NP-MRD: Showing NP-Card for 8-Chloro-3',4',5,7-tetrahydroxyisoflavone (NP0061920)

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Record Information

Version

2.0

Created at

2022-04-28 06:36:40 UTC

Updated at

2022-04-28 06:36:40 UTC

NP-MRD ID

NP0061920

Secondary Accession Numbers

None

Natural Product Identification

Common Name

8-Chloro-3',4',5,7-tetrahydroxyisoflavone

Description

8-Chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one belongs to the class of organic compounds known as isoflavones. These are polycyclic compounds containing a 2-isoflavene skeleton which bears a ketone group at the C4 carbon atom. 8-Chloro-3',4',5,7-tetrahydroxyisoflavone is found in Streptomyces sp. OH-1049. 8-Chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one is an extremely weak basic (essentially neutral) compound (based on its pKa).

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 31 33  0  0  0  0  0  0  0  0999 V2000
    0.2824   -0.0100    1.6352 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6377   -0.0147    0.4467 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2879    0.0701   -0.5727 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7260    0.1693   -0.3003 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5259    1.0742   -0.9701 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8766    1.1715   -0.7182 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5146    0.3646    0.2250 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8828    0.5082    0.4366 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7170   -0.5362    0.8915 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3030   -1.3688    1.8463 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3448   -0.6322    0.6329 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2014    0.0576   -1.8694 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4785   -0.0297   -2.1560 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3766   -0.1112   -1.2136 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7100   -0.2016   -1.5512 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2425   -0.2105   -3.2318 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.6318   -0.2866   -0.5126 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9746   -0.3772   -0.8813 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2289   -0.2806    0.8039 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8965   -0.1903    1.1446 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4378   -0.1802    2.4544 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9787   -0.1057    0.1063 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0464    1.7082   -1.7057 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5010    1.8891   -1.2520 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4356   -0.0192    1.0879 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2772   -1.3365    2.0645 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7787   -1.3494    1.1811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5613    0.1266   -2.6601 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.7153   -0.4429   -0.1877 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9663   -0.3474    1.5682 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.0202   -0.2365    3.2575 H   0  0  0  0  0  0  0  0  0  0  0  0
  8  7  1  0
  7  6  2  0
  6  5  1  0
  5  4  2  0
  4 11  1  0
 11  9  2  0
  9 10  1  0
  4  3  1  0
  3 12  2  0
 12 13  1  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 15 17  1  0
 17 18  1  0
 17 19  2  0
 19 20  1  0
 20 21  1  0
 20 22  2  0
 22  2  1  0
  2  1  2  0
  9  7  1  0
  2  3  1  0
 22 14  1  0
  8 25  1  0
  6 24  1  0
  5 23  1  0
 11 27  1  0
 10 26  1  0
 12 28  1  0
 18 29  1  0
 19 30  1  0
 21 31  1  0
M  END


  Mrv1533004161519182D          

 22 24  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0061920

> <DATABASE_NAME>
NP-MRD

> <SMILES>
OC1=CC=C(C=C1O)C1=COC2=C(Cl)C(O)=CC(O)=C2C1=O

> <INCHI_IDENTIFIER>
InChI=1S/C15H9ClO6/c16-13-11(20)4-10(19)12-14(21)7(5-22-15(12)13)6-1-2-8(17)9(18)3-6/h1-5,17-20H

> <INCHI_KEY>
PXEKXMKLPKBART-UHFFFAOYSA-N

> <FORMULA>
C15H9ClO6

> <MOLECULAR_WEIGHT>
320.68

> <EXACT_MASS>
320.0087657

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
31

> <JCHEM_AVERAGE_POLARIZABILITY>
29.731125119249075

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
8-chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

> <ALOGPS_LOGP>
3.31

> <JCHEM_LOGP>
3.3773517443333327

> <ALOGPS_LOGS>
-3.79

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
7.673584376439026

> <JCHEM_PKA_STRONGEST_ACIDIC>
5.197709464630764

> <JCHEM_PKA_STRONGEST_BASIC>
-5.390889420053926

> <JCHEM_POLAR_SURFACE_AREA>
107.22

> <JCHEM_REFRACTIVITY>
78.4686

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
5.16e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
8-chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 16-APR-15   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   16-APR-15         0                                  
HETATM    1  O   UNK     0      -4.001  -5.390   0.000  0.00  0.00           O+0
HETATM    2  C   UNK     0      -2.667  -4.620   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.667  -3.080   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000  -3.080   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000  -4.620   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -1.334  -5.390   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0      -1.334  -6.930   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       2.667   0.000   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       5.335   0.000   0.000  0.00  0.00           C+0
HETATM   14 Cl   UNK     0       5.335   1.540   0.000  0.00  0.00          Cl+0
HETATM   15  C   UNK     0       6.668  -0.770   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       8.002  -0.000   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       6.668  -2.310   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       5.335  -3.080   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0       5.335  -4.620   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   22  O   UNK     0       2.667  -4.620   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    7                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    9                                                  
CONECT    6    5    7                                                       
CONECT    7    6    2    8                                                  
CONECT    8    7                                                            
CONECT    9    5   10   21                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12                                                       
CONECT   12   11   13   20                                                  
CONECT   13   12   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18                                                            
CONECT   20   18   12   21                                                  
CONECT   21   20    9   22                                                  
CONECT   22   21                                                            
MASTER        0    0    0    0    0    0    0    0   22    0   48    0
END

View in JSmol

Synonyms

Value	Source
8-CTHIF	MeSH

Chemical Formula

C₁₅H₉ClO₆

Average Mass

320.6800 Da

Monoisotopic Mass

320.00877 Da

IUPAC Name

8-chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

Traditional Name

8-chloro-3-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one

CAS Registry Number

Not Available

SMILES

OC1=CC=C(C=C1O)C1=COC2=C(Cl)C(O)=CC(O)=C2C1=O

InChI Identifier

InChI=1S/C15H9ClO6/c16-13-11(20)4-10(19)12-14(21)7(5-22-15(12)13)6-1-2-8(17)9(18)3-6/h1-5,17-20H

InChI Key

PXEKXMKLPKBART-UHFFFAOYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Streptomyces sp. OH-1049	Bacteria	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as isoflavones. These are polycyclic compounds containing a 2-isoflavene skeleton which bears a ketone group at the C4 carbon atom.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Isoflavonoids

Sub Class

Isoflav-2-enes

Direct Parent

Isoflavones

Alternative Parents

Substituents

Hydroxyisoflavonoid
Isoflavone
Chromone
Benzopyran
1-benzopyran
Catechol
4-halophenol
2-halophenol
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Pyranone
Pyran
Monocyclic benzene moiety
Aryl halide
Aryl chloride
Benzenoid
Heteroaromatic compound
Vinylogous acid
Oxacycle
Organoheterocyclic compound
Organooxygen compound
Organochloride
Organohalogen compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.31	ALOGPS
logP	3.38	ChemAxon
logS	-3.8	ALOGPS
pKa (Strongest Acidic)	5.2	ChemAxon
pKa (Strongest Basic)	-5.4	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	107.22 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	78.47 m³·mol⁻¹	ChemAxon
Polarizability	29.73 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

5486848

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for 8-Chloro-3',4',5,7-tetrahydroxyisoflavone (NP0061920)

MOL for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

3D MOL for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

3D SDF for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

3D-SDF for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

PDB for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

3D PDB for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

SMILES for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

INCHI for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

Structure for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)

3D Structure for NP0061920 (8-Chloro-3',4',5,7-tetrahydroxyisoflavone)