NP-MRD: Showing NP-Card for Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide (NP0061718)

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Record Information

Version

2.0

Created at

2022-04-28 06:26:56 UTC

Updated at

2022-04-28 06:26:56 UTC

NP-MRD ID

NP0061718

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide

Description

CHEMBL2252625 belongs to the class of organic compounds known as naphthofurans. Naphthofurans are compounds containing a furan ring fused to a naphthalene moiety. Furan is a 5 membered- ring aromatic ring with four carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings. Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide is found in Ligularia fauriei, Ligularia macrophylla and Ligularia przewalskii. Based on a literature review very few articles have been published on CHEMBL2252625.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 37 40  0  0  0  0  0  0  0  0999 V2000
    3.3566    1.6144    0.3535 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8203    0.1999    0.4623 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8042   -0.3064   -0.1571 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6029   -1.7028    0.2080 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.2233   -1.9447    0.7354 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8674   -1.3016   -0.0594 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.0365   -1.1599    0.9225 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9990   -0.0859    0.4982 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3511    1.2756    0.3877 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8893    1.1121    0.1874 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2258    2.2165   -0.5058 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5581    3.4364   -0.5310 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8720    1.6677   -1.1537 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8356    0.2628   -1.1258 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.5849   -0.0535   -0.7645 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4033    0.0974   -2.0457 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5940   -1.9596    1.1638 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3725   -0.8293    1.3321 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3866   -0.6858    2.0960 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6428    1.8511   -0.6797 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1603    1.7773    1.0780 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4920    2.2664    0.6164 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7884   -2.4111   -0.6299 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2065   -1.6162    1.7962 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0566   -3.0417    0.7498 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2334   -2.0617   -0.8119 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6545   -0.8945    1.9344 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5991   -2.0934    1.0314 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5587   -0.3625   -0.4193 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7573   -0.0068    1.3060 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8363    1.8930   -0.3945 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4940    1.8617    1.3438 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4026    0.8354    1.1534 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.0470   -0.1821   -2.1187 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7550    0.1589   -2.9447 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0263    1.0010   -2.0408 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0293   -0.8279   -2.2091 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  6  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 11 13  1  0
 13 14  1  0
 14 15  1  0
 15 16  1  6
  4 17  1  0
 17 18  1  0
 18 19  2  0
 18  2  1  0
 14  3  1  0
 15  6  1  0
 15 10  1  0
  1 20  1  0
  1 21  1  0
  1 22  1  0
  4 23  1  6
  5 24  1  0
  5 25  1  0
  6 26  1  6
  7 27  1  0
  7 28  1  0
  8 29  1  0
  8 30  1  0
  9 31  1  0
  9 32  1  0
 10 33  1  1
 14 34  1  6
 16 35  1  0
 16 36  1  0
 16 37  1  0
M  END


  Mrv1652304282208262D          

 19 22  0  0  1  0            999 V2000
   -0.5974   -0.5081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4718   -1.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -1.6224    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.9405   -1.1059    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8149   -0.2905    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0459    0.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7238    0.0892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4138   -0.3630    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3671   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1361   -1.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6580   -0.8467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4817   -0.8933    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2116   -0.1529    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3462   -2.2834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6305   -1.5581    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.4136   -2.3541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5895   -2.3938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.0838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6343   -0.6595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  6  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
  8 13  1  6  0  0  0
 10 14  1  0  0  0  0
  9 15  1  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
  3 17  1  1  0  0  0
 17 18  2  0  0  0  0
  4 19  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0061718

> <DATABASE_NAME>
NP-MRD

> <SMILES>
CC1=C2[C@H](C[C@H]3CCC[C@@H]4C(=O)O[C@@H]2[C@@]34C)OC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C15H18O4/c1-7-11-10(18-13(7)16)6-8-4-3-5-9-14(17)19-12(11)15(8,9)2/h8-10,12H,3-6H2,1-2H3/t8-,9-,10+,12+,15+/m1/s1

> <INCHI_KEY>
XTSBENNQJJYWQF-HGBDMZGYSA-N

> <FORMULA>
C15H18O4

> <MOLECULAR_WEIGHT>
262.305

> <EXACT_MASS>
262.12050906

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
37

> <JCHEM_AVERAGE_POLARIZABILITY>
26.94700854044087

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,6S,8R,12S,15S)-3,15-dimethyl-5,14-dioxatetracyclo[6.6.1.0^{2,6}.0^{12,15}]pentadec-2-ene-4,13-dione

> <ALOGPS_LOGP>
2.49

> <JCHEM_LOGP>
2.207276302666667

> <ALOGPS_LOGS>
-2.62

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
12.401953980651967

> <JCHEM_PKA_STRONGEST_BASIC>
-6.6850407715046005

> <JCHEM_POLAR_SURFACE_AREA>
52.6

> <JCHEM_REFRACTIVITY>
66.70940000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.24e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,6S,8R,12S,15S)-3,15-dimethyl-5,14-dioxatetracyclo[6.6.1.0^{2,6}.0^{12,15}]pentadec-2-ene-4,13-dione

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -1.115  -0.948   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -0.881  -2.470   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.555  -3.028   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.756  -2.064   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       1.521  -0.542   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.086   0.016   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.218   0.167   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.506  -0.678   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.419  -2.215   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       5.854  -2.773   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.828  -1.580   0.000  0.00  0.00           C+0
HETATM   12  O   UNK     0       8.366  -1.668   0.000  0.00  0.00           O+0
HETATM   13  O   UNK     0       5.995  -0.285   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       6.246  -4.262   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       3.044  -2.909   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       2.639  -4.394   0.000  0.00  0.00           O+0
HETATM   17  C   UNK     0       1.100  -4.468   0.000  0.00  0.00           C+0
HETATM   18  O   UNK     0       0.256  -5.756   0.000  0.00  0.00           O+0
HETATM   19  C   UNK     0       3.051  -1.231   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4   17                                                  
CONECT    4    3    5   15   19                                             
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8                                                       
CONECT    8    7    9   13                                                  
CONECT    9    8   10   15                                                  
CONECT   10    9   11   14                                                  
CONECT   11   10   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11    8                                                       
CONECT   14   10                                                            
CONECT   15    9    4   16                                                  
CONECT   16   15   17                                                       
CONECT   17   16    3   18                                                  
CONECT   18   17                                                            
CONECT   19    4                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   44    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₁₈O₄

Average Mass

262.3050 Da

Monoisotopic Mass

262.12051 Da

IUPAC Name

(1R,6S,8R,12S,15S)-3,15-dimethyl-5,14-dioxatetracyclo[6.6.1.0^{2,6}.0^{12,15}]pentadec-2-ene-4,13-dione

Traditional Name

(1R,6S,8R,12S,15S)-3,15-dimethyl-5,14-dioxatetracyclo[6.6.1.0^{2,6}.0^{12,15}]pentadec-2-ene-4,13-dione

CAS Registry Number

Not Available

SMILES

CC1=C2[C@H](C[C@H]3CCC[C@@H]4C(=O)O[C@@H]2[C@@]34C)OC1=O

InChI Identifier

InChI=1S/C15H18O4/c1-7-11-10(18-13(7)16)6-8-4-3-5-9-14(17)19-12(11)15(8,9)2/h8-10,12H,3-6H2,1-2H3/t8-,9-,10+,12+,15+/m1/s1

InChI Key

XTSBENNQJJYWQF-HGBDMZGYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Ligularia fauriei	Plant	KNApSAcK
Ligularia macrophylla	LOTUS Database	35616633
Ligularia przewalskii	LOTUS Database	35616633

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as naphthofurans. Naphthofurans are compounds containing a furan ring fused to a naphthalene moiety. Furan is a 5 membered- ring aromatic ring with four carbon and one oxygen atoms. Naphthalene is a polycyclic aromatic hydrocarbon made up of two fused benzene rings.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Naphthofurans

Sub Class

Not Available

Direct Parent

Naphthofurans

Alternative Parents

Substituents

Naphthofuran
2-furanone
Dicarboxylic acid or derivatives
Gamma butyrolactone
Dihydrofuran
Oxolane
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Lactone
Carboxylic acid ester
Oxacycle
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organic oxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.49	ALOGPS
logP	2.21	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Acidic)	12.4	ChemAxon
pKa (Strongest Basic)	-6.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	52.6 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	66.71 m³·mol⁻¹	ChemAxon
Polarizability	26.95 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

30847795

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

12095918

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide (NP0061718)

MOL for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

3D MOL for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

3D SDF for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

3D-SDF for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

PDB for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

3D PDB for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

SMILES for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

INCHI for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

Structure for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)

3D Structure for NP0061718 (Eremophil-7(11)-en-6alpha,15:8alpha,12-diolide)