NP-MRD: Showing NP-Card for (+)-1-O-Acetylageratriol (NP0076016)

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Record Information

Version

2.0

Created at

2022-04-28 21:12:32 UTC

Updated at

2022-04-28 21:12:32 UTC

NP-MRD ID

NP0076016

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(+)-1-O-Acetylageratriol

Description

1-O-Acetylageratriol belongs to the class of organic compounds known as germacrane sesquiterpenoids. These are sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups. (+)-1-O-Acetylageratriol is found in Achillea ageratum . Based on a literature review very few articles have been published on 1-O-Acetylageratriol.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 47 47  0  0  0  0  0  0  0  0999 V2000
   -3.5618    1.1059   -0.4729 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1507    0.6527    0.6952 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6990    1.3748    1.9068 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2399   -0.4933    0.9246 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.9793   -0.2132    1.5735 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0486    0.7453    1.3712 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4385    2.0515    1.6775 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0612    0.8870    0.3201 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1778    2.0424   -0.3229 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0078   -0.1506   -0.1373 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2841    0.5310   -0.0801 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2443    0.3184    0.8565 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5109    1.0938    0.7913 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0155   -0.5441    1.7581 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8393   -0.9585   -1.3159 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8797   -0.7970   -2.3940 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4768   -1.4806   -2.2420 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0220   -2.2199   -3.1692 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0432   -1.2013   -0.9772 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2093   -1.9097   -0.1500 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3058   -1.4013   -0.3252 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2485    1.9440   -0.4841 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2831    0.7383   -1.4452 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5942    0.7997    2.2802 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0749    2.3726    1.6507 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9057    1.4118    2.6610 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8536   -1.1338    1.6533 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5490   -1.1903    1.9740 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3713    0.1250    2.6226 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7602    0.6125    2.2683 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6218    2.1483    2.6307 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5179    2.8501   -0.0426 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8795    2.2583   -1.1128 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1093   -0.8299    0.7707 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2786    0.5513    1.3662 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114    1.3195   -0.2505 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3389    2.0680    1.3169 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8596   -0.9139   -1.8577 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8827   -2.0743   -1.0765 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2473   -1.1645   -3.3677 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5888    0.2744   -2.5975 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4984   -2.3686   -4.1055 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9851   -2.6782   -3.0041 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0815   -0.1043   -1.0050 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5351   -2.8208   -0.1159 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1627   -1.1568   -0.9648 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4524   -2.4716   -0.0526 H   0  0  0  0  0  0  0  0  0  0  0  0
  3  2  1  0
  2  1  2  3
  2  4  1  0
  4 21  1  0
 21 19  1  0
 19 20  1  0
 19 17  1  0
 17 18  2  3
 17 16  1  0
 16 15  1  0
 15 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 12 14  2  0
 10  8  1  0
  8  9  2  3
  8  6  1  0
  6  7  1  0
  6  5  1  0
  5  4  1  0
  3 24  1  0
  3 25  1  0
  3 26  1  0
  1 22  1  0
  1 23  1  0
  4 27  1  1
 21 46  1  0
 21 47  1  0
 19 44  1  1
 20 45  1  0
 18 42  1  0
 18 43  1  0
 16 40  1  0
 16 41  1  0
 15 38  1  0
 15 39  1  0
 10 34  1  1
 13 35  1  0
 13 36  1  0
 13 37  1  0
  9 32  1  0
  9 33  1  0
  6 30  1  1
  7 31  1  0
  5 28  1  0
  5 29  1  0
M  END


  Mrv1652304282223122D          

 21 21  0  0  1  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  1 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 10 16  1  1  0  0  0
  7 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
  2 21  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0076016

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC(=C)[C@H]1C[C@@H](O)C(=C)CC[C@@H](OC(C)=O)C(=C)[C@@H](O)C1

> <INCHI_IDENTIFIER>
InChI=1S/C17H26O4/c1-10(2)14-8-15(19)11(3)6-7-17(21-13(5)18)12(4)16(20)9-14/h14-17,19-20H,1,3-4,6-9H2,2,5H3/t14-,15+,16-,17+/m0/s1

> <INCHI_KEY>
ANADBJSRPFTQQE-VVLHAWIVSA-N

> <FORMULA>
C17H26O4

> <MOLECULAR_WEIGHT>
294.391

> <EXACT_MASS>
294.183109317

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
47

> <JCHEM_AVERAGE_POLARIZABILITY>
32.482102457343245

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,3S,5S,7R)-3,7-dihydroxy-2,8-dimethylidene-5-(prop-1-en-2-yl)cyclodecyl acetate

> <ALOGPS_LOGP>
1.84

> <JCHEM_LOGP>
1.7440864766666664

> <ALOGPS_LOGS>
-2.51

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
18.685281851596077

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.540588998101718

> <JCHEM_PKA_STRONGEST_BASIC>
-1.186857071570758

> <JCHEM_POLAR_SURFACE_AREA>
66.76

> <JCHEM_REFRACTIVITY>
81.8359

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
9.07e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,3S,5S,7R)-3,7-dihydroxy-2,8-dimethylidene-5-(prop-1-en-2-yl)cyclodecyl acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.667   3.080   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       4.001   3.850   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.334   3.850   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0      -1.334   2.310   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       1.334  -2.310   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0      -0.000  -3.080   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -0.000  -4.620   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       6.668   2.310   0.000  0.00  0.00           O+0
CONECT    1    2   12                                                       
CONECT    2    1    3   21                                                  
CONECT    3    2    4    5                                                  
CONECT    4    3                                                            
CONECT    5    3    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   17                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   16                                                  
CONECT   11   10   12                                                       
CONECT   12   11    1   13                                                  
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13                                                            
CONECT   16   10                                                            
CONECT   17    7   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18                                                            
CONECT   21    2                                                            
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₇H₂₆O₄

Average Mass

294.3910 Da

Monoisotopic Mass

294.18311 Da

IUPAC Name

(1R,3S,5S,7R)-3,7-dihydroxy-2,8-dimethylidene-5-(prop-1-en-2-yl)cyclodecyl acetate

Traditional Name

(1R,3S,5S,7R)-3,7-dihydroxy-2,8-dimethylidene-5-(prop-1-en-2-yl)cyclodecyl acetate

CAS Registry Number

Not Available

SMILES

CC(=C)[C@H]1C[C@@H](O)C(=C)CC[C@@H](OC(C)=O)C(=C)[C@@H](O)C1

InChI Identifier

InChI=1S/C17H26O4/c1-10(2)14-8-15(19)11(3)6-7-17(21-13(5)18)12(4)16(20)9-14/h14-17,19-20H,1,3-4,6-9H2,2,5H3/t14-,15+,16-,17+/m0/s1

InChI Key

ANADBJSRPFTQQE-VVLHAWIVSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Achillea ageratum	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as germacrane sesquiterpenoids. These are sesquiterpenoids having the germacrane skeleton, with a structure characterized by a cyclodecane ring substituted with an isopropyl and two methyl groups.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Sesquiterpenoids

Direct Parent

Germacrane sesquiterpenoids

Alternative Parents

Substituents

Germacrane sesquiterpenoid
Secondary alcohol
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.84	ALOGPS
logP	1.74	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	14.54	ChemAxon
pKa (Strongest Basic)	-1.2	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	81.84 m³·mol⁻¹	ChemAxon
Polarizability	32.48 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00038193

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

100982314

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for (+)-1-O-Acetylageratriol (NP0076016)

MOL for NP0076016 ((+)-1-O-Acetylageratriol)

3D MOL for NP0076016 ((+)-1-O-Acetylageratriol)

3D SDF for NP0076016 ((+)-1-O-Acetylageratriol)

3D-SDF for NP0076016 ((+)-1-O-Acetylageratriol)

PDB for NP0076016 ((+)-1-O-Acetylageratriol)

3D PDB for NP0076016 ((+)-1-O-Acetylageratriol)

SMILES for NP0076016 ((+)-1-O-Acetylageratriol)

INCHI for NP0076016 ((+)-1-O-Acetylageratriol)

Structure for NP0076016 ((+)-1-O-Acetylageratriol)

3D Structure for NP0076016 ((+)-1-O-Acetylageratriol)