NP-MRD: Showing NP-Card for Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one (NP0059536)

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Record Information

Version

2.0

Created at

2022-04-28 04:45:29 UTC

Updated at

2022-04-28 04:45:29 UTC

NP-MRD ID

NP0059536

Secondary Accession Numbers

None

Natural Product Identification

Common Name

Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one

Description

(1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0²,⁶.0¹²,¹⁴]Tetradecan-4-one belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton. Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one is found in Artemisia fragrans. Based on a literature review very few articles have been published on (1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0²,⁶.0¹²,¹⁴]Tetradecan-4-one.

Structure

MOL SDF PDB SMILES InChI


  Mrv1652304282206452D          

 19 22  0  0  1  0            999 V2000
    4.2246   -0.2893    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5605    0.2003    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8045   -0.1301    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7126   -0.9500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.3767   -1.4395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1327   -1.1091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9566   -1.2803    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2926   -0.7908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3845    0.0291    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.1404    0.3594    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4764    0.8490    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6300    1.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8647   -2.1002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6207   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8209    0.9831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6458    0.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1354    1.6415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8953    0.1910    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.6782   -0.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  6  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  3 10  1  1  0  0  0
 10 11  1  0  0  0  0
  9 11  1  6  0  0  0
 10 12  1  6  0  0  0
  7 13  1  1  0  0  0
  4 14  1  6  0  0  0
  2 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
  1 18  1  0  0  0  0
 18 19  1  1  0  0  0
M  END
> <DATABASE_ID>
NP0059536

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C[C@H]1[C@@H]2CC[C@@]3(C)[C@@H](O)C[C@@H]4O[C@@]4(C)[C@H]3[C@@H]2OC1=O

> <INCHI_IDENTIFIER>
InChI=1S/C15H22O4/c1-7-8-4-5-14(2)9(16)6-10-15(3,19-10)12(14)11(8)18-13(7)17/h7-12,16H,4-6H2,1-3H3/t7-,8-,9-,10-,11+,12-,14-,15+/m0/s1

> <INCHI_KEY>
KSSFMQIBDVMDIX-NEIHSCRXSA-N

> <FORMULA>
C15H22O4

> <MOLECULAR_WEIGHT>
266.337

> <EXACT_MASS>
266.151809188

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
41

> <JCHEM_AVERAGE_POLARIZABILITY>
28.173912973269125

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0^{2,6}.0^{12,14}]tetradecan-4-one

> <ALOGPS_LOGP>
1.43

> <JCHEM_LOGP>
1.0735108229999997

> <ALOGPS_LOGS>
-2.06

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
14.604110594441185

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9719620259914254

> <JCHEM_POLAR_SURFACE_AREA>
59.059999999999995

> <JCHEM_REFRACTIVITY>
67.52310000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.31e+00 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0^{2,6}.0^{12,14}]tetradecan-4-one

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       7.886  -0.540   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       6.646   0.374   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       5.235  -0.243   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       5.064  -1.773   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       6.303  -2.687   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       7.714  -2.070   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.652  -2.390   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       2.413  -1.476   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       2.584   0.054   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       3.996   0.671   0.000  0.00  0.00           C+0
HETATM   11  O   UNK     0       2.756   1.585   0.000  0.00  0.00           O+0
HETATM   12  C   UNK     0       4.909   1.911   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0       3.481  -3.920   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       4.892  -3.304   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0       7.132   1.835   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0       8.672   1.824   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       9.586   3.064   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       9.138   0.357   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      10.599  -0.129   0.000  0.00  0.00           C+0
CONECT    1    2    6   18                                                  
CONECT    2    1    3   15                                                  
CONECT    3    2    4   10                                                  
CONECT    4    3    5    7   14                                             
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    4    8   13                                                  
CONECT    8    7    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9    3   11   12                                             
CONECT   11   10    9                                                       
CONECT   12   10                                                            
CONECT   13    7                                                            
CONECT   14    4                                                            
CONECT   15    2   16                                                       
CONECT   16   15   17   18                                                  
CONECT   17   16                                                            
CONECT   18   16    1   19                                                  
CONECT   19   18                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   44    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₂₂O₄

Average Mass

266.3370 Da

Monoisotopic Mass

266.15181 Da

IUPAC Name

(1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0^{2,6}.0^{12,14}]tetradecan-4-one

Traditional Name

(1R,2R,5S,6S,9R,10S,12S,14S)-10-hydroxy-5,9,14-trimethyl-3,13-dioxatetracyclo[7.5.0.0^{2,6}.0^{12,14}]tetradecan-4-one

CAS Registry Number

Not Available

SMILES

C[C@H]1[C@@H]2CC[C@@]3(C)[C@@H](O)C[C@@H]4O[C@@]4(C)[C@H]3[C@@H]2OC1=O

InChI Identifier

InChI=1S/C15H22O4/c1-7-8-4-5-14(2)9(16)6-10-15(3,19-10)12(14)11(8)18-13(7)17/h7-12,16H,4-6H2,1-3H3/t7-,8-,9-,10-,11+,12-,14-,15+/m0/s1

InChI Key

KSSFMQIBDVMDIX-NEIHSCRXSA-N

Experimental Spectra

Not Available

Predicted Spectra

Not Available

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Artemisia fragrans	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as eudesmanolides, secoeudesmanolides, and derivatives. These are terpenoids with a structure based on the eudesmanolide (a 3,5a,9-trimethyl-naphtho[1,2-b]furan-2-one derivative) or secoeudesmanolide (a 3,6-dimethyl-5-(pentan-2-yl)-1-benzofuran-2-one derivative) skeleton.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Terpene lactones

Direct Parent

Eudesmanolides, secoeudesmanolides, and derivatives

Alternative Parents

Substituents

Eudesmanolide
Sesquiterpenoid
Naphthofuran
Oxepane
Gamma butyrolactone
Cyclic alcohol
Tetrahydrofuran
Carboxylic acid ester
Lactone
Secondary alcohol
Carboxylic acid derivative
Dialkyl ether
Oxirane
Ether
Oxacycle
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Carbonyl group
Alcohol
Hydrocarbon derivative
Organic oxygen compound
Organic oxide
Organooxygen compound
Aliphatic heteropolycyclic compound

Molecular Framework

Aliphatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.43	ALOGPS
logP	1.07	ChemAxon
logS	-2.1	ALOGPS
pKa (Strongest Acidic)	14.6	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	59.06 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	67.52 m³·mol⁻¹	ChemAxon
Polarizability	28.17 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

162931842

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one (NP0059536)

MOL for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

3D MOL for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

3D SDF for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

3D-SDF for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

PDB for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

3D PDB for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

SMILES for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

INCHI for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

Structure for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)

3D Structure for NP0059536 (Decahydro-3-hydroxy-3a,6,8c-trimethyloxireno[7,8]naphtho[1,2-b]furan-7(2H)-one)