NP-MRD: Showing NP-Card for N-Demethylchanoclavine-II (NP0057937)

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Record Information

Version

2.0

Created at

2022-04-28 03:17:41 UTC

Updated at

2022-04-28 03:17:41 UTC

NP-MRD ID

NP0057937

Secondary Accession Numbers

None

Natural Product Identification

Common Name

N-Demethylchanoclavine-II

Description

Demethylchanoclavine belongs to the class of organic compounds known as 3-alkylindoles. 3-Alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position. N-Demethylchanoclavine-II is found in Claviceps sp. SD58. Based on a literature review very few articles have been published on Demethylchanoclavine.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 36 38  0  0  0  0  0  0  0  0999 V2000
    1.9758    1.6454    0.4900 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2344    0.3852   -0.2063 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4734   -0.6616    0.0163 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3289   -0.8135    0.8957 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.6917    0.2406    0.9385 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7315    1.1899    1.9343 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7395    2.1611    1.8957 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1773    0.8702 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6569    1.2276   -0.1260 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3817    0.9294   -1.2125 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8478   -0.1816   -1.8210 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7545   -0.5923   -1.0931 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6480    0.2952   -0.0427 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7349   -1.6869   -1.1271 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4598   -2.0455    0.3402 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.2945   -3.2439    0.4841 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3889    0.2992   -1.1892 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5912    0.5739   -0.5446 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0322    1.5128    1.5666 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8509    2.3417    0.2589 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.1188    2.1582    0.0660 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8002   -1.5539   -0.5706 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7095   -1.0872    1.9057 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0138    1.2050    2.7417 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7442    2.8877    2.6858 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4645    2.9277    0.8485 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2165    1.4629   -1.5354 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1981   -0.6662   -2.7067 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0909   -2.5594   -1.6972 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1401   -1.2522   -1.6333 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4283   -2.0204    0.8548 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1329   -3.6257    1.4431 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0489   -3.9427   -0.1920 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2254    1.1237   -1.9157 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.4016   -0.6670   -1.7098 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8474   -0.1444    0.0960 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2 17  1  0
 17 18  1  0
  2  3  2  0
  3  4  1  0
  4 15  1  0
 15 16  1  0
 15 14  1  0
 14 12  1  0
 12 11  2  0
 11 10  1  0
 10  9  1  0
  9  8  1  0
  8  7  2  0
  7  6  1  0
  6  5  2  0
  5 13  1  0
  5  4  1  0
 13 12  1  0
 13  9  2  0
  1 19  1  0
  1 20  1  0
  1 21  1  0
 17 34  1  0
 17 35  1  0
 18 36  1  0
  3 22  1  0
  4 23  1  1
 15 31  1  1
 16 32  1  0
 16 33  1  0
 14 29  1  0
 14 30  1  0
 11 28  1  0
 10 27  1  0
  8 26  1  0
  7 25  1  0
  6 24  1  0
M  END


  Mrv1652304282205172D          

 18 20  0  0  1  0            999 V2000
   -0.4959   -1.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2578   -1.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9252   -1.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8390   -0.3220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0853    0.0135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5821   -0.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7651    0.0135    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4326   -0.4714    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.3463   -1.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5926   -1.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3377   -2.4121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5127   -2.4121    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1862   -0.1359    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8805    0.8304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6457    1.1389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7611    1.9558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1114    2.4642    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2954    0.6305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  2 12  1  0  0  0  0
  8 13  1  6  0  0  0
  7 14  1  6  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
M  END
> <DATABASE_ID>
NP0057937

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C(CO)=C/[C@@H]1[C@H](N)CC2=CNC3=CC=CC1=C23

> <INCHI_IDENTIFIER>
InChI=1S/C15H18N2O/c1-9(8-18)5-12-11-3-2-4-14-15(11)10(7-17-14)6-13(12)16/h2-5,7,12-13,17-18H,6,8,16H2,1H3/b9-5+/t12-,13+/m0/s1

> <INCHI_KEY>
QPYLOULWBAJLGK-ZUYHJEFZSA-N

> <FORMULA>
C15H18N2O

> <MOLECULAR_WEIGHT>
242.322

> <EXACT_MASS>
242.141913208

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
36

> <JCHEM_AVERAGE_POLARIZABILITY>
27.52709363006855

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(2E)-3-[(6R,7S)-6-amino-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraen-7-yl]-2-methylprop-2-en-1-ol

> <ALOGPS_LOGP>
1.21

> <JCHEM_LOGP>
1.4408716410000002

> <ALOGPS_LOGS>
-3.21

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA>
17.057569196349647

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.159213122323212

> <JCHEM_PKA_STRONGEST_BASIC>
9.837120489341451

> <JCHEM_POLAR_SURFACE_AREA>
62.040000000000006

> <JCHEM_REFRACTIVITY>
74.19959999999999

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.50e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(2E)-3-[(6R,7S)-6-amino-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraen-7-yl]-2-methylprop-2-en-1-ol

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0      -0.926  -2.412   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.481  -3.038   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.727  -2.133   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       1.566  -0.601   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.159   0.025   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0      -1.087  -0.880   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       3.295   0.025   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       4.541  -0.880   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0       4.380  -2.412   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       2.973  -3.038   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       2.497  -4.503   0.000  0.00  0.00           C+0
HETATM   12  N   UNK     0       0.957  -4.503   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0       5.948  -0.254   0.000  0.00  0.00           N+0
HETATM   14  C   UNK     0       3.510   1.550   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       4.939   2.126   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       5.154   3.651   0.000  0.00  0.00           C+0
HETATM   17  O   UNK     0       3.941   4.600   0.000  0.00  0.00           O+0
HETATM   18  C   UNK     0       6.151   1.177   0.000  0.00  0.00           C+0
CONECT    1    2    6                                                       
CONECT    2    1    3   12                                                  
CONECT    3    2    4   10                                                  
CONECT    4    3    5    7                                                  
CONECT    5    4    6                                                       
CONECT    6    5    1                                                       
CONECT    7    4    8   14                                                  
CONECT    8    7    9   13                                                  
CONECT    9    8   10                                                       
CONECT   10    9    3   11                                                  
CONECT   11   10   12                                                       
CONECT   12   11    2                                                       
CONECT   13    8                                                            
CONECT   14    7   15                                                       
CONECT   15   14   16   18                                                  
CONECT   16   15   17                                                       
CONECT   17   16                                                            
CONECT   18   15                                                            
MASTER        0    0    0    0    0    0    0    0   18    0   40    0
END

View in JSmol

Synonyms

Not Available

Chemical Formula

C₁₅H₁₈N₂O

Average Mass

242.3220 Da

Monoisotopic Mass

242.14191 Da

IUPAC Name

(2E)-3-[(6R,7S)-6-amino-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraen-7-yl]-2-methylprop-2-en-1-ol

Traditional Name

(2E)-3-[(6R,7S)-6-amino-2-azatricyclo[6.3.1.0^{4,12}]dodeca-1(11),3,8(12),9-tetraen-7-yl]-2-methylprop-2-en-1-ol

CAS Registry Number

Not Available

SMILES

C\C(CO)=C/[C@@H]1[C@H](N)CC2=CNC3=CC=CC1=C23

InChI Identifier

InChI=1S/C15H18N2O/c1-9(8-18)5-12-11-3-2-4-14-15(11)10(7-17-14)6-13(12)16/h2-5,7,12-13,17-18H,6,8,16H2,1H3/b9-5+/t12-,13+/m0/s1

InChI Key

QPYLOULWBAJLGK-ZUYHJEFZSA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Claviceps sp. SD58	Fungi	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 3-alkylindoles. 3-Alkylindoles are compounds containing an indole moiety that carries an alkyl chain at the 3-position.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Indoles

Direct Parent

3-alkylindoles

Alternative Parents

Substituents

3-alkylindole
Isoindole or derivatives
Aralkylamine
Benzenoid
Pyrrole
Heteroaromatic compound
Azacycle
Hydrocarbon derivative
Organic oxygen compound
Primary amine
Primary alcohol
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic nitrogen compound
Amine
Alcohol
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	1.21	ALOGPS
logP	1.44	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	15.16	ChemAxon
pKa (Strongest Basic)	9.84	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	62.04 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	74.2 m³·mol⁻¹	ChemAxon
Polarizability	27.53 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00011214

Chemspider ID

4947526

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

6443543

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for N-Demethylchanoclavine-II (NP0057937)

MOL for NP0057937 (N-Demethylchanoclavine-II)

3D MOL for NP0057937 (N-Demethylchanoclavine-II)

3D SDF for NP0057937 (N-Demethylchanoclavine-II)

3D-SDF for NP0057937 (N-Demethylchanoclavine-II)

PDB for NP0057937 (N-Demethylchanoclavine-II)

3D PDB for NP0057937 (N-Demethylchanoclavine-II)

SMILES for NP0057937 (N-Demethylchanoclavine-II)

INCHI for NP0057937 (N-Demethylchanoclavine-II)

Structure for NP0057937 (N-Demethylchanoclavine-II)

3D Structure for NP0057937 (N-Demethylchanoclavine-II)