NP-MRD: Showing NP-Card for 1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene (NP0057797)

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Record Information

Version

1.0

Created at

2022-04-28 03:11:08 UTC

Updated at

2022-04-28 03:11:08 UTC

NP-MRD ID

NP0057797

Secondary Accession Numbers

None

Natural Product Identification

Common Name

1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene

Description

(1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. 1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene is found in Ligusticum ferulaceum and Ligusticum seguieri. Based on a literature review very few articles have been published on (1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate.

Structure

MOL 3D MOL SDF PDB SMILES InChI

     RDKit          3D

 39 39  0  0  0  0  0  0  0  0999 V2000
   -1.3549   -1.0444   -2.5096 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9353   -0.2145   -1.3539 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1111    0.3123   -1.5298 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7423    1.1119   -0.4999 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0805    1.2875    0.6232 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7762    2.1095    1.6322 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2226    2.3240    2.7200 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7467    0.7491    0.9266 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.8796    1.9958    1.2222 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8263   -0.0163    2.2556 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -0.0611   -0.1386 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.1919    0.3424   -0.4378 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2137   -0.5512   -0.1800 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9522   -1.6814    0.3033 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6195   -0.1953   -0.4661 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6214   -1.0112   -0.2379 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3849   -2.3600    0.3309 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0383   -0.6328   -0.5338 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1396    0.6404   -1.0580 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0506   -1.8525   -2.7731 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1960   -0.3231   -3.3413 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3760   -1.4460   -2.2282 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6142    0.1323   -2.4872 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7223    1.5301   -0.6894 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7445    2.5086    1.4150 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9470    2.1675    2.3087 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.1847    1.7845    0.9888 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2744    2.8792    0.7083 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5986    0.7015    3.0554 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8677   -0.3834    2.4094 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0750   -0.8182    2.2585 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0814   -1.1299    0.2862 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8568    0.7756   -0.8824 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7556   -2.9654   -0.3624 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.9335   -2.2665    1.3456 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.3571   -2.9300    0.3951 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6730   -0.7503    0.3747 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.4443   -1.3426   -1.2939 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.0093    0.6237   -2.0346 H   0  0  0  0  0  0  0  0  0  0  0  0
 17 16  1  0
 16 18  1  0
 18 19  1  0
 16 15  2  0
 15 13  1  0
 13 14  2  0
 13 12  1  0
 12 11  1  0
 11  2  1  0
  2  1  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  5  6  1  0
  6  7  2  0
  5  8  1  0
  8  9  1  1
  8 10  1  0
  8 11  1  0
 17 34  1  0
 17 35  1  0
 17 36  1  0
 18 37  1  0
 18 38  1  0
 19 39  1  0
 15 33  1  0
 11 32  1  1
  1 20  1  0
  1 21  1  0
  1 22  1  0
  3 23  1  0
  4 24  1  0
  6 25  1  0
  9 26  1  0
  9 27  1  0
  9 28  1  0
 10 29  1  0
 10 30  1  0
 10 31  1  0
M  END


  Mrv1652304282205112D          

 19 19  0  0  1  0            999 V2000
    0.0000   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3272    1.9659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1018    1.9659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  1  6  1  0  0  0  0
  5  7  1  0  0  0  0
  4  8  1  6  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
  3 16  1  0  0  0  0
  3 17  1  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
> <DATABASE_ID>
NP0057797

> <DATABASE_NAME>
NP-MRD

> <SMILES>
C\C(CO)=C/C(=O)O[C@@H]1C(C)=CC=C(C=O)C1(C)C

> <INCHI_IDENTIFIER>
InChI=1S/C15H20O4/c1-10(8-16)7-13(18)19-14-11(2)5-6-12(9-17)15(14,3)4/h5-7,9,14,16H,8H2,1-4H3/b10-7+/t14-/m1/s1

> <INCHI_KEY>
OITVWQNYQGPKEG-DNGMOHDESA-N

> <FORMULA>
C15H20O4

> <MOLECULAR_WEIGHT>
264.321

> <EXACT_MASS>
264.136159124

> <JCHEM_ACCEPTOR_COUNT>
3

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
28.324541150753507

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
(1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate

> <ALOGPS_LOGP>
2.32

> <JCHEM_LOGP>
1.7555070363333336

> <ALOGPS_LOGS>
-3.20

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.099061905868222

> <JCHEM_PKA_STRONGEST_BASIC>
-2.75547032237324

> <JCHEM_POLAR_SURFACE_AREA>
63.6

> <JCHEM_REFRACTIVITY>
75.1096

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.67e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
(1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 28-APR-22   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   28-APR-22         0                                  
HETATM    1  C   UNK     0       0.000  -0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.000   1.540   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       1.334   2.310   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       2.667   1.540   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.667   0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.334  -0.770   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0       4.001  -0.770   0.000  0.00  0.00           C+0
HETATM    8  O   UNK     0       4.001   2.310   0.000  0.00  0.00           O+0
HETATM    9  C   UNK     0       5.335   1.540   0.000  0.00  0.00           C+0
HETATM   10  O   UNK     0       5.335  -0.000   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       6.668   2.310   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0       8.002   1.540   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       9.336   2.310   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0      10.669   1.540   0.000  0.00  0.00           O+0
HETATM   15  C   UNK     0       8.002  -0.000   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       0.611   3.670   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       2.057   3.670   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      -1.334   2.310   0.000  0.00  0.00           C+0
HETATM   19  O   UNK     0      -2.667   1.540   0.000  0.00  0.00           O+0
CONECT    1    2    6                                                       
CONECT    2    1    3   18                                                  
CONECT    3    2    4   16   17                                             
CONECT    4    3    5    8                                                  
CONECT    5    4    6    7                                                  
CONECT    6    5    1                                                       
CONECT    7    5                                                            
CONECT    8    4    9                                                       
CONECT    9    8   10   11                                                  
CONECT   10    9                                                            
CONECT   11    9   12                                                       
CONECT   12   11   13   15                                                  
CONECT   13   12   14                                                       
CONECT   14   13                                                            
CONECT   15   12                                                            
CONECT   16    3                                                            
CONECT   17    3                                                            
CONECT   18    2   19                                                       
CONECT   19   18                                                            
MASTER        0    0    0    0    0    0    0    0   19    0   38    0
END

View in JSmol

Synonyms

Value	Source
(1R)-5-Formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoic acid	Generator

Chemical Formula

C₁₅H₂₀O₄

Average Mass

264.3210 Da

Monoisotopic Mass

264.13616 Da

IUPAC Name

(1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate

Traditional Name

(1R)-5-formyl-2,6,6-trimethylcyclohexa-2,4-dien-1-yl (2E)-4-hydroxy-3-methylbut-2-enoate

CAS Registry Number

Not Available

SMILES

C\C(CO)=C/C(=O)O[C@@H]1C(C)=CC=C(C=O)C1(C)C

InChI Identifier

InChI=1S/C15H20O4/c1-10(8-16)7-13(18)19-14-11(2)5-6-12(9-17)15(14,3)4/h5-7,9,14,16H,8H2,1-4H3/b10-7+/t14-/m1/s1

InChI Key

OITVWQNYQGPKEG-DNGMOHDESA-N

Experimental Spectra

Not Available

Predicted Spectra

Spectrum Type	Description	Depositor ID	Depositor Organization	Depositor	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 25 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 252 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 50 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 75 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 101 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 126 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 151 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 176 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 201 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 226 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Wishart Lab	Wishart Lab	David Wishart	2021-06-20	View Spectrum

Chemical Shift Submissions

Not Available

Species

Species of Origin

Species Name	Source	Reference
Ligusticum ferulaceum	LOTUS Database	35616633
Ligusticum seguieri	Plant	KNApSAcK

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acid esters

Direct Parent

Fatty acid esters

Alternative Parents

Substituents

Fatty acid ester
Alpha,beta-unsaturated carboxylic ester
Enoate ester
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Carbonyl group
Aldehyde
Alcohol
Aliphatic homomonocyclic compound

Molecular Framework

Aliphatic homomonocyclic compounds

External Descriptors

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.32	ALOGPS
logP	1.76	ChemAxon
logS	-3.2	ALOGPS
pKa (Strongest Acidic)	15.1	ChemAxon
pKa (Strongest Basic)	-2.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	63.6 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	75.11 m³·mol⁻¹	ChemAxon
Polarizability	28.32 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

163030072

PDB ID

Not Available

ChEBI ID

Not Available

Good Scents ID

Not Available

References

General References

Not Available

Showing NP-Card for 1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene (NP0057797)

MOL for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

3D MOL for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

3D SDF for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

3D-SDF for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

PDB for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

3D PDB for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

SMILES for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

INCHI for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

Structure for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)

3D Structure for NP0057797 (1,1,5-Trimethyl-2-formyl-6-((E)-3-hydroxymethyl-2-butenoyloxy)-2,4-cyclohexadiene)