NP-MRD: Showing NP-Card for Afrogenin (NP0078281)

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Record Information

Version

2.0

Created at

2022-04-28 23:22:30 UTC

Updated at

2022-04-28 23:22:30 UTC

NP-MRD ID

NP0078281

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Afrogenin

Description

Afrogenin belongs to the class of organic compounds known as cardenolides and derivatives. These are steroid lactones containing a furan-2-one moiety linked to the C17 atom of a cyclopenta[a]phenanthrene derivative. Thus, afrogenin is considered to be a sterol. Afrogenin is found in Asclepias curassavica . Based on a literature review very few articles have been published on Afrogenin.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292201222D          

 29 33  0  0  1  0            999 V2000
    2.6190   -0.6539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    0.1221    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8705    0.7528    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6826    0.6076    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9629   -0.1684    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4311   -0.7991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875   -0.1416    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0168    0.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3340    1.1139    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3072    1.9385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2939   -0.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1184   -0.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3987   -1.5420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1912   -1.7713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7474   -2.0484    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0646   -1.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3228   -0.9107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4850    1.4085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5902    1.5287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781    1.6739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2463    1.0432    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5266    0.2673    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9948   -0.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1827   -0.2182    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0976    0.5577    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4342    1.1884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9098    0.7029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3492   -0.8489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8069   -0.5086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  6  0  0  0
  7 11  1  6  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  5 17  1  6  0  0  0
  4 18  1  6  0  0  0
  3 19  1  1  0  0  0
 19 20  1  0  0  0  0
 21 20  1  6  0  0  0
 21 22  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 25 27  1  6  0  0  0
 24 28  1  1  0  0  0
 22 29  1  6  0  0  0
M  END

     RDKit          3D

 63 67  0  0  0  0  0  0  0  0999 V2000
   -2.8625    1.2340    0.6932 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2750    0.0348   -0.0010 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.9888   -0.2484   -1.3126 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4207   -0.6325   -1.1192 C   0  0  1  0  0  0  0  0  0  0  0  0
   -4.8788   -1.1329   -2.3583 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6486   -1.6979   -0.1041 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.9978   -1.6976    0.2486 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8504   -1.5086    1.1647 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4312   -1.2275    0.8365 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.6095   -1.1787    2.1007 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1271   -0.9327    1.7534 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0777    0.3827    1.0620 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8135    0.1590   -0.2614 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4117    1.1844   -1.2469 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0455    0.8251   -1.5823 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9286    0.9366   -0.3901 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8840    2.0559   -0.6597 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7485   -0.3150   -0.1068 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8948   -0.4835   -1.0085 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1749   -0.5461   -0.7036 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9847   -0.7185   -1.9005 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2320   -0.8170   -1.9960 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1160   -0.7584   -2.9710 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8191   -0.6289   -2.4825 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1442   -0.2086    1.3461 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2215    0.8076    1.9831 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9230    1.9380    2.4101 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2037    1.0820    0.9281 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9307    2.4760    1.0052 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1896    1.0108    1.7285 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8056    1.5045    0.1421 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2221    2.1316    0.6314 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9662    0.6521   -1.9602 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4629   -1.1052   -1.7783 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0828    0.2220   -0.8782 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6975   -0.7077   -2.6566 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4186   -2.6961   -0.5234 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0904   -2.2324    1.0741 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9073   -2.4505    1.7287 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2699   -0.7177    1.8079 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0057   -2.0549    0.2145 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9412   -0.2922    2.6796 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7513   -2.1191    2.6293 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.3964   -1.0402    2.6933 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1174   -1.8022    1.0746 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7988    1.0420    1.6400 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4616   -0.8403   -0.6409 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4736    2.2286   -0.8458 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9617    1.0980   -2.1883 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3188    1.4982   -2.4177 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0248   -0.2016   -1.9718 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2391    2.6102    0.2076 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.8045    1.6035   -1.1172 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4931    2.7395   -1.4691 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0041   -1.1601   -0.2211 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6421   -0.4860    0.2858 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2416    0.1824   -2.9518 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2924   -1.5915   -2.7338 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1737    0.0977    1.5268 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0121   -1.2226    1.8151 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7789    0.3992    2.9397 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4615    2.3370    3.1620 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6481    2.9796    1.4163 H   0  0  0  0  0  0  0  0  0  0  0  0
 16 17  1  6
 16 15  1  0
 15 14  1  0
 14 13  1  0
 13 12  1  0
 12 11  1  0
 11 10  1  0
 10  9  1  0
  9  8  1  0
  8  6  1  0
  6  7  1  0
  6  4  1  0
  4  5  1  0
  4  3  1  0
  3  2  1  0
  2  1  1  1
 12 28  1  0
 28 29  1  1
 28 26  1  0
 26 27  1  0
 26 25  1  0
 25 18  1  0
 18 19  1  0
 19 20  2  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 23 24  1  0
 28 16  1  0
 24 19  1  0
 18 16  1  0
  2 13  1  0
  2  9  1  0
 17 52  1  0
 17 53  1  0
 17 54  1  0
 15 50  1  0
 15 51  1  0
 14 48  1  0
 14 49  1  0
 13 47  1  6
 12 46  1  1
 11 44  1  0
 11 45  1  0
 10 42  1  0
 10 43  1  0
  9 41  1  6
  8 39  1  0
  8 40  1  0
  6 37  1  6
  7 38  1  0
  4 35  1  1
  5 36  1  0
  3 33  1  0
  3 34  1  0
  1 30  1  0
  1 31  1  0
  1 32  1  0
 29 63  1  0
 26 61  1  1
 27 62  1  0
 25 59  1  0
 25 60  1  0
 18 55  1  1
 20 56  1  0
 24 57  1  0
 24 58  1  0
M  END


  Mrv1652304292201222D          

 29 33  0  0  1  0            999 V2000
    2.6190   -0.6539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    0.1221    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8705    0.7528    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.6826    0.6076    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9629   -0.1684    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.4311   -0.7991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7875   -0.1416    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0168    0.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3340    1.1139    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3072    1.9385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2939   -0.7929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1184   -0.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3987   -1.5420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1912   -1.7713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7474   -2.0484    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0646   -1.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3228   -0.9107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4850    1.4085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5902    1.5287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781    1.6739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2463    1.0432    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5266    0.2673    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.9948   -0.3634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1827   -0.2182    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0976    0.5577    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4342    1.1884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9098    0.7029    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3492   -0.8489    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8069   -0.5086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  6  0  0  0
  7 11  1  6  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  5 17  1  6  0  0  0
  4 18  1  6  0  0  0
  3 19  1  1  0  0  0
 19 20  1  0  0  0  0
 21 20  1  6  0  0  0
 21 22  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 25 27  1  6  0  0  0
 24 28  1  1  0  0  0
 22 29  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0078281

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)[C@H](O)C[C@]34C)[C@@]1(O)[C@H](O)C[C@@H]2C1=CC(=O)OC1

> <INCHI_IDENTIFIER>
InChI=1S/C23H34O6/c1-21-10-18(25)17(24)8-13(21)3-4-15-14(21)5-6-22(2)16(9-19(26)23(15,22)28)12-7-20(27)29-11-12/h7,13-19,24-26,28H,3-6,8-11H2,1-2H3/t13-,14-,15+,16+,17+,18+,19+,21-,22+,23+/m0/s1

> <INCHI_KEY>
PPMVAFKDEJNUOY-WGIKCKTPSA-N

> <FORMULA>
C23H34O6

> <MOLECULAR_WEIGHT>
406.519

> <EXACT_MASS>
406.235538815

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
63

> <JCHEM_AVERAGE_POLARIZABILITY>
44.214193658390066

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
4-[(1S,2S,4R,5R,7S,10R,11S,12R,14R,15R)-4,5,11,12-tetrahydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-2,5-dihydrofuran-2-one

> <ALOGPS_LOGP>
0.64

> <JCHEM_LOGP>
0.9175473730000007

> <ALOGPS_LOGS>
-2.84

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.137730644435031

> <JCHEM_PKA_STRONGEST_ACIDIC>
7.150258692101992

> <JCHEM_PKA_STRONGEST_BASIC>
-3.148853322961153

> <JCHEM_POLAR_SURFACE_AREA>
107.22000000000001

> <JCHEM_REFRACTIVITY>
106.36359999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.89e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
4-[(1S,2S,4R,5R,7S,10R,11S,12R,14R,15R)-4,5,11,12-tetrahydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-5H-furan-2-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0       4.889  -1.221   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       4.366   0.228   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.358   1.405   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.874   1.134   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.398  -0.314   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.405  -1.492   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       8.937  -0.264   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.365   1.215   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       8.090   2.079   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       8.040   3.618   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       9.882  -1.480   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      11.421  -1.430   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      11.944  -2.878   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      13.424  -3.306   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0      10.728  -3.824   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       9.454  -2.959   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       8.069  -1.700   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       6.505   2.629   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       4.835   2.854   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       3.319   3.125   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.326   1.947   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.850   0.499   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       1.857  -0.678   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.341  -0.407   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -0.182   1.041   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       0.810   2.218   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0      -1.698   1.312   0.000  0.00  0.00           O+0
HETATM   28  O   UNK     0      -0.652  -1.585   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       3.373  -0.949   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3   22                                                  
CONECT    3    2    4   19                                                  
CONECT    4    3    5    9   18                                             
CONECT    5    4    6    7   17                                             
CONECT    6    5    1                                                       
CONECT    7    5    8   11                                                  
CONECT    8    7    9                                                       
CONECT    9    8    4   10                                                  
CONECT   10    9                                                            
CONECT   11    7   12   16                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16                                                       
CONECT   16   15   11                                                       
CONECT   17    5                                                            
CONECT   18    4                                                            
CONECT   19    3   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   22   26                                                  
CONECT   22   21    2   23   29                                             
CONECT   23   22   24                                                       
CONECT   24   23   25   28                                                  
CONECT   25   24   26   27                                                  
CONECT   26   25   21                                                       
CONECT   27   25                                                            
CONECT   28   24                                                            
CONECT   29   22                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   66    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₃H₃₄O₆

Average Mass

406.5190 Da

Monoisotopic Mass

406.23554 Da

IUPAC Name

4-[(1S,2S,4R,5R,7S,10R,11S,12R,14R,15R)-4,5,11,12-tetrahydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-2,5-dihydrofuran-2-one

Traditional Name

4-[(1S,2S,4R,5R,7S,10R,11S,12R,14R,15R)-4,5,11,12-tetrahydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-5H-furan-2-one

CAS Registry Number

Not Available

SMILES

C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)[C@H](O)C[C@]34C)[C@@]1(O)[C@H](O)C[C@@H]2C1=CC(=O)OC1

InChI Identifier

InChI=1S/C23H34O6/c1-21-10-18(25)17(24)8-13(21)3-4-15-14(21)5-6-22(2)16(9-19(26)23(15,22)28)12-7-20(27)29-11-12/h7,13-19,24-26,28H,3-6,8-11H2,1-2H3/t13-,14-,15+,16+,17+,18+,19+,21-,22+,23+/m0/s1

InChI Key

PPMVAFKDEJNUOY-WGIKCKTPSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Asclepias curassavica	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as cardenolides and derivatives. These are steroid lactones containing a furan-2-one moiety linked to the C17 atom of a cyclopenta[a]phenanthrene derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Steroids and steroid derivatives

Sub Class

Steroid lactones

Direct Parent

Cardenolides and derivatives

Alternative Parents

Substituents

Cardanolide-skeleton
3-hydroxysteroid
2-hydroxysteroid
14-hydroxysteroid
15-hydroxysteroid
Hydroxysteroid
3-beta-hydroxysteroid
2-furanone
Cyclic alcohol
Dihydrofuran
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tertiary alcohol
Lactone
Carboxylic acid ester
Secondary alcohol
Organoheterocyclic compound
Oxacycle
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Polyol
Organic oxide
Alcohol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.64	ALOGPS
logP	0.92	ChemAxon
logS	-2.8	ALOGPS
pKa (Strongest Acidic)	7.15	ChemAxon
pKa (Strongest Basic)	-3.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	107.22 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	106.36 m³·mol⁻¹	ChemAxon
Polarizability	44.21 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00042202

Chemspider ID

10367029

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

23252526

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Afrogenin (NP0078281)

MOL for NP0078281 (Afrogenin)

3D MOL for NP0078281 (Afrogenin)

3D SDF for NP0078281 (Afrogenin)

3D-SDF for NP0078281 (Afrogenin)

PDB for NP0078281 (Afrogenin)

3D PDB for NP0078281 (Afrogenin)

SMILES for NP0078281 (Afrogenin)

INCHI for NP0078281 (Afrogenin)

Structure for NP0078281 (Afrogenin)

3D Structure for NP0078281 (Afrogenin)