NP-MRD: Showing NP-Card for Swietenin E (NP0066540)

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Record Information

Version

2.0

Created at

2022-04-28 10:47:38 UTC

Updated at

2022-04-28 10:47:38 UTC

NP-MRD ID

NP0066540

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Swietenin E

Description

(1R,2S,5R,6R,10S,13S,14R,16S)-6-(furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0²,¹¹.0⁵,¹⁰]Heptadec-11-en-14-yl (2R)-2-methylbutanoate belongs to the class of organic compounds known as naphthopyrans. Naphthopyrans are compounds containing a pyran ring fused to a naphthalene moiety. Furan is a 6 membered-ring non-aromatic ring with five carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings. Swietenin E is found in Swietenia mahagoni and Swietenia mahagoni JACQ. . Based on a literature review very few articles have been published on (1R,2S,5R,6R,10S,13S,14R,16S)-6-(furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0²,¹¹.0⁵,¹⁰]Heptadec-11-en-14-yl (2R)-2-methylbutanoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI


  Mrv1652304282212472D          

 41 45  0  0  1  0            999 V2000
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M  END

     RDKit          3D

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M  END


  Mrv1652304282212472D          

 41 45  0  0  1  0            999 V2000
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    0.9213    4.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0970    4.4098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1254    5.2042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5615    5.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2084    5.1493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7447    4.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6856    4.9330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    4.2863    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.8312    5.0958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0505    5.3624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4525    5.6385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2931    6.4480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7713    4.0196    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3958    3.2761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467    2.5479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8095    1.6013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5428    0.8206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7334    0.6612    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0856    0.1993    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.8189   -0.5814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3617   -1.2028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8950    0.3587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  1  8  1  0  0  0  0
  8  9  1  1  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
 11  6  1  6  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  5 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 11 19  1  0  0  0  0
 15 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 24  2  0  0  0  0
 12 25  1  1  0  0  0
  4 26  1  1  0  0  0
  3 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 27 32  1  6  0  0  0
  2 33  1  0  0  0  0
  2 34  1  0  0  0  0
  1 35  1  6  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 38 41  1  6  0  0  0
M  END
> <DATABASE_ID>
NP0066540

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC[C@@H](C)C(=O)O[C@@H]1[C@@H]2C=C3[C@H](CC[C@]4(C)[C@H]3CC(=O)O[C@H]4C3=COC=C3)[C@](C)([C@@H]([C@@H](O)C(=O)OC)C1(C)C)C2=O

> <INCHI_IDENTIFIER>
InChI=1S/C32H42O9/c1-8-16(2)28(36)41-27-19-13-18-20(32(6,25(19)35)24(30(27,3)4)23(34)29(37)38-7)9-11-31(5)21(18)14-22(33)40-26(31)17-10-12-39-15-17/h10,12-13,15-16,19-21,23-24,26-27,34H,8-9,11,14H2,1-7H3/t16-,19-,20+,21+,23-,24+,26+,27-,31-,32-/m1/s1

> <INCHI_KEY>
AKVIKOHFNOZMCC-DWYXJJPNSA-N

> <FORMULA>
C32H42O9

> <MOLECULAR_WEIGHT>
570.679

> <EXACT_MASS>
570.282882932

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
83

> <JCHEM_AVERAGE_POLARIZABILITY>
60.1882599559709

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(1R,2S,5R,6R,10S,13S,14R,16S)-6-(furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadec-11-en-14-yl (2R)-2-methylbutanoate

> <ALOGPS_LOGP>
3.09

> <JCHEM_LOGP>
4.416998584333333

> <ALOGPS_LOGS>
-4.30

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
5

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
13.831554135720854

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.397966178209739

> <JCHEM_PKA_STRONGEST_BASIC>
-2.8887511667229964

> <JCHEM_POLAR_SURFACE_AREA>
129.34000000000003

> <JCHEM_REFRACTIVITY>
147.29900000000004

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
2.86e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2S,5R,6R,10S,13S,14R,16S)-6-(furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadec-11-en-14-yl (2R)-2-methylbutanoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       9.831   4.149   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      10.515   5.529   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      10.023   6.988   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       8.643   7.672   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       7.184   7.179   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       6.500   5.800   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       6.992   4.340   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       8.372   3.657   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       9.009   5.630   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0      10.191   4.643   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       4.963   5.702   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       4.110   6.984   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.794   8.364   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.331   8.462   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.573   6.886   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       1.889   5.506   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       2.742   4.224   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       2.059   2.844   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       4.279   4.322   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       1.720   8.168   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       0.181   8.232   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      -0.234   9.715   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0       1.048  10.568   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0       2.256   9.612   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       3.257   8.266   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       8.747   9.208   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      11.183   8.001   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0      10.885   9.512   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       9.428  10.010   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0      12.045  10.525   0.000  0.00  0.00           O+0
HETATM   31  C   UNK     0      11.747  12.036   0.000  0.00  0.00           C+0
HETATM   32  O   UNK     0      12.640   7.503   0.000  0.00  0.00           O+0
HETATM   33  C   UNK     0      11.939   6.115   0.000  0.00  0.00           C+0
HETATM   34  C   UNK     0      11.847   4.756   0.000  0.00  0.00           C+0
HETATM   35  O   UNK     0      10.844   2.989   0.000  0.00  0.00           O+0
HETATM   36  C   UNK     0      10.347   1.532   0.000  0.00  0.00           C+0
HETATM   37  O   UNK     0       8.836   1.234   0.000  0.00  0.00           O+0
HETATM   38  C   UNK     0      11.360   0.372   0.000  0.00  0.00           C+0
HETATM   39  C   UNK     0      10.862  -1.085   0.000  0.00  0.00           C+0
HETATM   40  C   UNK     0      11.875  -2.245   0.000  0.00  0.00           C+0
HETATM   41  C   UNK     0      12.871   0.670   0.000  0.00  0.00           C+0
CONECT    1    2    8   35                                                  
CONECT    2    1    3   33   34                                             
CONECT    3    2    4   27                                                  
CONECT    4    3    5    9   26                                             
CONECT    5    4    6   14                                                  
CONECT    6    5    7   11                                                  
CONECT    7    6    8                                                       
CONECT    8    7    1    9                                                  
CONECT    9    8    4   10                                                  
CONECT   10    9                                                            
CONECT   11    6   12   19                                                  
CONECT   12   11   13   15   25                                             
CONECT   13   12   14                                                       
CONECT   14   13    5                                                       
CONECT   15   12   16   20                                                  
CONECT   16   15   17                                                       
CONECT   17   16   18   19                                                  
CONECT   18   17                                                            
CONECT   19   17   11                                                       
CONECT   20   15   21   24                                                  
CONECT   21   20   22                                                       
CONECT   22   21   23                                                       
CONECT   23   22   24                                                       
CONECT   24   23   20                                                       
CONECT   25   12                                                            
CONECT   26    4                                                            
CONECT   27    3   28   32                                                  
CONECT   28   27   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28   31                                                       
CONECT   31   30                                                            
CONECT   32   27                                                            
CONECT   33    2                                                            
CONECT   34    2                                                            
CONECT   35    1   36                                                       
CONECT   36   35   37   38                                                  
CONECT   37   36                                                            
CONECT   38   36   39   41                                                  
CONECT   39   38   40                                                       
CONECT   40   39                                                            
CONECT   41   38                                                            
MASTER        0    0    0    0    0    0    0    0   41    0   90    0
END

View in JSmol

Synonyms

Value	Source
(1R,2S,5R,6R,10S,13S,14R,16S)-6-(Furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0,.0,]heptadec-11-en-14-yl (2R)-2-methylbutanoic acid	Generator

Chemical Formula

C₃₂H₄₂O₉

Average Mass

570.6790 Da

Monoisotopic Mass

570.28288 Da

IUPAC Name

(1R,2S,5R,6R,10S,13S,14R,16S)-6-(furan-3-yl)-16-[(1R)-1-hydroxy-2-methoxy-2-oxoethyl]-1,5,15,15-tetramethyl-8,17-dioxo-7-oxatetracyclo[11.3.1.0^{2,11}.0^{5,10}]heptadec-11-en-14-yl (2R)-2-methylbutanoate

Traditional Name

CAS Registry Number

Not Available

SMILES

CC[C@@H](C)C(=O)O[C@@H]1[C@@H]2C=C3[C@H](CC[C@]4(C)[C@H]3CC(=O)O[C@H]4C3=COC=C3)[C@](C)([C@@H]([C@@H](O)C(=O)OC)C1(C)C)C2=O

InChI Identifier

InChI=1S/C32H42O9/c1-8-16(2)28(36)41-27-19-13-18-20(32(6,25(19)35)24(30(27,3)4)23(34)29(37)38-7)9-11-31(5)21(18)14-22(33)40-26(31)17-10-12-39-15-17/h10,12-13,15-16,19-21,23-24,26-27,34H,8-9,11,14H2,1-7H3/t16-,19-,20+,21+,23-,24+,26+,27-,31-,32-/m1/s1

InChI Key

AKVIKOHFNOZMCC-DWYXJJPNSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Swietenia mahagoni	LOTUS Database	35616633
Swietenia mahagoni JACQ.	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthopyrans. Naphthopyrans are compounds containing a pyran ring fused to a naphthalene moiety. Furan is a 6 membered-ring non-aromatic ring with five carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthopyrans

Sub Class

Not Available

Direct Parent

Naphthopyrans

Alternative Parents

Substituents

Naphthopyran
Naphthalene
Tricarboxylic acid or derivatives
Delta valerolactone
Fatty acid ester
Cyclohexenone
Delta_valerolactone
Oxane
Pyran
Fatty acyl
Heteroaromatic compound
Furan
Methyl ester
Lactone
Ketone
Carboxylic acid ester
Secondary alcohol
Oxacycle
Carboxylic acid derivative
Alcohol
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.09	ALOGPS
logP	4.42	ChemAxon
logS	-4.3	ALOGPS
pKa (Strongest Acidic)	12.4	ChemAxon
pKa (Strongest Basic)	-2.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	129.34 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	147.3 m³·mol⁻¹	ChemAxon
Polarizability	60.19 Å³	ChemAxon
Number of Rings	5	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163073249

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Swietenin E (NP0066540)

MOL for NP0066540 (Swietenin E)

3D MOL for NP0066540 (Swietenin E)

3D SDF for NP0066540 (Swietenin E)

3D-SDF for NP0066540 (Swietenin E)

PDB for NP0066540 (Swietenin E)

3D PDB for NP0066540 (Swietenin E)

SMILES for NP0066540 (Swietenin E)

INCHI for NP0066540 (Swietenin E)

Structure for NP0066540 (Swietenin E)

3D Structure for NP0066540 (Swietenin E)