NP-MRD: Showing NP-Card for (-)-Cuanzine (NP0067319)

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Record Information

Version

2.0

Created at

2022-04-28 11:55:52 UTC

Updated at

2022-04-28 11:55:52 UTC

NP-MRD ID

NP0067319

Secondary Accession Numbers

None

Natural Product Identification

Common Name

(-)-Cuanzine

Description

Cuanzine belongs to the class of organic compounds known as indolonaphthyridine alkaloids. These are a numerous and relatively straightforward subgroup of the b-carbolines, e.G. Canthin-6-one, in which an additional C3 unit is attached between C-1 and the indole nitrogen to form an additional ring. The group includes a few dimeric examples, such as Haplophytine. (-)-Cuanzine is found in Voacanga chalotiana. (-)-Cuanzine was first documented in 2022 (PMID: 35312322). Based on a literature review very few articles have been published on Cuanzine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282213552D          

 29 34  0  0  1  0            999 V2000
    5.9528   -0.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6368   -0.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8188    0.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3168   -0.5906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6328   -1.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4508   -1.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9008   -2.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3021   -1.4579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4944   -0.6557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8957   -0.0880    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3037   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9125   -1.1249    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5112   -1.6926    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3189   -2.4949    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9176   -3.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7085   -2.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5280   -2.7295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9293   -2.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1216   -1.3596    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6540   -0.6799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1560   -0.0251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9338   -0.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4421    0.5301    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6888    0.7106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2770    1.2891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8937    0.9308    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6869    1.7294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5027    0.8262    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0047    1.4809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13  8  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  7 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 22  1  6  0  0  0
 10 23  1  1  0  0  0
 10 24  1  6  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  3 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END

     RDKit          3D

 55 60  0  0  0  0  0  0  0  0999 V2000
    2.5704    3.8152   -1.8613 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0591    3.1037   -0.7717 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0965    2.0786   -0.9140 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7523    1.8773   -2.1163 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5709    1.3426    0.2493 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.3060    1.8192    1.3755 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8396    1.6846    0.5723 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9226    0.7804    0.0585 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1345    1.2040   -1.4190 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6265    0.9776   -1.5352 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1731    1.2624   -0.3217 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2173    1.2310    0.6475 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.6912    0.3292    1.7719 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6221   -1.1240    1.3100 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2510   -1.4968    1.0763 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2058   -2.8461    0.6019 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9323   -3.3282    0.0044 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1281   -2.2592    0.0577 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2477   -0.9368    0.0972 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7661   -0.1085    0.1642 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8560   -0.8793    0.1680 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2091   -0.6141    0.2233 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6261    0.6865    0.2897 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9991    1.0485    0.3496 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1874   -1.6094    0.2157 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7854   -2.9268    0.1498 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4435   -3.2391    0.0931 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5018   -2.2353    0.1022 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6947   -0.6528    0.0634 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0956    4.8271   -1.8555 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6623    4.0084   -1.7064 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4044    3.2777   -2.8147 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.4427    1.1188    2.0294 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0365    1.8168    1.6727 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0500    2.7036    0.1392 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5584    0.4950   -2.0187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8918    2.2591   -1.5289 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7637   -0.0766   -1.8670 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9918    1.6300   -2.3451 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1506    2.2493    1.0904 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0099    0.4288    2.6234 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7247    0.5358    2.0443 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1376   -1.7427    2.0475 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1501   -1.1883    0.3294 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0846   -2.9681   -0.0975 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4816   -3.5034    1.4785 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1274   -3.5828   -1.0666 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5922   -4.2543    0.5071 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.1322    2.1151    0.5920 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5245    0.4860    1.1638 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4338    0.7900   -0.6467 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2307   -1.3190    0.2617 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.5092   -3.7220    0.1418 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976   -4.2790    0.0402 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0813   -1.0896   -0.9163 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  1  1
  5  7  1  0
  8  7  1  1
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 12 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 29  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 22 23  1  0
 23 24  1  0
 22 25  1  0
 25 26  2  0
 26 27  1  0
 27 28  2  0
 20  5  1  0
 28 21  1  0
 12  8  1  0
 29 15  1  0
 29  8  1  0
 28 18  1  0
  1 30  1  0
  1 31  1  0
  1 32  1  0
  6 33  1  0
  7 34  1  0
  7 35  1  0
  9 36  1  0
  9 37  1  0
 10 38  1  0
 10 39  1  0
 12 40  1  1
 13 41  1  0
 13 42  1  0
 14 43  1  0
 14 44  1  0
 16 45  1  0
 16 46  1  0
 17 47  1  0
 17 48  1  0
 29 55  1  6
 24 49  1  0
 24 50  1  0
 24 51  1  0
 25 52  1  0
 26 53  1  0
 27 54  1  0
M  END


  Mrv1652304282213552D          

 29 34  0  0  1  0            999 V2000
    5.9528   -0.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6368   -0.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8188    0.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3168   -0.5906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6328   -1.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4508   -1.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9008   -2.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3021   -1.4579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4944   -0.6557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8957   -0.0880    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3037   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9125   -1.1249    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5112   -1.6926    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.3189   -2.4949    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9176   -3.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7085   -2.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5280   -2.7295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9293   -2.1619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1216   -1.3596    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6540   -0.6799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1560   -0.0251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9338   -0.3002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4421    0.5301    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6888    0.7106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2770    1.2891    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8937    0.9308    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6869    1.7294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5027    0.8262    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0047    1.4809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13  8  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  7 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 22  1  6  0  0  0
 10 23  1  1  0  0  0
 10 24  1  6  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  3 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0067319

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)[C@@]1(O)C[C@]23CCO[C@H]2CCN2CCC4=C([C@H]32)N1C1=C(OC)C=CC=C41

> <INCHI_IDENTIFIER>
InChI=1S/C22H26N2O5/c1-27-15-5-3-4-13-14-6-9-23-10-7-16-21(8-11-29-16)12-22(26,20(25)28-2)24(17(13)15)18(14)19(21)23/h3-5,16,19,26H,6-12H2,1-2H3/t16-,19+,21+,22-/m0/s1

> <INCHI_KEY>
QDDMEOMLOUPIRE-MQYXYMALSA-N

> <FORMULA>
C22H26N2O5

> <MOLECULAR_WEIGHT>
398.459

> <EXACT_MASS>
398.184171945

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
55

> <JCHEM_AVERAGE_POLARIZABILITY>
42.15033896823662

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (1S,3S,17S,21S)-3-hydroxy-6-methoxy-18-oxa-4,14-diazahexacyclo[9.9.2.0^{1,17}.0^{4,22}.0^{5,10}.0^{14,21}]docosa-5,7,9,11(22)-tetraene-3-carboxylate

> <ALOGPS_LOGP>
1.65

> <JCHEM_LOGP>
1.6544989106666668

> <ALOGPS_LOGS>
-2.59

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
6

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
10.525131765328378

> <JCHEM_PKA_STRONGEST_BASIC>
6.246266354228768

> <JCHEM_POLAR_SURFACE_AREA>
73.16

> <JCHEM_REFRACTIVITY>
105.92779999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.02e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl (1S,3S,17S,21S)-3-hydroxy-6-methoxy-18-oxa-4,14-diazahexacyclo[9.9.2.0^{1,17}.0^{4,22}.0^{5,10}.0^{14,21}]docosa-5,7,9,11(22)-tetraene-3-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      11.112  -1.503   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.522  -0.081   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       8.995   0.120   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.058  -1.102   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.648  -2.525   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      10.175  -2.725   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       7.281  -3.781   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       6.164  -2.721   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       6.523  -1.224   0.000  0.00  0.00           N+0
HETATM   10  C   UNK     0       5.405  -0.164   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.300  -0.375   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       3.570  -2.100   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.688  -3.159   0.000  0.00  0.00           C+0
HETATM   14  N   UNK     0       4.329  -4.657   0.000  0.00  0.00           N+0
HETATM   15  C   UNK     0       5.446  -5.717   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       6.923  -5.279   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       2.852  -5.095   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       1.735  -4.035   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.094  -2.538   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       1.221  -1.269   0.000  0.00  0.00           O+0
HETATM   21  C   UNK     0       2.158  -0.047   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       3.610  -0.560   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       6.425   0.990   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       5.019   1.326   0.000  0.00  0.00           C+0
HETATM   25  O   UNK     0       6.117   2.406   0.000  0.00  0.00           O+0
HETATM   26  O   UNK     0       3.535   1.737   0.000  0.00  0.00           O+0
HETATM   27  C   UNK     0       3.149   3.228   0.000  0.00  0.00           C+0
HETATM   28  O   UNK     0       8.405   1.542   0.000  0.00  0.00           O+0
HETATM   29  C   UNK     0       9.342   2.764   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4   28                                                  
CONECT    4    3    5    9                                                  
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8   16                                                  
CONECT    8    7    9   13                                                  
CONECT    9    8    4   10                                                  
CONECT   10    9   11   23   24                                             
CONECT   11   10   12                                                       
CONECT   12   11   13   19   22                                             
CONECT   13   12    8   14                                                  
CONECT   14   13   15   17                                                  
CONECT   15   14   16                                                       
CONECT   16   15    7                                                       
CONECT   17   14   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   12   20                                                  
CONECT   20   19   21                                                       
CONECT   21   20   22                                                       
CONECT   22   21   12                                                       
CONECT   23   10                                                            
CONECT   24   10   25   26                                                  
CONECT   25   24                                                            
CONECT   26   24   27                                                       
CONECT   27   26                                                            
CONECT   28    3   29                                                       
CONECT   29   28                                                            
MASTER        0    0    0    0    0    0    0    0   29    0   68    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₂₆N₂O₅

Average Mass

398.4590 Da

Monoisotopic Mass

398.18417 Da

IUPAC Name

methyl (1S,3S,17S,21S)-3-hydroxy-6-methoxy-18-oxa-4,14-diazahexacyclo[9.9.2.0^{1,17}.0^{4,22}.0^{5,10}.0^{14,21}]docosa-5,7,9,11(22)-tetraene-3-carboxylate

Traditional Name

methyl (1S,3S,17S,21S)-3-hydroxy-6-methoxy-18-oxa-4,14-diazahexacyclo[9.9.2.0^{1,17}.0^{4,22}.0^{5,10}.0^{14,21}]docosa-5,7,9,11(22)-tetraene-3-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)[C@@]1(O)C[C@]23CCO[C@H]2CCN2CCC4=C([C@H]32)N1C1=C(OC)C=CC=C41

InChI Identifier

InChI=1S/C22H26N2O5/c1-27-15-5-3-4-13-14-6-9-23-10-7-16-21(8-11-29-16)12-22(26,20(25)28-2)24(17(13)15)18(14)19(21)23/h3-5,16,19,26H,6-12H2,1-2H3/t16-,19+,21+,22-/m0/s1

InChI Key

QDDMEOMLOUPIRE-MQYXYMALSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Voacanga chalotiana	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as indolonaphthyridine alkaloids. These are a numerous and relatively straightforward subgroup of the b-carbolines, e.G. Canthin-6-one, in which an additional C3 unit is attached between C-1 and the indole nitrogen to form an additional ring. The group includes a few dimeric examples, such as Haplophytine.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Indolonaphthyridine alkaloids

Sub Class

Not Available

Direct Parent

Indolonaphthyridine alkaloids

Alternative Parents

Substituents

Indolo[3,2-1de][1,5]naphthyridine
Beta-carboline
Pyridoindole
Diazanaphthalene
Alpha-amino acid or derivatives
Naphthyridine
3-alkylindole
Indole
Indole or derivatives
Anisole
Alkyl aryl ether
Aralkylamine
Piperidine
Benzenoid
Methyl ester
Pyrrole
Oxolane
Heteroaromatic compound
Tertiary aliphatic amine
Tertiary amine
Amino acid or derivatives
Carboxylic acid ester
Azacycle
Alkanolamine
Organoheterocyclic compound
Oxacycle
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Ether
Dialkyl ether
Organic nitrogen compound
Hydrocarbon derivative
Carbonyl group
Organic oxide
Organopnictogen compound
Organonitrogen compound
Amine
Organic oxygen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.65	ALOGPS
logP	1.65	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Acidic)	10.53	ChemAxon
pKa (Strongest Basic)	6.25	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	73.16 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	105.93 m³·mol⁻¹	ChemAxon
Polarizability	42.15 Å³	ChemAxon
Number of Rings	6	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00025045

Chemspider ID

10207482

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

11036745

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Zhang W, Wang Z, Lin G, Xue Y, Wu M, Tang P, Chen F: Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids. Org Lett. 2022 Apr 1;24(12):2409-2413. doi: 10.1021/acs.orglett.2c00661. Epub 2022 Mar 21. [PubMed:35312322 ]

Showing NP-Card for (-)-Cuanzine (NP0067319)

MOL for NP0067319 ((-)-Cuanzine)

3D MOL for NP0067319 ((-)-Cuanzine)

3D SDF for NP0067319 ((-)-Cuanzine)

3D-SDF for NP0067319 ((-)-Cuanzine)

PDB for NP0067319 ((-)-Cuanzine)

3D PDB for NP0067319 ((-)-Cuanzine)

SMILES for NP0067319 ((-)-Cuanzine)

INCHI for NP0067319 ((-)-Cuanzine)

Structure for NP0067319 ((-)-Cuanzine)

3D Structure for NP0067319 ((-)-Cuanzine)