NP-MRD: Showing NP-Card for 19R-Hydroxy-11-methoxy-tabersonine (NP0066849)

Jump To Section:

Identification Spectra BioTaxonomy ChemoTaxonomy Physical properties Links References XML

Record Information

Version

2.0

Created at

2022-04-28 11:05:12 UTC

Updated at

2022-04-28 11:05:12 UTC

NP-MRD ID

NP0066849

Secondary Accession Numbers

None

Natural Product Identification

Common Name

19R-Hydroxy-11-methoxy-tabersonine

Description

Vandrikidine belongs to the class of organic compounds known as plumeran-type alkaloids. These are alkaloids with a structure based on the plumeran skeleton. Plumeran is a pentacyclic compound that consists of a pyrrolidine ring shed to the quinoline moiety of pyrido[3,2-c]carbazole ring system. 19R-Hydroxy-11-methoxy-tabersonine is found in Alstonia yunnanensis, Catharanthus roseus and Melodinus suaveolens. Based on a literature review very few articles have been published on Vandrikidine.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282213052D          

 28 32  0  0  1  0            999 V2000
    5.4285    1.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0125    0.6269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7998   -0.1702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0031   -0.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4191    0.1981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6318    0.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6844   -0.1772    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8144   -0.9919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1738   -1.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4032   -1.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2733   -0.4022    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9139    0.1177    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7840    0.9324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0135    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3729    0.7073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5028   -0.1074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7529    1.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2030    0.4645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6327   -0.9221    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8622   -0.6272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7627   -1.7368    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3037   -2.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6631   -2.8463    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0742   -2.6213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2041   -3.4360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6293   -1.1201    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8091    0.8412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0218    1.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  7  5  1  1  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
  7 18  1  0  0  0  0
 11 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  1  6  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 26  1  0  0  0  0
  4 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END

     RDKit          3D

 54 58  0  0  0  0  0  0  0  0999 V2000
   -4.1355    4.1740    0.3731 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4224    2.9671    0.5128 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0642    2.8461    0.3295 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3906    3.8405    0.0209 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4475    1.5547    0.5016 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1427    1.4427    0.3248 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9189    2.3221   -0.0225 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1206    1.5446   -0.2021 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3854    1.9010   -0.6008 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4128    0.9892   -0.7876 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6673    1.4248   -1.1923 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6881    0.4541   -1.3704 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1271   -0.3451   -0.5545 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8458   -0.7266   -0.1469 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.2133    0.0278 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4466    0.1107    0.5144 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.5369   -0.2651    1.9892 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2211   -1.7452    2.0070 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1657   -2.1360    0.6220 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5424   -3.3591    0.3912 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9689   -3.1884    0.6908 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5354   -2.0287    0.4907 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8109   -0.8323   -0.0363 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.3826   -0.5472   -1.4084 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1582   -1.7527   -2.2752 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7664   -0.3534   -1.3211 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2535    0.3336    0.8394 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -0.9959   -0.1102 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.4519    5.0498    0.3085 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8212    4.2486    1.2366 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7187    4.1090   -0.5660 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8640    3.3570   -0.1346 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.5863    2.9435   -0.7766 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.2637   -0.3477   -2.0013 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.9377   -0.0267   -0.3827 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.5963    0.9102   -1.8208 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8922   -1.0910   -0.6871 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6920   -1.7836    0.0172 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5932   -0.0857    2.3553 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0817    0.3462    2.6440 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6948   -1.9774    2.5684 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0714   -2.2809    2.4754 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0600   -4.1469    0.9782 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4180   -3.6089   -0.6911 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5622   -4.0065    1.0750 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5924   -1.8757    0.7051 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8812    0.3111   -1.9022 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8736   -1.7228   -3.1428 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1366   -1.7987   -2.6791 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3804   -2.7182   -1.7459 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2428   -1.2075   -1.2534 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3168    0.5506    0.5223 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3077    0.1082    1.8994 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0055   -1.0986   -1.1597 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  3  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  1  0
  8  9  2  0
  9 10  1  0
 10 11  1  0
 11 12  1  0
 10 13  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  1  1
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 23 22  1  0
 23 27  1  1
 23 24  1  0
 24 25  1  0
 24 26  1  0
 23 28  1  0
 27  5  1  0
 16  6  1  0
 28 16  1  0
 15  8  1  0
 28 19  1  0
  1 29  1  0
  1 30  1  0
  1 31  1  0
  7 32  1  0
  9 33  1  0
 12 34  1  0
 12 35  1  0
 12 36  1  0
 13 37  1  0
 14 38  1  0
 17 39  1  0
 17 40  1  0
 18 41  1  0
 18 42  1  0
 20 43  1  0
 20 44  1  0
 21 45  1  0
 22 46  1  0
 27 52  1  0
 27 53  1  0
 24 47  1  6
 25 48  1  0
 25 49  1  0
 25 50  1  0
 26 51  1  0
 28 54  1  6
M  END


  Mrv1652304282213052D          

 28 32  0  0  1  0            999 V2000
    5.4285    1.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0125    0.6269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7998   -0.1702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0031   -0.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4191    0.1981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6318    0.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6844   -0.1772    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8144   -0.9919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1738   -1.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4032   -1.2169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2733   -0.4022    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.9139    0.1177    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7840    0.9324    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0135    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3729    0.7073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5028   -0.1074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7529    1.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2030    0.4645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6327   -0.9221    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8622   -0.6272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7627   -1.7368    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3037   -2.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6631   -2.8463    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0742   -2.6213    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2041   -3.4360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6293   -1.1201    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8091    0.8412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0218    1.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  7  5  1  1  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
  7 18  1  0  0  0  0
 11 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  1  6  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8 26  1  0  0  0  0
  4 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0066849

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC(=O)C1=C2NC3=CC(OC)=CC=C3[C@@]22CCN3CC=C[C@](C1)([C@@H](C)O)[C@@H]23

> <INCHI_IDENTIFIER>
InChI=1S/C22H26N2O4/c1-13(25)21-7-4-9-24-10-8-22(20(21)24)16-6-5-14(27-2)11-17(16)23-18(22)15(12-21)19(26)28-3/h4-7,11,13,20,23,25H,8-10,12H2,1-3H3/t13-,20+,21+,22+/m1/s1

> <INCHI_KEY>
ASAFZNAXYPDIJR-MCLJMYSDSA-N

> <FORMULA>
C22H26N2O4

> <MOLECULAR_WEIGHT>
382.46

> <EXACT_MASS>
382.189257325

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
54

> <JCHEM_AVERAGE_POLARIZABILITY>
41.4038243804567

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
methyl (1R,12S,19R)-12-[(1R)-1-hydroxyethyl]-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,9,13-pentaene-10-carboxylate

> <ALOGPS_LOGP>
2.64

> <JCHEM_LOGP>
1.1213814133333333

> <ALOGPS_LOGS>
-2.89

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
14.901557459384243

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.56383520946557

> <JCHEM_PKA_STRONGEST_BASIC>
8.566305975589364

> <JCHEM_POLAR_SURFACE_AREA>
71.03

> <JCHEM_REFRACTIVITY>
109.30350000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
4.95e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
methyl (1R,12S,19R)-12-[(1R)-1-hydroxyethyl]-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,9,13-pentaene-10-carboxylate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      10.133   2.258   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      11.223   1.170   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.826  -0.318   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       9.339  -0.718   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       8.249   0.370   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       8.646   1.858   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.878  -0.331   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       7.120  -1.852   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       5.924  -2.822   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.486  -2.272   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       4.244  -0.751   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       5.439   0.220   0.000  0.00  0.00           C+0
HETATM   13  N   UNK     0       5.197   1.740   0.000  0.00  0.00           N+0
HETATM   14  C   UNK     0       3.759   2.291   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.563   1.320   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       2.805  -0.200   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       7.005   2.158   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       7.846   0.867   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       3.048  -1.721   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.609  -1.171   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0       3.290  -3.242   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       6.167  -4.343   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       4.971  -5.313   0.000  0.00  0.00           O+0
HETATM   24  O   UNK     0       7.605  -4.893   0.000  0.00  0.00           O+0
HETATM   25  C   UNK     0       7.848  -6.414   0.000  0.00  0.00           C+0
HETATM   26  N   UNK     0       8.641  -2.091   0.000  0.00  0.00           N+0
HETATM   27  O   UNK     0      12.710   1.570   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0      13.107   3.058   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3   27                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   26                                                  
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8   12   18                                             
CONECT    8    7    9   26                                                  
CONECT    9    8   10   22                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   16   19                                             
CONECT   12   11    7   13                                                  
CONECT   13   12   14   17                                                  
CONECT   14   13   15                                                       
CONECT   15   14   16                                                       
CONECT   16   15   11                                                       
CONECT   17   13   18                                                       
CONECT   18   17    7                                                       
CONECT   19   11   20   21                                                  
CONECT   20   19                                                            
CONECT   21   19                                                            
CONECT   22    9   23   24                                                  
CONECT   23   22                                                            
CONECT   24   22   25                                                       
CONECT   25   24                                                            
CONECT   26    8    4                                                       
CONECT   27    2   28                                                       
CONECT   28   27                                                            
MASTER        0    0    0    0    0    0    0    0   28    0   64    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₂₂H₂₆N₂O₄

Average Mass

382.4600 Da

Monoisotopic Mass

382.18926 Da

IUPAC Name

methyl (1R,12S,19R)-12-[(1R)-1-hydroxyethyl]-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,9,13-pentaene-10-carboxylate

Traditional Name

methyl (1R,12S,19R)-12-[(1R)-1-hydroxyethyl]-5-methoxy-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2,4,6,9,13-pentaene-10-carboxylate

CAS Registry Number

Not Available

SMILES

COC(=O)C1=C2NC3=CC(OC)=CC=C3[C@@]22CCN3CC=C[C@](C1)([C@@H](C)O)[C@@H]23

InChI Identifier

InChI=1S/C22H26N2O4/c1-13(25)21-7-4-9-24-10-8-22(20(21)24)16-6-5-14(27-2)11-17(16)23-18(22)15(12-21)19(26)28-3/h4-7,11,13,20,23,25H,8-10,12H2,1-3H3/t13-,20+,21+,22+/m1/s1

InChI Key

ASAFZNAXYPDIJR-MCLJMYSDSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Alstonia yunnanensis	Plant	KNApSAcK
Catharanthus roseus	Plant	KNApSAcK
Melodinus suaveolens	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as plumeran-type alkaloids. These are alkaloids with a structure based on the plumeran skeleton. Plumeran is a pentacyclic compound that consists of a pyrrolidine ring shed to the quinoline moiety of pyrido[3,2-c]carbazole ring system.

Kingdom

Organic compounds

Super Class

Alkaloids and derivatives

Class

Plumeran-type alkaloids

Sub Class

Not Available

Direct Parent

Plumeran-type alkaloids

Alternative Parents

Substituents

Plumeran-type alkaloid
Carbazole
Indole or derivatives
Dihydroindole
Anisole
Phenol ether
Alkyl aryl ether
Aralkylamine
Secondary aliphatic/aromatic amine
Benzenoid
N-alkylpyrrolidine
1,3-aminoalcohol
Vinylogous amide
Pyrrolidine
Alpha,beta-unsaturated carboxylic ester
Methyl ester
Enoate ester
Secondary alcohol
Amino acid or derivatives
Tertiary aliphatic amine
Tertiary amine
Carboxylic acid ester
Organoheterocyclic compound
Secondary amine
Monocarboxylic acid or derivatives
Azacycle
Carboxylic acid derivative
Ether
Enamine
Organic oxygen compound
Hydrocarbon derivative
Carbonyl group
Organic oxide
Amine
Organonitrogen compound
Organooxygen compound
Alcohol
Organic nitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.64	ALOGPS
logP	1.12	ChemAxon
logS	-2.9	ALOGPS
pKa (Strongest Acidic)	13.56	ChemAxon
pKa (Strongest Basic)	8.57	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	71.03 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	109.3 m³·mol⁻¹	ChemAxon
Polarizability	41.4 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00024499

Chemspider ID

28424488

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

70691524

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for 19R-Hydroxy-11-methoxy-tabersonine (NP0066849)

MOL for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

3D MOL for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

3D SDF for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

3D-SDF for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

PDB for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

3D PDB for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

SMILES for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

INCHI for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

Structure for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)

3D Structure for NP0066849 (19R-Hydroxy-11-methoxy-tabersonine)