NP-MRD: Showing NP-Card for 5-Cinnamoyl-10-acetyltaxicin I (NP0077481)

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Record Information

Version

2.0

Created at

2022-04-28 22:37:31 UTC

Updated at

2022-04-28 22:37:31 UTC

NP-MRD ID

NP0077481

Secondary Accession Numbers

None

Natural Product Identification

Common Name

5-Cinnamoyl-10-acetyltaxicin I

Description

5-Cinnamoyl-10-acetyltaxicin I belongs to the class of organic compounds known as taxanes and derivatives. These are diterpenoids with a structure based either on the taxane skeleton, or a derivative thereof. In term of phytochemistry, several derivatives of the taxane skeleton exist: 2(3->20)-Abeotaxane, 3,11-cyclotaxane, 11(15->1),11(10->9)-abeotaxane, 3,8-seco-taxane, and 11(15->1)-abeotaxane, among others. More complex skeletons have been found recently, which include the taxane-derived [3.3.3] Propellane ring system. 5-Cinnamoyl-10-acetyltaxicin I is found in Taxus baccata . Based on a literature review very few articles have been published on 5-Cinnamoyl-10-acetyltaxicin I.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304292200372D          

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M  END

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  Mrv1652304292200372D          

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    3.3216    0.0854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4585    0.6930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0158   -0.5407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7628    2.1336    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929    2.2309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7373   -0.6467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  6  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  7  1  0  0  0  0
  5  8  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 13 18  1  0  0  0  0
  2 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  1 27  1  0  0  0  0
 27 28  1  1  0  0  0
 26 29  1  6  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 25 33  1  0  0  0  0
 20 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 24 36  1  0  0  0  0
 20 37  1  6  0  0  0
 19 38  1  1  0  0  0
  1 39  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0077481

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=O)O[C@H]1[C@H](O)[C@]2(C)CC[C@H](OC(=O)\C=C\C3=CC=CC=C3)C(=C)[C@H]2[C@H](O)[C@]2(O)CC(=O)C(C)=C1C2(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C31H38O8/c1-17-21(33)16-31(37)27(35)25-18(2)22(39-23(34)13-12-20-10-8-7-9-11-20)14-15-30(25,6)28(36)26(38-19(3)32)24(17)29(31,4)5/h7-13,22,25-28,35-37H,2,14-16H2,1,3-6H3/b13-12+/t22-,25-,26+,27-,28-,30+,31+/m0/s1

> <INCHI_KEY>
NGQXSOASEIXLIY-WDWXCWQWSA-N

> <FORMULA>
C31H38O8

> <MOLECULAR_WEIGHT>
538.637

> <EXACT_MASS>
538.256668184

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
77

> <JCHEM_AVERAGE_POLARIZABILITY>
56.99509120033865

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,2S,3R,5S,8R,9R,10R)-10-(acetyloxy)-1,2,9-trihydroxy-8,12,15,15-tetramethyl-4-methylidene-13-oxotricyclo[9.3.1.0^{3,8}]pentadec-11-en-5-yl (2E)-3-phenylprop-2-enoate

> <ALOGPS_LOGP>
2.63

> <JCHEM_LOGP>
3.201920610999999

> <ALOGPS_LOGS>
-4.48

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.67870308019328

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.924260375294711

> <JCHEM_PKA_STRONGEST_BASIC>
-3.386366122587696

> <JCHEM_POLAR_SURFACE_AREA>
130.36

> <JCHEM_REFRACTIVITY>
144.46740000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
6

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.80e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,2S,3R,5S,8R,9R,10R)-10-(acetyloxy)-1,2,9-trihydroxy-8,12,15,15-tetramethyl-4-methylidene-13-oxotricyclo[9.3.1.0^{3,8}]pentadec-11-en-5-yl (2E)-3-phenylprop-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 29-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   29-APR-22         0                                  
HETATM    1  C   UNK     0       8.385   0.263   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.094   1.775   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       9.259   2.783   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.968   4.296   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      10.714   2.279   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      11.004   0.766   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       9.840  -0.241   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      11.878   3.286   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0      13.333   2.782   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      13.624   1.269   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0      14.498   3.790   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      14.207   5.302   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0      15.372   6.310   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      15.081   7.822   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      16.246   8.830   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      17.701   8.325   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      17.991   6.813   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      16.827   5.805   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       6.740   2.662   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       5.125   2.443   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       3.533   2.727   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       2.422   1.606   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       0.920   1.945   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       2.945   0.118   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       4.505  -0.309   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       5.870  -1.199   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       7.456  -1.003   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       8.235  -2.332   0.000  0.00  0.00           O+0
HETATM   29  O   UNK     0       5.523  -2.699   0.000  0.00  0.00           O+0
HETATM   30  C   UNK     0       4.050  -3.149   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       3.702  -4.649   0.000  0.00  0.00           O+0
HETATM   32  C   UNK     0       2.924  -2.098   0.000  0.00  0.00           C+0
HETATM   33  C   UNK     0       4.937   1.040   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0       6.200   0.159   0.000  0.00  0.00           C+0
HETATM   35  C   UNK     0       6.456   1.294   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       1.896  -1.009   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0       5.157   3.983   0.000  0.00  0.00           O+0
HETATM   38  O   UNK     0       7.080   4.164   0.000  0.00  0.00           O+0
HETATM   39  C   UNK     0       8.843  -1.207   0.000  0.00  0.00           C+0
CONECT    1    2    7   27   39                                             
CONECT    2    1    3   19                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6    8                                                  
CONECT    6    5    7                                                       
CONECT    7    6    1                                                       
CONECT    8    5    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   13                                                       
CONECT   19    2   20   38                                                  
CONECT   20   19   21   33   37                                             
CONECT   21   20   22                                                       
CONECT   22   21   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25   36                                                  
CONECT   25   24   26   33                                                  
CONECT   26   25   27   29                                                  
CONECT   27   26    1   28                                                  
CONECT   28   27                                                            
CONECT   29   26   30                                                       
CONECT   30   29   31   32                                                  
CONECT   31   30                                                            
CONECT   32   30                                                            
CONECT   33   25   20   34   35                                             
CONECT   34   33                                                            
CONECT   35   33                                                            
CONECT   36   24                                                            
CONECT   37   20                                                            
CONECT   38   19                                                            
CONECT   39    1                                                            
MASTER        0    0    0    0    0    0    0    0   39    0   84    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₃₁H₃₈O₈

Average Mass

538.6370 Da

Monoisotopic Mass

538.25667 Da

IUPAC Name

(1S,2S,3R,5S,8R,9R,10R)-10-(acetyloxy)-1,2,9-trihydroxy-8,12,15,15-tetramethyl-4-methylidene-13-oxotricyclo[9.3.1.0^{3,8}]pentadec-11-en-5-yl (2E)-3-phenylprop-2-enoate

Traditional Name

(1S,2S,3R,5S,8R,9R,10R)-10-(acetyloxy)-1,2,9-trihydroxy-8,12,15,15-tetramethyl-4-methylidene-13-oxotricyclo[9.3.1.0^{3,8}]pentadec-11-en-5-yl (2E)-3-phenylprop-2-enoate

CAS Registry Number

Not Available

SMILES

CC(=O)O[C@H]1[C@H](O)[C@]2(C)CC[C@H](OC(=O)\C=C\C3=CC=CC=C3)C(=C)[C@H]2[C@H](O)[C@]2(O)CC(=O)C(C)=C1C2(C)C

InChI Identifier

InChI=1S/C31H38O8/c1-17-21(33)16-31(37)27(35)25-18(2)22(39-23(34)13-12-20-10-8-7-9-11-20)14-15-30(25,6)28(36)26(38-19(3)32)24(17)29(31,4)5/h7-13,22,25-28,35-37H,2,14-16H2,1,3-6H3/b13-12+/t22-,25-,26+,27-,28-,30+,31+/m0/s1

InChI Key

NGQXSOASEIXLIY-WDWXCWQWSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Taxus baccata	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as taxanes and derivatives. These are diterpenoids with a structure based either on the taxane skeleton, or a derivative thereof. In term of phytochemistry, several derivatives of the taxane skeleton exist: 2(3->20)-Abeotaxane, 3,11-cyclotaxane, 11(15->1),11(10->9)-abeotaxane, 3,8-seco-taxane, and 11(15->1)-abeotaxane, among others. More complex skeletons have been found recently, which include the taxane-derived [3.3.3] Propellane ring system.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Diterpenoids

Direct Parent

Taxanes and derivatives

Alternative Parents

Substituents

Taxane diterpenoid
Cinnamic acid ester
Cinnamic acid or derivatives
Styrene
Cyclohexenone
Fatty acid ester
Fatty acyl
Benzenoid
Dicarboxylic acid or derivatives
Monocyclic benzene moiety
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tertiary alcohol
Cyclic ketone
Secondary alcohol
Ketone
Carboxylic acid ester
Polyol
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aromatic homopolycyclic compound

Molecular Framework

Aromatic homopolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.63	ALOGPS
logP	3.2	ChemAxon
logS	-4.5	ALOGPS
pKa (Strongest Acidic)	12.92	ChemAxon
pKa (Strongest Basic)	-3.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	130.36 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	144.47 m³·mol⁻¹	ChemAxon
Polarizability	57 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00040834

Chemspider ID

4475088

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5315894

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for 5-Cinnamoyl-10-acetyltaxicin I (NP0077481)

MOL for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

3D MOL for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

3D SDF for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

3D-SDF for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

PDB for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

3D PDB for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

SMILES for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

INCHI for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

Structure for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)

3D Structure for NP0077481 (5-Cinnamoyl-10-acetyltaxicin I)