NP-MRD: Showing NP-Card for 3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid (NP0060082)

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Record Information

Version

2.0

Created at

2022-04-28 05:11:48 UTC

Updated at

2022-04-28 05:11:48 UTC

NP-MRD ID

NP0060082

Secondary Accession Numbers

None

Natural Product Identification

Common Name

3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid

Description

Kaempferol 5-O-glucuronide belongs to the class of organic compounds known as flavonoid o-glucuronides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to glucuronic acid. Thus, kaempferol 5-O-glucuronide is considered to be a flavonoid. Kaempferol 5-O-glucuronide is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. 3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid is found in Leucanthemum vulgare . Based on a literature review very few articles have been published on kaempferol 5-O-glucuronide.

Structure

MOL 3D MOL SDF PDB SMILES InChI

  Mrv1652304282207112D          

 33 36  0  0  1  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  8 14  2  0  0  0  0
 14 15  1  0  0  0  0
 11 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 10 19  2  0  0  0  0
 18 20  1  0  0  0  0
 16 21  1  0  0  0  0
 22 21  1  6  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 26 28  1  6  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 25 31  1  1  0  0  0
 24 32  1  6  0  0  0
 23 33  1  1  0  0  0
M  END

     RDKit          3D

 51 54  0  0  0  0  0  0  0  0999 V2000
   -3.8299   -0.6932   -3.2748 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8256   -0.7654   -2.5163 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0838   -0.6605   -3.0973 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6671   -0.9583   -1.0343 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.3419   -1.0265   -0.7260 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8545   -0.0346    0.1080 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4700   -0.0604    0.0545 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5699   -0.3352    1.0391 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8811   -0.6560    2.3339 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0794   -0.9225    3.2802 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2612   -1.2492    4.6016 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4015   -0.8632    2.9068 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7687   -0.5408    1.5996 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0201   -0.4869    1.2550 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4791   -0.1927    0.0495 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9292   -0.1722   -0.1843 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7231   -0.4738    0.9277 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0821   -0.4873    0.8365 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7075   -0.2062   -0.3456 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0906   -0.2295   -0.4005 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9332    0.0913   -1.4434 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5393    0.1071   -1.3575 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5287    0.0752   -0.9029 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8846    0.3917   -2.1835 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1721    0.0314   -0.5876 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3034    0.2780   -1.4653 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7806   -0.2849    0.6977 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4462    1.2776   -0.3818 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.7605    2.3735    0.1313 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8858    1.2793    0.1103 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.5813    2.3898   -0.3151 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5108   -0.0233   -0.2501 C   0  0  2  0  0  0  0  0  0  0  0  0
   -6.0695   -0.6938    0.8462 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1912    0.0799   -3.7897 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0858   -1.9962   -0.8606 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2301   -0.2785    1.1296 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9371   -0.7046    2.6379 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3480   -0.4700    5.2560 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1569   -1.0743    3.6573 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.2870   -0.7034    1.8856 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.6839   -0.7222    1.7065 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.6151    0.6253   -0.2029 H   0  0  0  0  0  0  0  0  0  0  0  0
    7.3852    0.3165   -2.3860 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9822    0.3411   -2.2262 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.2033    0.5845   -2.8824 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3766    1.3396   -1.4834 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4184    2.9962    0.5259 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8075    1.3140    1.2367 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3610    2.4942    0.3028 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4026    0.2279   -0.9007 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5394   -0.6483    1.6593 H   0  0  0  0  0  0  0  0  0  0  0  0
 31 30  1  0
 30 28  1  0
 28 29  1  0
 28  6  1  0
  6  7  1  0
  7  8  1  0
  8 27  1  0
 27 13  2  0
 13 14  1  0
 14 15  1  0
 15 23  2  0
 23 24  1  0
 23 25  1  0
 25 26  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 19 21  1  0
 21 22  2  0
 13 12  1  0
 12 10  2  0
 10 11  1  0
 10  9  1  0
  6  5  1  0
  5  4  1  0
  4 32  1  0
 32 33  1  0
  4  2  1  0
  2  3  1  0
  2  1  2  0
 32 30  1  0
  9  8  2  0
 25 27  1  0
 22 16  1  0
 31 49  1  0
 30 48  1  1
 28 46  1  6
 29 47  1  0
  6 36  1  1
 24 45  1  0
 17 40  1  0
 18 41  1  0
 20 42  1  0
 21 43  1  0
 22 44  1  0
 12 39  1  0
 11 38  1  0
  9 37  1  0
  4 35  1  6
 32 50  1  6
 33 51  1  0
  3 34  1  0
M  END

  Mrv1652304282207112D          

 33 36  0  0  1  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
  8 14  2  0  0  0  0
 14 15  1  0  0  0  0
 11 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 10 19  2  0  0  0  0
 18 20  1  0  0  0  0
 16 21  1  0  0  0  0
 22 21  1  6  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 26 28  1  6  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 25 31  1  1  0  0  0
 24 32  1  6  0  0  0
 23 33  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0060082

> <DATABASE_NAME>
NP-MRD

> <SMILES>
O[C@@H]1[C@@H](O)[C@H](OC2=C3C(OC(=C(O)C3=O)C3=CC=C(O)C=C3)=CC(O)=C2)O[C@@H]([C@H]1O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)18-15(26)13(24)12-10(31-18)5-9(23)6-11(12)32-21-17(28)14(25)16(27)19(33-21)20(29)30/h1-6,14,16-17,19,21-23,25-28H,(H,29,30)/t14-,16-,17+,19-,21+/m0/s1

> <INCHI_KEY>
AESGYRCGOWUBNU-JENRNSKYSA-N

> <FORMULA>
C21H18O12

> <MOLECULAR_WEIGHT>
462.363

> <EXACT_MASS>
462.07982602

> <JCHEM_ACCEPTOR_COUNT>
12

> <JCHEM_ATOM_COUNT>
51

> <JCHEM_AVERAGE_POLARIZABILITY>
43.092482353955035

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
7

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2S,3S,4S,5R,6S)-6-{[3,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-5-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

> <ALOGPS_LOGP>
0.77

> <JCHEM_LOGP>
-0.13792876966666665

> <ALOGPS_LOGS>
-2.43

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
6.333559584935662

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.6660937295769087

> <JCHEM_PKA_STRONGEST_BASIC>
-3.6868270616939993

> <JCHEM_POLAR_SURFACE_AREA>
203.43999999999997

> <JCHEM_REFRACTIVITY>
106.89309999999998

> <JCHEM_ROTATABLE_BOND_COUNT>
4

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
1.70e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2S,3S,4S,5R,6S)-6-{[3,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-5-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -4.001  -2.310   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0      -2.667  -3.080   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0      -2.667  -4.620   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0      -4.001  -5.390   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0      -5.335  -4.620   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -5.335  -3.080   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0      -6.668  -5.390   0.000  0.00  0.00           O+0
HETATM    8  C   UNK     0      -1.334  -2.310   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0       0.000  -3.080   0.000  0.00  0.00           O+0
HETATM   10  C   UNK     0       1.334  -2.310   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       0.000   1.540   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0      -1.334  -0.770   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      -2.667   0.000   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       2.667  -0.000   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.001  -2.310   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       2.667  -3.080   0.000  0.00  0.00           C+0
HETATM   20  O   UNK     0       5.335  -3.080   0.000  0.00  0.00           O+0
HETATM   21  O   UNK     0       2.667   1.540   0.000  0.00  0.00           O+0
HETATM   22  C   UNK     0       4.001   2.310   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       6.668   2.310   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.668   3.850   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0       5.335   4.620   0.000  0.00  0.00           C+0
HETATM   27  O   UNK     0       4.001   3.850   0.000  0.00  0.00           O+0
HETATM   28  C   UNK     0       5.335   6.160   0.000  0.00  0.00           C+0
HETATM   29  O   UNK     0       6.668   6.930   0.000  0.00  0.00           O+0
HETATM   30  O   UNK     0       4.001   6.930   0.000  0.00  0.00           O+0
HETATM   31  O   UNK     0       8.002   4.620   0.000  0.00  0.00           O+0
HETATM   32  O   UNK     0       8.002   1.540   0.000  0.00  0.00           O+0
HETATM   33  O   UNK     0       5.335  -0.000   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3    8                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5                                                       
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5                                                            
CONECT    8    2    9   14                                                  
CONECT    9    8   10                                                       
CONECT   10    9   11   19                                                  
CONECT   11   10   12   16                                                  
CONECT   12   11   13   14                                                  
CONECT   13   12                                                            
CONECT   14   12    8   15                                                  
CONECT   15   14                                                            
CONECT   16   11   17   21                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19   20                                                  
CONECT   19   18   10                                                       
CONECT   20   18                                                            
CONECT   21   16   22                                                       
CONECT   22   21   23   27                                                  
CONECT   23   22   24   33                                                  
CONECT   24   23   25   32                                                  
CONECT   25   24   26   31                                                  
CONECT   26   25   27   28                                                  
CONECT   27   26   22                                                       
CONECT   28   26   29   30                                                  
CONECT   29   28                                                            
CONECT   30   28                                                            
CONECT   31   25                                                            
CONECT   32   24                                                            
CONECT   33   23                                                            
MASTER        0    0    0    0    0    0    0    0   33    0   72    0
END

View in JSmol

Synonyms

Value	Source
Kaempferol 5-glucuronide	ChEBI
Kaempferol 5-O-beta-D-glucopyranosiduronic acid	ChEBI
Kaempferol 5-O-beta-D-glucoronopyranoside	ChEBI
Kaempferol 5-O-b-D-glucopyranosiduronate	Generator
Kaempferol 5-O-b-D-glucopyranosiduronic acid	Generator
Kaempferol 5-O-beta-D-glucopyranosiduronate	Generator
Kaempferol 5-O-β-D-glucopyranosiduronate	Generator
Kaempferol 5-O-β-D-glucopyranosiduronic acid	Generator
Kaempferol 5-O-b-D-glucoronopyranoside	Generator
Kaempferol 5-O-β-D-glucoronopyranoside	Generator

Chemical Formula

C₂₁H₁₈O₁₂

Average Mass

462.3630 Da

Monoisotopic Mass

462.07983 Da

IUPAC Name

(2S,3S,4S,5R,6S)-6-{[3,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-5-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

Traditional Name

(2S,3S,4S,5R,6S)-6-{[3,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-5-yl]oxy}-3,4,5-trihydroxyoxane-2-carboxylic acid

CAS Registry Number

Not Available

SMILES

O[C@@H]1[C@@H](O)[C@H](OC2=C3C(OC(=C(O)C3=O)C3=CC=C(O)C=C3)=CC(O)=C2)O[C@@H]([C@H]1O)C(O)=O

InChI Identifier

InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)18-15(26)13(24)12-10(31-18)5-9(23)6-11(12)32-21-17(28)14(25)16(27)19(33-21)20(29)30/h1-6,14,16-17,19,21-23,25-28H,(H,29,30)/t14-,16-,17+,19-,21+/m0/s1

InChI Key

AESGYRCGOWUBNU-JENRNSKYSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Chrysanthemum vulgare	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as flavonoid o-glucuronides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to glucuronic acid.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Flavonoids

Sub Class

Flavonoid glycosides

Direct Parent

Flavonoid O-glucuronides

Alternative Parents

Substituents

Flavonoid-5-o-glucuronide
3-hydroxyflavone
3-hydroxyflavonoid
4'-hydroxyflavonoid
7-hydroxyflavonoid
Flavone
Hydroxyflavonoid
Phenolic glycoside
1-o-glucuronide
O-glucuronide
Glucuronic acid or derivatives
Hexose monosaccharide
O-glycosyl compound
Chromone
Glycosyl compound
Benzopyran
1-benzopyran
1-hydroxy-2-unsubstituted benzenoid
Beta-hydroxy acid
Pyranone
Phenol
Monocyclic benzene moiety
Benzenoid
Pyran
Oxane
Hydroxy acid
Monosaccharide
Heteroaromatic compound
Vinylogous ester
Secondary alcohol
Monocarboxylic acid or derivatives
Acetal
Polyol
Oxacycle
Carboxylic acid derivative
Carboxylic acid
Organoheterocyclic compound
Hydrocarbon derivative
Alcohol
Carbonyl group
Organooxygen compound
Organic oxygen compound
Organic oxide
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

trihydroxyflavone (CHEBI:75723 )
kaempferol O-glucuronide (CHEBI:75723 )

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.77	ALOGPS
logP	-0.14	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	2.67	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	12	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	203.44 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	106.89 m³·mol⁻¹	ChemAxon
Polarizability	43.09 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

30785677

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

57330529

PDB ID

Not Available

ChEBI ID

75723

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for 3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid (NP0060082)

MOL for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

3D MOL for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

3D SDF for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

3D-SDF for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

PDB for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

3D PDB for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

SMILES for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

INCHI for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

Structure for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)

3D Structure for NP0060082 (3,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-5-yl beta-D-glucopyranosiduronic acid)