NP-MRD: Showing NP-Card for Oripavine (NP0070262)

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Record Information

Version

2.0

Created at

2022-04-28 15:33:26 UTC

Updated at

2022-04-28 15:33:26 UTC

NP-MRD ID

NP0070262

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Oripavine

Description

Oripavine belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic. Oripavine is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Oripavine is found in Berberis nervosa, Papaver bracteatum , Papaver macrantha, Papaver orientale, Papaver orientale L. , Papaver pinnatifidum and Papaver somniferum . Oripavine was first documented in 2018 (PMID: 32625895). Based on a literature review a small amount of articles have been published on Oripavine (PMID: 34359458) (PMID: 32650010) (PMID: 31066088) (PMID: 29408320).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 41 45  0  0  0  0  0  0  0  0999 V2000
    4.1677    1.5929   -1.7840 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3433    2.0481   -0.7061 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0108    1.5945   -0.6724 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2628    1.7969   -1.7423 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1366    1.3426   -1.7599 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6378    0.7474   -0.7282 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0226    0.2410   -0.6289 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1075   -1.2022   -0.0919 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7681   -1.7598    0.2360 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5066   -3.1267    0.2476 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7961   -3.5846    0.5173 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8521   -2.7037    0.7765 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1086   -3.1739    1.0350 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5646   -1.3576    0.7582 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2924   -0.9689    0.4960 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1488    0.4963    0.5317 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7043    0.9993    1.6554 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8943    1.7996    1.2031 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7299    1.1436    0.2446 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9486    0.6283    0.7606 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5561    0.9375    0.5370 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3433   -0.1931    0.9570 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7142    1.9183   -2.7478 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1595    2.0832   -1.7157 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.2629    0.4919   -1.7059 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6728    2.2953   -2.6073 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7239    1.5229   -2.6579 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4760    0.2341   -1.6404 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7303   -1.2566    0.8075 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5552   -1.8766   -0.8516 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2935   -3.8286    0.0521 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9998   -4.6421    0.5275 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.3653   -4.1498    1.0588 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9939    0.1562    2.3035 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0757    1.6738    2.2739 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5657    2.7827    0.8110 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5108    2.0048    2.1051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7183    1.4539    0.7308 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8543    0.3341    1.8156 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3538   -0.1682    0.1100 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6870    1.6735    1.3854 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  2  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 12 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  1
 17 18  1  0
 18 19  1  0
 19 20  1  0
 16 21  1  0
 21 22  1  0
 21  3  1  0
 16  6  1  0
 19  7  1  0
 15  9  1  0
 22 14  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
  4 26  1  0
  5 27  1  0
  7 28  1  6
  8 29  1  0
  8 30  1  0
 10 31  1  0
 11 32  1  0
 13 33  1  0
 17 34  1  0
 17 35  1  0
 18 36  1  0
 18 37  1  0
 20 38  1  0
 20 39  1  0
 20 40  1  0
 21 41  1  1
M  END


  Mrv1652304282217332D          

 22 26  0  0  1  0            999 V2000
    1.1946    0.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4253    0.5106    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0483    1.2217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8220    1.4915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3716    0.8650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7951    0.2444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1132    0.0052    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8414   -0.5488    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5596   -0.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4115    0.0149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7784    0.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2780    1.4529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4067    1.4781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6266    1.9894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2542    1.6401    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8341    0.8443    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8935   -0.1689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1304   -0.3475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6108    1.1226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8798   -0.6643    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2192   -0.4633    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0441   -0.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  6  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  1  0  0  0
  8  9  1  0  0  0  0
  1  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
  1 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15  3  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  2 18  1  0  0  0  0
 16 19  1  0  0  0  0
 10 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0070262

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC=C2[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3C)[C@H]1O5

> <INCHI_IDENTIFIER>
InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3/t12-,17+,18+/m1/s1

> <INCHI_KEY>
ZKLXUUYLEHCAMF-UUWFMWQGSA-N

> <FORMULA>
C18H19NO3

> <MOLECULAR_WEIGHT>
297.354

> <EXACT_MASS>
297.136493476

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_ATOM_COUNT>
41

> <JCHEM_AVERAGE_POLARIZABILITY>
31.888804199521246

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1S,5R,13R)-14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,14,16-pentaen-10-ol

> <ALOGPS_LOGP>
2.58

> <JCHEM_LOGP>
1.2523337115537196

> <ALOGPS_LOGS>
-2.54

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.07053932461924

> <JCHEM_PKA_STRONGEST_BASIC>
8.3764358127059

> <JCHEM_POLAR_SURFACE_AREA>
41.93000000000001

> <JCHEM_REFRACTIVITY>
86.1774

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.66e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1S,5R,13R)-14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,14,16-pentaen-10-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       2.230   1.285   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.794   0.953   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.090   2.280   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.534   2.784   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -2.560   1.615   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.484   0.456   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       0.211   0.010   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       1.571  -1.024   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       2.911  -0.117   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.501   0.028   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.186   1.431   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.252   2.712   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.626   2.759   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       1.170   3.714   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      -0.475   3.061   0.000  0.00  0.00           C+0
HETATM   16  N   UNK     0      -1.557   1.576   0.000  0.00  0.00           N+0
HETATM   17  C   UNK     0      -1.668  -0.315   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -0.243  -0.649   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      -3.007   2.096   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       5.376  -1.240   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0      -2.276  -0.865   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -3.816  -0.840   0.000  0.00  0.00           C+0
CONECT    1    2    9   13                                                  
CONECT    2    1    3    7   18                                             
CONECT    3    2    4   15                                                  
CONECT    4    3    5                                                       
CONECT    5    4    6                                                       
CONECT    6    5    7   21                                                  
CONECT    7    6    2    8                                                  
CONECT    8    7    9                                                       
CONECT    9    8    1   10                                                  
CONECT   10    9   11   20                                                  
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12    1   14                                                  
CONECT   14   13   15                                                       
CONECT   15   14    3   16                                                  
CONECT   16   15   17   19                                                  
CONECT   17   16   18                                                       
CONECT   18   17    2                                                       
CONECT   19   16                                                            
CONECT   20   10                                                            
CONECT   21    6   22                                                       
CONECT   22   21                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   52    0
END

View in JSmol

Synonyms

Value	Source
6-Demethoxythebaine	MeSH
O(3)-Dimethylthebaine	MeSH
Oripavine hydrochloride, (5alpha)-isomer	MeSH

Chemical Formula

C₁₈H₁₉NO₃

Average Mass

297.3540 Da

Monoisotopic Mass

297.13649 Da

IUPAC Name

(1S,5R,13R)-14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,14,16-pentaen-10-ol

Traditional Name

(1S,5R,13R)-14-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,14,16-pentaen-10-ol

CAS Registry Number

Not Available

SMILES

COC1=CC=C2[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3C)[C@H]1O5

InChI Identifier

InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3/t12-,17+,18+/m1/s1

InChI Key

ZKLXUUYLEHCAMF-UUWFMWQGSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Berberis nervosa	LOTUS Database	35616633
Papaver bracteatum	Plant	KNApSAcK
Papaver macrantha	Plant	KNApSAcK
Papaver orientale	LOTUS Database	35616633
Papaver orientale L.	Plant	KNApSAcK
Papaver pinnatifidum	Plant	KNApSAcK
Papaver somniferum	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Morphinans

Sub Class

Not Available

Direct Parent

Morphinans

Alternative Parents

Substituents

Morphinan
Phenanthrene
Tetralin
Coumaran
Alkyl aryl ether
1-hydroxy-2-unsubstituted benzenoid
Aralkylamine
Piperidine
Benzenoid
Tertiary amine
Tertiary aliphatic amine
Ether
Oxacycle
Azacycle
Organoheterocyclic compound
Organopnictogen compound
Organooxygen compound
Organonitrogen compound
Organic oxygen compound
Hydrocarbon derivative
Amine
Organic nitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

morphinane alkaloid (CHEBI:7782 )
Isoquinoline alkaloids (C06175 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.58	ALOGPS
logP	1.25	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	10.07	ChemAxon
pKa (Strongest Basic)	8.38	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	41.93 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	86.18 m³·mol⁻¹	ChemAxon
Polarizability	31.89 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00028775

Chemspider ID

4575366

KEGG Compound ID

C06175

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Oripavine

METLIN ID

Not Available

PubChem Compound

5462306

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Casado-Hidalgo G, Perez-Quintanilla D, Morante-Zarcero S, Sierra I: Mesostructured Silica-Coated Magnetic Nanoparticles to Extract Six Opium Alkaloids in Poppy Seeds Prior to Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Analysis. Foods. 2021 Jul 8;10(7). pii: foods10071587. doi: 10.3390/foods10071587. [PubMed:34359458 ]
Kachhap S, Wojdyla Z, Komorek P, Kluza A, Kurpiewska K, Jachimska B, Borowski T: It takes two to tango - The case of thebaine 6-O-demethylase. Int J Biol Macromol. 2020 Nov 15;163:718-729. doi: 10.1016/j.ijbiomac.2020.07.030. Epub 2020 Jul 7. [PubMed:32650010 ]
Flury U, Cahill JL, Nixon RL: Occupational contact dermatitis caused by opioids: A case series. Contact Dermatitis. 2019 Nov;81(5):332-335. doi: 10.1111/cod.13305. Epub 2019 Jun 3. [PubMed:31066088 ]
Knutsen HK, Alexander J, Barregard L, Bignami M, Bruschweiler B, Ceccatelli S, Cottrill B, Dinovi M, Edler L, Grasl-Kraupp B, Hogstrand C, Hoogenboom LR, Nebbia CS, Oswald IP, Petersen A, Rose M, Roudot AC, Schwerdtle T, Vollmer G, Wallace H, Benford D, Calo G, Dahan A, Dusemund B, Mulder P, Nemeth-Zamborine E, Arcella D, Baert K, Cascio C, Levorato S, Schutte M, Vleminckx C: Update of the Scientific Opinion on opium alkaloids in poppy seeds. EFSA J. 2018 May 16;16(5):e05243. doi: 10.2903/j.efsa.2018.5243. eCollection 2018 May. [PubMed:32625895 ]
Kluza A, Niedzialkowska E, Kurpiewska K, Wojdyla Z, Quesne M, Kot E, Porebski PJ, Borowski T: Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway. J Struct Biol. 2018 Jun;202(3):229-235. doi: 10.1016/j.jsb.2018.01.007. Epub 2018 Feb 14. [PubMed:29408320 ]

Showing NP-Card for Oripavine (NP0070262)

MOL for NP0070262 (Oripavine)

3D MOL for NP0070262 (Oripavine)

3D SDF for NP0070262 (Oripavine)

3D-SDF for NP0070262 (Oripavine)

PDB for NP0070262 (Oripavine)

3D PDB for NP0070262 (Oripavine)

SMILES for NP0070262 (Oripavine)

INCHI for NP0070262 (Oripavine)

Structure for NP0070262 (Oripavine)

3D Structure for NP0070262 (Oripavine)