NP-MRD: Showing NP-Card for Balantiolide (NP0061271)

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Record Information

Version

2.0

Created at

2022-04-28 06:07:38 UTC

Updated at

2022-04-28 06:07:38 UTC

NP-MRD ID

NP0061271

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Balantiolide

Description

(3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-1,3-dihydro-2-benzofuran-1-one belongs to the class of organic compounds known as benzofuranones. These are organic compounds containing a benzene ring fused to a furanone. Balantiolide is found in Balantiopsis rosea. Based on a literature review very few articles have been published on (3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-1,3-dihydro-2-benzofuran-1-one.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 42 44  0  0  0  0  0  0  0  0999 V2000
   -4.6175    2.2844   -0.7532 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2384    1.0582   -1.2963 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3414    0.1785   -0.7375 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0793   -0.9959   -1.4111 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1804   -1.8952   -0.8668 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9610   -3.0557   -1.5922 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5521   -1.6128    0.3448 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7961   -0.4473    1.0368 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7098    0.4402    0.4597 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9910   -0.4210    2.2776 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.0312    0.7319    2.3683 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8554    0.6965    1.1779 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5750    1.3776    0.0150 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4317    1.3234   -1.0719 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5910    0.5768   -1.0008 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4770    0.4962   -2.0686 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2134    1.1835   -3.2701 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8868   -0.1113    0.1572 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0697   -0.8715    0.2265 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3548   -1.5745    1.4336 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0246   -0.0437    1.2208 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3021   -1.6495    2.2414 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5986   -2.3728    1.1193 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1490   -3.5081    0.7709 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6230    2.5410   -1.1900 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9295    3.1111   -0.9354 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8284    2.1372    0.3441 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5745   -1.2131   -2.3608 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3102   -3.7295   -1.2191 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8947    1.3534    1.0119 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6787   -0.4272    3.1675 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6087    0.5437    3.2575 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5305    1.6901    2.5048 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3266    1.9661   -0.0469 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1818    1.8638   -1.9564 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.4265    0.6507   -3.8633 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8503    2.2155   -3.0758 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1117    1.2617   -3.9036 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.6098   -2.3512    1.6567 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3148   -0.8236    2.2691 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.3693   -1.9723    1.4288 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2917   -0.6054    2.1297 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  2  0
  4  5  1  0
  5  6  1  0
  5  7  2  0
  7 23  1  0
 23 24  2  0
 23 22  1  0
 22 10  1  0
 10 11  1  0
 11 12  1  0
 12 21  2  0
 21 18  1  0
 18 19  1  0
 19 20  1  0
 18 15  2  0
 15 16  1  0
 16 17  1  0
 15 14  1  0
 14 13  2  0
 10  8  1  0
  8  9  2  0
  9  3  1  0
  8  7  1  0
 13 12  1  0
  1 25  1  0
  1 26  1  0
  1 27  1  0
  4 28  1  0
  6 29  1  0
 10 31  1  1
 11 32  1  0
 11 33  1  0
 21 42  1  0
 20 39  1  0
 20 40  1  0
 20 41  1  0
 17 36  1  0
 17 37  1  0
 17 38  1  0
 14 35  1  0
 13 34  1  0
  9 30  1  0
M  END


  Mrv1652304282208072D          

 24 26  0  0  1  0            999 V2000
   -1.5371    1.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822    0.4841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441    1.4402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961    0.8271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
  8 17  1  0  0  0  0
 13 18  1  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
  1 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0061271

> <DATABASE_NAME>
NP-MRD

> <SMILES>
COC1=CC(O)=C2C(=O)O[C@@H](CC3=CC(OC)=C(OC)C=C3)C2=C1

> <INCHI_IDENTIFIER>
InChI=1S/C18H18O6/c1-21-11-8-12-15(24-18(20)17(12)13(19)9-11)6-10-4-5-14(22-2)16(7-10)23-3/h4-5,7-9,15,19H,6H2,1-3H3/t15-/m0/s1

> <INCHI_KEY>
FKDLKTRZXXUJIJ-HNNXBMFYSA-N

> <FORMULA>
C18H18O6

> <MOLECULAR_WEIGHT>
330.336

> <EXACT_MASS>
330.1103383

> <JCHEM_ACCEPTOR_COUNT>
5

> <JCHEM_ATOM_COUNT>
42

> <JCHEM_AVERAGE_POLARIZABILITY>
34.14961450259149

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-1,3-dihydro-2-benzofuran-1-one

> <ALOGPS_LOGP>
2.92

> <JCHEM_LOGP>
3.4742723549999988

> <ALOGPS_LOGS>
-3.97

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.452979891829465

> <JCHEM_PKA_STRONGEST_ACIDIC>
9.47459807375189

> <JCHEM_PKA_STRONGEST_BASIC>
-4.068504756103633

> <JCHEM_POLAR_SURFACE_AREA>
74.22000000000001

> <JCHEM_REFRACTIVITY>
87.0462

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
3.54e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-3H-2-benzofuran-1-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -2.869   2.368   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -1.839   3.513   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -0.333   3.192   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.143   1.728   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -0.887   0.583   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -2.393   0.904   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       1.650   1.408   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.126  -0.057   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       3.590  -0.533   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       4.924   0.237   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       6.258  -0.533   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       6.258  -2.073   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       4.924  -2.843   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       3.590  -2.073   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       2.126  -2.549   0.000  0.00  0.00           C+0
HETATM   16  O   UNK     0       1.650  -4.013   0.000  0.00  0.00           O+0
HETATM   17  O   UNK     0       1.220  -1.303   0.000  0.00  0.00           O+0
HETATM   18  O   UNK     0       4.924  -4.383   0.000  0.00  0.00           O+0
HETATM   19  O   UNK     0       7.591   0.237   0.000  0.00  0.00           O+0
HETATM   20  C   UNK     0       8.925  -0.533   0.000  0.00  0.00           C+0
HETATM   21  O   UNK     0      -2.315   4.977   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0      -1.284   6.122   0.000  0.00  0.00           C+0
HETATM   23  O   UNK     0      -4.376   2.688   0.000  0.00  0.00           O+0
HETATM   24  C   UNK     0      -5.406   1.544   0.000  0.00  0.00           C+0
CONECT    1    2    6   23                                                  
CONECT    2    1    3   21                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5    7                                                  
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    4    8                                                       
CONECT    8    7    9   17                                                  
CONECT    9    8   10   14                                                  
CONECT   10    9   11                                                       
CONECT   11   10   12   19                                                  
CONECT   12   11   13                                                       
CONECT   13   12   14   18                                                  
CONECT   14   13    9   15                                                  
CONECT   15   14   16   17                                                  
CONECT   16   15                                                            
CONECT   17   15    8                                                       
CONECT   18   13                                                            
CONECT   19   11   20                                                       
CONECT   20   19                                                            
CONECT   21    2   22                                                       
CONECT   22   21                                                            
CONECT   23    1   24                                                       
CONECT   24   23                                                            
MASTER        0    0    0    0    0    0    0    0   24    0   52    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₈H₁₈O₆

Average Mass

330.3360 Da

Monoisotopic Mass

330.11034 Da

IUPAC Name

(3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-1,3-dihydro-2-benzofuran-1-one

Traditional Name

(3S)-3-[(3,4-dimethoxyphenyl)methyl]-7-hydroxy-5-methoxy-3H-2-benzofuran-1-one

CAS Registry Number

Not Available

SMILES

COC1=CC(O)=C2C(=O)O[C@@H](CC3=CC(OC)=C(OC)C=C3)C2=C1

InChI Identifier

InChI=1S/C18H18O6/c1-21-11-8-12-15(24-18(20)17(12)13(19)9-11)6-10-4-5-14(22-2)16(7-10)23-3/h4-5,7-9,15,19H,6H2,1-3H3/t15-/m0/s1

InChI Key

FKDLKTRZXXUJIJ-HNNXBMFYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Balantiopsis rosea	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as benzofuranones. These are organic compounds containing a benzene ring fused to a furanone.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzofurans

Sub Class

Benzofuranones

Direct Parent

Benzofuranones

Alternative Parents

Substituents

Isobenzofuranone
O-dimethoxybenzene
Dimethoxybenzene
Phthalide
Benzofuranone
Isocoumaran
Phenoxy compound
Methoxybenzene
Phenol ether
Anisole
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Benzenoid
Monocyclic benzene moiety
Vinylogous acid
Lactone
Carboxylic acid ester
Oxacycle
Monocarboxylic acid or derivatives
Ether
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.92	ALOGPS
logP	3.47	ChemAxon
logS	-4	ALOGPS
pKa (Strongest Acidic)	9.47	ChemAxon
pKa (Strongest Basic)	-4.1	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	74.22 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	87.05 m³·mol⁻¹	ChemAxon
Polarizability	34.15 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163010432

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Showing NP-Card for Balantiolide (NP0061271)

MOL for NP0061271 (Balantiolide)

3D MOL for NP0061271 (Balantiolide)

3D SDF for NP0061271 (Balantiolide)

3D-SDF for NP0061271 (Balantiolide)

PDB for NP0061271 (Balantiolide)

3D PDB for NP0061271 (Balantiolide)

SMILES for NP0061271 (Balantiolide)

INCHI for NP0061271 (Balantiolide)

Structure for NP0061271 (Balantiolide)

3D Structure for NP0061271 (Balantiolide)