NP-MRD: Showing NP-Card for (-)-Salignarine C (NP0081159)

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Record Information

Version

2.0

Created at

2022-04-29 02:07:41 UTC

Updated at

2022-04-29 02:07:41 UTC

NP-MRD ID

NP0081159

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(-)-Salignarine C

Description

Salignarine C belongs to the class of organic compounds known as hydroxysteroids. Hydroxysteroids are compounds containing an steroid backbone, with at least one hydrogen substituted by a hydroxyl group. (-)-Salignarine C is found in Sarcococca saligna . Based on a literature review very few articles have been published on Salignarine C.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292204072D          

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M  END

     RDKit          3D

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M  END


  Mrv1652304292204072D          

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M  END
> <DATABASE_ID>
NP0081159

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@H]([C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](NC(=O)C=C(C)C)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C)N(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C28H46N2O2/c1-17(2)14-26(32)29-24-15-19-8-9-20-22-11-10-21(18(3)30(6)7)27(22,4)13-12-23(20)28(19,5)16-25(24)31/h8,14,18,20-25,31H,9-13,15-16H2,1-7H3,(H,29,32)/t18-,20-,21+,22-,23-,24+,25-,27+,28-/m0/s1

> <INCHI_KEY>
DYWKDRVBLDKWSU-UGNLMWPZSA-N

> <FORMULA>
C28H46N2O2

> <MOLECULAR_WEIGHT>
442.688

> <EXACT_MASS>
442.355928729

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
78

> <JCHEM_AVERAGE_POLARIZABILITY>
54.720314676392164

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
N-[(1S,2R,4S,5R,10S,11S,14S,15S)-14-[(1S)-1-(dimethylamino)ethyl]-4-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]-3-methylbut-2-enamide

> <ALOGPS_LOGP>
4.05

> <JCHEM_LOGP>
4.105954658000001

> <ALOGPS_LOGS>
-5.15

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
16.086565643819185

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.527075942818957

> <JCHEM_PKA_STRONGEST_BASIC>
10.300271166615799

> <JCHEM_POLAR_SURFACE_AREA>
52.57

> <JCHEM_REFRACTIVITY>
133.57760000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.10e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
N-[(1S,2R,4S,5R,10S,11S,14S,15S)-14-[(1S)-1-(dimethylamino)ethyl]-4-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]-3-methylbut-2-enamide

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0      17.059  -0.771   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      16.067   0.406   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      14.551   0.135   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      14.028  -1.314   0.000  0.00  0.00           O+0
HETATM    5  N   UNK     0      13.558   1.312   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0      12.042   1.041   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      11.519  -0.407   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      12.512  -1.585   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      10.003  -0.678   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       9.010   0.499   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       9.533   1.947   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.541   3.125   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       7.025   2.854   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.502   1.405   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       7.494   0.228   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.971  -1.221   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       5.455  -1.492   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.462  -0.314   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       4.986   1.134   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.770   2.079   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.495   1.215   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.923  -0.264   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       1.978  -1.480   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       2.558  -2.907   0.000  0.00  0.00           C+0
HETATM   25  N   UNK     0       0.452  -1.269   0.000  0.00  0.00           N+0
HETATM   26  C   UNK     0      -0.493  -2.485   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      -0.128   0.157   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       3.791  -1.700   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      11.049   2.218   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       8.487  -0.949   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      18.575  -0.500   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0      16.536  -2.220   0.000  0.00  0.00           C+0
CONECT    1    2   31   32                                                  
CONECT    2    1    3                                                       
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7   29                                                  
CONECT    7    6    8    9                                                  
CONECT    8    7                                                            
CONECT    9    7   10                                                       
CONECT   10    9   11   15   30                                             
CONECT   11   10   12   29                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15   19                                                  
CONECT   15   14   10   16                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19   22   28                                             
CONECT   19   18   14   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   18   23                                                  
CONECT   23   22   24   25                                                  
CONECT   24   23                                                            
CONECT   25   23   26   27                                                  
CONECT   26   25                                                            
CONECT   27   25                                                            
CONECT   28   18                                                            
CONECT   29   11    6                                                       
CONECT   30   10                                                            
CONECT   31    1                                                            
CONECT   32    1                                                            
MASTER        0    0    0    0    0    0    0    0   32    0   70    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₈H₄₆N₂O₂

Average Mass

442.6880 Da

Monoisotopic Mass

442.35593 Da

IUPAC Name

N-[(1S,2R,4S,5R,10S,11S,14S,15S)-14-[(1S)-1-(dimethylamino)ethyl]-4-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]-3-methylbut-2-enamide

Traditional Name

N-[(1S,2R,4S,5R,10S,11S,14S,15S)-14-[(1S)-1-(dimethylamino)ethyl]-4-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]-3-methylbut-2-enamide

CAS Registry Number

Not Available

SMILES

C[C@@H]([C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](NC(=O)C=C(C)C)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C)N(C)C

InChI Identifier

InChI=1S/C28H46N2O2/c1-17(2)14-26(32)29-24-15-19-8-9-20-22-11-10-21(18(3)30(6)7)27(22,4)13-12-23(20)28(19,5)16-25(24)31/h8,14,18,20-25,31H,9-13,15-16H2,1-7H3,(H,29,32)/t18-,20-,21+,22-,23-,24+,25-,27+,28-/m0/s1

InChI Key

DYWKDRVBLDKWSU-UGNLMWPZSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Sarcococca saligna	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hydroxysteroids. Hydroxysteroids are compounds containing an steroid backbone, with at least one hydrogen substituted by a hydroxyl group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Hydroxysteroids

Direct Parent

Hydroxysteroids

Alternative Parents

Substituents

22-azasteroid
Pregnane-skeleton
Steroidal alkaloid
Pregnane-type alkaloid
2-hydroxysteroid
Hydroxysteroid
Azasteroid
Delta-5-steroid
Alkaloid or derivatives
N-acyl-amine
Cyclic alcohol
Amino acid or derivatives
Carboxamide group
Tertiary aliphatic amine
Tertiary amine
Secondary carboxylic acid amide
Secondary alcohol
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Carbonyl group
Amine
Alcohol
Organonitrogen compound
Organooxygen compound
Organic nitrogen compound
Organic oxygen compound
Aliphatic homopolycyclic compound

Molecular Framework

Aliphatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	4.05	ALOGPS
logP	4.11	ChemAxon
logS	-5.2	ALOGPS
pKa (Strongest Acidic)	14.53	ChemAxon
pKa (Strongest Basic)	10.3	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	52.57 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	133.58 m³·mol⁻¹	ChemAxon
Polarizability	54.72 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00046887

Chemspider ID

8726605

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

10551214

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for (-)-Salignarine C (NP0081159)

MOL for NP0081159 ((-)-Salignarine C)

3D MOL for NP0081159 ((-)-Salignarine C)

3D SDF for NP0081159 ((-)-Salignarine C)

3D-SDF for NP0081159 ((-)-Salignarine C)

PDB for NP0081159 ((-)-Salignarine C)

3D PDB for NP0081159 ((-)-Salignarine C)

SMILES for NP0081159 ((-)-Salignarine C)

INCHI for NP0081159 ((-)-Salignarine C)

Structure for NP0081159 ((-)-Salignarine C)

3D Structure for NP0081159 ((-)-Salignarine C)