NP-MRD: Showing NP-Card for Bgugaine (NP0069623)

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Record Information

Version

2.0

Created at

2022-04-28 14:59:29 UTC

Updated at

2022-04-28 14:59:29 UTC

NP-MRD ID

NP0069623

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Bgugaine

Description

BGUGAINE belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. Bgugaine is found in Arisarum vulgare . Bgugaine was first documented in 2009 (PMID: 19401921). Based on a literature review a small amount of articles have been published on BGUGAINE (PMID: 32991808) (PMID: 23489623) (PMID: 23438148) (PMID: 20938943).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 59 59  0  0  0  0  0  0  0  0999 V2000
    6.7730    2.4947    1.0003 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3283    2.2113    1.3876 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1253    0.7113    1.4233 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4113    0.0957    0.0596 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2110   -1.3856    0.0936 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9026   -1.8730    0.4919 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6556   -1.6091   -0.2025 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0991   -0.2697   -0.3727 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7652   -0.3011   -1.1378 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2848   -1.1074   -0.4322 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6011   -1.0861   -1.2240 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6208   -1.8957   -0.4953 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9508   -1.9506   -1.1373 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7187   -0.6928   -1.2923 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1177   -0.0290   -0.0471 C   0  0  2  0  0  0  0  0  0  0  0  0
   -5.9225    1.2467   -0.2317 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0039    1.6998    1.2379 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9726    0.8798    1.9873 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0989    0.3383    0.9033 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3479    1.5083    0.4733 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8263    2.6087   -0.1015 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.1085    3.4126    1.5224 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3666    1.6160    1.3272 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1872    2.6264    2.4017 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.6102    2.6805    0.6966 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.8245    0.2747    2.1819 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1108    0.5103    1.7754 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8616    0.6580   -0.6951 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.5275    0.2952   -0.1064 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6377   -1.8800   -0.8246 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.9492   -1.7497    0.8917 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9982   -3.0201    0.5771 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.7984   -1.6237    1.6165 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8554   -2.2285    0.3397 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6454   -2.1258   -1.2231 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6751    0.5009   -0.8719 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7998    0.1964    0.6201 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.9966   -0.8276   -2.0945 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.4361    0.7080   -1.3913 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0242   -2.1877   -0.3529 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4133   -0.7346    0.5826 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8897   -0.0384   -1.3447 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3809   -1.5661   -2.2281 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7210   -1.5135    0.5417 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2225   -2.9443   -0.4265 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5712   -2.6878   -0.5601 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8058   -2.4815   -2.1313 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2360   -0.0134   -2.0413 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6820   -0.9850   -1.8225 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8104   -0.7189    0.5066 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9543    1.0370   -0.5908 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4305    1.9880   -0.8598 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7668    2.7786    1.2547 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9911    1.4487    1.6467 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3793    0.0934    2.6146 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3884    1.5790    2.6139 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2635    1.2455    0.6512 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5340    2.4070    1.0881 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4305    1.6760   -0.6152 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 19 15  1  0
  1 21  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  0
  2 25  1  0
  3 26  1  0
  3 27  1  0
  4 28  1  0
  4 29  1  0
  5 30  1  0
  5 31  1  0
  6 32  1  0
  6 33  1  0
  7 34  1  0
  7 35  1  0
  8 36  1  0
  8 37  1  0
  9 38  1  0
  9 39  1  0
 10 40  1  0
 10 41  1  0
 11 42  1  0
 11 43  1  0
 12 44  1  0
 12 45  1  0
 13 46  1  0
 13 47  1  0
 14 48  1  0
 14 49  1  0
 15 50  1  1
 16 51  1  0
 16 52  1  0
 17 53  1  0
 17 54  1  0
 18 55  1  0
 18 56  1  0
 20 57  1  0
 20 58  1  0
 20 59  1  0
M  END


  Mrv1652304282216592D          

 20 20  0  0  1  0            999 V2000
   -0.9806    2.5546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5681    3.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2389    3.0975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3251    2.2771    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4286    1.9415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6001    1.1345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7540    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4685    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1830    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3264    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0409    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7553    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4698    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1843    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8987    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6132    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3277    2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  7  1  1  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0069623

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CCCCCCCCCCCCCC[C@@H]1CCCN1C

> <INCHI_IDENTIFIER>
InChI=1S/C19H39N/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(19)2/h19H,3-18H2,1-2H3/t19-/m1/s1

> <INCHI_KEY>
NCSCAOYXUUEXIP-LJQANCHMSA-N

> <FORMULA>
C19H39N

> <MOLECULAR_WEIGHT>
281.528

> <EXACT_MASS>
281.30825026

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
59

> <JCHEM_AVERAGE_POLARIZABILITY>
39.698451816782054

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2R)-1-methyl-2-tetradecylpyrrolidine

> <ALOGPS_LOGP>
7.74

> <JCHEM_LOGP>
6.8698883319999995

> <ALOGPS_LOGS>
-6.82

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
10.140987452983435

> <JCHEM_POLAR_SURFACE_AREA>
3.24

> <JCHEM_REFRACTIVITY>
91.6839

> <JCHEM_ROTATABLE_BOND_COUNT>
13

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
4.28e-05 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2R)-1-methyl-2-tetradecylpyrrolidine

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -1.830   4.769   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.060   6.102   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.446   5.782   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.607   4.251   0.000  0.00  0.00           C+0
HETATM    5  N   UNK     0      -0.800   3.624   0.000  0.00  0.00           N+0
HETATM    6  C   UNK     0      -1.120   2.118   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.941   3.481   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.274   4.251   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.608   3.481   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.942   4.251   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       7.275   3.481   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.609   4.251   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.943   3.481   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0      11.276   4.251   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      12.610   3.481   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      13.944   4.251   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      15.277   3.481   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      16.611   4.251   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      17.945   3.481   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      19.278   4.251   0.000  0.00  0.00           C+0
CONECT    1    2    5                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5    7                                                  
CONECT    5    4    1    6                                                  
CONECT    6    5                                                            
CONECT    7    4    8                                                       
CONECT    8    7    9                                                       
CONECT    9    8   10                                                       
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13                                                       
CONECT   13   12   14                                                       
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19                                                            
MASTER        0    0    0    0    0    0    0    0   20    0   40    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₉H₃₉N

Average Mass

281.5280 Da

Monoisotopic Mass

281.30825 Da

IUPAC Name

(2R)-1-methyl-2-tetradecylpyrrolidine

Traditional Name

(2R)-1-methyl-2-tetradecylpyrrolidine

CAS Registry Number

Not Available

SMILES

CCCCCCCCCCCCCC[C@@H]1CCCN1C

InChI Identifier

InChI=1S/C19H39N/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(19)2/h19H,3-18H2,1-2H3/t19-/m1/s1

InChI Key

NCSCAOYXUUEXIP-LJQANCHMSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Arisarum vulgare	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as n-alkylpyrrolidines. N-alkylpyrrolidines are compounds containing a pyrrolidine moiety that is substituted at the N1-position with an alkyl group. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyrrolidines

Sub Class

N-alkylpyrrolidines

Direct Parent

N-alkylpyrrolidines

Alternative Parents

Substituents

N-alkylpyrrolidine
Tertiary aliphatic amine
Tertiary amine
Azacycle
Organic nitrogen compound
Organopnictogen compound
Hydrocarbon derivative
Organonitrogen compound
Amine
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	7.74	ALOGPS
logP	6.87	ChemAxon
logS	-6.8	ALOGPS
pKa (Strongest Basic)	10.14	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	3.24 Å²	ChemAxon
Rotatable Bond Count	13	ChemAxon
Refractivity	91.68 m³·mol⁻¹	ChemAxon
Polarizability	39.7 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00027936

Chemspider ID

406085

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

461557

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Maddocks CJ, Ermanis K, Clarke PA: Asymmetric "Clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines. Org Lett. 2020 Oct 16;22(20):8116-8121. doi: 10.1021/acs.orglett.0c03090. Epub 2020 Sep 29. [PubMed:32991808 ]
Majik MS, Naik D, Bhat C, Tilve S, Tilvi S, D'Souza L: Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2353-6. doi: 10.1016/j.bmcl.2013.02.051. Epub 2013 Feb 22. [PubMed:23489623 ]
Shu C, Liu MQ, Wang SS, Li L, Ye LW: Gold-catalyzed oxidative cyclization of chiral homopropargyl amides: synthesis of enantioenriched gamma-lactams. J Org Chem. 2013 Apr 5;78(7):3292-9. doi: 10.1021/jo400127x. Epub 2013 Mar 5. [PubMed:23438148 ]
Xiao KJ, Wang Y, Ye KY, Huang PQ: Versatile one-pot reductive alkylation of lactams/amides via amide activation: application to the concise syntheses of bioactive alkaloids (+/-)-bgugaine, (+/-)-coniine, (+)-preussin, and (-)-cassine. Chemistry. 2010 Nov 15;16(43):12792-6. doi: 10.1002/chem.201002054. [PubMed:20938943 ]
Benamar M, Melhaoui A, Zyad A, Bouabdallah I, Aziz M: Anti-cancer effect of two alkaloids: 2R and 2S-bgugaine on mastocytoma P815 and carcinoma Hep. Nat Prod Res. 2009;23(7):659-64. doi: 10.1080/14786410802340861. [PubMed:19401921 ]

Showing NP-Card for Bgugaine (NP0069623)

MOL for NP0069623 (Bgugaine)

3D MOL for NP0069623 (Bgugaine)

3D SDF for NP0069623 (Bgugaine)

3D-SDF for NP0069623 (Bgugaine)

PDB for NP0069623 (Bgugaine)

3D PDB for NP0069623 (Bgugaine)

SMILES for NP0069623 (Bgugaine)

INCHI for NP0069623 (Bgugaine)

Structure for NP0069623 (Bgugaine)

3D Structure for NP0069623 (Bgugaine)