NP-MRD: Showing NP-Card for D-(-)-Nuciferine (NP0068112)

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Record Information

Version

2.0

Created at

2022-04-28 13:07:00 UTC

Updated at

2022-04-28 13:07:00 UTC

NP-MRD ID

NP0068112

Secondary Accession Numbers

None

Natural Product Identification

Common Name

D-(-)-Nuciferine

Description

Nuciferine belongs to the class of organic compounds known as aporphines. These are quinoline alkaloids containing the dibenzo[de,g]quinoline ring system or a dehydrogenated derivative thereof. D-(-)-Nuciferine is found in Annona cherimola, Annona cherimolia, Artabotrys venustus, Cissampelos pareira , Hexalobus monopetalus, Liriodendron tulipifera, Nelumbo caerulea, Nelumbo nucifera , Paliurus hemsleyanus, Papaver caucasicum, Plumula nelumbensis, Ziziphus jujuba and Zizyphus vulgaris. D-(-)-Nuciferine was first documented in 2021 (PMID: 35003297). Based on a literature review a small amount of articles have been published on Nuciferine (PMID: 35350700) (PMID: 35298888) (PMID: 35167658) (PMID: 35098593).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 43 46  0  0  0  0  0  0  0  0999 V2000
    2.5650   -4.3057    0.4084 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5829   -2.9098    0.4429 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4604   -2.1119    0.3461 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1852   -2.5578    0.2045 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8616   -1.6672    0.1181 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6518   -0.2991    0.1748 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6471    0.1904    0.3222 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6768   -0.7137    0.4011 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0003   -0.3167    0.5302 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6832   -0.2903   -0.7737 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8818    1.6427    0.3595 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1279    2.1196    0.6706 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2697    3.4973    0.8418 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1964    4.3462    0.7054 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0299    3.8458    0.3971 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2005    2.4846    0.2193 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5321    1.9737   -0.1787 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8132    0.5482    0.1187 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.8078    0.1190   -0.8637 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0278    0.8673   -0.6331 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9957   -1.2726   -0.9843 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2613   -2.1372   -0.0281 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7147   -4.7359   -0.1267 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5894   -4.7734    1.4274 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5149   -4.6487   -0.0898 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0055   -3.6335    0.1609 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5821    0.3225   -0.7143 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9385   -1.3263   -1.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0125    0.1254   -1.5348 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0003    1.5684    0.8446 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2252    3.9373    1.0862 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3160    5.4354    0.8432 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8900    4.4921    0.2852 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7239    2.2115   -1.2717 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2694    2.6070    0.3810 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3306    0.5299    1.1315 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8742    0.3356   -1.1066 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2059    1.0506    0.4467 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9245    1.8468   -1.1423 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0952   -1.4901   -0.8503 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7569   -1.5981   -2.0194 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2174   -3.1697   -0.4657 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7062   -2.1398    0.9856 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  8  2  0
  8  9  1  0
  9 10  1  0
  8  7  1  0
  7  6  2  0
  6 18  1  0
 18 17  1  0
 17 16  1  0
 16 15  2  0
 15 14  1  0
 14 13  2  0
 13 12  1  0
 12 11  2  0
 18 19  1  0
 19 20  1  0
 19 21  1  0
 21 22  1  0
 22  5  1  0
  5  4  2  0
  4  3  1  0
 11  7  1  0
  5  6  1  0
 11 16  1  0
  1 23  1  0
  1 24  1  0
  1 25  1  0
 10 27  1  0
 10 28  1  0
 10 29  1  0
 18 36  1  1
 17 34  1  0
 17 35  1  0
 15 33  1  0
 14 32  1  0
 13 31  1  0
 12 30  1  0
 20 37  1  0
 20 38  1  0
 20 39  1  0
 21 40  1  0
 21 41  1  0
 22 42  1  0
 22 43  1  0
  4 26  1  0
M  END


  Mrv1652304282215072D          

 22 25  0  0  1  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  6  0  0  0
 17 18  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0068112

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=C(OC)C2=C3[C@@H](CC4=CC=CC=C24)N(C)CCC3=C1

> <INCHI_IDENTIFIER>
InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1

> <INCHI_KEY>
ORJVQPIHKOARKV-OAHLLOKOSA-N

> <FORMULA>
C19H21NO2

> <MOLECULAR_WEIGHT>
295.382

> <EXACT_MASS>
295.15722892

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
43

> <JCHEM_AVERAGE_POLARIZABILITY>
33.82816761716992

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(9R)-15,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene

> <ALOGPS_LOGP>
3.38

> <JCHEM_LOGP>
3.3860694963333327

> <ALOGPS_LOGS>
-3.89

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_BASIC>
7.469808258724138

> <JCHEM_POLAR_SURFACE_AREA>
21.700000000000003

> <JCHEM_REFRACTIVITY>
88.9527

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.77e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(9R)-15,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       9.336  -0.770   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       9.336  -2.310   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       8.002  -3.080   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.002   0.000   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       5.335  -4.620   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.001  -5.390   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       2.667  -4.620   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   17  N   UNK     0       2.667   0.000   0.000  0.00  0.00           N+0
HETATM   18  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       4.001  -6.930   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       5.335  -7.700   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       6.668  -5.390   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       6.668  -6.930   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4                                                       
CONECT    4    3    5   10                                                  
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8                                                       
CONECT    8    7    9   17                                                  
CONECT    9    8   10   14                                                  
CONECT   10    9    4   11                                                  
CONECT   11   10   12   21                                                  
CONECT   12   11   13   19                                                  
CONECT   13   12   14                                                       
CONECT   14   13    9   15                                                  
CONECT   15   14   16                                                       
CONECT   16   15   17                                                       
CONECT   17   16    8   18                                                  
CONECT   18   17                                                            
CONECT   19   12   20                                                       
CONECT   20   19                                                            
CONECT   21   11   22                                                       
CONECT   22   21                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   50    0
END

View in JSmol

Synonyms

Value	Source
L-5,6-Dimethoxyaporphine	MeSH
Nuciferine, (+-)-isomer	MeSH
Nuciferine, (S)-isomer	MeSH

Chemical Formula

C₁₉H₂₁NO₂

Average Mass

295.3820 Da

Monoisotopic Mass

295.15723 Da

IUPAC Name

(9R)-15,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene

Traditional Name

(9R)-15,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene

CAS Registry Number

Not Available

SMILES

COC1=C(OC)C2=C3[C@@H](CC4=CC=CC=C24)N(C)CCC3=C1

InChI Identifier

InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1

InChI Key

ORJVQPIHKOARKV-OAHLLOKOSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Annona cherimola	LOTUS Database	35616633
Annona cherimolia	Plant	KNApSAcK
Artabotrys venustus	LOTUS Database	35616633
Cissampelos pareira	Plant	KNApSAcK
Hexalobus monopetalus	LOTUS Database	35616633
Liriodendron tulipifera	LOTUS Database	35616633
Nelumbo caerulea	Plant	KNApSAcK
Nelumbo nucifera	Plant	KNApSAcK
Paliurus hemsleyanus	LOTUS Database	35616633
Papaver caucasicum	Plant	KNApSAcK
Plumula nelumbensis	-	KNApSAcK
Ziziphus jujuba	LOTUS Database	35616633
Zizyphus vulgaris	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aporphines. These are quinoline alkaloids containing the dibenzo[de,g]quinoline ring system or a dehydrogenated derivative thereof.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Aporphines

Sub Class

Not Available

Direct Parent

Aporphines

Alternative Parents

Substituents

Aporphine
Benzoquinoline
Phenanthrene
Naphthalene
Quinoline
Tetrahydroisoquinoline
Anisole
Aralkylamine
Alkyl aryl ether
Benzenoid
Tertiary aliphatic amine
Tertiary amine
Organoheterocyclic compound
Azacycle
Ether
Hydrocarbon derivative
Organonitrogen compound
Organooxygen compound
Organic oxygen compound
Organic nitrogen compound
Organopnictogen compound
Amine
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.38	ALOGPS
logP	3.39	ChemAxon
logS	-3.9	ALOGPS
pKa (Strongest Basic)	7.47	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	21.7 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	88.95 m³·mol⁻¹	ChemAxon
Polarizability	33.83 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00001905

Chemspider ID

9740

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Nuciferine

METLIN ID

Not Available

PubChem Compound

10146

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Xu X, Wang W, Chen Y, Zhang Q, Li B, Zhong Y, Tu Y, Zhang W, Xu G, Jiang L: Simultaneous Determination of Ten Bioactive Components from Shenling Baizhu San in Rat Plasma by UHPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Two Models of Ulcerative Colitis Rats. Evid Based Complement Alternat Med. 2021 Dec 29;2021:3518241. doi: 10.1155/2021/3518241. eCollection 2021. [PubMed:35003297 ]
Zheng L, Jiang H, Li R, Song L, Chen R, Dong H: The Pharmacological Mechanisms of Xiaochaihutang in Treating Breast Cancer Based on Network Pharmacology. Contrast Media Mol Imaging. 2022 Mar 9;2022:3900636. doi: 10.1155/2022/3900636. eCollection 2022. [PubMed:35350700 ]
Bai X, Liu X, Li S, An H, Kang X, Guo S: Nuciferine Inhibits TMEM16A in Dietary Adjuvant Therapy for Lung Cancer. J Agric Food Chem. 2022 Mar 30;70(12):3687-3696. doi: 10.1021/acs.jafc.1c08375. Epub 2022 Mar 17. [PubMed:35298888 ]
Wu M, Qi F, Qiu R, Feng J, Ren X, Rong S, Ma H, Pan H, Chang D: Electrochemical Detection of Nuciferine in the Lotus Leaf Based on Efficient Catalysis by Zirconium-MOFs. J AOAC Int. 2022 Jun 29;105(4):1175-1182. doi: 10.1093/jaoacint/qsac024. [PubMed:35167658 ]
Yu X, Chen ML, Liu Y, Li CH, Qiu XL, Ren XL, Wang M, Zhang DQ: An eco-friendly extraction and purification method of nuciferine from Folium nelumbinis with p-sulfonatocalix[6]arenes. Phytochem Anal. 2022 Jun;33(4):543-553. doi: 10.1002/pca.3108. Epub 2022 Jan 31. [PubMed:35098593 ]

Showing NP-Card for D-(-)-Nuciferine (NP0068112)

MOL for NP0068112 (D-(-)-Nuciferine)

3D MOL for NP0068112 (D-(-)-Nuciferine)

3D SDF for NP0068112 (D-(-)-Nuciferine)

3D-SDF for NP0068112 (D-(-)-Nuciferine)

PDB for NP0068112 (D-(-)-Nuciferine)

3D PDB for NP0068112 (D-(-)-Nuciferine)

SMILES for NP0068112 (D-(-)-Nuciferine)

INCHI for NP0068112 (D-(-)-Nuciferine)

Structure for NP0068112 (D-(-)-Nuciferine)

3D Structure for NP0068112 (D-(-)-Nuciferine)