NP-MRD: Showing NP-Card for Vitrofolal A (NP0080938)

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Record Information

Version

2.0

Created at

2022-04-29 01:54:33 UTC

Updated at

2022-04-29 01:54:33 UTC

NP-MRD ID

NP0080938

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Vitrofolal A

Description

4-(3,4-Dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. Vitrofolal A is found in Vitex rotundifolia . 4-(3,4-Dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 43 45  0  0  0  0  0  0  0  0999 V2000
    5.1647   -0.4820   -1.8161 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4953    0.3527   -0.8659 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1628    0.0166   -0.5561 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5292   -1.0547   -1.1306 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2259   -1.3651   -0.8134 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5257   -0.5967    0.0974 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8202   -0.9787    0.4937 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9719   -2.1967    1.1892 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2069   -2.5431    1.6602 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3958   -3.8102    2.3896 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5388   -4.0844    2.8004 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2773   -1.7020    1.4505 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1535   -0.5127    0.7763 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2264    0.3226    0.5662 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0826    1.5027   -0.1139 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8550    1.8876   -0.6103 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6702    3.0645   -1.2941 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7784    1.0445   -0.3996 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5588    1.4726   -0.9368 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3476    1.0719   -2.3004 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8819   -0.1452    0.2809 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1599    0.4771    0.6743 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4786    0.7936    0.3550 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1144    1.8800    0.9404 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3973    2.6725    1.8781 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1275   -1.5463   -1.4531 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6114   -0.3817   -2.7722 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2173   -0.2214   -1.9208 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.1106   -1.6327   -1.8393 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7472   -2.2162   -1.2804 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0833   -2.7898    1.3069 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5725   -4.4569    2.5507 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2622   -1.9758    1.8265 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1959    0.0298    0.9506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9194    2.1900   -0.2959 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7711    3.3396   -1.6324 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7626    0.9595   -2.4792 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571    0.0338   -2.4553 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7570    1.7614   -3.0318 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6846    1.1318    1.4152 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.9732    2.0516    2.7012 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0765    3.4551    2.2957 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5194    3.1811    1.3986 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6 22  1  0
 22 23  2  0
 23 24  1  0
 24 25  1  0
  6  7  1  0
  7 21  1  0
 21 18  2  0
 18 19  1  0
 19 20  1  0
 18 16  1  0
 16 17  1  0
 16 15  2  0
 15 14  1  0
 14 13  2  0
 13 12  1  0
 12  9  2  0
  9 10  1  0
 10 11  2  0
  9  8  1  0
 23  3  1  0
  8  7  2  0
 13 21  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  4 29  1  0
  5 30  1  0
 22 40  1  0
 25 41  1  0
 25 42  1  0
 25 43  1  0
 20 37  1  0
 20 38  1  0
 20 39  1  0
 17 36  1  0
 15 35  1  0
 14 34  1  0
 12 33  1  0
 10 32  1  0
  8 31  1  0
M  END


  Mrv1533004191523202D          

 25 27  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  1  0  0  0  0
 11 25  2  0  0  0  0
 17 25  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0080938

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC=C(C=C1OC)C1=C2C(OC)=C(O)C=CC2=CC(C=O)=C1

> <INCHI_IDENTIFIER>
InChI=1S/C20H18O5/c1-23-17-7-5-13(10-18(17)24-2)15-9-12(11-21)8-14-4-6-16(22)20(25-3)19(14)15/h4-11,22H,1-3H3

> <INCHI_KEY>
IBFBBRQOIORQJM-UHFFFAOYSA-N

> <FORMULA>
C20H18O5

> <MOLECULAR_WEIGHT>
338.359

> <EXACT_MASS>
338.11542368

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
35.4205214368082

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-(3,4-dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde

> <ALOGPS_LOGP>
3.30

> <JCHEM_LOGP>
3.5458711606666666

> <ALOGPS_LOGS>
-4.89

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.321174104733194

> <JCHEM_PKA_STRONGEST_BASIC>
-4.425261728092705

> <JCHEM_POLAR_SURFACE_AREA>
64.99000000000001

> <JCHEM_REFRACTIVITY>
95.59889999999997

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.37e-03 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-(3,4-dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 19-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   19-APR-15         0                                  
HETATM    1  C   UNK     0       4.001 -10.010   0.000  0.00  0.00           C+0
HETATM    2  O   UNK     0       2.667  -9.240   0.000  0.00  0.00           O+0
HETATM    3  C   UNK     0       2.667  -7.700   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.334  -6.930   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.334  -5.390   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.001  -5.390   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.001  -6.930   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       5.335  -7.700   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       5.335  -9.240   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       0.000   1.540   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       8.002  -3.080   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       6.668  -5.390   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
CONECT    1    2                                                            
CONECT    2    1    3                                                       
CONECT    3    2    4    8                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   11                                                  
CONECT    7    6    8                                                       
CONECT    8    7    3    9                                                  
CONECT    9    8   10                                                       
CONECT   10    9                                                            
CONECT   11    6   12   25                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   16                                                  
CONECT   14   13   15                                                       
CONECT   15   14                                                            
CONECT   16   13   17                                                       
CONECT   17   16   18   25                                                  
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   25                                                  
CONECT   23   22   24                                                       
CONECT   24   23                                                            
CONECT   25   22   11   17                                                  
MASTER        0    0    0    0    0    0    0    0   25    0   54    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₀H₁₈O₅

Average Mass

338.3590 Da

Monoisotopic Mass

338.11542 Da

IUPAC Name

4-(3,4-dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde

Traditional Name

4-(3,4-dimethoxyphenyl)-6-hydroxy-5-methoxynaphthalene-2-carbaldehyde

CAS Registry Number

Not Available

SMILES

COC1=CC=C(C=C1OC)C1=C2C(OC)=C(O)C=CC2=CC(C=O)=C1

InChI Identifier

InChI=1S/C20H18O5/c1-23-17-7-5-13(10-18(17)24-2)15-9-12(11-21)8-14-4-6-16(22)20(25-3)19(14)15/h4-11,22H,1-3H3

InChI Key

IBFBBRQOIORQJM-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Vitex rotundifolia	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Naphthalenes

Sub Class

Naphthols and derivatives

Direct Parent

Naphthols and derivatives

Alternative Parents

Substituents

2-naphthol
Dimethoxybenzene
O-dimethoxybenzene
Phenoxy compound
Anisole
Phenol ether
Methoxybenzene
Alkyl aryl ether
1-hydroxy-2-unsubstituted benzenoid
Phenol
Aryl-aldehyde
Monocyclic benzene moiety
Ether
Organooxygen compound
Organic oxygen compound
Organic oxide
Aldehyde
Hydrocarbon derivative
Aromatic homopolycyclic compound

Molecular Framework

Aromatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.3	ALOGPS
logP	3.55	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	9.32	ChemAxon
pKa (Strongest Basic)	-4.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	64.99 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	95.6 m³·mol⁻¹	ChemAxon
Polarizability	35.42 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

21592421

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Vitrofolal A (NP0080938)

MOL for NP0080938 (Vitrofolal A)

3D MOL for NP0080938 (Vitrofolal A)

3D SDF for NP0080938 (Vitrofolal A)

3D-SDF for NP0080938 (Vitrofolal A)

PDB for NP0080938 (Vitrofolal A)

3D PDB for NP0080938 (Vitrofolal A)

SMILES for NP0080938 (Vitrofolal A)

INCHI for NP0080938 (Vitrofolal A)

Structure for NP0080938 (Vitrofolal A)

3D Structure for NP0080938 (Vitrofolal A)