NP-MRD: Showing NP-Card for (+)-Kadcoccilactone I (NP0076742)

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Record Information

Version

2.0

Created at

2022-04-28 21:56:01 UTC

Updated at

2022-04-28 21:56:01 UTC

NP-MRD ID

NP0076742

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-Kadcoccilactone I

Description

(1S,3R,7R,10S,12R,13R,14S,15S,17R,18S,19S,21S)-1,12-dihydroxy-9,9,14,18-tetramethyl-19-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-5-oxo-4,8,20-trioxahexacyclo[11.10.0.0³,⁷.0³,¹⁰.0¹⁴,²¹.0¹⁷,²¹]Tricosan-15-yl acetate belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups. (+)-Kadcoccilactone I is found in Kadsura coccinea. Based on a literature review very few articles have been published on (1S,3R,7R,10S,12R,13R,14S,15S,17R,18S,19S,21S)-1,12-dihydroxy-9,9,14,18-tetramethyl-19-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-5-oxo-4,8,20-trioxahexacyclo[11.10.0.0³,⁷.0³,¹⁰.0¹⁴,²¹.0¹⁷,²¹]Tricosan-15-yl acetate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282223562D          

 41 47  0  0  1  0            999 V2000
    4.3232    0.3094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END

     RDKit          3D

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M  END


  Mrv1652304282223562D          

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    1.1328    0.3512    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9537    0.2687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7171    1.0639    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.1038    1.1464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2789    1.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0341    2.2848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4337    2.3683    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0493    1.8190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5163    3.1892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0056   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8279   -2.5546    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4186   -3.2709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8343   -3.9835    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5936   -3.2746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2991   -1.6974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8028    0.7974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7112   -2.2133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2042   -0.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5136   -0.0855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8819    0.4451    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.6827    1.2457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8598    1.3037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4230    2.0035    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5503    0.5389    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2412   -1.6744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9283   -1.2456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  6  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  6  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  6  0  0  0
 16 18  1  1  0  0  0
 18 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 22 24  1  1  0  0  0
 15 25  1  6  0  0  0
 12 26  1  1  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 11 30  1  6  0  0  0
  7 31  1  1  0  0  0
  5 32  1  1  0  0  0
  3 33  1  0  0  0  0
 33 34  1  0  0  0  0
 35 34  1  1  0  0  0
  2 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
  2 39  1  1  0  0  0
 33 40  1  0  0  0  0
 33 41  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0076742

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1C[C@H](OC1=O)[C@H]1O[C@]23CC[C@]4(O)C[C@]56OC(=O)C[C@H]5OC(C)(C)[C@@H]6C[C@@H](O)[C@H]4[C@@]2(C)[C@H](C[C@@H]3[C@@H]1C)OC(C)=O

> <INCHI_IDENTIFIER>
InChI=1S/C31H44O10/c1-14-9-19(38-26(14)35)24-15(2)17-10-21(37-16(3)32)28(6)25-18(33)11-20-27(4,5)39-22-12-23(34)40-30(20,22)13-29(25,36)7-8-31(17,28)41-24/h14-15,17-22,24-25,33,36H,7-13H2,1-6H3/t14-,15-,17+,18+,19-,20-,21-,22+,24-,25-,28+,29-,30+,31-/m0/s1

> <INCHI_KEY>
QWSVMFDDOBRKPA-CCNRQIHUSA-N

> <FORMULA>
C31H44O10

> <MOLECULAR_WEIGHT>
576.683

> <EXACT_MASS>
576.293447617

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_ATOM_COUNT>
85

> <JCHEM_AVERAGE_POLARIZABILITY>
61.427790249353606

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1S,3R,7R,10S,12R,13R,14S,15S,17R,18S,19S,21S)-1,12-dihydroxy-9,9,14,18-tetramethyl-19-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-5-oxo-4,8,20-trioxahexacyclo[11.10.0.0^{3,7}.0^{3,10}.0^{14,21}.0^{17,21}]tricosan-15-yl acetate

> <ALOGPS_LOGP>
2.26

> <JCHEM_LOGP>
1.0171382973333338

> <ALOGPS_LOGS>
-3.98

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
7

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
15.037604405242625

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.214018308813785

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8800811208895656

> <JCHEM_POLAR_SURFACE_AREA>
137.82

> <JCHEM_REFRACTIVITY>
141.281

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
6.00e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,3R,7R,10S,12R,13R,14S,15S,17R,18S,19S,21S)-1,12-dihydroxy-9,9,14,18-tetramethyl-19-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-5-oxo-4,8,20-trioxahexacyclo[11.10.0.0^{3,7}.0^{3,10}.0^{14,21}.0^{17,21}]tricosan-15-yl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       8.070   0.578   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.673   0.015   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.045  -1.479   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.108  -2.701   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.569  -2.731   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.585  -1.546   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.899  -0.038   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       5.750   0.987   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.287   0.504   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.974  -1.003   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.123  -2.029   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.503  -3.438   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.970  -3.284   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.644  -1.779   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.494  -0.754   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.115   0.656   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       3.647   0.502   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       1.339   1.986   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -0.194   2.140   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      -0.521   3.645   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -1.930   4.265   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       0.810   4.421   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       1.959   3.396   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       0.964   5.953   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      -0.010  -1.081   0.000  0.00  0.00           C+0
HETATM   26  O   UNK     0       5.279  -4.769   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       4.515  -6.106   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       5.291  -7.436   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       2.975  -6.113   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0       6.158  -3.168   0.000  0.00  0.00           C+0
HETATM   31  O   UNK     0       7.099   1.489   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0       6.928  -4.132   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0      11.581  -1.587   0.000  0.00  0.00           C+0
HETATM   34  O   UNK     0      12.159  -0.160   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0      10.980   0.831   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0      10.608   2.325   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0       9.072   2.434   0.000  0.00  0.00           C+0
HETATM   38  O   UNK     0       8.256   3.740   0.000  0.00  0.00           O+0
HETATM   39  O   UNK     0       8.494   1.006   0.000  0.00  0.00           O+0
HETATM   40  C   UNK     0      11.650  -3.126   0.000  0.00  0.00           C+0
HETATM   41  C   UNK     0      12.933  -2.325   0.000  0.00  0.00           C+0
CONECT    1    2    7                                                       
CONECT    2    1    3   35   39                                             
CONECT    3    2    4   33                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6   32                                                  
CONECT    6    5    7   11                                                  
CONECT    7    6    1    8   31                                             
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11   14   17                                             
CONECT   11   10    6   12   30                                             
CONECT   12   11   13   26                                                  
CONECT   13   12   14                                                       
CONECT   14   13   10   15                                                  
CONECT   15   14   16   25                                                  
CONECT   16   15   17   18                                                  
CONECT   17   16   10                                                       
CONECT   18   16   19   23                                                  
CONECT   19   18   20                                                       
CONECT   20   19   21   22                                                  
CONECT   21   20                                                            
CONECT   22   20   23   24                                                  
CONECT   23   22   18                                                       
CONECT   24   22                                                            
CONECT   25   15                                                            
CONECT   26   12   27                                                       
CONECT   27   26   28   29                                                  
CONECT   28   27                                                            
CONECT   29   27                                                            
CONECT   30   11                                                            
CONECT   31    7                                                            
CONECT   32    5                                                            
CONECT   33    3   34   40   41                                             
CONECT   34   33   35                                                       
CONECT   35   34    2   36                                                  
CONECT   36   35   37                                                       
CONECT   37   36   38   39                                                  
CONECT   38   37                                                            
CONECT   39   37    2                                                       
CONECT   40   33                                                            
CONECT   41   33                                                            
MASTER        0    0    0    0    0    0    0    0   41    0   94    0
END

View in JSmol

Synonyms

Value	Source
(1S,3R,7R,10S,12R,13R,14S,15S,17R,18S,19S,21S)-1,12-Dihydroxy-9,9,14,18-tetramethyl-19-[(2S,4S)-4-methyl-5-oxooxolan-2-yl]-5-oxo-4,8,20-trioxahexacyclo[11.10.0.0,.0,.0,.0,]tricosan-15-yl acetic acid	Generator

Chemical Formula

C₃₁H₄₄O₁₀

Average Mass

576.6830 Da

Monoisotopic Mass

576.29345 Da

IUPAC Name

Traditional Name

CAS Registry Number

Not Available

SMILES

C[C@H]1C[C@H](OC1=O)[C@H]1O[C@]23CC[C@]4(O)C[C@]56OC(=O)C[C@H]5OC(C)(C)[C@@H]6C[C@@H](O)[C@H]4[C@@]2(C)[C@H](C[C@@H]3[C@@H]1C)OC(C)=O

InChI Identifier

InChI=1S/C31H44O10/c1-14-9-19(38-26(14)35)24-15(2)17-10-21(37-16(3)32)28(6)25-18(33)11-20-27(4,5)39-22-12-23(34)40-30(20,22)13-29(25,36)7-8-31(17,28)41-24/h14-15,17-22,24-25,33,36H,7-13H2,1-6H3/t14-,15-,17+,18+,19-,20-,21-,22+,24-,25-,28+,29-,30+,31-/m0/s1

InChI Key

QWSVMFDDOBRKPA-CCNRQIHUSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Kadsura coccinea	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Tricarboxylic acids and derivatives

Direct Parent

Tricarboxylic acids and derivatives

Alternative Parents

Substituents

Tricarboxylic acid or derivatives
Furofuran
Gamma butyrolactone
Tetrahydrofuran
Tertiary alcohol
Cyclic alcohol
Secondary alcohol
Lactone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Ether
Dialkyl ether
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.26	ALOGPS
logP	1.02	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	14.21	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	137.82 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	141.28 m³·mol⁻¹	ChemAxon
Polarizability	61.43 Å³	ChemAxon
Number of Rings	7	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162949924

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for (+)-Kadcoccilactone I (NP0076742)

MOL for NP0076742 ((+)-Kadcoccilactone I)

3D MOL for NP0076742 ((+)-Kadcoccilactone I)

3D SDF for NP0076742 ((+)-Kadcoccilactone I)

3D-SDF for NP0076742 ((+)-Kadcoccilactone I)

PDB for NP0076742 ((+)-Kadcoccilactone I)

3D PDB for NP0076742 ((+)-Kadcoccilactone I)

SMILES for NP0076742 ((+)-Kadcoccilactone I)

INCHI for NP0076742 ((+)-Kadcoccilactone I)

Structure for NP0076742 ((+)-Kadcoccilactone I)

3D Structure for NP0076742 ((+)-Kadcoccilactone I)