NP-MRD: Showing NP-Card for [3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one (NP0061710)

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Record Information

Version

2.0

Created at

2022-04-28 06:26:36 UTC

Updated at

2022-04-28 06:26:36 UTC

NP-MRD ID

NP0061710

Secondary Accession Numbers

None

Natural Product Identification

Common Name

[3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one

Description

Xanthanodiene belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring. [3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one is found in Cassinia uncata, Ratibida columnifera and Xanthium canadense. [3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one was first documented in 2016 (PMID: 26936835). Based on a literature review very few articles have been published on Xanthanodiene.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 37 39  0  0  0  0  0  0  0  0999 V2000
    3.1862   -0.8185   -1.4555 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7937    0.2945   -0.8760 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6398    1.0917    0.0111 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8584    0.9102    0.2991 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8981    2.1516    0.5422 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5443    1.7336    0.4067 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2025    0.7091    1.4736 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2032    0.3300    1.1984 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1077    0.5839    2.1240 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5595    0.2459    1.9580 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7698   -0.6721    0.7724 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9552   -0.1003   -0.3697 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.3947   -0.5853   -1.7091 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4775   -0.3087   -0.1102 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.1610   -1.7981    0.0591 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3481    0.1998   -1.2294 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5078    1.0304   -0.9230 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1841   -1.2351   -1.3162 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5426   -1.3964   -2.1117 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8228    2.5491    0.3975 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.3201    1.1884    2.4659 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8661   -0.1796    1.3928 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8603    1.0614    3.0830 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0794    1.2088    1.6921 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0156   -0.1354    2.8761 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4244   -1.6740    1.0816 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8161   -0.7495    0.4852 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1151    1.0036   -0.3387 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4704   -0.8597   -1.6707 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3353    0.2282   -2.4883 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7735   -1.4276   -2.0992 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7614   -2.0814   -0.4897 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.0105   -2.0643    1.1222 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9756   -2.4262   -0.3514 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6641   -0.6514   -1.9039 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3357    0.7996   -1.9046 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.6791    1.8438   -1.6945 H   0  0  0  0  0  0  0  0  0  0  0  0
 13 12  1  0
 12 11  1  0
 11 10  1  0
 10  9  1  0
  9  8  2  0
  8  7  1  0
  7  6  1  0
  6  5  1  0
  5  3  1  0
  3  4  2  0
  3  2  1  0
  2  1  2  3
  2 17  1  0
 17 16  1  0
 16 14  1  0
 14 15  1  1
 14 12  1  0
 14  8  1  0
 17  6  1  0
 13 29  1  0
 13 30  1  0
 13 31  1  0
 12 28  1  6
 11 26  1  0
 11 27  1  0
 10 24  1  0
 10 25  1  0
  9 23  1  0
  7 21  1  0
  7 22  1  0
  6 20  1  6
  1 18  1  0
  1 19  1  0
 17 37  1  6
 16 35  1  0
 16 36  1  0
 15 32  1  0
 15 33  1  0
 15 34  1  0
M  END


  Mrv1652304282208262D          

 17 19  0  0  1  0            999 V2000
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  1  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
  8 15  1  1  0  0  0
  4 16  1  1  0  0  0
  3 17  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0061710

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1CCC=C2C[C@H]3OC(=O)C(=C)[C@H]3C[C@]12C

> <INCHI_IDENTIFIER>
InChI=1S/C15H20O2/c1-9-5-4-6-11-7-13-12(8-15(9,11)3)10(2)14(16)17-13/h6,9,12-13H,2,4-5,7-8H2,1,3H3/t9-,12+,13+,15+/m0/s1

> <INCHI_KEY>
JCQHNWRLZMISTB-XRFFLINXSA-N

> <FORMULA>
C15H20O2

> <MOLECULAR_WEIGHT>
232.323

> <EXACT_MASS>
232.146329884

> <JCHEM_ACCEPTOR_COUNT>
1

> <JCHEM_ATOM_COUNT>
37

> <JCHEM_AVERAGE_POLARIZABILITY>
25.994773372027325

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3aR,4aR,5S,9aR)-4a,5-dimethyl-3-methylidene-2H,3H,3aH,4H,4aH,5H,6H,7H,9H,9aH-naphtho[2,3-b]furan-2-one

> <ALOGPS_LOGP>
3.77

> <JCHEM_LOGP>
3.3000416516666675

> <ALOGPS_LOGS>
-3.58

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_BASIC>
-6.86534050298953

> <JCHEM_POLAR_SURFACE_AREA>
26.3

> <JCHEM_REFRACTIVITY>
67.2699

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.12e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3aR,4aR,5S,9aR)-4a,5-dimethyl-3-methylidene-3aH,4H,5H,6H,7H,9H,9aH-naphtho[2,3-b]furan-2-one

> <JCHEM_VEBER_RULE>
1

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       8.925   2.073   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       8.925   3.613   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       7.591   4.383   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       6.258   3.613   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.258   2.073   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.591   1.303   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.924   1.303   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       3.590   2.073   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.590   3.613   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.924   4.383   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.126   4.089   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       1.650   5.553   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       1.220   2.843   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      -0.320   2.843   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0       2.126   1.597   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       6.258   5.153   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       7.591   5.923   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3                                                       
CONECT    3    2    4   17                                                  
CONECT    4    3    5   10   16                                             
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5    8                                                       
CONECT    8    7    9   15                                                  
CONECT    9    8   10   11                                                  
CONECT   10    9    4                                                       
CONECT   11    9   12   13                                                  
CONECT   12   11                                                            
CONECT   13   11   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13    8                                                       
CONECT   16    4                                                            
CONECT   17    3                                                            
MASTER        0    0    0    0    0    0    0    0   17    0   38    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₀O₂

Average Mass

232.3230 Da

Monoisotopic Mass

232.14633 Da

IUPAC Name

(3aR,4aR,5S,9aR)-4a,5-dimethyl-3-methylidene-2H,3H,3aH,4H,4aH,5H,6H,7H,9H,9aH-naphtho[2,3-b]furan-2-one

Traditional Name

(3aR,4aR,5S,9aR)-4a,5-dimethyl-3-methylidene-3aH,4H,5H,6H,7H,9H,9aH-naphtho[2,3-b]furan-2-one

CAS Registry Number

Not Available

SMILES

C[C@H]1CCC=C2C[C@H]3OC(=O)C(=C)[C@H]3C[C@]12C

InChI Identifier

InChI=1S/C15H20O2/c1-9-5-4-6-11-7-13-12(8-15(9,11)3)10(2)14(16)17-13/h6,9,12-13H,2,4-5,7-8H2,1,3H3/t9-,12+,13+,15+/m0/s1

InChI Key

JCQHNWRLZMISTB-XRFFLINXSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Cassinia uncata	LOTUS Database	35616633
Ratibida columnaris	LOTUS Database	35616633
Xanthium canadense	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as terpene lactones. These are prenol lipids containing a lactone ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Terpene lactones

Alternative Parents

Substituents

Terpene lactone
Eremophilanolide or secoeremophilanolide
Sesquiterpenoid
Naphthofuran
Gamma butyrolactone
Oxolane
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Lactone
Carboxylic acid ester
Oxacycle
Monocarboxylic acid or derivatives
Organoheterocyclic compound
Carboxylic acid derivative
Organooxygen compound
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.77	ALOGPS
logP	3.3	ChemAxon
logS	-3.6	ALOGPS
pKa (Strongest Basic)	-6.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	26.3 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	67.27 m³·mol⁻¹	ChemAxon
Polarizability	25.99 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00017327

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

14191322

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Olivaro C, Rostan V, Bandera D, Moyna G, Vazquez A: Xanthane sesquiterpenoids from the roots and flowers of Xanthium cavanillesii. Nat Prod Res. 2016 Oct;30(19):2238-42. doi: 10.1080/14786419.2016.1149709. Epub 2016 Mar 2. [PubMed:26936835 ]

Showing NP-Card for [3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one (NP0061710)

MOL for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

3D MOL for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

3D SDF for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

3D-SDF for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

PDB for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

3D PDB for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

SMILES for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

INCHI for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

Structure for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)

3D Structure for NP0061710 ([3aR-(3aalpha,4abeta,5beta,9aalpha)]-3a,4,4a,5,6,7,9,9a-octahydro-4a,5-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one)