NP-MRD: Showing NP-Card for Prenantheside B (NP0073685)

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Record Information

Version

2.0

Created at

2022-04-28 18:54:36 UTC

Updated at

2022-04-28 18:54:36 UTC

NP-MRD ID

NP0073685

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Prenantheside B

Description

[(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-dodecahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 2-(4-hydroxyphenyl)acetate belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative. Prenantheside B is found in Nabalus acerifolius Maxim. Based on a literature review very few articles have been published on [(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-dodecahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 2-(4-hydroxyphenyl)acetate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282220542D          

 40 44  0  0  1  0            999 V2000
    3.6659   -0.2370    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
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  1 40  1  1  0  0  0
M  END

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M  END


  Mrv1652304282220542D          

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    5.9228    5.0022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1549    4.7008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8138    6.1194    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1689   -2.4374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7019   -1.8518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9527   -0.5921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6412   -1.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9157    0.2321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5607    0.7464    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1204    0.4515    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  1  7  1  0  0  0  0
  7  8  1  1  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  6  0  0  0
 10 12  1  1  0  0  0
 13 12  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  1  0  0  0
 17 20  1  1  0  0  0
 16 21  1  6  0  0  0
 15 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 27 32  1  0  0  0  0
 30 33  1  0  0  0  0
  5 34  1  1  0  0  0
  5 35  1  6  0  0  0
  2 36  1  6  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  2  0  0  0  0
 38 40  1  0  0  0  0
  1 40  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0073685

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@@]1(O)CC[C@@H]2[C@H](OC(=O)C2=C)[C@H]2[C@H]1C[C@@H](O[C@H]1O[C@H](COC(=O)CC3=CC=C(O)C=C3)[C@@H](O)[C@H](O)[C@@H]1O)C2=C

> <INCHI_IDENTIFIER>
InChI=1S/C29H36O11/c1-13-17-8-9-29(3,36)18-11-19(14(2)22(18)26(17)40-27(13)35)38-28-25(34)24(33)23(32)20(39-28)12-37-21(31)10-15-4-6-16(30)7-5-15/h4-7,17-20,22-26,28,30,32-34,36H,1-2,8-12H2,3H3/t17-,18+,19+,20+,22+,23+,24-,25-,26-,28-,29+/m0/s1

> <INCHI_KEY>
CVDZSJQRLCCTGM-ZGMNDRBISA-N

> <FORMULA>
C29H36O11

> <MOLECULAR_WEIGHT>
560.596

> <EXACT_MASS>
560.225761979

> <JCHEM_ACCEPTOR_COUNT>
9

> <JCHEM_ATOM_COUNT>
76

> <JCHEM_AVERAGE_POLARIZABILITY>
57.83494917513358

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
[(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-dodecahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 2-(4-hydroxyphenyl)acetate

> <ALOGPS_LOGP>
0.70

> <JCHEM_LOGP>
1.077946998999999

> <ALOGPS_LOGS>
-2.92

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.211226693179754

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.495585734159935

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9036221427732976

> <JCHEM_POLAR_SURFACE_AREA>
172.21

> <JCHEM_REFRACTIVITY>
137.65910000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
7

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
6.81e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
[(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-octahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (4-hydroxyphenyl)acetate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       6.843  -0.442   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       7.803  -1.646   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.461  -3.148   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.073  -3.816   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       4.686  -3.148   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       4.343  -1.646   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.303  -0.442   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.455   0.843   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.996   2.285   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.970   0.433   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.901  -1.105   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       1.766   1.393   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0       1.996   2.916   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0       3.429   3.479   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       3.659   5.002   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.455   5.962   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       1.021   5.399   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       0.792   3.876   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -0.642   3.314   0.000  0.00  0.00           O+0
HETATM   20  O   UNK     0      -0.183   6.359   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       2.684   7.485   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       5.092   5.564   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       5.322   7.087   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       6.755   7.650   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       7.959   6.689   0.000  0.00  0.00           O+0
HETATM   26  C   UNK     0       6.985   9.172   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0       8.418   9.735   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       8.648  11.258   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0      10.081  11.820   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      11.286  10.860   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0      11.056   9.338   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       9.622   8.775   0.000  0.00  0.00           C+0
HETATM   33  O   UNK     0      12.719  11.423   0.000  0.00  0.00           O+0
HETATM   34  O   UNK     0       4.049  -4.550   0.000  0.00  0.00           O+0
HETATM   35  C   UNK     0       3.177  -3.457   0.000  0.00  0.00           C+0
HETATM   36  C   UNK     0       9.245  -1.105   0.000  0.00  0.00           C+0
HETATM   37  C   UNK     0      10.530  -1.954   0.000  0.00  0.00           C+0
HETATM   38  C   UNK     0       9.176   0.433   0.000  0.00  0.00           C+0
HETATM   39  O   UNK     0      10.380   1.393   0.000  0.00  0.00           O+0
HETATM   40  O   UNK     0       7.691   0.843   0.000  0.00  0.00           O+0
CONECT    1    2    7   40                                                  
CONECT    2    1    3   36                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6   34   35                                             
CONECT    6    5    7   11                                                  
CONECT    7    6    1    8                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8   11   12                                                  
CONECT   11   10    6                                                       
CONECT   12   10   13                                                       
CONECT   13   12   14   18                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16   22                                                  
CONECT   16   15   17   21                                                  
CONECT   17   16   18   20                                                  
CONECT   18   17   13   19                                                  
CONECT   19   18                                                            
CONECT   20   17                                                            
CONECT   21   16                                                            
CONECT   22   15   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26   28   32                                                  
CONECT   28   27   29                                                       
CONECT   29   28   30                                                       
CONECT   30   29   31   33                                                  
CONECT   31   30   32                                                       
CONECT   32   31   27                                                       
CONECT   33   30                                                            
CONECT   34    5                                                            
CONECT   35    5                                                            
CONECT   36    2   37   38                                                  
CONECT   37   36                                                            
CONECT   38   36   39   40                                                  
CONECT   39   38                                                            
CONECT   40   38    1                                                       
MASTER        0    0    0    0    0    0    0    0   40    0   88    0
END

View in JSmol

Synonyms

Value	Source
[(2R,3S,4S,5S,6S)-6-{[(3as,6R,6ar,8R,9as,9BS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-dodecahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 2-(4-hydroxyphenyl)acetic acid	Generator

Chemical Formula

C₂₉H₃₆O₁₁

Average Mass

560.5960 Da

Monoisotopic Mass

560.22576 Da

IUPAC Name

[(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-dodecahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl 2-(4-hydroxyphenyl)acetate

Traditional Name

[(2R,3S,4S,5S,6S)-6-{[(3aS,6R,6aR,8R,9aS,9bS)-6-hydroxy-6-methyl-3,9-dimethylidene-2-oxo-octahydroazuleno[4,5-b]furan-8-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (4-hydroxyphenyl)acetate

CAS Registry Number

Not Available

SMILES

C[C@@]1(O)CC[C@@H]2[C@H](OC(=O)C2=C)[C@H]2[C@H]1C[C@@H](O[C@H]1O[C@H](COC(=O)CC3=CC=C(O)C=C3)[C@@H](O)[C@H](O)[C@@H]1O)C2=C

InChI Identifier

InChI=1S/C29H36O11/c1-13-17-8-9-29(3,36)18-11-19(14(2)22(18)26(17)40-27(13)35)38-28-25(34)24(33)23(32)20(39-28)12-37-21(31)10-15-4-6-16(30)7-5-15/h4-7,17-20,22-26,28,30,32-34,36H,1-2,8-12H2,3H3/t17-,18+,19+,20+,22+,23+,24-,25-,26-,28-,29+/m0/s1

InChI Key

CVDZSJQRLCCTGM-ZGMNDRBISA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Nabalus acerifolius Maxim.	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as guaianolides and derivatives. These are diterpene lactones with a structure characterized by the presence of a gamma-lactone fused to a guaiane, forming 3,6,9-trimethyl-azuleno[4,5-b]furan-2-one or a derivative.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Guaianolides and derivatives

Alternative Parents

Substituents

Terpene glycoside
Guaianolide-skeleton
Sesquiterpenoid
Guaiane sesquiterpenoid
O-glycosyl compound
Glycosyl compound
1-hydroxy-2-unsubstituted benzenoid
Phenol
Benzenoid
Oxane
Monosaccharide
Gamma butyrolactone
Dicarboxylic acid or derivatives
Monocyclic benzene moiety
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Tetrahydrofuran
Tertiary alcohol
Cyclic alcohol
Secondary alcohol
Lactone
Carboxylic acid ester
Oxacycle
Organoheterocyclic compound
Polyol
Carboxylic acid derivative
Acetal
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.7	ALOGPS
logP	1.08	ChemAxon
logS	-2.9	ALOGPS
pKa (Strongest Acidic)	9.5	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	9	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	172.21 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	137.66 m³·mol⁻¹	ChemAxon
Polarizability	57.83 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162889406

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Prenantheside B (NP0073685)

MOL for NP0073685 (Prenantheside B)

3D MOL for NP0073685 (Prenantheside B)

3D SDF for NP0073685 (Prenantheside B)

3D-SDF for NP0073685 (Prenantheside B)

PDB for NP0073685 (Prenantheside B)

3D PDB for NP0073685 (Prenantheside B)

SMILES for NP0073685 (Prenantheside B)

INCHI for NP0073685 (Prenantheside B)

Structure for NP0073685 (Prenantheside B)

3D Structure for NP0073685 (Prenantheside B)