDF for NP0081195 ((-)-Taxuyunnanine N)

PDB for NP0081195 ((-)-Taxuyunnanine N)

3D PDB for NP0081195 ((-)-Taxuyunnanine N)

SMILES for NP0081195 ((-)-Taxuyunnanine N)

INCHI for NP0081195 ((-)-Taxuyunnanine N)

Structure for NP0081195 ((-)-Taxuyunnanine N)

3D Structure for NP0081195 ((-)-Taxuyunnanine N)